A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.

abstract：:Signaling circuits often coordinate cellular membranes and actin filaments at distinct sites to direct cell behavior. In this issue of Developmental Cell, Bershteyn et al. outline how the molecular scaffold protein, MIM, which bends membranes and binds actin filaments, is at the middle of one such circuit to regulate ...

journal_title：Developmental cell

authors： Kozminski KG,Schafer DA

更新日期：2010-08-17 00:00:00

abstract：:The appearance of Oskar protein occurs coincident with localization of oskar mRNA to the posterior pole of the Drosophila oocyte, and earlier accumulation of the protein is prevented by translational repression. We find that the nascent polypeptide-associated complex (NAC) is required for correct localization of oskar...

journal_title：Developmental cell

authors： Braat AK,Yan N,Arn E,Harrison D,Macdonald PM

更新日期：2004-07-01 00:00:00

abstract：:Drosophila proprioceptors (chordotonal organs) are structured as a linear array of four lineage-related cells: a neuron, a glial cell, and two accessory cells, called cap and ligament, between which the neuron is stretched. To function properly as stretch receptors, chordotonal organs must be stably anchored at both e...

journal_title：Developmental cell

authors： Inbal A,Volk T,Salzberg A

更新日期：2004-08-01 00:00:00

abstract：:Angiogenesis is responsible for tissue vascularization during development, as well as in pathological contexts, including cancer and ischemia. Vascular endothelial growth factors (VEGFs) regulate angiogenesis by acting through VEGF receptors to induce endothelial cell signaling. VEGF is processed in the extracellular ...

journal_title：Developmental cell

authors： De Angelis JE,Lagendijk AK,Chen H,Tromp A,Bower NI,Tunny KA,Brooks AJ,Bakkers J,Francois M,Yap AS,Simons C,Wicking C,Hogan BM,Smith KA

更新日期：2017-01-23 00:00:00

abstract：:The development of multicellular organisms requires the precisely coordinated regulation of an evolutionarily conserved group of signaling pathways. Temporal and spatial control of these signaling cascades is achieved through networks of regulatory proteins, segregation of pathway components in specific subcellular co...

journal_title：Developmental cell

authors： Balmer S,Dussert A,Collu GM,Benitez E,Iomini C,Mlodzik M

更新日期：2015-09-28 00:00:00

abstract：:A central enigma in epigenetics is how epigenetic factors are guided to specific genomic sites for their function. Previously, we reported that a Piwi-piRNA complex associates with the piRNA-complementary site in the Drosophila genome and regulates its epigenetic state. Here, we report that Piwi-piRNA complexes bind t...

journal_title：Developmental cell

authors： Huang XA,Yin H,Sweeney S,Raha D,Snyder M,Lin H

更新日期：2013-03-11 00:00:00

abstract：:In migrating cells, Rho family GTPases and their effectors play a central role in polarizing and in organizing the actin and microtubule cytoskeletons. A study by Fukata et al. in the June 28th issue of Cell now shows that the Rac1/Cdc42 effector IQGAP1 captures microtubules by binding to CLIP170. ...

journal_title：Developmental cell

authors： Brunner D

更新日期：2002-07-01 00:00:00

abstract：:In this issue of Developmental Cell, Gui et al. (2016) show that an abscisic acid-inducible remorin protein in rice directly interacts with critical brassinosteroid signaling components to attenuate the brassinosteroid response, thus illuminating one aspect of the brassinosteroid/abscisic acid antagonism. ...

journal_title：Developmental cell

authors： Clouse SD

更新日期：2016-07-25 00:00:00

abstract：:In multicellular organisms, cell size is tightly controlled by nutrients and growth factors. Increasing ambient glucose induces enhanced protein synthesis and cell size. Continued exposure of cells to high glucose in vivo, as apparent under pathological conditions, results in cell hypertrophy and tissue damage. We dem...

journal_title：Developmental cell

authors： Wu L,Derynck R

更新日期：2009-07-01 00:00:00

abstract：:The anterior visceral endoderm plays a pivotal role in establishing anterior-posterior polarity of the mouse embryo, but the molecular nature of the signals required remains to be determined. Here, we demonstrate that Cerberus-like(-/-);Lefty1(-/-) compound mutants can develop a primitive streak ectopically in the emb...

journal_title：Developmental cell

authors： Perea-Gomez A,Vella FD,Shawlot W,Oulad-Abdelghani M,Chazaud C,Meno C,Pfister V,Chen L,Robertson E,Hamada H,Behringer RR,Ang SL

更新日期：2002-11-01 00:00:00

abstract：:While autophagy is thought to be an essential process in some cancer cells, it is unknown if or how such cancer cells can circumvent autophagy inhibition. To address this, we developed a CRISPR/Cas9 assay with dynamic live-cell imaging to measure acute effects of knockout (KO) of autophagy genes compared to known esse...

journal_title：Developmental cell

authors： Towers CG,Fitzwalter BE,Regan D,Goodspeed A,Morgan MJ,Liu CW,Gustafson DL,Thorburn A

更新日期：2019-09-23 00:00:00

abstract：:Reporting in Developmental Cell, Schlaitz et al. (2013) show that endoplasmic reticulum (ER) membrane exclusion from the mitotic spindle is an active process requiring REEP membrane proteins. REEP protein depletion results in ER membrane retention on the spindle and chromosomes, leading to defects in chromosome segreg...

journal_title：Developmental cell

authors： Burke B

更新日期：2013-08-12 00:00:00

abstract：:Hedgehog (Hh) signaling during development and in postembryonic tissues requires activation of the 7TM oncoprotein Smoothened (Smo) by mechanisms that may involve endogenous lipidic modulators. Exogenous Smo ligands previously identified include the plant sterol cyclopamine (and its therapeutically useful synthetic mi...

journal_title：Developmental cell

authors： Myers BR,Sever N,Chong YC,Kim J,Belani JD,Rychnovsky S,Bazan JF,Beachy PA

更新日期：2013-08-26 00:00:00

abstract：:Novel body structures are often generated by the redeployment of ancestral components of the genome. In this issue of Developmental Cell, Glassford et al. (2015) present a thorough analysis of the co-option of a gene regulatory network in the origin of an evolutionary novelty. ...

journal_title：Developmental cell

authors： Preger-Ben Noon E,Frankel N

更新日期：2015-09-14 00:00:00

abstract：:Small GTPase Cdc42 triggers polarity establishment in budding yeast. In this issue of Developmental Cell, Okada et al. (2013) combine in silico modeling and cell biology to show that Cdc42, septins, and the exocytosis pathway are integrated in a feedback system to define and insulate the site of polarity in the membra...

journal_title：Developmental cell

authors： Caudron F,Barral Y

更新日期：2013-07-29 00:00:00

abstract：:Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals. ...

journal_title：Developmental cell

authors： Scott K

更新日期：2003-03-01 00:00:00

abstract：:A century ago, Oscar Hertwig discovered that cells orient their cleavage plane orthogonal to their long axis. Reporting recently in Nature, Bosveld et al. (2016) shed light on how, showing that NuMA/Mud localization at tricellular junctions provides mitotic cells with the memory of interphase shape used to orient clea...

journal_title：Developmental cell

authors： Michel M,Dahmann C

更新日期：2016-03-21 00:00:00

abstract：:MicroRNAs are abundant in animal genomes, yet little is known about their functions in vivo. Here, we report the production of 80 new Drosophila miRNA mutants by targeted homologous recombination. These mutants remove 104 miRNAs. Together with 15 previously reported mutants, this collection includes 95 mutants deletin...

journal_title：Developmental cell

authors： Chen YW,Song S,Weng R,Verma P,Kugler JM,Buescher M,Rouam S,Cohen SM

更新日期：2014-12-22 00:00:00

abstract：:Wingless (Wg) is a morphogen required for the patterning of many Drosophila tissues. Several lines of evidence implicate heparan sulfate-modified proteoglycans (HSPGs) such as Dally-like protein (Dlp) in the control of Wg distribution and signaling. We show that dlp is required to limit Wg levels in the matrix, contra...

journal_title：Developmental cell

authors： Kirkpatrick CA,Dimitroff BD,Rawson JM,Selleck SB

更新日期：2004-10-01 00:00:00

abstract：:Actomyosin flows are involved in a variety of cellular processes, including cytokinesis, cell migration, polarization, and morphogenesis. In epithelia, flow polarization orients cell deformations. It is unclear, however, how flows are polarized and how global patterns of junction remodeling emerge from flow polarizati...

journal_title：Developmental cell

authors： Levayer R,Lecuit T

更新日期：2013-07-29 00:00:00

abstract：:Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional ...

journal_title：Developmental cell

authors： Langer EM,Feng Y,Zhaoyuan H,Rauscher FJ 3rd,Kroll KL,Longmore GD

更新日期：2008-03-01 00:00:00

abstract：:During the first five rounds of cell division in the mouse embryo, spindles assemble in the absence of centrioles. Spindle formation initiates around chromosomes, but the microtubule nucleating process remains unclear. Here we demonstrate that Plk4, a protein kinase known as a master regulator of centriole formation, ...

journal_title：Developmental cell

authors： Coelho PA,Bury L,Sharif B,Riparbelli MG,Fu J,Callaini G,Glover DM,Zernicka-Goetz M

更新日期：2013-12-09 00:00:00

abstract：:Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures defined as regions of the ER that tightly associate with the plasma membrane. However, little is known about the mechanisms that tether these organelles together and why such connections are maintained. Using a quantitative proteomic appr...

journal_title：Developmental cell

authors： Manford AG,Stefan CJ,Yuan HL,Macgurn JA,Emr SD

更新日期：2012-12-11 00:00:00

abstract：:Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...

journal_title：Developmental cell

authors： Shimada Y,Yonemura S,Ohkura H,Strutt D,Uemura T

更新日期：2006-02-01 00:00:00

abstract：:Cell locomotion entails functional and structural cooperation between cell surface adhesion and the actin cytoskeleton. A new paper by DeMali et al. provides new insights into the link between actin assembly and integrin adhesion at the leading edges of migrating cells. ...

journal_title：Developmental cell

authors： Kovacs EM,Yap AS

更新日期：2002-12-01 00:00:00

abstract：:Wnt/β-catenin signaling plays critical roles during embryogenesis, tissue homeostasis, and regeneration. How Wnt-receptor complex activity is regulated is not yet fully understood. Here, we identify the Ly6 family protein LY6/PLAUR domain-containing 6 (Lypd6) as a positive feedback regulator of Wnt/β-catenin signaling...

journal_title：Developmental cell

authors： Özhan G,Sezgin E,Wehner D,Pfister AS,Kühl SJ,Kagermeier-Schenk B,Kühl M,Schwille P,Weidinger G

更新日期：2013-08-26 00:00:00

abstract：:A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies o...

journal_title：Developmental cell

authors： He F,Wen Y,Deng J,Lin X,Lu LJ,Jiao R,Ma J

更新日期：2008-10-01 00:00:00

abstract：:Cells commit to mitosis by abruptly activating the mitotic cyclin-Cdk complexes. During Drosophila gastrulation, mitosis is associated with the transcriptional activation of cdc25(string), a phosphatase that activates Cdk1. Here, we demonstrate that the switch-like entry into mitosis observed in the Drosophila embryo ...

journal_title：Developmental cell

authors： Di Talia S,Wieschaus EF

更新日期：2012-04-17 00:00:00

abstract：:Determination of left-right asymmetry in mouse embryos is established by a leftward fluid flow that is generated by clockwise rotation of node cilia. How node cilia achieve stable unidirectional rotation has remained unknown, however. Here we show that brief exposure to the microtubule-stabilizing drug paclitaxel (Tax...

journal_title：Developmental cell

authors： Shinohara K,Chen D,Nishida T,Misaki K,Yonemura S,Hamada H

更新日期：2015-10-26 00:00:00

abstract：:Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...

journal_title：Developmental cell

authors： Gonzales KAU,Fuchs E

更新日期：2017-11-20 00:00:00