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Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress.

Abstract：

:The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintained in completely non stressed conditions. Behavioral tests and biochemical analysis were applied to investigating a regulatory mechanism of anti-stress of AF. Treatment with AF significantly restored the depressant-like behaviors. Besides, AF increased the levels of 5-hydroxytryptophan (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), noradrenaline (NE) and dopamine (DA) in the hippocampus and increased the level of brain-derived neurotrophic factor (BDNF) in serum and protein expression in hippocampus. In addition, AF decreased the levels of hypothalamo-pituitary-adrenal (HPA) cascade, reduced the level of NO and cGMP in serum and inhibited the overexpression of 5-HT2AR mRNA and protein expression. Taken together, AF can modulate the NO-mediated network pathway in the hippocampus against stress-induced depressive-like behaviors. These physiological and behavioral changes allow rats to avoid potential deleterious effects of stress that may result from chronically elevated levels of glucocorticosteroids over days.

journal_name

Chin J Nat Med

journal_title

Chinese journal of natural medicines

authors

Zhu YL,Wang LY,Zhao DP,Wang CL,Zhang R,Fei WT,Wang JX,Zhang JJ

doi

10.1016/S1875-5364(20)60030-9

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

872-880

issue

11

eissn

2095-6975

issn

1875-5364

pii

S1875-5364(20)60030-9

journal_volume

18

pub_type

杂志文章

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