当前位置： SCI文献检索 > Chinese Journal of Natural Medicines期刊下所有文献 > Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer's disease.

Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer's disease.

Abstract：

:Naodesheng (NDS) formula, which consists of Rhizoma Chuanxiong, Lobed Kudzuvine, Carthamus tinctorius, Radix Notoginseng, and Crataegus pinnatifida, is widely applied for the treatment of cardio/cerebrovascular ischemic diseases, ischemic stroke, and sequelae of cerebral hemorrhage, etc. At present, the studies on NDS formula for Alzheimer's disease (AD) only focus on single component of this prescription, and there is no report about the synergistic mechanism of the constituents in NDS formula for the potential treatment of dementia. Therefore, the present study aimed to predict the potential targets and uncover the mechanisms of NDS formula for the treatment of AD. Firstly, we collected the constituents in NDS formula and key targets toward AD. Then, drug-likeness, oral bioavailability, and blood-brain barrier permeability were evaluated to find drug-like and lead-like constituents for treatment of central nervous system diseases. By combining the advantages of machine learning, molecular docking, and pharmacophore mapping, we attempted to predict the targets of constituents and find potential multi-target compounds from NDS formula. Finally, we built constituent-target network, constituent-target-target network and target-biological pathway network to study the network pharmacology of the constituents in NDS formula. To the best of our knowledge, this represented the first to study the mechanism of NDS formula for potential efficacy for AD treatment by means of the virtual screening and network pharmacology methods.

journal_name

Chin J Nat Med

journal_title

Chinese journal of natural medicines

authors

Pang XC,Kang,Fang JS,Zhao Y,Xu LJ,Lian WW,Liu AL,DU GH

doi

10.1016/S1875-5364(18)30029-3

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

53-62

issue

1

eissn

2095-6975

issn

1875-5364

pii

S1875-5364(18)30029-3

journal_volume

16

pub_type

杂志文章

相关文献

Chinese Journal of Natural Medicines文献大全
  • Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo.

    abstract：:Isochlorogenic acid A (ICQA), which has anti-inflammatory, hepatoprotective, and antiviral properties, is commonly presented in fruits, vegetables, coffee, plant-based food products, and herbal medicines. These herbal medicines are usually used in combination with other medicines in the clinic. However, little is know...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30103-0

    authors： Wang J,Wang H,Peng Y,Wang GJ,Hao HP

    更新日期：2016-11-01 00:00:00

  • Flavonoids rather than alkaloids as the diagnostic constituents to distinguish Sophorae Flavescentis Radix from Sophorae Tonkinensis Radix et Rhizoma: an HPLC fingerprint study.

    abstract：:Sophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applicati...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30137-7

    authors： Ding PL,He CM,Cheng ZH,Chen DF

    更新日期：2018-12-01 00:00:00

  • Effects of feeding tyrosine and phenylalanine on the accumulation of phenylethanoid glycosides to Cistanche deserticola cell suspension culture.

    abstract：AIM:To investigate the effects of feeding phenylalanine (Phe) and tyrosine (Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides (PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola. METHOD:A cell suspension culture of C. deserticola was established and pr...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60045-5

    authors： Hu GS,Jia JM,Kim DH

    更新日期：2014-05-01 00:00:00

  • Two symmetrical unsaturated acids isolated from Viscum album.

    abstract：:In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectro...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30016-0

    authors： Cao D,Wang LQ,Han XM,Guan HR,Lei M,Wei YH,Cheng L,Yang PM,Sun ZL,Gao W,Dai JK

    更新日期：2019-02-01 00:00:00

  • A new cytochalasin from endophytic Phomopsis sp. IFB-E060.

    abstract：AIM:To study the chemical constituents of the solid culture of the endophyte Phomopsis sp. IFB-E060 in Vatica mangachapoi. METHOD:Isolation and purification were performed through silica gel column chromatography, gel filtration over Sephadex LH-20, ODS column chromatography, and HPLC. Structures of the isolated compo...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60080-7

    authors： Shen L,Luo Q,Shen ZP,Li LY,Zhang XJ,Wei ZQ,Fu Y,Song YC,Tan RX

    更新日期：2014-07-01 00:00:00

  • Comparison of anti-bacterial activity of three types of di-O-caffeoylquinic acids in Lonicera japonica flowers based on microcalorimetry.

    abstract：:The anti-bacterial activities of three types of di-O-caffeoylquinic acids (diCQAs) in Lonicera japonica flowers, a traditional Chinese medicine (TCM), on Bacillus shigae growth were investigated and compared by microcalorimetry. The three types of diCQAs were 3, 4-di-O-caffeoylquinic acid (3, 4-diCQA), 3, 5-di-O-caffe...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60017-0

    authors： Han J,Lv QY,Jin SY,Zhang TT,Jin SX,Li XY,Yuan HL

    更新日期：2014-02-01 00:00:00

  • Quantification of Panax notoginseng saponins metabolites in rat plasma with in vivo gut microbiota-mediated biotransformation by HPLC-MS/MS.

    abstract：:Panax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbiota of PNS metabolism in vivo remains poorly understood. In this study, pseudo ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30026-3

    authors： Guo YP,Chen MY,Shao L,Zhang W,Rao T,Zhou HH,Huang WH

    更新日期：2019-03-01 00:00:00

  • Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway.

    abstract：:The saponin ginsenoside Rk1 is a major compound isolated from ginseng. Ginsenoside Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of metabolism. However, the effect and mechanism of anti-inflammatory action of ginsenoside Rk1 has not been fully clarified....

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30106-1

    authors： Yu Q,Zeng KW,Ma XL,Jiang Y,Tu PF,Wang XM

    更新日期：2017-10-01 00:00:00

  • Guidelines and strategy of the International Conference of Harmonization (ICH) and its member states to overcome existing impurity control problems for antibiotics in China.

    abstract：:In the present report, we review the technical guidelines and principles on impurity research and control for antibiotics established by various agencies, including the International Conference of Harmonization (ICH), the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the China Food and...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(15)30044-3

    authors： Jiang Y,Xia JP,Yang JH,Zhang ZF,Hu CQ,Zhang ZR

    更新日期：2015-07-01 00:00:00

  • Phytochemical progress made in investigations of Angelica sinensis (Oliv.) Diels.

    abstract：:The phytochemical progress on Angelica sinensis (Oliv.) Diels over the past decades is summarized. Since 1970s, 165 chemical constituents, including phthalides, phenylpropanoids, terpenoids and essential oils, aromatic compounds, alkaloids, alkynes, sterols, fatty acids, and polysaccharides have been isolated or detec...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(15)30010-8

    authors： Ma JP,Guo ZB,Jin L,Li YD

    更新日期：2015-04-01 00:00:00

  • Characterization and evaluation in vivo of baicalin-nanocrystals prepared by an ultrasonic-homogenization-fluid bed drying method.

    abstract：AIM:To improve the absorption and bioavailability of baicalin using a nanocrystal (or nanosuspension) drug delivery system. METHODS:A tandem, ultrasonic-homogenization-fluid bed drying technology was applied to prepare baicalin-nanocrystal dried powders, and the physicochemical properties of baicalin-nanocrystals were...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60012-1

    authors： Shi-Ying J,Jin H,Shi-Xiao J,Qing-Yuan L,Jin-Xia B,Chen HG,Rui-Sheng L,Wei W,Hai-Long Y

    更新日期：2014-01-01 00:00:00

  • An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families.

    abstract：:Current study systematically investigated the interaction of two alkaloids, anisodine and monocrotaline, with organic cation transporter OCT1, 2, 3, MATE1 and MATE2-K by using in vitro stably transfected HEK293 cells. Both anisodine and monocrotaline inhibited the OCTs and MATE transporters. The lowest IC50 was 12.9 µ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30070-6

    authors： Chen JY,Brockmöller J,Tzvetkov MV,Wang LJ,Chen XJ

    更新日期：2019-07-01 00:00:00

  • A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species.

    abstract：:Dendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book "Shen Nong's Materia Medica". It's well known that bioactivities are usually related to the ingredients' basis. Based on the previous research, Dend...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(20)30001-7

    authors： Yue H,Zeng H,Ding K

    更新日期：2020-01-01 00:00:00

  • Modified Da-chai-hu Decoction regulates the expression of occludin and NF-κB to alleviate organ injury in severe acute pancreatitis rats.

    abstract：:Modified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal formulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30041-X

    authors： Zhao G,Zhuo YZ,Cui LH,Li CX,Chen SY,Li D,Liu JH,Li DH,Cui NQ,Zhang SK

    更新日期：2019-05-20 00:00:00

  • Quality control of traditional Chinese medicines: a review.

    abstract：:Traditional Chinese medicines (TCMs) are in great demand all over the world, especially in the developing world, for primary health care due to their superior merits such as low cost, minimal side effects, better cultural acceptability, and compatibility with humans. However, Chinese medicines consist of several herbs...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(13)60069-2

    authors： Song XY,Li YD,Shi YP,Jin L,Chen J

    更新日期：2013-11-01 00:00:00

  • Progress on the pharmacological research of puerarin: a review.

    abstract：:Contemporary pharmacological research has demonstrated that puerarin, the most important phytoestrogen extracted from Pueraria lobata(Willd.) Ohwi, has protecting functions on the cardiovascular system, nervous system, osteoporosis, liver injury, and inflammation in vivo and in vitro. Most of these research studies fo...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(14)60064-9

    authors： Wei SY,Chen Y,Xu XY

    更新日期：2014-06-01 00:00:00

  • Novel natural product therapeutics targeting both inflammation and cancer.

    abstract：:Inflammation is recently recognized as one of the hallmarks of human cancer. Chronic inflammatory response plays a critical role in cancer development, progression, metastasis, and resistance to chemotherapy. Conversely, the oncogenic aberrations also generate an inflammatory microenvironment, enabling the development...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(17)30062-6

    authors： Qin J,Wang W,Zhang R

    更新日期：2017-06-01 00:00:00

  • Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress.

    abstract：:The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintai...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)60030-9

    authors： Zhu YL,Wang LY,Zhao DP,Wang CL,Zhang R,Fei WT,Wang JX,Zhang JJ

    更新日期：2020-11-01 00:00:00

  • A new ursane-type triterpenoid saponin from the aerial parts of Clematoclethra scandens subsp. actinidioides.

    abstract：:A new ursane-type triterpenoid saponin, 2α,3α,24-trihydroxyurs-12,20(30)-dien-28-oic acid β-D-glucopyranosyl ester (1), together with six known triterpenoid saponins, was isolated and characterized from the aerial parts of Clematoclethra scandens subsp. actinidioides. ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(15)60008-5

    authors： Xiao SJ,Chen F,Ding LS,Zhou Y

    更新日期：2015-01-01 00:00:00

  • Potent anti-angiogenic activity of B19--a mono-carbonyl analogue of curcumin.

    abstract：AIM:The compound B19 (C21H22O5) is a newly synthesized, mono-carbonyl analog of curcumin that has exhibited potential antitumor effects. This present study was performed to identify the anti-angiogenic activity of this compound. METHODS AND RESULTS:B19 inhibited migration and tube formation of human umbilical vein end...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60002-9

    authors： Sun L,Liu J,Lin SS,Shi WT,Zhu J,Liang G,Yuan ST

    更新日期：2014-01-01 00:00:00

  • Antioxidant and cardioprotective effects of Ilex cornuta on myocardial ischemia injury.

    abstract：:Previous studies have indicated that the Ilex genus exhibits antioxidant, neuroprotective, hepatoprotective, and anti-inflammatory activities. However, the pharmacologic action and mechanisms of Ilex cornuta against cardiac diseases have not yet been explored. The present study was designed to investigate the antioxid...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30025-0

    authors： Yuan Y,Pan S,Yang SL,Liu YL,Xu QM

    更新日期：2017-02-01 00:00:00

  • Bacopa monnieri extracts prevent hydrogen peroxide-induced oxidative damage in a cellular model of neuroblastoma IMR32 cells.

    abstract：:Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide (H2O2), a precursor of deleterious reactive oxygen species, elicits oxidative stress, resulting in severe brain injuries. Bacopa monnieri is we...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30017-7

    authors： Bhatia G,Dhuna V,Dhuna K,Kaur M,Singh J

    更新日期：2017-11-01 00:00:00

  • Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu.

    abstract：AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill. METHOD:Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compound...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60104-7

    authors： Fan QY,Yin X,Li ZH,Li Y,Liu JK,Feng T,Zhao BH

    更新日期：2014-09-01 00:00:00

  • 17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester from Streptomyces sp. SR107.

    abstract：:A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on th...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30018-3

    authors： Liu MY,Li SR,Chun-Hua LU

    更新日期：2016-12-01 00:00:00

  • Panax notoginseng saponins prevent colitis-associated colorectal cancer development: the role of gut microbiota.

    abstract：:Gut microbiota dysbiosis is a risk factor for colorectal cancer (CRC) in inflammatory bowel disease (IBD). In this study, the effects of Panax notoginseng saponins (PNS) on colitis-associated CRC progression were evaluated on an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. In vivo, PNS significantly re...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)30060-1

    authors： Chen L,Chen MY,Shao L,Zhang W,Rao T,Zhou HH,Huang WH

    更新日期：2020-07-01 00:00:00

  • Effects of Bunao-Fuyuan decoction serum on proliferation and migration of vascular smooth muscle cells in atherosclerotic.

    abstract：:Atherosclerosis (AS) is a chronic inflammatory disease, the main causes of which include abnormal lipid metabolism, endothelial injury, physical and chemical injury, hemodynamic injury, genetic factors and so on. These causes can lead to inflammatory injury of blood vessels and local dysfunction. Bunao-Fuyuan decoctio...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(21)60004-3

    authors： Guo HY,Lu ZY,Zhao B,Jiang WW,Xiong YH,Wang K

    更新日期：2021-01-01 00:00:00

  • A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena.

    abstract：:A new γ-alkylated-γ-butyrolactone, named melongenolide A (1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A (1), (+)-syringaresinol (2), (+)-lyoniresinol (3), 5,5'-dimethoxy lariciresinol (4), (+)-(7R,8R)-4-hydroxy-3,3',5'-tri...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(15)30068-6

    authors： Sun J,Huo HX,Huang Z,Zhang J,Li J,Tu PF

    更新日期：2015-09-01 00:00:00

  • Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κ B inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells.

    abstract：:Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanism...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30030-5

    authors： Gong WX,Zhou YZ,Qin XM,DU GH

    更新日期：2019-04-01 00:00:00

  • Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology.

    abstract：:Guanxinshutong capsule (GXSTC) is an effective and safe traditional Chinese medicine used in the treatment of cardiovascular diseases (CVDs) for many years. However, the targets of this herbal formula and the underlying molecular mechanisms of action involved in the treatment of CVDs are still unclear. In the present ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30060-8

    authors： Liu F,DU X,Liu PR,Sun YH,Zhang YM

    更新日期：2018-04-01 00:00:00

  • Purification, structure characterization and antioxidant activity of polysaccharides from Saposhnikovia divaricata.

    abstract：:Polysaccharide from traditional Chinese herb, Saposhnikovia divaricata (Turcz.) Schischk. (SD) was extracted, fractionated and characterized in this work. Four fractions were prepared. Their molecular weight, monosaccharide compositions, linkage modes and structural properties were characterized with SEC-MALS-RI, HPAE...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30096-2

    authors： Meng Y,Yi L,Chen L,Hao J,Li DX,Xue J,Xu NY,Zhang ZQ

    更新日期：2019-10-01 00:00:00