A new β-carboline alkaloid from the seeds of Griffonia simplicifolia.

Abstract:

AIM:To study the chemical constituents from the seeds of Griffonia simplicifolia Baill. METHODS:The chemical constituents were isolated and purified by a combination of chromatographic materials including silica gel, Sephadex LH-20, and preparative TLC. Their structures were elucidated on the basis of MS and NMR data analysis. The cytotoxic activities were evaluated against HepG2 cancer cell line using the MTT colorimetric method. RESULTS:A new β-carboline alkaloid, griffonine (1), together with seven known alkaloids, hyrtioerectine B (2), 3-carboxy-6-hydroxy-β-carboline (3), hyrtiosulawesine (4), 5-hydroxyindole-3-carbaldehyde (5), 5-hydroxy-3-(2-hydroxyethyl) indole (6), trigonelline (7), and 5-hydroxytryptamine (8) were isolated and identified. Alkaloids 1, 2 and 4 showed growth inhibitory effects on the HepG2 cell line with IC50 values of 23.5, 9.6 and 19.3 μmol·L(-1), respectively. CONCLUSION:Alkaloid 1 is new and was named griffonine. Alkaloids 2-7 were isolated from this plant for the first time. Alkaloids 1, 2 and 4 were potentially cytotoxic.

journal_name

Chin J Nat Med

authors

Wang XZ,Wu FH,Qu W,Liang JY

doi

10.1016/S1875-5364(13)60059-X

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

401-5

issue

4

eissn

2095-6975

issn

1875-5364

pii

S1875-5364(13)60059-X

journal_volume

11

pub_type

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