Abstract：
:In yeast and animal cells, the sterol composition of membranes is a key factor that controls the polarity of membrane proteins by regulating their intracellular trafficking or lateral diffusion. A recent study in Nature Cell Biology demonstrates that plant sterols play a major role in the acquisition of cell polarity by modulating endocytosis after cell division.
journal_name
Dev Celljournal_title
Developmental cellauthors
Jaillais Y,Gaude Tdoi
10.1016/j.devcel.2008.02.007subject
Has Abstractpub_date
2008-03-01 00:00:00pages
318-20issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(08)00077-4journal_volume
14pub_type
杂志文章abstract：:Changes to cell shape and interaction drive animal tissue morphogenesis. Reporting now in Developmental Cell, Del Signore et al. (2018) describe active lengthening of cell-cell contacts by Arp2/3-based actin networks. Through cycles of contact lengthening and shortening, the developing Drosophila eye passes through va...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.02.003
更新日期：2018-02-26 00:00:00
abstract：:The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, c...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2007.03.020
更新日期：2007-04-01 00:00:00
abstract：:Brassinosteroids (BRs) are essential hormones for plant growth and development. BRs regulate gene expression by inducing dephosphorylation of two key transcription factors, BZR1 and BZR2/BES1, through a signal transduction pathway that involves cell-surface receptors (BRI1 and BAK1) and a GSK3 kinase (BIN2). How BR-re...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.06.009
更新日期：2007-08-01 00:00:00
abstract：:Spindle checkpoint silencing is crucial for cell-cycle progression, but mechanisms underlying this process remain mysterious. Two papers, one in this issue of Developmental Cell (Meadows et al., 2011) and one in Current Biology (Rosenberg et al., 2011), begin to show how phosphatase PP1-gamma connects chromosome-micro...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2011.05.017
更新日期：2011-06-14 00:00:00
abstract：:Little is known about the mechanisms governing neonatal growth and maturation of organs. Here we demonstrate that calcineurin/Nuclear Factor of Activated T cells (Cn/NFAT) signaling regulates neonatal pancreatic development in mouse and human islets. Inactivation of calcineurin b1 (Cnb1) in mouse islets impaired dense...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.05.014
更新日期：2012-07-17 00:00:00
abstract：:Tetrapod limbs display a great variety of forms and functions. In an attempt to understand factors influencing this diversity, Cretekos and colleagues, in a recent issue of Genes & Development, provide molecular insight into the evolution of wing morphology in bats. ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.01.011
更新日期：2008-02-01 00:00:00
abstract：:Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formatio...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.05.023
更新日期：2018-06-18 00:00:00
abstract：:The combination of fluid and mechanical properties exhibited by cell membranes enables a wealth of physical phenomena, many of which also have biological functions. A recent study in Cell (Shi et al., 2018) now shows that membrane tension in the cell may not be as simple as it first seemed. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.12.011
更新日期：2019-01-07 00:00:00
abstract：:Recent studies have yielded a number of important insights into the mechanisms of hair follicle development and cycling and have highlighted the particularly important roles played by stem cells and Wnt signaling pathways. ...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(01)00022-3
更新日期：2001-07-01 00:00:00
abstract：:The mechanism responsible for subdividing the embryo into individual tissues is a fundamental, yet still poorly understood, question in developmental biology. Various general hypotheses have been proposed, involving differences in cell adhesion, contractility, or contact-mediated repulsion. However, the key parameter ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.09.004
更新日期：2013-10-14 00:00:00
abstract：:Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long distances and organizes the intracellular microtubule (MT) network. How dynein motor activity is harnessed for these diverse functions remains unknown. Here, we have uncovered a mechanism for how processive dynein-dynactin compl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.12.023
更新日期：2018-01-22 00:00:00
abstract：:Cell-to-cell communication coordinates the behavior of individual cells to establish organ patterning and development. Although mobile signals are known to be important in lateral root development, the role of plasmodesmata (PD)-mediated transport in this process has not been investigated. Here, we show that changes i...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.06.010
更新日期：2013-07-29 00:00:00
abstract：:The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00336-8
更新日期：2003-11-01 00:00:00
abstract：:Developmental processes that control root system architecture are critical for soil exploration by plants, allowing for uptake of water and nutrients. Conversion of the auxin precursor indole-3-butyric acid (IBA) to active auxin (indole-3-acetic acid; IAA) modulates lateral root formation. However, mechanisms governin...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.06.010
更新日期：2019-09-09 00:00:00
abstract：:Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including ischemia and cancer. Despite their importance, mechanisms by which pathways mediated by these transcription factors interact with one another are not fully unde...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.04.021
更新日期：2015-06-08 00:00:00
abstract：:Cell constriction promotes epithelial sheet invagination during embryogenesis across phyla. However, how this cell response is linked to global patterning information during organogenesis remains unclear. To address this issue, we have used the Drosophila eye and studied the formation of the morphogenetic furrow (MF),...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.09.015
更新日期：2007-11-01 00:00:00
abstract：:The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network plays fundamental roles in cell growth, survival, and migration and is frequently activated in cancer. Here, we show that the activities of the signaling network propagate as coordinated waves, biased by growth factor, which drive actin-based ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.08.001
更新日期：2020-09-14 00:00:00
abstract：:The size of an organism is determined by the number and size of its constituent cells. The insulin/IGF-1 signaling systems have been long recognized to play a critical role in the determination of body size. Now the generation of mice deficient for a RhoGAP suggests that this small G protein might also regulate the gr...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(02)00183-1
更新日期：2002-05-01 00:00:00
abstract：:In this issue of Developmental Cell, Chakraborty et al. report that efficient advancement through G1/S phase requires the downregulation of Nup96 levels during M phase. The authors show that oscillations in Nup96 levels plays a key role in maintaining normal cell proliferation, likely by regulating the export of speci...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2008.10.010
更新日期：2008-11-01 00:00:00
abstract：:The developmental mechanisms that orchestrate differentiation of specific nephron segments are incompletely understood, and the factors that maintain their terminal differentiation after nephrogenesis remain largely unknown. Here, the transcription factor AP-2β is shown to be required for the differentiation of distal...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.05.026
更新日期：2020-08-10 00:00:00
abstract：:DSL ligands promote proteolysis of the Notch receptor, to release active Notch intracellular domain (N(ICD)). Conversely, the E3 ubiquitin ligase Deltex can activate ligand-independent Notch proteolysis and signaling. Here we show that Deltex effects require endocytic trafficking by HOPS and AP-3 complexes. Our data s...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.09.002
更新日期：2008-11-01 00:00:00
abstract：:To maintain proper organ size, nature has devised trans-organ communication systems-involving both paracrine and circulating regulatory factors-to safeguard homeostasis. In this issue of Developmental Cell, Ji et al. (2019) now describe an enterohepatic feedback loop that balances tissue size and function in the mamma...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.02.008
更新日期：2019-02-25 00:00:00
abstract：:A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies o...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.09.004
更新日期：2008-10-01 00:00:00
abstract：:In a recent issue of Nature, Bohnert and Kenyon (2017) describe a signaling pathway that prevents transgenerational inheritance of cytoplasmic protein aggregates. Fertilizing sperm trigger aggregate clearance in the ovum by a microautophagy-like effector mechanism mediated by inter-organelle communication between lyso...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.12.016
更新日期：2018-01-08 00:00:00
abstract：:DNA crosslinking agents are commonly used in cancer chemotherapy; however, responses of normal tissues to these agents have not been widely investigated. We reveal in mouse interfollicular epidermal, mammary and hair follicle epithelia that genotoxicity does not promote apoptosis but paradoxically induces hyperplasia ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.09.021
更新日期：2020-12-07 00:00:00
abstract：:Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.12.014
更新日期：2016-01-11 00:00:00
abstract：:In a recent issue of Molecular Cell, Cairo et al. (2013) report that the spindle checkpoint protein Mad1 shuttles between unattached kinetochores and nuclear pores. Mobile Mad1 inhibits the import receptor Kap121p, thus indirectly changing spindle dynamics. This adds nuclear transport control to the mitotic roles of M...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2013.01.003
更新日期：2013-01-28 00:00:00
abstract：:Epithelial tubes are found in many vital organs and require uniform and correct tube diameters for optimal function. Tube size depends on apical membrane growth and subapical cytoskeletal reorganization, but the cues that coordinate these events to ensure functional tube shape remain elusive. We find that epithelial t...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.07.012
更新日期：2005-09-01 00:00:00
abstract：:Novel body structures are often generated by the redeployment of ancestral components of the genome. In this issue of Developmental Cell, Glassford et al. (2015) present a thorough analysis of the co-option of a gene regulatory network in the origin of an evolutionary novelty. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.08.022
更新日期：2015-09-14 00:00:00
abstract：:SAG/RBX2/ROC2 protein is an essential RING component of SCF E3 ubiquitin ligase. The role of SAG during embryogenesis remains unknown. We report a critical role for SAG in controlling vascular and neural development by modulating RAS activity via promoting degradation of neurofibromatosis type 1 (NF1). Mice mutant for...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.09.014
更新日期：2011-12-13 00:00:00
