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Screening and evaluation of commonly-used anti-influenza Chinese herbal medicines based on anti-neuraminidase activity.

Abstract：

:Anti-influenza Chinese herbal medicines (anti-flu CHMs) have advantages in preventing and treating influenza virus infection. Despite various data on antiviral activities of some anti-flu CHMs have been reported, most of them could not be compared using the standard evaluation methods for antiviral activity. This situation poses an obstacle to a wide application of anti-flu CHMs. Thus, it was necessary to develop an evaluation method to estimate antiviral activities of anti-flu CHMs. In the present study, we searched for anti-flu CHMs, based on clinic usage, to select study objects from commonly-used patented anti-flu Chinese medicines. Then, a neuraminidase-based bioassay, optimized and verified by HPLC method by our research group, was adopted to detect antiviral activities of selected 26 anti-flu CHMs. Finally, eight of these herbs, including Coptidis Rhizoma, Isatidis Folium, Lonicerae Flos, Scutellaria Radix, Cyrtomium Rhizome, Houttuynia Cordata, Gardeniae Fructus, and Chrysanthemi Indici Flos, were shown to have strong antiviral activities with half maximal inhibitory concentration (IC50) values being 2.02 to 6.78 mg·mL-1 (expressed as raw materials). In contrast, the IC50 value of positive control peramivir was 0.38 mg·mL-1. Considering the extract yields of CHMs, the active component in these herbs may have a stronger antiviral activity than peramivir, suggesting that these herbs could be further researched for active compounds. Moreover, the proposed neuraminidase-based bioassay was high-throughput and simple and could be used for evaluation and screening of anti-flu CHMs as well as for their quality control.

journal_name

Chin J Nat Med

journal_title

Chinese journal of natural medicines

authors

Han X,Zhang DK,Guo YM,Feng WW,Dong Q,Zhang CE,Zhou YF,Liu Y,Wang JB,Zhao YL,Xiao XH,Yang M

doi

10.1016/S1875-5364(16)30095-4

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

794-800

issue

10

eissn

2095-6975

issn

1875-5364

pii

S1875-5364(16)30095-4

journal_volume

14

pub_type

杂志文章

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