Evolution of the registration regulations for proprietary Chinese medicines in China.

abstract：AIM:JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities. METHOD:These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo...

journal_title：Chinese journal of natural medicines

authors： Liu MY,Xiao L,Chen GH,Wang YX,Xiong WX,Li F,Liu Y,Huang XL,Deng YF,Zhang Z,Sun HY,Liu QH,Yin M

更新日期：2014-10-01 00:00:00

abstract：AIM:The current study was undertaken to assess anti-hyperlipidemic activity of Pistacia lentiscus fatty oil (PLFO) in rabbits following a hyperlipidemic diet. METHOD:Twenty healthy female (WNZ) rabbits were divided into four groups of five animals each: (a) normal control (NC group) receiving standard diet, (b) hyperl...

journal_title：Chinese journal of natural medicines

authors： Djerrou Z

更新日期：2014-08-01 00:00:00

abstract：:Dendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book "Shen Nong's Materia Medica". It's well known that bioactivities are usually related to the ingredients' basis. Based on the previous research, Dend...

journal_title：Chinese journal of natural medicines

authors： Yue H,Zeng H,Ding K

更新日期：2020-01-01 00:00:00

abstract：:Guanxinshutong capsule (GXSTC) is an effective and safe traditional Chinese medicine used in the treatment of cardiovascular diseases (CVDs) for many years. However, the targets of this herbal formula and the underlying molecular mechanisms of action involved in the treatment of CVDs are still unclear. In the present ...

journal_title：Chinese journal of natural medicines

authors： Liu F,DU X,Liu PR,Sun YH,Zhang YM

更新日期：2018-04-01 00:00:00

abstract：:Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J-N (1-5), together with four known furostanol saponins (6-9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 ...

journal_title：Chinese journal of natural medicines

authors： Li YZ,Song B,Zheng XD,Huang WL,Zhang HW,Jiang Y,Yue ZG,Song XM,Liu JL

更新日期：2019-08-01 00:00:00

abstract：:Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability...

journal_title：Chinese journal of natural medicines

authors： Jin ZH,Qiu W,Liu H,Jiang XH,Wang L

更新日期：2018-02-01 00:00:00

abstract：:In our previous study, we have elucidated the chemical profile of YGS40, a fraction of Yi-Gan San (YGS), used for the treatment of Alzheimer's disease (AD). Oxidative stress-induced apoptosis is implicated in neurodegenerative disorders such as AD. The aim of the present study was to explore the protective effects of ...

journal_title：Chinese journal of natural medicines

authors： Zhao YR,Qu W,Liu WY,Hong H,Feng F,Chen H,Xie N

更新日期：2015-06-01 00:00:00

abstract：:Previous studies have indicated that the Ilex genus exhibits antioxidant, neuroprotective, hepatoprotective, and anti-inflammatory activities. However, the pharmacologic action and mechanisms of Ilex cornuta against cardiac diseases have not yet been explored. The present study was designed to investigate the antioxid...

journal_title：Chinese journal of natural medicines

authors： Yuan Y,Pan S,Yang SL,Liu YL,Xu QM

更新日期：2017-02-01 00:00:00

abstract：:Saposhnikoviae divaricata (Turcz.) Schischk (SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarin...

journal_title：Chinese journal of natural medicines

authors： Kreiner J,Pang E,Lenon GB,Yang AWH

更新日期：2017-04-01 00:00:00

abstract：:Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of hum...

journal_title：Chinese journal of natural medicines

authors： Chen L,Wang WL,Song TF,Xie X,Ye XW,Liang Y,Huang HC,Yan SL,Lian XY,Zhang ZZ

更新日期：2017-08-01 00:00:00

abstract：AIM:To study the chemical constituents of the solid culture of the endophyte Phomopsis sp. IFB-E060 in Vatica mangachapoi. METHOD:Isolation and purification were performed through silica gel column chromatography, gel filtration over Sephadex LH-20, ODS column chromatography, and HPLC. Structures of the isolated compo...

journal_title：Chinese journal of natural medicines

authors： Shen L,Luo Q,Shen ZP,Li LY,Zhang XJ,Wei ZQ,Fu Y,Song YC,Tan RX

更新日期：2014-07-01 00:00:00

abstract：:The present study was designed to develop and validate a sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) method to separate and identify the chemical constituents of Qixue Shuangbu Tincture (QXSBT), a classic traditional Chines...

journal_title：Chinese journal of natural medicines

authors： Chen LW,Wang Q,Qin KM,Wang XL,Wang B,Chen DN,Cai BC,Cai T

更新日期：2016-02-01 00:00:00

abstract：:A new γ-alkylated-γ-butyrolactone, named melongenolide A (1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A (1), (+)-syringaresinol (2), (+)-lyoniresinol (3), 5,5'-dimethoxy lariciresinol (4), (+)-(7R,8R)-4-hydroxy-3,3',5'-tri...

journal_title：Chinese journal of natural medicines

authors： Sun J,Huo HX,Huang Z,Zhang J,Li J,Tu PF

更新日期：2015-09-01 00:00:00

abstract：:The anti-bacterial activities of three types of di-O-caffeoylquinic acids (diCQAs) in Lonicera japonica flowers, a traditional Chinese medicine (TCM), on Bacillus shigae growth were investigated and compared by microcalorimetry. The three types of diCQAs were 3, 4-di-O-caffeoylquinic acid (3, 4-diCQA), 3, 5-di-O-caffe...

journal_title：Chinese journal of natural medicines

authors： Han J,Lv QY,Jin SY,Zhang TT,Jin SX,Li XY,Yuan HL

更新日期：2014-02-01 00:00:00

abstract：:Neokotalanol, a potent α-glucosidase inhibitor isolated from Salacia reticulata, was synthesized through a key coupling reaction between a perbenzylated thiosugar and an appropriately protected perseitol triflate derived from D-mannose. This key step was found to be quite temperature dependent, and a simultaneous cycl...

journal_title：Chinese journal of natural medicines

authors： Xie WJ,Tanabe G,Tsutsui N,Wu XM,Muraoka O

更新日期：2013-11-01 00:00:00

abstract：:The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia t...

journal_title：Chinese journal of natural medicines

authors： Zhou JC,Zhang XW

更新日期：2019-11-01 00:00:00

abstract：:Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide (H2O2), a precursor of deleterious reactive oxygen species, elicits oxidative stress, resulting in severe brain injuries. Bacopa monnieri is we...

journal_title：Chinese journal of natural medicines

authors： Bhatia G,Dhuna V,Dhuna K,Kaur M,Singh J

更新日期：2017-11-01 00:00:00

abstract：AIM:To investigate the effects of feeding phenylalanine (Phe) and tyrosine (Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides (PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola. METHOD:A cell suspension culture of C. deserticola was established and pr...

journal_title：Chinese journal of natural medicines

authors： Hu GS,Jia JM,Kim DH

更新日期：2014-05-01 00:00:00

abstract：AIM:To study the chemical constituents from the seeds of Griffonia simplicifolia Baill. METHODS:The chemical constituents were isolated and purified by a combination of chromatographic materials including silica gel, Sephadex LH-20, and preparative TLC. Their structures were elucidated on the basis of MS and NMR data ...

journal_title：Chinese journal of natural medicines

authors： Wang XZ,Wu FH,Qu W,Liang JY

更新日期：2013-07-01 00:00:00

abstract：:Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanism...

journal_title：Chinese journal of natural medicines

authors： Gong WX,Zhou YZ,Qin XM,DU GH

更新日期：2019-04-01 00:00:00

abstract：AIM:To study the chemical constituents in the flowers and fruits of Rabdosia excisa. METHODS:The compounds were isolated and purified by silica gel column chromatography and their structures were identified by spectroscopic methods. RESULTS:Sixteen compounds isolated from the flowers and fruits of this plant were ide...

journal_title：Chinese journal of natural medicines

authors： Wu YX,Zhang W,Li JC,Liu N

更新日期：2012-01-01 00:00:00

abstract：:Sophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applicati...

journal_title：Chinese journal of natural medicines

authors： Ding PL,He CM,Cheng ZH,Chen DF

更新日期：2018-12-01 00:00:00

abstract：:Modified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal formulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present...

journal_title：Chinese journal of natural medicines

authors： Zhao G,Zhuo YZ,Cui LH,Li CX,Chen SY,Li D,Liu JH,Li DH,Cui NQ,Zhang SK

更新日期：2019-05-20 00:00:00

abstract：:Two new steroidal saponins, named timosaponin P (1) and timosaponin Q (2), were isolated from the rhizome parts of Anemarrhena asphodeloides Bunge using various chromatographic methods. Their structures and absolute configurations were elucidated by a combination of spectroscopic and spectrometric data, including 1D, ...

journal_title：Chinese journal of natural medicines

authors： Sun XH,Zhu FT,Zhang YW,Chen FF,Yu Y,Song NN,Huang XF

更新日期：2017-03-01 00:00:00

abstract：:Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol ...

journal_title：Chinese journal of natural medicines

authors： Xu XY,Wang DY,Ku CF,Zhao Y,Cheng H,Liu KL,Rong LJ,Zhang HJ

更新日期：2019-12-01 00:00:00

abstract：:Naodesheng (NDS) formula, which consists of Rhizoma Chuanxiong, Lobed Kudzuvine, Carthamus tinctorius, Radix Notoginseng, and Crataegus pinnatifida, is widely applied for the treatment of cardio/cerebrovascular ischemic diseases, ischemic stroke, and sequelae of cerebral hemorrhage, etc. At present, the studies on NDS...

journal_title：Chinese journal of natural medicines

authors： Pang XC,Kang,Fang JS,Zhao Y,Xu LJ,Lian WW,Liu AL,DU GH

更新日期：2018-01-01 00:00:00

abstract：:The present study aimed to establish a pharmacodynamic method using the pySolo software to explore the influence of freeze-dried powders of Shuangxia Decoction (SXD) on the sleep of normal Drosophila melanogaster and the Drosophila melanogaster whose sleep was divested by light. The dose-effect and the time-effect rel...

journal_title：Chinese journal of natural medicines

authors： Zhang ZQ,Degejin,Geng D,Zhang Q,Tian Y,Xi Y,Wang WQ,Tang HQ,Xu B,Lin HY,Sun YK

更新日期：2016-09-01 00:00:00

abstract：:Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that...

journal_title：Chinese journal of natural medicines

authors： Sun R,Zhang HM,Chen BA

更新日期：2018-09-01 00:00:00

abstract：:The present study was designed to investigate the effects of start codon of nosM on the biosynthesis of nosiheptide. Target genes were amplified by overlap PCR. After homologous recombination to construct engineered strains, nosiheptide production was analyzed by HPLC. Three mutants with different start codon of nosM ...

journal_title：Chinese journal of natural medicines

authors： Jiang L,Xue YJ,Liu WY,Ma M,Wu XR,Wang SZ,Chen YJ

更新日期：2015-11-01 00:00:00

abstract：:A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on th...

journal_title：Chinese journal of natural medicines

authors： Liu MY,Li SR,Chun-Hua LU

更新日期：2016-12-01 00:00:00