当前位置： SCI文献检索 > Chinese Journal of Natural Medicines期刊下所有文献 > Akkermansia muciniphila: a promising target for the therapy of metabolic syndrome and related diseases.

Akkermansia muciniphila: a promising target for the therapy of metabolic syndrome and related diseases.

Abstract：

:The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia that can be cultured in vitro, A. muciniphila is much easier to detect by metagenomic analysis of intestinal flora. In the past few years, A. muciniphila has been getting increasing attention for the positive correlation between its intestinal colonization and host homeostatic metabolism. In this review, we summarize the relationship between A. muciniphila and host health and diseases, especially focusing on metabolic diseases and related mechanisms, as well as the natural food and drug-derived substrates affecting its colonization in the host, expecting to provide evidence and clues for the development of drugs targeting A. muciniphila.

journal_name

Chin J Nat Med

journal_title

Chinese journal of natural medicines

authors

Zhou JC,Zhang XW

doi

10.1016/S1875-5364(19)30101-3

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

835-841

issue

11

eissn

2095-6975

issn

1875-5364

pii

S1875-5364(19)30101-3

journal_volume

17

pub_type

杂志文章,评审

相关文献

Chinese Journal of Natural Medicines文献大全
  • A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species.

    abstract：:Dendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book "Shen Nong's Materia Medica". It's well known that bioactivities are usually related to the ingredients' basis. Based on the previous research, Dend...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(20)30001-7

    authors： Yue H,Zeng H,Ding K

    更新日期：2020-01-01 00:00:00

  • Anti-hypercholesterolemic effect of Pistacia lentiscus fatty oil in egg yolk-fed rabbits: a comparative study with simvastatin.

    abstract：AIM:The current study was undertaken to assess anti-hyperlipidemic activity of Pistacia lentiscus fatty oil (PLFO) in rabbits following a hyperlipidemic diet. METHOD:Twenty healthy female (WNZ) rabbits were divided into four groups of five animals each: (a) normal control (NC group) receiving standard diet, (b) hyperl...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60086-8

    authors： Djerrou Z

    更新日期：2014-08-01 00:00:00

  • Oral JS-38, a metabolite from Xenorhabdus sp., has both anti-tumor activity and the ability to elevate peripheral neutrophils.

    abstract：AIM:JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities. METHOD:These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60117-5

    authors： Liu MY,Xiao L,Chen GH,Wang YX,Xiong WX,Li F,Liu Y,Huang XL,Deng YF,Zhang Z,Sun HY,Liu QH,Yin M

    更新日期：2014-10-01 00:00:00

  • Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κ B inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells.

    abstract：:Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanism...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30030-5

    authors： Gong WX,Zhou YZ,Qin XM,DU GH

    更新日期：2019-04-01 00:00:00

  • Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry.

    abstract：:Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical c...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)30015-7

    authors： Liu ZH,Wang YQ,Mei XD,Wang F,Yang XZ,Li XD,Jiang F,Zhang JY

    更新日期：2020-02-01 00:00:00

  • Global identification of chemical constituents and rat metabolites of Si-Miao-Wan by liquid chromatography-electrospray ionization/quadrupole time-of-flight mass spectrometry.

    abstract：:Si-Miao-Wan (SMW), a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, and Achyranthis Bidentatae Radix, has been used for the treatment of gout and gouty arthritis for many years. In the present study, a liquid chromatography quadrupole-time-of-fli...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30082-1

    authors： Lu JJ,Hu XW,Li P,Chen J

    更新日期：2017-07-01 00:00:00

  • Chemical constituents and pharmacologic actions of Cynomorium plants.

    abstract：:The stem of Cynomorium songaricum is a traditional Chinese medicine reputed to have tonic effects. C. coccineum growing in northern Africa and the Mediterranean region is regarded in Arabian medical practice as the "treasure of drugs". The major constituents of Cynomorium plants have been revealed to be phenolic compo...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(13)60049-7

    authors： Meng HC,Wang S,Li Y,Kuang YY,Ma CM

    更新日期：2013-07-01 00:00:00

  • Combination of LC/MS and GC/MS based metabolomics to study the hepatotoxic effect of realgar nanoparticles in rats.

    abstract：:Realgar nanoparticles (NPs) are increasingly used as therapeutic agents for their enhanced anti-proliferation effect and cytotoxicity on cancer cells. However, the alteration of particle size may enhance biological reactivity as well as toxicity. A LC/MS and GC/MS based metabolomics approach was employed to explore th...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30098-5

    authors： Zhang MH,Chen JQ,Guo HM,Li RT,Gao YQ,Tian Y,Zhang ZJ,Huang Y

    更新日期：2017-09-01 00:00:00

  • Flavonoids rather than alkaloids as the diagnostic constituents to distinguish Sophorae Flavescentis Radix from Sophorae Tonkinensis Radix et Rhizoma: an HPLC fingerprint study.

    abstract：:Sophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applicati...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30137-7

    authors： Ding PL,He CM,Cheng ZH,Chen DF

    更新日期：2018-12-01 00:00:00

  • Phytochemical progress made in investigations of Angelica sinensis (Oliv.) Diels.

    abstract：:The phytochemical progress on Angelica sinensis (Oliv.) Diels over the past decades is summarized. Since 1970s, 165 chemical constituents, including phthalides, phenylpropanoids, terpenoids and essential oils, aromatic compounds, alkaloids, alkynes, sterols, fatty acids, and polysaccharides have been isolated or detec...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(15)30010-8

    authors： Ma JP,Guo ZB,Jin L,Li YD

    更新日期：2015-04-01 00:00:00

  • Traditional Chinese Medicine: an effective treatment for 2019 novel coronavirus pneumonia (NCP).

    abstract：:The novel coronavirus pneumonia broke out in 2019 and spread rapidly. In 30 different countries, there are over seventy thousand patients have been diagnosed in total. Therefore, it is urgent to develop the effective program to prevent and treat for the novel coronavirus pneumonia. In view of Traditional Chinese Medic...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(20)30022-4

    authors： DU HZ,Hou XY,Miao YH,Huang BS,Liu DH

    更新日期：2020-03-01 00:00:00

  • Purification, structure characterization and antioxidant activity of polysaccharides from Saposhnikovia divaricata.

    abstract：:Polysaccharide from traditional Chinese herb, Saposhnikovia divaricata (Turcz.) Schischk. (SD) was extracted, fractionated and characterized in this work. Four fractions were prepared. Their molecular weight, monosaccharide compositions, linkage modes and structural properties were characterized with SEC-MALS-RI, HPAE...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30096-2

    authors： Meng Y,Yi L,Chen L,Hao J,Li DX,Xue J,Xu NY,Zhang ZQ

    更新日期：2019-10-01 00:00:00

  • Cytotoxic constituents from the leaves of Broussonetia papyrifera.

    abstract：AIM:To investigate the chemical constituents from the leaves of Broussonetia papyrifera. METHODS:The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatography and preparative HPLC. Their structures were elucidated on the basis of 1D and 2D NMR anal...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(13)60027-8

    authors： Ran XK,Wang XT,Liu PP,Chi YX,Wang BJ,Dou DQ,Kang TG,Xiong W

    更新日期：2013-05-01 00:00:00

  • Screening and evaluation of commonly-used anti-influenza Chinese herbal medicines based on anti-neuraminidase activity.

    abstract：:Anti-influenza Chinese herbal medicines (anti-flu CHMs) have advantages in preventing and treating influenza virus infection. Despite various data on antiviral activities of some anti-flu CHMs have been reported, most of them could not be compared using the standard evaluation methods for antiviral activity. This situ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30095-4

    authors： Han X,Zhang DK,Guo YM,Feng WW,Dong Q,Zhang CE,Zhou YF,Liu Y,Wang JB,Zhao YL,Xiao XH,Yang M

    更新日期：2016-10-01 00:00:00

  • Carbazole alkaloids isolated from the branch and leaf extracts of Clausena lansium.

    abstract：:The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of ext...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30087-6

    authors： Peng WW,Zheng LX,Ji CJ,Shi XG,Xiong ZH,Shangguan XC

    更新日期：2018-07-01 00:00:00

  • Advances in the pharmacological activities and mechanisms of diosgenin.

    abstract：:Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions. Diosgenin has shown a vast range ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(15)30053-4

    authors： Chen Y,Tang YM,Yu SL,Han YW,Kou JP,Liu BL,Yu BY

    更新日期：2015-08-01 00:00:00

  • Quantification of Panax notoginseng saponins metabolites in rat plasma with in vivo gut microbiota-mediated biotransformation by HPLC-MS/MS.

    abstract：:Panax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbiota of PNS metabolism in vivo remains poorly understood. In this study, pseudo ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30026-3

    authors： Guo YP,Chen MY,Shao L,Zhang W,Rao T,Zhou HH,Huang WH

    更新日期：2019-03-01 00:00:00

  • A new cytochalasin from endophytic Phomopsis sp. IFB-E060.

    abstract：AIM:To study the chemical constituents of the solid culture of the endophyte Phomopsis sp. IFB-E060 in Vatica mangachapoi. METHOD:Isolation and purification were performed through silica gel column chromatography, gel filtration over Sephadex LH-20, ODS column chromatography, and HPLC. Structures of the isolated compo...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60080-7

    authors： Shen L,Luo Q,Shen ZP,Li LY,Zhang XJ,Wei ZQ,Fu Y,Song YC,Tan RX

    更新日期：2014-07-01 00:00:00

  • Five new polyhydroxylated furostanol saponins from the rhizomes of Tupistra chinensis.

    abstract：:Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J-N (1-5), together with four known furostanol saponins (6-9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30065-2

    authors： Li YZ,Song B,Zheng XD,Huang WL,Zhang HW,Jiang Y,Yue ZG,Song XM,Liu JL

    更新日期：2019-08-01 00:00:00

  • Saposhnikoviae divaricata: a phytochemical, pharmacological, and pharmacokinetic review.

    abstract：:Saposhnikoviae divaricata (Turcz.) Schischk (SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarin...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(17)30042-0

    authors： Kreiner J,Pang E,Lenon GB,Yang AWH

    更新日期：2017-04-01 00:00:00

  • Cycloartenol triterpenoid saponins from Cimicifuga simplex (Ranunculaceae) and their biological effects.

    abstract：:The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga ge...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(15)60011-5

    authors： Wu L,Chen ZL,Su Y,Wang QH,Kuang HX

    更新日期：2015-02-01 00:00:00

  • Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4.

    abstract：:The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria (MFMC) on PPARγ (Peroxisome Proliferator Activated Receptor gamma) and GLUT-4 (Glucose transporter-4) with respect to glucose transport. Various concentrations of MFMC ranging from 62.5 to 500 μg·mL(-1) w...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60132-1

    authors： Kumar PM,Venkataranganna MV,Manjunath K,Viswanatha GL,Ashok G

    更新日期：2014-12-01 00:00:00

  • Enhancement of oral bioavailability and immune response of Ginsenoside Rh2 by co-administration with piperine.

    abstract：:Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30041-4

    authors： Jin ZH,Qiu W,Liu H,Jiang XH,Wang L

    更新日期：2018-02-01 00:00:00

  • Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity.

    abstract：:In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30020-6

    authors： Li JH,Pan JT,Yin YQ

    更新日期：2016-03-01 00:00:00

  • Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress.

    abstract：:The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintai...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)60030-9

    authors： Zhu YL,Wang LY,Zhao DP,Wang CL,Zhang R,Fei WT,Wang JX,Zhang JJ

    更新日期：2020-11-01 00:00:00

  • Protective effect of turmeric extract on ethotrexate-induced intestinal damage and oxidative stress.

    abstract：AIM:The most important side effect of methotrexate (MTX) is mucositis. The purpose of this study was to evaluate the effect of turmeric extract on intestinal damage and oxidative stress in rats receiving methotrexate. METHODS:Experiments were performed on male Wistar albino rats divided into six groups. First group re...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(13)60087-4

    authors： Moghadam AR,Mohajeri D,Namvaran-Abbas-Abad A,Manafi H,Shahi D,Mazani M

    更新日期：2013-09-01 00:00:00

  • Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology.

    abstract：:Guanxinshutong capsule (GXSTC) is an effective and safe traditional Chinese medicine used in the treatment of cardiovascular diseases (CVDs) for many years. However, the targets of this herbal formula and the underlying molecular mechanisms of action involved in the treatment of CVDs are still unclear. In the present ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30060-8

    authors： Liu F,DU X,Liu PR,Sun YH,Zhang YM

    更新日期：2018-04-01 00:00:00

  • Pharmacodynamic study on insomnia-curing effects of Shuangxia Decoction in Drosophila melanogaster.

    abstract：:The present study aimed to establish a pharmacodynamic method using the pySolo software to explore the influence of freeze-dried powders of Shuangxia Decoction (SXD) on the sleep of normal Drosophila melanogaster and the Drosophila melanogaster whose sleep was divested by light. The dose-effect and the time-effect rel...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30077-2

    authors： Zhang ZQ,Degejin,Geng D,Zhang Q,Tian Y,Xi Y,Wang WQ,Tang HQ,Xu B,Lin HY,Sun YK

    更新日期：2016-09-01 00:00:00

  • The importance of start codon of nosM in nosiheptide production.

    abstract：:The present study was designed to investigate the effects of start codon of nosM on the biosynthesis of nosiheptide. Target genes were amplified by overlap PCR. After homologous recombination to construct engineered strains, nosiheptide production was analyzed by HPLC. Three mutants with different start codon of nosM ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(15)30089-3

    authors： Jiang L,Xue YJ,Liu WY,Ma M,Wu XR,Wang SZ,Chen YJ

    更新日期：2015-11-01 00:00:00

  • Taurochenodeoxycholic acid mediates cAMP-PKA-CREB signaling pathway.

    abstract：:Taurochenodeoxycholic acid (TCDCA) is one of the main effective components of bile acid, playing critical roles in apoptosis and immune responses through the TGR5 receptor. In this study, we reveal the interaction between TCDCA and TGR5 receptor in TGR5-knockdown H1299 cells and the regulation of inflammation via the ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)60033-4

    authors： Qi YC,Duan GZ,Mao W,Liu Q,Zhang YL,Li PF

    更新日期：2020-12-01 00:00:00