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Five new polyhydroxylated furostanol saponins from the rhizomes of Tupistra chinensis.

Abstract：

:Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J-N (1-5), together with four known furostanol saponins (6-9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values of 72.5 ± 2.4 and 77.3 ± 2.5 μmol·L-1, respectively. Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC50 value of 88.6 ± 2.1 μmol·L-1.

journal_name

Chin J Nat Med

journal_title

Chinese journal of natural medicines

authors

Li YZ,Song B,Zheng XD,Huang WL,Zhang HW,Jiang Y,Yue ZG,Song XM,Liu JL

doi

10.1016/S1875-5364(19)30065-2

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

624-630

issue

8

eissn

2095-6975

issn

1875-5364

pii

S1875-5364(19)30065-2

journal_volume

17

pub_type

杂志文章

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