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Pharmacodynamic study on insomnia-curing effects of Shuangxia Decoction in Drosophila melanogaster.

Abstract：

:The present study aimed to establish a pharmacodynamic method using the pySolo software to explore the influence of freeze-dried powders of Shuangxia Decoction (SXD) on the sleep of normal Drosophila melanogaster and the Drosophila melanogaster whose sleep was divested by light. The dose-effect and the time-effect relationships of SXD on sleep were examined. The effect-onset concentration of SXD was 0.25%, the plateau appeared at the concentration of 2.5% and the total sleep time showed a downtrend when the concentration was greater than 2.5%. The sleep time was the longest on the fourth day after SXD was given. The fruit fly sleep deprivation model was repeated by light stimulation at night. The middle dosage group (2.5%) had the best insomnia-curing effect. In conclusion, using the pySolo software, an approach for the pharmacodynamics study was established with Drosophila melanogaster as a model organism to determine the insomnia-curing effects of the traditional Chinese medicine (TCM). Our results demonstrated the reliability of this method. The freeze-dried powders of SXD could effectively improve the sleep quality of Drosophila melanogaster.

journal_name

Chin J Nat Med

journal_title

Chinese journal of natural medicines

authors

Zhang ZQ,Degejin,Geng D,Zhang Q,Tian Y,Xi Y,Wang WQ,Tang HQ,Xu B,Lin HY,Sun YK

doi

10.1016/S1875-5364(16)30077-2

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

653-660

issue

9

eissn

2095-6975

issn

1875-5364

pii

S1875-5364(16)30077-2

journal_volume

14

pub_type

杂志文章

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