Bioactive phenazines from an earwig-associated Streptomyces sp.

abstract：:The novel coronavirus pneumonia broke out in 2019 and spread rapidly. In 30 different countries, there are over seventy thousand patients have been diagnosed in total. Therefore, it is urgent to develop the effective program to prevent and treat for the novel coronavirus pneumonia. In view of Traditional Chinese Medic...

journal_title：Chinese journal of natural medicines

authors： DU HZ,Hou XY,Miao YH,Huang BS,Liu DH

更新日期：2020-03-01 00:00:00

abstract：:Traditional Chinese medicines (TCMs) are in great demand all over the world, especially in the developing world, for primary health care due to their superior merits such as low cost, minimal side effects, better cultural acceptability, and compatibility with humans. However, Chinese medicines consist of several herbs...

journal_title：Chinese journal of natural medicines

authors： Song XY,Li YD,Shi YP,Jin L,Chen J

更新日期：2013-11-01 00:00:00

abstract：AIM:The most important side effect of methotrexate (MTX) is mucositis. The purpose of this study was to evaluate the effect of turmeric extract on intestinal damage and oxidative stress in rats receiving methotrexate. METHODS:Experiments were performed on male Wistar albino rats divided into six groups. First group re...

journal_title：Chinese journal of natural medicines

authors： Moghadam AR,Mohajeri D,Namvaran-Abbas-Abad A,Manafi H,Shahi D,Mazani M

更新日期：2013-09-01 00:00:00

abstract：:Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology. In the present study, we investigated the melanogenic activity of six structurally distinct compounds, namely, scopoletin, kaempferol, chrysin, vitamin D3, piperine, and 6-benzylaminopurine. We d...

journal_title：Chinese journal of natural medicines

authors： Heriniaina RM,Dong J,Kalavagunta PK,Wu HL,Yan DS,Shang J

更新日期：2018-10-01 00:00:00

abstract：:Dendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book "Shen Nong's Materia Medica". It's well known that bioactivities are usually related to the ingredients' basis. Based on the previous research, Dend...

journal_title：Chinese journal of natural medicines

authors： Yue H,Zeng H,Ding K

更新日期：2020-01-01 00:00:00

abstract：:In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectro...

journal_title：Chinese journal of natural medicines

authors： Cao D,Wang LQ,Han XM,Guan HR,Lei M,Wei YH,Cheng L,Yang PM,Sun ZL,Gao W,Dai JK

更新日期：2019-02-01 00:00:00

abstract：:Guanxinshutong capsule (GXSTC) is an effective and safe traditional Chinese medicine used in the treatment of cardiovascular diseases (CVDs) for many years. However, the targets of this herbal formula and the underlying molecular mechanisms of action involved in the treatment of CVDs are still unclear. In the present ...

journal_title：Chinese journal of natural medicines

authors： Liu F,DU X,Liu PR,Sun YH,Zhang YM

更新日期：2018-04-01 00:00:00

abstract：AIM:JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities. METHOD:These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo...

journal_title：Chinese journal of natural medicines

authors： Liu MY,Xiao L,Chen GH,Wang YX,Xiong WX,Li F,Liu Y,Huang XL,Deng YF,Zhang Z,Sun HY,Liu QH,Yin M

更新日期：2014-10-01 00:00:00

abstract：:Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability...

journal_title：Chinese journal of natural medicines

authors： Jin ZH,Qiu W,Liu H,Jiang XH,Wang L

更新日期：2018-02-01 00:00:00

abstract：:Polysaccharides from Chinese medicines are attracting increasing attention to their wide range of valuable biological activities. As these polysaccharides are mostly from edible materials, their safety can be greatly ensured. Therefore, the Chinese medicine polysaccharides have been the focus of research and developme...

journal_title：Chinese journal of natural medicines

authors： Li LF,Wong TL,Han QB

更新日期：2019-12-01 00:00:00

abstract：:Previous studies have indicated that the Ilex genus exhibits antioxidant, neuroprotective, hepatoprotective, and anti-inflammatory activities. However, the pharmacologic action and mechanisms of Ilex cornuta against cardiac diseases have not yet been explored. The present study was designed to investigate the antioxid...

journal_title：Chinese journal of natural medicines

authors： Yuan Y,Pan S,Yang SL,Liu YL,Xu QM

更新日期：2017-02-01 00:00:00

abstract：AIM:The current study was undertaken to assess anti-hyperlipidemic activity of Pistacia lentiscus fatty oil (PLFO) in rabbits following a hyperlipidemic diet. METHOD:Twenty healthy female (WNZ) rabbits were divided into four groups of five animals each: (a) normal control (NC group) receiving standard diet, (b) hyperl...

journal_title：Chinese journal of natural medicines

authors： Djerrou Z

更新日期：2014-08-01 00:00:00

abstract：AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill. METHOD:Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compound...

journal_title：Chinese journal of natural medicines

authors： Fan QY,Yin X,Li ZH,Li Y,Liu JK,Feng T,Zhao BH

更新日期：2014-09-01 00:00:00

abstract：AIM:To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae). METHOD:The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis. RESULTS:A new quinoline alkaloid, 5-methoxylrob...

journal_title：Chinese journal of natural medicines

authors： Sun JB,Qu W,Guan FQ,Li LZ,Liang JY

更新日期：2014-03-01 00:00:00

abstract：:The present study was designed to synthesize 2-Cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide (1), a lactone derivative of oleanolic acid (OA) and evaluate its anti-inflammatory activity. Compound 1 significantly diminished nitric oxide (NO) production and down-regulated the mRNA expression of iNOS, COX-2, ...

journal_title：Chinese journal of natural medicines

authors： Mou Y,Jian YL,Chen T,Huang ZJ,Qiao YX,Peng SX,Zhang DY,Ji H,Zhang YH

更新日期：2017-05-01 00:00:00

abstract：:The present study was designed to develop and evaluate glycyrrhetinic acid-graft-hyaluronic acid (HGA) conjugate for intravenous paclitaxel (PTX) delivery. Lyophilized PTX-loaded self-assembled HGA nanoparticles (PTX/HGAs) were prepared and characterized by dynamic light scattering measurements. Hemolysis test, intrav...

journal_title：Chinese journal of natural medicines

authors： Zhang L,Zhou JP,Yao J

更新日期：2015-12-01 00:00:00

abstract：:The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpe...

journal_title：Chinese journal of natural medicines

authors： Mei YD,Zhang N,Zhang WY,Tang JS,Zhou H,Yu Y,Yao XS

更新日期：2019-01-01 00:00:00

abstract：:The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections, including concentrate density, concentrate temperature, ethanol content, flow rate and stir rate in the addition of ...

journal_title：Chinese journal of natural medicines

authors： Sun LQ,Wang SY,Li YJ,Wang YX,Wang ZZ,Huang WZ,Wang YS,Bi YA,Ding G,Xiao W

更新日期：2016-01-01 00:00:00

abstract：:The present study was designed to investigate the effects of start codon of nosM on the biosynthesis of nosiheptide. Target genes were amplified by overlap PCR. After homologous recombination to construct engineered strains, nosiheptide production was analyzed by HPLC. Three mutants with different start codon of nosM ...

journal_title：Chinese journal of natural medicines

authors： Jiang L,Xue YJ,Liu WY,Ma M,Wu XR,Wang SZ,Chen YJ

更新日期：2015-11-01 00:00:00

abstract：:Atherosclerosis (AS) is a chronic inflammatory disease, the main causes of which include abnormal lipid metabolism, endothelial injury, physical and chemical injury, hemodynamic injury, genetic factors and so on. These causes can lead to inflammatory injury of blood vessels and local dysfunction. Bunao-Fuyuan decoctio...

journal_title：Chinese journal of natural medicines

authors： Guo HY,Lu ZY,Zhao B,Jiang WW,Xiong YH,Wang K

更新日期：2021-01-01 00:00:00

abstract：:The saponin ginsenoside Rk1 is a major compound isolated from ginseng. Ginsenoside Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of metabolism. However, the effect and mechanism of anti-inflammatory action of ginsenoside Rk1 has not been fully clarified....

journal_title：Chinese journal of natural medicines

authors： Yu Q,Zeng KW,Ma XL,Jiang Y,Tu PF,Wang XM

更新日期：2017-10-01 00:00:00

abstract：:Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of hum...

journal_title：Chinese journal of natural medicines

authors： Chen L,Wang WL,Song TF,Xie X,Ye XW,Liang Y,Huang HC,Yan SL,Lian XY,Zhang ZZ

更新日期：2017-08-01 00:00:00

abstract：:In the present report, we review the technical guidelines and principles on impurity research and control for antibiotics established by various agencies, including the International Conference of Harmonization (ICH), the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the China Food and...

journal_title：Chinese journal of natural medicines

authors： Jiang Y,Xia JP,Yang JH,Zhang ZF,Hu CQ,Zhang ZR

更新日期：2015-07-01 00:00:00

abstract：:Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical c...

journal_title：Chinese journal of natural medicines

authors： Liu ZH,Wang YQ,Mei XD,Wang F,Yang XZ,Li XD,Jiang F,Zhang JY

更新日期：2020-02-01 00:00:00

abstract：:The probiotic Akkermansia muciniphila (A. muciniphila) is an intestinal bacterium that was first identified in human feces in 2004. Its specialization in mucin degradation makes it a key microorganism that maintains intestinal mucosal barrier function. As an unique representative strain of the phylum Verrucomicrobia t...

journal_title：Chinese journal of natural medicines

authors： Zhou JC,Zhang XW

更新日期：2019-11-01 00:00:00

abstract：:Novel series of limonin derivatives (V-A-1-V-A-8, V-B-1-V-B-8) were synthesized by adding various tertiary amines onto the C (7)-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic solubility of the novel compounds were significantly improved, compared with li...

journal_title：Chinese journal of natural medicines

authors： Wang SC,Yang Y,Liu J,Jiang AD,Chu ZX,Chen SY,Gong GQ,He GW,Xu YG,Zhu QH

更新日期：2018-03-01 00:00:00

abstract：:Sophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applicati...

journal_title：Chinese journal of natural medicines

authors： Ding PL,He CM,Cheng ZH,Chen DF

更新日期：2018-12-01 00:00:00

abstract：:The stem of Cynomorium songaricum is a traditional Chinese medicine reputed to have tonic effects. C. coccineum growing in northern Africa and the Mediterranean region is regarded in Arabian medical practice as the "treasure of drugs". The major constituents of Cynomorium plants have been revealed to be phenolic compo...

journal_title：Chinese journal of natural medicines

authors： Meng HC,Wang S,Li Y,Kuang YY,Ma CM

更新日期：2013-07-01 00:00:00

abstract：AIM:To reveal the profile of astragalosides for better quality evaluation of Radix Astragali, this study was aimed to investigate the transformation of astragalosides under different conditions. METHOD:Seven major astragalosides were selected for evaluation under acidic, neutral and alkaline conditions. The transforma...

journal_title：Chinese journal of natural medicines

authors： Chu C,Liu EH,Qi LW,Li P

更新日期：2014-04-01 00:00:00

abstract：:Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that...

journal_title：Chinese journal of natural medicines

authors： Sun R,Zhang HM,Chen BA

更新日期：2018-09-01 00:00:00