Discovery of novel limonin derivatives as potent anti-inflammatory and analgesic agents.

abstract：:Dendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book "Shen Nong's Materia Medica". It's well known that bioactivities are usually related to the ingredients' basis. Based on the previous research, Dend...

journal_title：Chinese journal of natural medicines

authors： Yue H,Zeng H,Ding K

更新日期：2020-01-01 00:00:00

abstract：:In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectro...

journal_title：Chinese journal of natural medicines

authors： Cao D,Wang LQ,Han XM,Guan HR,Lei M,Wei YH,Cheng L,Yang PM,Sun ZL,Gao W,Dai JK

更新日期：2019-02-01 00:00:00

abstract：:In the present report, we review the technical guidelines and principles on impurity research and control for antibiotics established by various agencies, including the International Conference of Harmonization (ICH), the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the China Food and...

journal_title：Chinese journal of natural medicines

authors： Jiang Y,Xia JP,Yang JH,Zhang ZF,Hu CQ,Zhang ZR

更新日期：2015-07-01 00:00:00

abstract：:The present study was designed to develop and evaluate glycyrrhetinic acid-graft-hyaluronic acid (HGA) conjugate for intravenous paclitaxel (PTX) delivery. Lyophilized PTX-loaded self-assembled HGA nanoparticles (PTX/HGAs) were prepared and characterized by dynamic light scattering measurements. Hemolysis test, intrav...

journal_title：Chinese journal of natural medicines

authors： Zhang L,Zhou JP,Yao J

更新日期：2015-12-01 00:00:00

abstract：:Gut microbiota dysbiosis is a risk factor for colorectal cancer (CRC) in inflammatory bowel disease (IBD). In this study, the effects of Panax notoginseng saponins (PNS) on colitis-associated CRC progression were evaluated on an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. In vivo, PNS significantly re...

journal_title：Chinese journal of natural medicines

authors： Chen L,Chen MY,Shao L,Zhang W,Rao T,Zhou HH,Huang WH

更新日期：2020-07-01 00:00:00

abstract：AIM:The most important side effect of methotrexate (MTX) is mucositis. The purpose of this study was to evaluate the effect of turmeric extract on intestinal damage and oxidative stress in rats receiving methotrexate. METHODS:Experiments were performed on male Wistar albino rats divided into six groups. First group re...

journal_title：Chinese journal of natural medicines

authors： Moghadam AR,Mohajeri D,Namvaran-Abbas-Abad A,Manafi H,Shahi D,Mazani M

更新日期：2013-09-01 00:00:00

abstract：:Modified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal formulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present...

journal_title：Chinese journal of natural medicines

authors： Zhao G,Zhuo YZ,Cui LH,Li CX,Chen SY,Li D,Liu JH,Li DH,Cui NQ,Zhang SK

更新日期：2019-05-20 00:00:00

abstract：:Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol ...

journal_title：Chinese journal of natural medicines

authors： Xu XY,Wang DY,Ku CF,Zhao Y,Cheng H,Liu KL,Rong LJ,Zhang HJ

更新日期：2019-12-01 00:00:00

abstract：:Considering that high levels of nitric oxide (NO) exert anti-cancer effect and the derivatives of oleanolic acid (OA) have shown potent anti-cancer activity, new O2-vinyl diazeniumdiolate-based NO releasing derivatives (5a-l, 11a-l) of OA were designed, synthesized, and biologically evaluated in the present study. The...

journal_title：Chinese journal of natural medicines

authors： Zou Y,Yan C,Liu JC,Huang ZJ,Xu JY,Zhou JP,Zhang HB,Zhang YH

更新日期：2017-12-01 00:00:00

abstract：:The present study was designed to synthesize 2-Cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide (1), a lactone derivative of oleanolic acid (OA) and evaluate its anti-inflammatory activity. Compound 1 significantly diminished nitric oxide (NO) production and down-regulated the mRNA expression of iNOS, COX-2, ...

journal_title：Chinese journal of natural medicines

authors： Mou Y,Jian YL,Chen T,Huang ZJ,Qiao YX,Peng SX,Zhang DY,Ji H,Zhang YH

更新日期：2017-05-01 00:00:00

abstract：:To investigate the non-alkaloidal chemical constituents of the stems and leaves of Melodinus suaveolens and their antibacterial activities. Compounds were isolated and purified by repeated silica gel, Sephadex LH-20, RP18, and preparative HPLC. Their structures were elucidated by comparison with published spectroscopi...

journal_title：Chinese journal of natural medicines

authors： Li JL,Lunga PK,Zhao YL,Qin XJ,Yang XW,Liu YP,Luo XD

更新日期：2015-04-01 00:00:00

abstract：AIM:To investigate the active chloroform fraction of the ethanol extract of Ipomoea carnea flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats. METHOD:Except for the control group, all of the rats were sensitized with intranasal application of 5 μL of 10% toluene diisocyanate (...

journal_title：Chinese journal of natural medicines

authors： Smita J,Patil UK

更新日期：2014-03-01 00:00:00

abstract：:Atherosclerosis (AS) is a chronic inflammatory disease, the main causes of which include abnormal lipid metabolism, endothelial injury, physical and chemical injury, hemodynamic injury, genetic factors and so on. These causes can lead to inflammatory injury of blood vessels and local dysfunction. Bunao-Fuyuan decoctio...

journal_title：Chinese journal of natural medicines

authors： Guo HY,Lu ZY,Zhao B,Jiang WW,Xiong YH,Wang K

更新日期：2021-01-01 00:00:00

abstract：:Traditional Chinese medicines (TCMs) are in great demand all over the world, especially in the developing world, for primary health care due to their superior merits such as low cost, minimal side effects, better cultural acceptability, and compatibility with humans. However, Chinese medicines consist of several herbs...

journal_title：Chinese journal of natural medicines

authors： Song XY,Li YD,Shi YP,Jin L,Chen J

更新日期：2013-11-01 00:00:00

abstract：:Sophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applicati...

journal_title：Chinese journal of natural medicines

authors： Ding PL,He CM,Cheng ZH,Chen DF

更新日期：2018-12-01 00:00:00

abstract：:Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of hum...

journal_title：Chinese journal of natural medicines

authors： Chen L,Wang WL,Song TF,Xie X,Ye XW,Liang Y,Huang HC,Yan SL,Lian XY,Zhang ZZ

更新日期：2017-08-01 00:00:00

abstract：AIM:To study the chemical constituents of the aerial parts of Cirsium setosum (Willd.) MB.. METHODS:The chemical constituents were isolated and purified by various chromatographic techniques. Their structures were determined on the basis of physical properties and spectroscopic data. RESULTS:A new megastigmane glycos...

journal_title：Chinese journal of natural medicines

authors： Jiang H,Meng YH,Yang L,Wang QH,Yang BY,Liu C,Kuang HX

更新日期：2013-09-01 00:00:00

abstract：:Radix Adenophorae, a traditional Chinese medicine, has been reported to have a variety of biological functions. In the present study, a polysaccharide component, Radix Adenophorae Polysaccharide (RAPS), was purified from Radix Adenophorae by decoloring with ADS-7 macroporous adsorption resin, DEAE-52 cellulose ion-exc...

journal_title：Chinese journal of natural medicines

authors： Li JW,Liu Y,Li BH,Wang YY,Wang H,Zhou CL

更新日期：2016-05-01 00:00:00

abstract：:In this review, we provide a comprehensive overview on the registration of proprietary Chinese medicines (PCMs) in China over the past century by examining published literature and historical data. We will examine this evolving administrative practice for PCMs registration in China, which is divided to the following f...

journal_title：Chinese journal of natural medicines

authors： Yuan L,Wu ZA,Shao ML

更新日期：2017-01-01 00:00:00

abstract：AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill. METHOD:Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compound...

journal_title：Chinese journal of natural medicines

authors： Fan QY,Yin X,Li ZH,Li Y,Liu JK,Feng T,Zhao BH

更新日期：2014-09-01 00:00:00

abstract：AIM:The current study was undertaken to assess anti-hyperlipidemic activity of Pistacia lentiscus fatty oil (PLFO) in rabbits following a hyperlipidemic diet. METHOD:Twenty healthy female (WNZ) rabbits were divided into four groups of five animals each: (a) normal control (NC group) receiving standard diet, (b) hyperl...

journal_title：Chinese journal of natural medicines

authors： Djerrou Z

更新日期：2014-08-01 00:00:00

abstract：:The saponin ginsenoside Rk1 is a major compound isolated from ginseng. Ginsenoside Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of metabolism. However, the effect and mechanism of anti-inflammatory action of ginsenoside Rk1 has not been fully clarified....

journal_title：Chinese journal of natural medicines

authors： Yu Q,Zeng KW,Ma XL,Jiang Y,Tu PF,Wang XM

更新日期：2017-10-01 00:00:00

abstract：:Panax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbiota of PNS metabolism in vivo remains poorly understood. In this study, pseudo ...

journal_title：Chinese journal of natural medicines

authors： Guo YP,Chen MY,Shao L,Zhang W,Rao T,Zhou HH,Huang WH

更新日期：2019-03-01 00:00:00

abstract：:The phytochemical progress on Angelica sinensis (Oliv.) Diels over the past decades is summarized. Since 1970s, 165 chemical constituents, including phthalides, phenylpropanoids, terpenoids and essential oils, aromatic compounds, alkaloids, alkynes, sterols, fatty acids, and polysaccharides have been isolated or detec...

journal_title：Chinese journal of natural medicines

authors： Ma JP,Guo ZB,Jin L,Li YD

更新日期：2015-04-01 00:00:00

abstract：:The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections, including concentrate density, concentrate temperature, ethanol content, flow rate and stir rate in the addition of ...

journal_title：Chinese journal of natural medicines

authors： Sun LQ,Wang SY,Li YJ,Wang YX,Wang ZZ,Huang WZ,Wang YS,Bi YA,Ding G,Xiao W

更新日期：2016-01-01 00:00:00

abstract：AIM:To investigate the chemical constituents from the leaves of Broussonetia papyrifera. METHODS:The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatography and preparative HPLC. Their structures were elucidated on the basis of 1D and 2D NMR anal...

journal_title：Chinese journal of natural medicines

authors： Ran XK,Wang XT,Liu PP,Chi YX,Wang BJ,Dou DQ,Kang TG,Xiong W

更新日期：2013-05-01 00:00:00

abstract：:This study engineered β-carotene ketolase CrtW and β-carotene hydroxylase CrtZ to improve biosynthesis of astaxanthin in Escherichia coli. Firstly, crtW was randomly mutated to increase CrtW activities on conversion from β-carotene to astaxanthin. A crtW* mutant with A6T, T105A and L239M mutations has improved 5.35-fo...

journal_title：Chinese journal of natural medicines

authors： Li D,Li Y,Xu JY,Li QY,Tang JL,Jia SR,Bi CH,Dai ZB,Zhu XN,Zhang XL

更新日期：2020-09-01 00:00:00

abstract：:Naodesheng (NDS) formula, which consists of Rhizoma Chuanxiong, Lobed Kudzuvine, Carthamus tinctorius, Radix Notoginseng, and Crataegus pinnatifida, is widely applied for the treatment of cardio/cerebrovascular ischemic diseases, ischemic stroke, and sequelae of cerebral hemorrhage, etc. At present, the studies on NDS...

journal_title：Chinese journal of natural medicines

authors： Pang XC,Kang,Fang JS,Zhao Y,Xu LJ,Lian WW,Liu AL,DU GH

更新日期：2018-01-01 00:00:00

abstract：AIM:To investigate the molecular signaling mechanism by which the plant-derived, pentacyclic triterpene maslinic acid (MA) exerts anti-diabetic effects. METHOD:HepG2 cells were stimulated with various concentrations of MA. The effects of MA on glycogen phosphorylase a (GPa) activity and the cellular glycogen content w...

journal_title：Chinese journal of natural medicines

authors： Liu J,Wang X,Chen YP,Mao LF,Shang J,Sun HB,Zhang LY

更新日期：2014-04-01 00:00:00

abstract：:The aim of the study was to investigate the effects of Siwu decoction on hyperuricemia, kidney inflammation, and dysfunction in hyperuricemic mice. Siwu decoction at 363.8, 727.5, and 1 455 mg·kg(-1) was orally administered to potassium oxonate-induced hyperuricemic mice for 7 days. Serum urate, creatinine, and blood ...

journal_title：Chinese journal of natural medicines

authors： Wang R,Ma CH,Zhou F,Kong LD

更新日期：2016-07-01 00:00:00