Abstract:
:Realgar nanoparticles (NPs) are increasingly used as therapeutic agents for their enhanced anti-proliferation effect and cytotoxicity on cancer cells. However, the alteration of particle size may enhance biological reactivity as well as toxicity. A LC/MS and GC/MS based metabolomics approach was employed to explore the mechanism of realgar NPs-induced hepatotoxicity and identify potential biomarkers. Male Sprague-Dawley rats were administrated intragastrically with realgar or realgar NPs at a dose of 1.0 g·kg-1·d-1 for 28 days and toxic effects of realgar NPs on liver tissues were examined by biochemical indicator analysis and histopathologic examination. Increased levels of serum enzymes and high hepatic steatosis were discovered in the realgar NPs treated group. Multivariate data analysis revealed that rats with realgar NPs-induced hepatotoxicity could be distinctively differentiated from the animals in the control and realgar treated groups. In addition, 21 and 32 endogenous metabolites were apparently changed in the serum and live extracts, respectively. Realgar NPs might induce free fatty acid and triglyceride accumulation, resulting in hepatotoxicity. In conclusion, the present study represents the first comprehensive LC/MS- and GC/MS-based metabolomics analysis of realgar NPs-induced hepatotoxicity, which may help further research of nanotoxicity.
journal_name
Chin J Nat Medjournal_title
Chinese journal of natural medicinesauthors
Zhang MH,Chen JQ,Guo HM,Li RT,Gao YQ,Tian Y,Zhang ZJ,Huang Ydoi
10.1016/S1875-5364(17)30098-5subject
Has Abstractpub_date
2017-09-01 00:00:00pages
684-694issue
9eissn
2095-6975issn
1875-5364pii
S1875-5364(17)30098-5journal_volume
15pub_type
杂志文章abstract::The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities ...
journal_title:Chinese journal of natural medicines
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doi:10.1016/S1875-5364(15)30080-7
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journal_title:Chinese journal of natural medicines
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更新日期:2017-12-01 00:00:00
abstract::Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical c...
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更新日期:2020-02-01 00:00:00
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journal_title:Chinese journal of natural medicines
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doi:10.1016/S1875-5364(20)30030-3
更新日期:2020-04-01 00:00:00
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journal_title:Chinese journal of natural medicines
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doi:10.1016/S1875-5364(14)60062-5
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(13)60040-0
更新日期:2013-03-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(14)60002-9
更新日期:2014-01-01 00:00:00
abstract::This study engineered β-carotene ketolase CrtW and β-carotene hydroxylase CrtZ to improve biosynthesis of astaxanthin in Escherichia coli. Firstly, crtW was randomly mutated to increase CrtW activities on conversion from β-carotene to astaxanthin. A crtW* mutant with A6T, T105A and L239M mutations has improved 5.35-fo...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
abstract::Modified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal formulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2019-05-20 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(17)30085-7
更新日期:2017-08-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(13)60027-8
更新日期:2013-05-01 00:00:00
abstract::Taurochenodeoxycholic acid (TCDCA) is one of the main effective components of bile acid, playing critical roles in apoptosis and immune responses through the TGR5 receptor. In this study, we reveal the interaction between TCDCA and TGR5 receptor in TGR5-knockdown H1299 cells and the regulation of inflammation via the ...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(20)60033-4
更新日期:2020-12-01 00:00:00
abstract:AIM:To investigate the active chloroform fraction of the ethanol extract of Ipomoea carnea flowers on hematological changes in toluene diisocyanate-induced inflammation in Wistar rats. METHOD:Except for the control group, all of the rats were sensitized with intranasal application of 5 μL of 10% toluene diisocyanate (...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(14)60027-3
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(19)30026-3
更新日期:2019-03-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(19)30016-0
更新日期:2019-02-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(12)60010-7
更新日期:2012-01-01 00:00:00
abstract::Neokotalanol, a potent α-glucosidase inhibitor isolated from Salacia reticulata, was synthesized through a key coupling reaction between a perbenzylated thiosugar and an appropriately protected perseitol triflate derived from D-mannose. This key step was found to be quite temperature dependent, and a simultaneous cycl...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
abstract::Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章,评审
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更新日期:2018-09-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(15)30037-6
更新日期:2015-06-01 00:00:00
abstract::The saponin ginsenoside Rk1 is a major compound isolated from ginseng. Ginsenoside Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of metabolism. However, the effect and mechanism of anti-inflammatory action of ginsenoside Rk1 has not been fully clarified....
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(17)30106-1
更新日期:2017-10-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(17)30018-3
更新日期:2016-12-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(14)60104-7
更新日期:2014-09-01 00:00:00
abstract::The phytochemical progress on Angelica sinensis (Oliv.) Diels over the past decades is summarized. Since 1970s, 165 chemical constituents, including phthalides, phenylpropanoids, terpenoids and essential oils, aromatic compounds, alkaloids, alkynes, sterols, fatty acids, and polysaccharides have been isolated or detec...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章,评审
doi:10.1016/S1875-5364(15)30010-8
更新日期:2015-04-01 00:00:00
abstract::Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more promi...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(16)30039-5
更新日期:2016-06-01 00:00:00
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journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(17)30025-0
更新日期:2017-02-01 00:00:00
abstract:AIM:To study the chemical constituents from the seeds of Griffonia simplicifolia Baill. METHODS:The chemical constituents were isolated and purified by a combination of chromatographic materials including silica gel, Sephadex LH-20, and preparative TLC. Their structures were elucidated on the basis of MS and NMR data ...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(13)60059-X
更新日期:2013-07-01 00:00:00
abstract::Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability...
journal_title:Chinese journal of natural medicines
pub_type: 杂志文章
doi:10.1016/S1875-5364(18)30041-4
更新日期:2018-02-01 00:00:00