Sizing up lung stem cells.

Abstract:

:Mammalian lungs are comprised of conducting airways and alveoli. How the distinct epithelial linings of these two zones are differentially specified and maintained is not fully understood. In this issue of Developmental Cell, two groups find critical roles for the Hippo pathway in regulation of lung progenitor cell differentiation.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Rock JR

doi

10.1016/j.devcel.2014.07.002

subject

Has Abstract

pub_date

2014-07-28 00:00:00

pages

112-4

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(14)00422-5

journal_volume

30

pub_type

评论,杂志文章
  • Radial WNT5A-Guided Post-mitotic Filopodial Pathfinding Is Critical for Midgut Tube Elongation.

    abstract::The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.06.011

    authors: Wang S,Cebrian C,Schnell S,Gumucio DL

    更新日期:2018-07-16 00:00:00

  • Cilia Control Fat Deposition during Tissue Repair.

    abstract::Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2017.06.023

    authors: Perdiguero E,Serrano AL,Muñoz-Cánoves P

    更新日期:2017-07-24 00:00:00

  • Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.

    abstract::While autophagy is thought to be an essential process in some cancer cells, it is unknown if or how such cancer cells can circumvent autophagy inhibition. To address this, we developed a CRISPR/Cas9 assay with dynamic live-cell imaging to measure acute effects of knockout (KO) of autophagy genes compared to known esse...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.07.010

    authors: Towers CG,Fitzwalter BE,Regan D,Goodspeed A,Morgan MJ,Liu CW,Gustafson DL,Thorburn A

    更新日期:2019-09-23 00:00:00

  • Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.

    abstract::Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediating these invasions, however, remains unclear. Utilizing the genetically and visually accessible model of anchor cell (AC) inva...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.06.006

    authors: Hagedorn EJ,Yashiro H,Ziel JW,Ihara S,Wang Z,Sherwood DR

    更新日期:2009-08-01 00:00:00

  • Regulation of activin/nodal signaling by Rap2-directed receptor trafficking.

    abstract::We show that Rap2, a member of the Ras GTPase family, positively regulates Activin/Nodal signaling activity by controlling the trafficking of its receptors. In the absence of ligand activation, Rap2 directs internalized Activin/Nodal receptors into a recycling pathway, thereby preventing their degradation and maintain...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.05.004

    authors: Choi SC,Kim GH,Lee SJ,Park E,Yeo CY,Han JK

    更新日期:2008-07-01 00:00:00

  • The undiscovered country: chromosome territories and the organization of transcription.

    abstract::The interchromosome domain (ICD) model proposes that genes are selectively positioned at the surfaces of chromosome territories to facilitate their regulation. A paper in the May 13 issue of the Journal of Cell Biology provides evidence that supports a reinterpretation of this model. ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(02)00196-x

    authors: Kosak ST,Groudine M

    更新日期:2002-06-01 00:00:00

  • Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

    abstract::Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.01.005

    authors: Langer EM,Feng Y,Zhaoyuan H,Rauscher FJ 3rd,Kroll KL,Longmore GD

    更新日期:2008-03-01 00:00:00

  • Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeast.

    abstract::Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins. Mei2 is degraded via a ubiquitin-proteasome pathway in a phosphorylation-dependent fashion. The E2 Ubc2 and the E3 Ubr1 are requ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(01)00037-5

    authors: Kitamura K,Katayama S,Dhut S,Sato M,Watanabe Y,Yamamoto M,Toda T

    更新日期:2001-09-01 00:00:00

  • Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition.

    abstract::Renewing tissues have the remarkable ability to continually produce both proliferative progenitor and specialized differentiated cell types. How are complex milieus of microenvironmental signals interpreted to coordinate tissue-cell-type composition? Here, we investigate the responses of intestinal epithelium to indiv...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.12.020

    authors: Sanman LE,Chen IW,Bieber JM,Steri V,Trentesaux C,Hann B,Klein OD,Wu LF,Altschuler SJ

    更新日期:2021-01-15 00:00:00

  • Putting Your Best Egg Forward.

    abstract::In a recent issue of Nature, Bohnert and Kenyon (2017) describe a signaling pathway that prevents transgenerational inheritance of cytoplasmic protein aggregates. Fertilizing sperm trigger aggregate clearance in the ovum by a microautophagy-like effector mechanism mediated by inter-organelle communication between lyso...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2017.12.016

    authors: Patil CK,Denic V

    更新日期:2018-01-08 00:00:00

  • Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development.

    abstract::Smad4 is a central intracellular effector of TGF-beta signaling. Smad-independent TGF-beta pathways, such as those mediated by p38 MAPK, have been identified in cell culture systems, but their in vivo functional mechanisms remain unclear. In this study, we investigated the role of TGF-beta signaling in tooth and palat...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.06.004

    authors: Xu X,Han J,Ito Y,Bringas P Jr,Deng C,Chai Y

    更新日期:2008-08-01 00:00:00

  • DEPDC1B coordinates de-adhesion events and cell-cycle progression at mitosis.

    abstract::Cells entering mitosis become rounded, lose attachment to the substrate, and increase their cortical rigidity. Pivotal to these events is the dismantling of focal adhesions (FAs). How mitotic reshaping is linked to commitment to divide is unclear. Here, we show that DEPDC1B, a protein that accumulates in G2, coordinat...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2014.09.009

    authors: Marchesi S,Montani F,Deflorian G,D'Antuono R,Cuomo A,Bologna S,Mazzoccoli C,Bonaldi T,Di Fiore PP,Nicassio F

    更新日期:2014-11-24 00:00:00

  • A molecular switch for the orientation of epithelial cell polarization.

    abstract::The formation of epithelial tissues containing lumens requires not only the apical-basolateral polarization of cells, but also the coordinated orientation of this polarity such that the apical surfaces of neighboring cells all point toward the central lumen. Defects in extracellular matrix (ECM) signaling lead to inve...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2014.08.027

    authors: Bryant DM,Roignot J,Datta A,Overeem AW,Kim M,Yu W,Peng X,Eastburn DJ,Ewald AJ,Werb Z,Mostov KE

    更新日期:2014-10-27 00:00:00

  • Aberrant epigenetic landscape in cancer: how cellular identity goes awry.

    abstract::Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human diseases, such as cancer. Our aim here is to provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and microRNA regul...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2010.10.005

    authors: Berdasco M,Esteller M

    更新日期:2010-11-16 00:00:00

  • Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.

    abstract::Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2015.12.014

    authors: Huang J,Liu X,Li D,Shao Z,Cao H,Zhang Y,Trompouki E,Bowman TV,Zon LI,Yuan GC,Orkin SH,Xu J

    更新日期:2016-01-11 00:00:00

  • Exit from proliferation during leaf development in Arabidopsis thaliana: a not-so-gradual process.

    abstract::Early leaf growth is sustained by cell proliferation and subsequent cell expansion that initiates at the leaf tip and proceeds in a basipetal direction. Using detailed kinematic and gene expression studies to map these stages during early development of the third leaf of Arabidopsis thaliana, we showed that the cell-c...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.11.011

    authors: Andriankaja M,Dhondt S,De Bodt S,Vanhaeren H,Coppens F,De Milde L,Mühlenbock P,Skirycz A,Gonzalez N,Beemster GT,Inzé D

    更新日期:2012-01-17 00:00:00

  • ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology.

    abstract::Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures defined as regions of the ER that tightly associate with the plasma membrane. However, little is known about the mechanisms that tether these organelles together and why such connections are maintained. Using a quantitative proteomic appr...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2012.11.004

    authors: Manford AG,Stefan CJ,Yuan HL,Macgurn JA,Emr SD

    更新日期:2012-12-11 00:00:00

  • Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration.

    abstract::Directional cell migration is critical for metazoan development. We define two molecular pathways that activate the Arp2/3 complex during neuroblast migration in Caenorhabditis elegans. The transmembrane protein MIG-13/Lrp12 is linked to the Arp2/3 nucleation-promoting factors WAVE or WASP through direct interactions ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.09.029

    authors: Zhu Z,Chai Y,Jiang Y,Li W,Hu H,Li W,Wu JW,Wang ZX,Huang S,Ou G

    更新日期:2016-10-24 00:00:00

  • Neutrophil Extracellular Traps: The Biology of Chromatin Externalization.

    abstract::Neutrophils are essential to the homeostatic mission of safeguarding host tissues, responding rapidly and diversely to breaches of the host's barriers to infection, and returning tissues to a sterile state. In response to specific stimuli, neutrophils extrude modified chromatin structures decorated with specific cytop...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2018.01.019

    authors: Sollberger G,Tilley DO,Zychlinsky A

    更新日期:2018-03-12 00:00:00

  • Beyond stereospecificity: liquids and mesoscale organization of cytoplasm.

    abstract::The cytoplasm is not a homogenous solution but instead consists of large dynamic assemblies that arise from transient molecular interactions. Some of these structures have been shown to represent liquid droplets of concentrated protein and RNA. Liquid phase separation of cytoplasm may be a fundamental principle of cyt...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.06.013

    authors: Hyman AA,Brangwynne CP

    更新日期:2011-07-19 00:00:00

  • Plant cell polarity: sterols enter into action after cytokinesis.

    abstract::In yeast and animal cells, the sterol composition of membranes is a key factor that controls the polarity of membrane proteins by regulating their intracellular trafficking or lateral diffusion. A recent study in Nature Cell Biology demonstrates that plant sterols play a major role in the acquisition of cell polarity ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.02.007

    authors: Jaillais Y,Gaude T

    更新日期:2008-03-01 00:00:00

  • Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis.

    abstract::Netrin-1 was recently proposed to play an important role in embryonic and pathological angiogenesis. However, data reported led to the apparently contradictory conclusions that netrin-1 is either a pro- or an antiangiogenic factor. Here, we reconcile these opposing observations by demonstrating that netrin-1 acts as a...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.02.006

    authors: Castets M,Coissieux MM,Delloye-Bourgeois C,Bernard L,Delcros JG,Bernet A,Laudet V,Mehlen P

    更新日期:2009-04-01 00:00:00

  • Cyclin-like oscillations in levels of the nucleoporin Nup96 control G1/S progression.

    abstract::In this issue of Developmental Cell, Chakraborty et al. report that efficient advancement through G1/S phase requires the downregulation of Nup96 levels during M phase. The authors show that oscillations in Nup96 levels plays a key role in maintaining normal cell proliferation, likely by regulating the export of speci...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2008.10.010

    authors: Wozniak RW,Goldfarb DS

    更新日期:2008-11-01 00:00:00

  • GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic responses.

    abstract::Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signal...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2012.02.002

    authors: Whitford R,Fernandez A,Tejos R,Pérez AC,Kleine-Vehn J,Vanneste S,Drozdzecki A,Leitner J,Abas L,Aerts M,Hoogewijs K,Baster P,De Groodt R,Lin YC,Storme V,Van de Peer Y,Beeckman T,Madder A,Devreese B,Luschnig C,Friml

    更新日期:2012-03-13 00:00:00

  • Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression.

    abstract::Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regulation of both the Hippo-Yap and Rac1-Pak1 pathways. Using genetically engineered murine liver models, we show that co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by N...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.09.027

    authors: Shi Y,Bollam SR,White SM,Laughlin SZ,Graham GT,Wadhwa M,Chen H,Nguyen C,Vitte J,Giovannini M,Toretsky J,Yi C

    更新日期:2016-11-21 00:00:00

  • An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.

    abstract::In vertebrates, the microtubule binding protein TPX2 is required for meiotic and mitotic spindle assembly. TPX2 is also known to bind to and activate Aurora A kinase and target it to the spindle. However, the relationship between the TPX2-Aurora A interaction and the role of TPX2 in spindle assembly is unclear. Here, ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2005.07.002

    authors: Ozlü N,Srayko M,Kinoshita K,Habermann B,O'toole ET,Müller-Reichert T,Schmalz N,Desai A,Hyman AA

    更新日期:2005-08-01 00:00:00

  • Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila.

    abstract::Somatic muscle formation in Drosophila requires fusion of muscle founder cells with fusion-competent myoblasts. In a genetic screen for genes that control muscle development, we identified antisocial (ants), a gene that encodes an ankyrin repeat-, TPR repeat-, and RING finger-containing protein, required for myoblast ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(01)00084-3

    authors: Chen EH,Olson EN

    更新日期:2001-11-01 00:00:00

  • How the sea squirt nucleus tells mesoderm not to be endoderm.

    abstract::Sea squirts are simple invertebrate chordates. In this issue of Developmental Cell, Takatori et al. show nuclear migration within ascidian mesendodermal cells enables polarized localization of Not mRNA, which encodes a homeobox protein that distinguishes mesoderm from endoderm fates. The link between nuclear migration...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2010.10.002

    authors: Parton RM,Davis I

    更新日期:2010-10-19 00:00:00

  • Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.

    abstract::Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively stud...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2017.09.018

    authors: Curran S,Strandkvist C,Bathmann J,de Gennes M,Kabla A,Salbreux G,Baum B

    更新日期:2017-11-20 00:00:00

  • Formation of the BMP activity gradient in the Drosophila embryo.

    abstract::The dorsoventral axis of the Drosophila embryo is patterned by a gradient of bone morphogenetic protein (BMP) ligands. In a process requiring at least three additional extracellular proteins, a broad domain of weak signaling forms and then abruptly sharpens into a narrow dorsal midline peak. Using experimental and com...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2005.04.009

    authors: Mizutani CM,Nie Q,Wan FY,Zhang YT,Vilmos P,Sousa-Neves R,Bier E,Marsh JL,Lander AD

    更新日期:2005-06-01 00:00:00