Abstract:
:The kinase Plk1 plays multiple roles in regulating mitotic progression, including stabilization of spindle poles, but its substrates are largely unknown. A new study by Yamamoto and coworkers has identified a centrosomal protein, Kizuna (Kiz), as a mitotic substrate of Plk1 (Oshimori et al., 2006). Phosphorylation of Kiz ensures the integrity of spindle poles in the face of severe pulling forces exerted by the chromosome-attached spindle microtubules.
journal_name
Dev Celljournal_title
Developmental cellauthors
Fry AM,Baxter JEdoi
10.1016/j.devcel.2006.09.012subject
Has Abstractpub_date
2006-10-01 00:00:00pages
431-2issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(06)00405-9journal_volume
11pub_type
杂志文章abstract::Specialized areas in the vertebrate retina are critical for high-acuity vision, yet the molecular mechanisms driving the development of high-acuity areas (HAAs) remain largely unknown. In Developmental Cell, da Silva and Cepko (2017) show that restricted degradation of retinoic acid and elevated FGF8 signaling give ri...
journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
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abstract::In multicellular organisms, cell size is tightly controlled by nutrients and growth factors. Increasing ambient glucose induces enhanced protein synthesis and cell size. Continued exposure of cells to high glucose in vivo, as apparent under pathological conditions, results in cell hypertrophy and tissue damage. We dem...
journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
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journal_title:Developmental cell
pub_type: 杂志文章
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更新日期:2018-09-24 00:00:00
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更新日期:2019-05-06 00:00:00
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journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2007.06.010
更新日期:2007-08-01 00:00:00
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更新日期:2011-11-15 00:00:00
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更新日期:2009-04-01 00:00:00
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journal_title:Developmental cell
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