Abstract:
:Wnt/β-catenin signaling plays critical roles during embryogenesis, tissue homeostasis, and regeneration. How Wnt-receptor complex activity is regulated is not yet fully understood. Here, we identify the Ly6 family protein LY6/PLAUR domain-containing 6 (Lypd6) as a positive feedback regulator of Wnt/β-catenin signaling. lypd6 enhances Wnt signaling in zebrafish and Xenopus embryos and in mammalian cells, and it is required for wnt8-mediated patterning of the mesoderm and neuroectoderm during zebrafish gastrulation. Lypd6 is GPI anchored to the plasma membrane and physically interacts with the Wnt receptor Frizzled8 and the coreceptor Lrp6. Biophysical and biochemical evidence indicates that Lypd6 preferentially localizes to raft membrane domains, where Lrp6 is phosphorylated upon Wnt stimulation. lypd6 knockdown or mislocalization of the Lypd6 protein to nonraft membrane domains shifts Lrp6 phosphorylation to these domains and inhibits Wnt signaling. Thus, Lypd6 appears to control Lrp6 activation specifically in membrane rafts, which is essential for downstream signaling.
journal_name
Dev Celljournal_title
Developmental cellauthors
Özhan G,Sezgin E,Wehner D,Pfister AS,Kühl SJ,Kagermeier-Schenk B,Kühl M,Schwille P,Weidinger Gdoi
10.1016/j.devcel.2013.07.020subject
Has Abstractpub_date
2013-08-26 00:00:00pages
331-45issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(13)00450-4journal_volume
26pub_type
杂志文章abstract::One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an ant...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.11.027
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abstract::The majority of excitatory synaptic transmission in the brain occurs at dendritic spines, which are actin-rich protrusions on the dendrites. The asymmetric nature of these structures suggests that proteins regulating cell polarity might be involved in their formation. Indeed, the polarity protein PAR-3 is required for...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.11.020
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journal_title:Developmental cell
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abstract::One of today's most powerful technologies in biomedical research--the creation of mutant mice by gene targeting in embryonic stem (ES) cells--was finally celebrated in this year's Nobel Prize in Medicine. The history of how ES cells were first discovered and genetically manipulated highlights the importance of collabo...
journal_title:Developmental cell
pub_type: 传,社论,历史文章
doi:10.1016/j.devcel.2007.11.012
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abstract::Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...
journal_title:Developmental cell
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doi:10.1016/s1534-5807(03)00298-3
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journal_title:Developmental cell
pub_type: 杂志文章,评审
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.05.013
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.04.003
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00020-0
更新日期:2003-02-01 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.06.002
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2020.10.019
更新日期:2020-12-07 00:00:00
abstract::The kinase Plk1 plays multiple roles in regulating mitotic progression, including stabilization of spindle poles, but its substrates are largely unknown. A new study by Yamamoto and coworkers has identified a centrosomal protein, Kizuna (Kiz), as a mitotic substrate of Plk1 (Oshimori et al., 2006). Phosphorylation of ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.09.012
更新日期:2006-10-01 00:00:00
abstract::Messenger RNAs (mRNAs) are synthesized in the cell nucleus and transported through nuclear pores to the cytoplasm for protein synthesis. Reporting in Nature Cell Biology, Mor et al. now track in living cells in real time the journey of single mRNA molecules as they transit from nucleus to cytoplasm. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2010.05.021
更新日期:2010-06-15 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.04.011
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.06.015
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.07.008
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.11.004
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abstract::Chronic inflammation is associated with tumorigenesis, but how acute inflammation affects the tumor microenvironment is less known. Recently, Antonio et al. (2015) found that neutrophils attracted to an acute wound such as a biopsy drive cell proliferation of nearby pre-neoplastic cells, suggesting that acute wounds m...
journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 评论,杂志文章
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journal_title:Developmental cell
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journal_title:Developmental cell
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abstract::The Drosophila lipoprotein particle, Lipophorin, bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens. Here we show that Lipophorin interacts with the he...
journal_title:Developmental cell
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