当前位置： SCI文献检索 > Chinese Journal of Natural Medicines期刊下所有文献 > Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4.

Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4.

Abstract：

:The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria (MFMC) on PPARγ (Peroxisome Proliferator Activated Receptor gamma) and GLUT-4 (Glucose transporter-4) with respect to glucose transport. Various concentrations of MFMC ranging from 62.5 to 500 μg·mL(-1) were evaluated for glucose uptake activity in vitro using L6 myotubes, rosiglitazone was used as a reference standard. The MFMC showed significant and dose-dependent increase in glucose uptake at the tested concentrations, further, the glucose uptake activity of MFMC (500 μg·mL(-1)) was comparable with rosigilitazone. Furthermore, MFMC has shown up-regulation of GLUT-4 and PPARγ gene expressions in L6 myotubes. In addition, the MFMC when incubated along with cycloheximide (CHX), which is a protein synthesis inhibitor, has shown complete blockade of glucose uptake. This indicates that new protein synthesis is required for increased GLUT-4 translocation. In conclusion, these findings suggest that MFMC is enhancing the glucose uptake significantly and dose dependently through the enhanced expression of PPARγ and GLUT-4 in vitro.

journal_name

Chin J Nat Med

journal_title

Chinese journal of natural medicines

authors

Kumar PM,Venkataranganna MV,Manjunath K,Viswanatha GL,Ashok G

doi

10.1016/S1875-5364(14)60132-1

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

895-900

issue

12

eissn

2095-6975

issn

1875-5364

pii

S1875-5364(14)60132-1

journal_volume

12

pub_type

杂志文章

相关文献

Chinese Journal of Natural Medicines文献大全
  • Panax notoginseng saponins prevent colitis-associated colorectal cancer development: the role of gut microbiota.

    abstract：:Gut microbiota dysbiosis is a risk factor for colorectal cancer (CRC) in inflammatory bowel disease (IBD). In this study, the effects of Panax notoginseng saponins (PNS) on colitis-associated CRC progression were evaluated on an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. In vivo, PNS significantly re...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)30060-1

    authors： Chen L,Chen MY,Shao L,Zhang W,Rao T,Zhou HH,Huang WH

    更新日期：2020-07-01 00:00:00

  • A new sesquiterpene lactone from the fruits of Illicium henryi.

    abstract：AIM:To study the chemical constituents of the fruits of Illicium henryi. METHOD:Chromatographic separations on silica gel, Sephadex LH-20 gel and MCI gel were used to isolate the compounds. The structures were elucidated based on extensive spectroscopic data analyses. RESULTS:Seven compounds were obtained and their s...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60074-1

    authors： Liu JF,Li HJ,Zhang JM,Wang LX,Wang YF,Liu MQ,Bi YF,Zhang YB

    更新日期：2014-06-01 00:00:00

  • Advances in the pharmacological activities and mechanisms of diosgenin.

    abstract：:Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions. Diosgenin has shown a vast range ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(15)30053-4

    authors： Chen Y,Tang YM,Yu SL,Han YW,Kou JP,Liu BL,Yu BY

    更新日期：2015-08-01 00:00:00

  • A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species.

    abstract：:Dendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book "Shen Nong's Materia Medica". It's well known that bioactivities are usually related to the ingredients' basis. Based on the previous research, Dend...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章,评审

    doi：10.1016/S1875-5364(20)30001-7

    authors： Yue H,Zeng H,Ding K

    更新日期：2020-01-01 00:00:00

  • Chemical constituents of flowers and fruits of Rabdosia excisa.

    abstract：AIM:To study the chemical constituents in the flowers and fruits of Rabdosia excisa. METHODS:The compounds were isolated and purified by silica gel column chromatography and their structures were identified by spectroscopic methods. RESULTS:Sixteen compounds isolated from the flowers and fruits of this plant were ide...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(12)60010-7

    authors： Wu YX,Zhang W,Li JC,Liu N

    更新日期：2012-01-01 00:00:00

  • Transformation of astragalosides from radix astragali under acidic, neutral, and alkaline extraction conditions monitored by LC-ESI-TOF/MS.

    abstract：AIM:To reveal the profile of astragalosides for better quality evaluation of Radix Astragali, this study was aimed to investigate the transformation of astragalosides under different conditions. METHOD:Seven major astragalosides were selected for evaluation under acidic, neutral and alkaline conditions. The transforma...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60062-5

    authors： Chu C,Liu EH,Qi LW,Li P

    更新日期：2014-04-01 00:00:00

  • Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities.

    abstract：:The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpe...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30006-8

    authors： Mei YD,Zhang N,Zhang WY,Tang JS,Zhou H,Yu Y,Yao XS

    更新日期：2019-01-01 00:00:00

  • Characterization and evaluation in vivo of baicalin-nanocrystals prepared by an ultrasonic-homogenization-fluid bed drying method.

    abstract：AIM:To improve the absorption and bioavailability of baicalin using a nanocrystal (or nanosuspension) drug delivery system. METHODS:A tandem, ultrasonic-homogenization-fluid bed drying technology was applied to prepare baicalin-nanocrystal dried powders, and the physicochemical properties of baicalin-nanocrystals were...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60012-1

    authors： Shi-Ying J,Jin H,Shi-Xiao J,Qing-Yuan L,Jin-Xia B,Chen HG,Rui-Sheng L,Wei W,Hai-Long Y

    更新日期：2014-01-01 00:00:00

  • Effects of Bunao-Fuyuan decoction serum on proliferation and migration of vascular smooth muscle cells in atherosclerotic.

    abstract：:Atherosclerosis (AS) is a chronic inflammatory disease, the main causes of which include abnormal lipid metabolism, endothelial injury, physical and chemical injury, hemodynamic injury, genetic factors and so on. These causes can lead to inflammatory injury of blood vessels and local dysfunction. Bunao-Fuyuan decoctio...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(21)60004-3

    authors： Guo HY,Lu ZY,Zhao B,Jiang WW,Xiong YH,Wang K

    更新日期：2021-01-01 00:00:00

  • Taurochenodeoxycholic acid mediates cAMP-PKA-CREB signaling pathway.

    abstract：:Taurochenodeoxycholic acid (TCDCA) is one of the main effective components of bile acid, playing critical roles in apoptosis and immune responses through the TGR5 receptor. In this study, we reveal the interaction between TCDCA and TGR5 receptor in TGR5-knockdown H1299 cells and the regulation of inflammation via the ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)60033-4

    authors： Qi YC,Duan GZ,Mao W,Liu Q,Zhang YL,Li PF

    更新日期：2020-12-01 00:00:00

  • Pharmacodynamic study on insomnia-curing effects of Shuangxia Decoction in Drosophila melanogaster.

    abstract：:The present study aimed to establish a pharmacodynamic method using the pySolo software to explore the influence of freeze-dried powders of Shuangxia Decoction (SXD) on the sleep of normal Drosophila melanogaster and the Drosophila melanogaster whose sleep was divested by light. The dose-effect and the time-effect rel...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30077-2

    authors： Zhang ZQ,Degejin,Geng D,Zhang Q,Tian Y,Xi Y,Wang WQ,Tang HQ,Xu B,Lin HY,Sun YK

    更新日期：2016-09-01 00:00:00

  • Anti-colorectal cancer effects of tripolinolate A from Tripolium vulgare.

    abstract：:Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of hum...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30085-7

    authors： Chen L,Wang WL,Song TF,Xie X,Ye XW,Liang Y,Huang HC,Yan SL,Lian XY,Zhang ZZ

    更新日期：2017-08-01 00:00:00

  • Effects of six compounds with different chemical structures on melanogenesis.

    abstract：:Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology. In the present study, we investigated the melanogenic activity of six structurally distinct compounds, namely, scopoletin, kaempferol, chrysin, vitamin D3, piperine, and 6-benzylaminopurine. We d...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30116-X

    authors： Heriniaina RM,Dong J,Kalavagunta PK,Wu HL,Yan DS,Shang J

    更新日期：2018-10-01 00:00:00

  • Total synthesis of D-glycero-D-mannno-heptose 1β, 7-bisphosphate with 3-O-amyl amine linker and its monophosphate derivative.

    abstract：:D-Glycero-D-mannno-heptose 1β, 7-bisphosphate (HBPβ) is an important intermediate for constructing the core structure of Gram-negative bacterial lipopolysaccharides and was reported as a pathogen-associated molecular pattern (PAMP) that regulates immune responses. HBPβ with 3-O-amyl amine linker and its monophosphate ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)30075-3

    authors： Zou XP,Qin CJ,Hu J,Fu JJ,Tian GZ,Moscovitz O,Seeberger PH,Yin J

    更新日期：2020-08-01 00:00:00

  • Anti-HIV lignans from Justicia procumbens.

    abstract：:Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30117-7

    authors： Xu XY,Wang DY,Ku CF,Zhao Y,Cheng H,Liu KL,Rong LJ,Zhang HJ

    更新日期：2019-12-01 00:00:00

  • Total synthesis of neokotalanol, a potent α-glucosidase inhibitor isolated from Salacia reticulata.

    abstract：:Neokotalanol, a potent α-glucosidase inhibitor isolated from Salacia reticulata, was synthesized through a key coupling reaction between a perbenzylated thiosugar and an appropriately protected perseitol triflate derived from D-mannose. This key step was found to be quite temperature dependent, and a simultaneous cycl...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(13)60079-5

    authors： Xie WJ,Tanabe G,Tsutsui N,Wu XM,Muraoka O

    更新日期：2013-11-01 00:00:00

  • Analgesic effects and structural elucidation of two new flavone C-glycosides from Artemisa sacrorum.

    abstract：:The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(15)30080-7

    authors： Wang QH,Han NR,Dai NY,Wu RJ,Wu JS

    更新日期：2015-10-01 00:00:00

  • Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease.

    abstract：:Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more promi...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30039-5

    authors： Guo H,Dong YQ,Ye BP

    更新日期：2016-06-01 00:00:00

  • An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families.

    abstract：:Current study systematically investigated the interaction of two alkaloids, anisodine and monocrotaline, with organic cation transporter OCT1, 2, 3, MATE1 and MATE2-K by using in vitro stably transfected HEK293 cells. Both anisodine and monocrotaline inhibited the OCTs and MATE transporters. The lowest IC50 was 12.9 µ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(19)30070-6

    authors： Chen JY,Brockmöller J,Tzvetkov MV,Wang LJ,Chen XJ

    更新日期：2019-07-01 00:00:00

  • Global identification of chemical constituents and rat metabolites of Si-Miao-Wan by liquid chromatography-electrospray ionization/quadrupole time-of-flight mass spectrometry.

    abstract：:Si-Miao-Wan (SMW), a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, and Achyranthis Bidentatae Radix, has been used for the treatment of gout and gouty arthritis for many years. In the present study, a liquid chromatography quadrupole-time-of-fli...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30082-1

    authors： Lu JJ,Hu XW,Li P,Chen J

    更新日期：2017-07-01 00:00:00

  • Antioxidant and cardioprotective effects of Ilex cornuta on myocardial ischemia injury.

    abstract：:Previous studies have indicated that the Ilex genus exhibits antioxidant, neuroprotective, hepatoprotective, and anti-inflammatory activities. However, the pharmacologic action and mechanisms of Ilex cornuta against cardiac diseases have not yet been explored. The present study was designed to investigate the antioxid...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30025-0

    authors： Yuan Y,Pan S,Yang SL,Liu YL,Xu QM

    更新日期：2017-02-01 00:00:00

  • Improved anti-tumor activity and safety profile of a paclitaxel-loaded glycyrrhetinic acid-graft-hyaluronic acid conjugate as a synergistically targeted drug delivery system.

    abstract：:The present study was designed to develop and evaluate glycyrrhetinic acid-graft-hyaluronic acid (HGA) conjugate for intravenous paclitaxel (PTX) delivery. Lyophilized PTX-loaded self-assembled HGA nanoparticles (PTX/HGAs) were prepared and characterized by dynamic light scattering measurements. Hemolysis test, intrav...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(15)30097-2

    authors： Zhang L,Zhou JP,Yao J

    更新日期：2015-12-01 00:00:00

  • Carbazole alkaloids isolated from the branch and leaf extracts of Clausena lansium.

    abstract：:The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of ext...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30087-6

    authors： Peng WW,Zheng LX,Ji CJ,Shi XG,Xiong ZH,Shangguan XC

    更新日期：2018-07-01 00:00:00

  • Impact of parameter fluctuations on the performance of ethanol precipitation in production of Re Du Ning Injections, based on HPLC fingerprints and principal component analysis.

    abstract：:The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections, including concentrate density, concentrate temperature, ethanol content, flow rate and stir rate in the addition of ...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.3724/SP.J.1009.2015.00073

    authors： Sun LQ,Wang SY,Li YJ,Wang YX,Wang ZZ,Huang WZ,Wang YS,Bi YA,Ding G,Xiao W

    更新日期：2016-01-01 00:00:00

  • Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu.

    abstract：AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill. METHOD:Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compound...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(14)60104-7

    authors： Fan QY,Yin X,Li ZH,Li Y,Liu JK,Feng T,Zhao BH

    更新日期：2014-09-01 00:00:00

  • Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway.

    abstract：:The saponin ginsenoside Rk1 is a major compound isolated from ginseng. Ginsenoside Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of metabolism. However, the effect and mechanism of anti-inflammatory action of ginsenoside Rk1 has not been fully clarified....

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(17)30106-1

    authors： Yu Q,Zeng KW,Ma XL,Jiang Y,Tu PF,Wang XM

    更新日期：2017-10-01 00:00:00

  • Synthesis and anti-hepatocellular carcinoma activity of novel O2-vinyl diazeniumdiolate-based nitric oxide-releasing derivatives of oleanolic acid.

    abstract：:Considering that high levels of nitric oxide (NO) exert anti-cancer effect and the derivatives of oleanolic acid (OA) have shown potent anti-cancer activity, new O2-vinyl diazeniumdiolate-based NO releasing derivatives (5a-l, 11a-l) of OA were designed, synthesized, and biologically evaluated in the present study. The...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(18)30009-8

    authors： Zou Y,Yan C,Liu JC,Huang ZJ,Xu JY,Zhou JP,Zhang HB,Zhang YH

    更新日期：2017-12-01 00:00:00

  • Four new steroids from the marine soft coral-derived fungus Penicillium sp. SCSIO41201.

    abstract：:Penicildiones A-D (1-4), four new steroids derivatives together with three known compounds including 16α-methylpregna-17α,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (5), stachybotrylactone B (6) and stachybotrin (7) were isolated from the soft coral-derived fungus Penicillium sp. SCSIO41201, cultured in the...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(20)30030-3

    authors： Long JY,Wang JF,Liao SR,Lin XP,Zhou XF,Li YQ,Yang B,Liu YH

    更新日期：2020-04-01 00:00:00

  • Cytotoxic constituents from the leaves of Broussonetia papyrifera.

    abstract：AIM:To investigate the chemical constituents from the leaves of Broussonetia papyrifera. METHODS:The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatography and preparative HPLC. Their structures were elucidated on the basis of 1D and 2D NMR anal...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(13)60027-8

    authors： Ran XK,Wang XT,Liu PP,Chi YX,Wang BJ,Dou DQ,Kang TG,Xiong W

    更新日期：2013-05-01 00:00:00

  • Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo.

    abstract：:Isochlorogenic acid A (ICQA), which has anti-inflammatory, hepatoprotective, and antiviral properties, is commonly presented in fruits, vegetables, coffee, plant-based food products, and herbal medicines. These herbal medicines are usually used in combination with other medicines in the clinic. However, little is know...

    journal_title：Chinese journal of natural medicines

    pub_type： 杂志文章

    doi：10.1016/S1875-5364(16)30103-0

    authors： Wang J,Wang H,Peng Y,Wang GJ,Hao HP

    更新日期：2016-11-01 00:00:00