Abstract：
:Isochlorogenic acid A (ICQA), which has anti-inflammatory, hepatoprotective, and antiviral properties, is commonly presented in fruits, vegetables, coffee, plant-based food products, and herbal medicines. These herbal medicines are usually used in combination with other medicines in the clinic. However, little is known about the regulatory effects of ICQA on drug-metabolizing enzymes and the herb-drug interactions. In the present study, we evaluated the inhibitory potentials of ICQA on CYP1A2, CYP2C9, CYP2C19, CYP3A4, CYP2D6, and CYP2E1 in vitro based on a cocktail approach. The P450 and UGT activities in mice treated with ICQA for a prolonged period were also determined. Our results demonstrated that ICQA exhibited a weak inhibitory effect on CYP2C9 in human liver microsomes with IC50 being 57.25 μmol·L-1 and Ki being 26.77 μmol·L-1. In addition, ICQA inhibited UGT1A6 activity by 25%, in the mice treated with ICQA (i.p.) at 30 mg·kg-1 for 14 d, compared with the control group. Moreover, ICQA showed no mechanism-based inhibition on CYP2C9 or UGT1A6. In conclusion, our results further confirm a safe use of ICQA in clinical practice.
journal_name
Chin J Nat Medjournal_title
Chinese journal of natural medicinesauthors
Wang J,Wang H,Peng Y,Wang GJ,Hao HPdoi
10.1016/S1875-5364(16)30103-0subject
Has Abstractpub_date
2016-11-01 00:00:00pages
865-870issue
11eissn
2095-6975issn
1875-5364pii
S1875-5364(16)30103-0journal_volume
14pub_type
杂志文章abstract：:The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintai...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(20)60030-9
更新日期：2020-11-01 00:00:00
abstract：:Gut microbiota dysbiosis is a risk factor for colorectal cancer (CRC) in inflammatory bowel disease (IBD). In this study, the effects of Panax notoginseng saponins (PNS) on colitis-associated CRC progression were evaluated on an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. In vivo, PNS significantly re...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
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journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
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更新日期：2015-07-01 00:00:00
abstract：:The aim of the study was to investigate the effects of Siwu decoction on hyperuricemia, kidney inflammation, and dysfunction in hyperuricemic mice. Siwu decoction at 363.8, 727.5, and 1 455 mg·kg(-1) was orally administered to potassium oxonate-induced hyperuricemic mice for 7 days. Serum urate, creatinine, and blood ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30059-0
更新日期：2016-07-01 00:00:00
abstract：AIM:To investigate the radioprotective effect of adenine on irradiated lymphocytes and discover the possible mechanisms of protection. METHODS:Lymphocytes were pretreated for 12 h with adenine (0.001-0.1 μmol·L(-1)) and then exposed to 4 Gy radiation. Cell viability was observed by the MTS assay, apoptosis was detecte...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(13)60040-0
更新日期：2013-03-01 00:00:00
abstract：AIM:To improve the absorption and bioavailability of baicalin using a nanocrystal (or nanosuspension) drug delivery system. METHODS:A tandem, ultrasonic-homogenization-fluid bed drying technology was applied to prepare baicalin-nanocrystal dried powders, and the physicochemical properties of baicalin-nanocrystals were...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
abstract：:The present study was designed to investigate the effects of start codon of nosM on the biosynthesis of nosiheptide. Target genes were amplified by overlap PCR. After homologous recombination to construct engineered strains, nosiheptide production was analyzed by HPLC. Three mutants with different start codon of nosM ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(15)30089-3
更新日期：2015-11-01 00:00:00
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journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(17)30025-0
更新日期：2017-02-01 00:00:00
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journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(18)30087-6
更新日期：2018-07-01 00:00:00
abstract：:Anti-influenza Chinese herbal medicines (anti-flu CHMs) have advantages in preventing and treating influenza virus infection. Despite various data on antiviral activities of some anti-flu CHMs have been reported, most of them could not be compared using the standard evaluation methods for antiviral activity. This situ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30095-4
更新日期：2016-10-01 00:00:00
abstract：:In our previous study, we have elucidated the chemical profile of YGS40, a fraction of Yi-Gan San (YGS), used for the treatment of Alzheimer's disease (AD). Oxidative stress-induced apoptosis is implicated in neurodegenerative disorders such as AD. The aim of the present study was to explore the protective effects of ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(15)30037-6
更新日期：2015-06-01 00:00:00
abstract：:D-Glycero-D-mannno-heptose 1β, 7-bisphosphate (HBPβ) is an important intermediate for constructing the core structure of Gram-negative bacterial lipopolysaccharides and was reported as a pathogen-associated molecular pattern (PAMP) that regulates immune responses. HBPβ with 3-O-amyl amine linker and its monophosphate ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(20)30075-3
更新日期：2020-08-01 00:00:00
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journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30039-5
更新日期：2016-06-01 00:00:00
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journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(16)30071-1
更新日期：2016-08-01 00:00:00
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journal_title：Chinese journal of natural medicines
pub_type： 社论
doi：10.1016/S1875-5364(19)30107-4
更新日期：2019-12-01 00:00:00
abstract：:Naodesheng (NDS) formula, which consists of Rhizoma Chuanxiong, Lobed Kudzuvine, Carthamus tinctorius, Radix Notoginseng, and Crataegus pinnatifida, is widely applied for the treatment of cardio/cerebrovascular ischemic diseases, ischemic stroke, and sequelae of cerebral hemorrhage, etc. At present, the studies on NDS...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(18)30029-3
更新日期：2018-01-01 00:00:00
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journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(18)30052-9
更新日期：2018-03-01 00:00:00
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journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
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更新日期：2013-07-01 00:00:00
abstract：:The novel coronavirus pneumonia broke out in 2019 and spread rapidly. In 30 different countries, there are over seventy thousand patients have been diagnosed in total. Therefore, it is urgent to develop the effective program to prevent and treat for the novel coronavirus pneumonia. In view of Traditional Chinese Medic...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章,评审
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更新日期：2020-03-01 00:00:00
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journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
abstract：:Taurochenodeoxycholic acid (TCDCA) is one of the main effective components of bile acid, playing critical roles in apoptosis and immune responses through the TGR5 receptor. In this study, we reveal the interaction between TCDCA and TGR5 receptor in TGR5-knockdown H1299 cells and the regulation of inflammation via the ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(20)60033-4
更新日期：2020-12-01 00:00:00
abstract：AIM:To study the chemical constituents of the aerial parts of Cirsium setosum (Willd.) MB.. METHODS:The chemical constituents were isolated and purified by various chromatographic techniques. Their structures were determined on the basis of physical properties and spectroscopic data. RESULTS:A new megastigmane glycos...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(13)60097-7
更新日期：2013-09-01 00:00:00
abstract：:Sophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applicati...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(18)30137-7
更新日期：2018-12-01 00:00:00
abstract：:The present study was designed to synthesize 2-Cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide (1), a lactone derivative of oleanolic acid (OA) and evaluate its anti-inflammatory activity. Compound 1 significantly diminished nitric oxide (NO) production and down-regulated the mRNA expression of iNOS, COX-2, ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(17)30055-9
更新日期：2017-05-01 00:00:00
abstract：:Panax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbiota of PNS metabolism in vivo remains poorly understood. In this study, pseudo ...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(19)30026-3
更新日期：2019-03-01 00:00:00
abstract：:A new γ-alkylated-γ-butyrolactone, named melongenolide A (1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A (1), (+)-syringaresinol (2), (+)-lyoniresinol (3), 5,5'-dimethoxy lariciresinol (4), (+)-(7R,8R)-4-hydroxy-3,3',5'-tri...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(15)30068-6
更新日期：2015-09-01 00:00:00
abstract：:Si-Miao-Wan (SMW), a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, and Achyranthis Bidentatae Radix, has been used for the treatment of gout and gouty arthritis for many years. In the present study, a liquid chromatography quadrupole-time-of-fli...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(17)30082-1
更新日期：2017-07-01 00:00:00
abstract：AIM:The current study was undertaken to assess anti-hyperlipidemic activity of Pistacia lentiscus fatty oil (PLFO) in rabbits following a hyperlipidemic diet. METHOD:Twenty healthy female (WNZ) rabbits were divided into four groups of five animals each: (a) normal control (NC group) receiving standard diet, (b) hyperl...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(14)60086-8
更新日期：2014-08-01 00:00:00
abstract：:Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability...
journal_title：Chinese journal of natural medicines
pub_type： 杂志文章
doi：10.1016/S1875-5364(18)30041-4
更新日期：2018-02-01 00:00:00
