Abstract:
:The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay. Two new flavone C-glycosides, named as Sacroroside A and B (Compounds 1 and 2) were isolated from the EtOAc crude extract of the aerial parts ofArtemisa sacrorum Ledeb. They showed significant analgesic effects. In conclusion, Compounds 1 and 2 are new natural products, which show significant analgesic effects in a dose-dependent manner.
journal_name
Chin J Nat Medjournal_title
Chinese journal of natural medicinesauthors
Wang QH,Han NR,Dai NY,Wu RJ,Wu JSdoi
10.1016/S1875-5364(15)30080-7subject
Has Abstractpub_date
2015-10-01 00:00:00pages
786-90issue
10eissn
2095-6975issn
1875-5364pii
S1875-5364(15)30080-7journal_volume
13pub_type
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