RhoGAP: the next big thing for small mice?


:The size of an organism is determined by the number and size of its constituent cells. The insulin/IGF-1 signaling systems have been long recognized to play a critical role in the determination of body size. Now the generation of mice deficient for a RhoGAP suggests that this small G protein might also regulate the growth of animals.


Dev Cell


Developmental cell


Birnbaum MJ





Has Abstract


2002-05-01 00:00:00














  • Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.

    abstract::Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Huang J,Liu X,Li D,Shao Z,Cao H,Zhang Y,Trompouki E,Bowman TV,Zon LI,Yuan GC,Orkin SH,Xu J

    更新日期:2016-01-11 00:00:00

  • Regulation of ARGONAUTE10 Expression Enables Temporal and Spatial Precision in Axillary Meristem Initiation in Arabidopsis.

    abstract::Axillary meristems (AMs) give rise to lateral shoots and are critical to plant architecture. Understanding how developmental cues and environmental signals impact AM development will enable the improvement of plant architecture in agriculture. Here, we show that ARGONAUTE10 (AGO10), which sequesters miR165/166, promot...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Zhang C,Fan L,Le BH,Ye P,Mo B,Chen X

    更新日期:2020-12-07 00:00:00

  • A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size.

    abstract::The Hippo/Yki and RB/E2F pathways both regulate tissue growth by affecting cell proliferation and survival, but interactions between these parallel control systems are poorly defined. In this study, we demonstrate that interaction between Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Zhang P,Pei C,Wang X,Xiang J,Sun BF,Cheng Y,Qi X,Marchetti M,Xu JW,Sun YP,Edgar BA,Yuan Z

    更新日期:2017-12-04 00:00:00

  • EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality.

    abstract::Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Cayuso J,Dzementsei A,Fischer JC,Karemore G,Caviglia S,Bartholdson J,Wright GJ,Ober EA

    更新日期:2016-11-07 00:00:00

  • Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting.

    abstract::Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Centanin L,Dekanty A,Romero N,Irisarri M,Gorr TA,Wappner P

    更新日期:2008-04-01 00:00:00

  • The bacterial cytoskeleton: in vivo dynamics of the actin-like protein Mbl of Bacillus subtilis.

    abstract::Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Carballido-López R,Errington J

    更新日期:2003-01-01 00:00:00

  • ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology.

    abstract::Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures defined as regions of the ER that tightly associate with the plasma membrane. However, little is known about the mechanisms that tether these organelles together and why such connections are maintained. Using a quantitative proteomic appr...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Manford AG,Stefan CJ,Yuan HL,Macgurn JA,Emr SD

    更新日期:2012-12-11 00:00:00

  • Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects.

    abstract::Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Zalc A,Rattenbach R,Auradé F,Cadot B,Relaix F

    更新日期:2015-04-06 00:00:00

  • Tissue Sculpting by Fibrils.

    abstract::In this issue of Developmental Cell, Isabella and Horne-Badovinac (2016) show that Rab10 directs site-specific secretion of basement membrane components, which assemble into fibrils that spool out to elongate the Drosophila egg chamber. These findings establish the basement membrane's active role in tissue sculpting. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Jayadev R,Sherwood DR

    更新日期:2016-07-11 00:00:00

  • A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition.

    abstract::Ribosomes perform protein synthesis but are also involved in signaling processes, the full extent of which are still being uncovered. We report that phenotypes of mutating ribosomal proteins (Rps) are largely due to signaling. Using Drosophila, we discovered that a bZip-domain protein, Xrp1, becomes elevated in Rp mut...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Lee CH,Kiparaki M,Blanco J,Folgado V,Ji Z,Kumar A,Rimesso G,Baker NE

    更新日期:2018-08-20 00:00:00

  • Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.

    abstract::All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated transgenic mice expressing a tamoxifen-inducible Ngn3 fusion protei...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Johansson KA,Dursun U,Jordan N,Gu G,Beermann F,Gradwohl G,Grapin-Botton A

    更新日期:2007-03-01 00:00:00

  • Sex and the MHC.

    abstract::Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章,评审


    authors: Scott K

    更新日期:2003-03-01 00:00:00

  • The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling.

    abstract::The Frizzled (Fz) receptor is required cell autonomously in Wnt/beta-catenin and planar cell polarity (PCP) signaling. In addition to these requirements, Fz acts nonautonomously during PCP establishment: wild-type cells surrounding fz(-) patches reorient toward the fz(-) cells. The molecular mechanism(s) of nonautonom...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Wu J,Mlodzik M

    更新日期:2008-09-01 00:00:00

  • Painting a Clearer Picture of Chromatin.

    abstract::Elucidating chromatin's 3D shape is critical to understanding its function, but the fine structure of chromatin domains remains poorly resolved. In a recent report in Nature, Boettiger et al. (2016) visualize chromatin in super-resolution, gaining unprecedented insight into chromatin architecture. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Finn EH,Misteli T,Shachar S

    更新日期:2016-02-22 00:00:00

  • A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action.

    abstract::The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase-mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular C...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Lin A

    更新日期:2006-03-01 00:00:00

  • Dissecting mitochondrial fusion.

    abstract::Because mitochondria have outer and inner membranes, the fusion of two mitochondria requires the coordinated fusion of four lipid bilayers. Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Chan DC

    更新日期:2006-11-01 00:00:00

  • PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress.

    abstract::Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells sense and regulate its levels in vivo remains unclear. Here we show that PCYT1A, the rate-li...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Haider A,Wei YC,Lim K,Barbosa AD,Liu CH,Weber U,Mlodzik M,Oras K,Collier S,Hussain MM,Dong L,Patel S,Alvarez-Guaita A,Saudek V,Jenkins BJ,Koulman A,Dymond MK,Hardie RC,Siniossoglou S,Savage DB

    更新日期:2018-05-21 00:00:00

  • Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans.

    abstract::Membrane repair is essential for cell and organism survival. Exocytosis and endocytosis facilitate membrane repair in small wounds within a single cell; however, it remains unclear how large wounds in the plasma membrane are repaired in metazoans. Here, we show that wounding triggers rapid transcriptional upregulation...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Meng X,Yang Q,Yu X,Zhou J,Ren X,Zhou Y,Xu S

    更新日期:2020-09-14 00:00:00

  • Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development.

    abstract::Smad4 is a central intracellular effector of TGF-beta signaling. Smad-independent TGF-beta pathways, such as those mediated by p38 MAPK, have been identified in cell culture systems, but their in vivo functional mechanisms remain unclear. In this study, we investigated the role of TGF-beta signaling in tooth and palat...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Xu X,Han J,Ito Y,Bringas P Jr,Deng C,Chai Y

    更新日期:2008-08-01 00:00:00

  • Dynamic Control of dNTP Synthesis in Early Embryos.

    abstract::Exponential increase of cell numbers in early embryos requires large amounts of DNA precursors (deoxyribonucleoside triphosphates (dNTPs)). Little is understood about how embryos satisfy this demand. We examined dNTP metabolism in the early Drosophila embryo, in which gastrulation is preceded by 13 sequential nuclear ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Song Y,Marmion RA,Park JO,Biswas D,Rabinowitz JD,Shvartsman SY

    更新日期:2017-08-07 00:00:00

  • An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development.

    abstract::Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Miao R,Li M,Zhang Q,Yang C,Wang X

    更新日期:2020-01-06 00:00:00

  • Cell-cycle-dependent spatial sequestration of the DnaA replication initiator protein in Bacillus subtilis.

    abstract::Initiation of DNA replication must be restricted to occur only once per cell cycle. In most bacteria, DnaA protein binds replication origins and promotes the initiation of DNA replication. We have found that in Bacillus subtilis, DnaA only colocalizes with origin regions at early or late stages of the cell cycle, when...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Soufo CD,Soufo HJ,Noirot-Gros MF,Steindorf A,Noirot P,Graumann PL

    更新日期:2008-12-01 00:00:00

  • An ankyrin repeat domain of AKR2 drives chloroplast targeting through coincident binding of two chloroplast lipids.

    abstract::In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targetin...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Kim DH,Park MJ,Gwon GH,Silkov A,Xu ZY,Yang EC,Song S,Song K,Kim Y,Yoon HS,Honig B,Cho W,Cho Y,Hwang I

    更新日期:2014-09-08 00:00:00

  • Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal.

    abstract::Large intergenic noncoding (linc) RNAs constitute a new dimension of posttranscriptional gene regulation. In this issue of Developmental Cell, Wang et al. (2013) find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR-145, thus regulating core pluripotency factors Oct...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Cheng EC,Lin H

    更新日期:2013-04-15 00:00:00

  • A Place for RNAi.

    abstract::Processing bodies (P bodies) are discrete cytoplasmic foci to which mRNA is routed for degradation. In mammalian cells, they are also associated with miRNA-induced translational silencing and siRNA-induced mRNA degradation. In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting prot...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审


    authors: Anderson P

    更新日期:2005-09-01 00:00:00

  • Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.

    abstract::In multicellular organisms, cell size is tightly controlled by nutrients and growth factors. Increasing ambient glucose induces enhanced protein synthesis and cell size. Continued exposure of cells to high glucose in vivo, as apparent under pathological conditions, results in cell hypertrophy and tissue damage. We dem...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Wu L,Derynck R

    更新日期:2009-07-01 00:00:00

  • SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion.

    abstract::Migrating fibroblasts undergo contact inhibition of locomotion (CIL), a process that was discovered five decades ago and still is not fully understood at the molecular level. We identify the Slit2-Robo4-srGAP2 signaling network as a key regulator of CIL in fibroblasts. CIL involves highly dynamic contact protrusions w...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Fritz RD,Menshykau D,Martin K,Reimann A,Pontelli V,Pertz O

    更新日期:2015-10-12 00:00:00

  • Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.

    abstract::In vertebrate embryos, retinoic acid (RA) synthesized in the mesoderm by Raldh2 emanates to the hindbrain neuroepithelium, where it induces anteroposterior (AP)-restricted Hox expression patterns and rhombomere segmentation. However, how appropriate spatiotemporal RA activity is generated in the hindbrain is poorly un...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Vitobello A,Ferretti E,Lampe X,Vilain N,Ducret S,Ori M,Spetz JF,Selleri L,Rijli FM

    更新日期:2011-04-19 00:00:00

  • Bypassing transcription: a shortcut in cytokinin-auxin interactions.

    abstract::In this issue of Developmental Cell, Marhavý et al. (2011) uncover a transcription-independent molecular mechanism of interaction between auxin and cytokinin in the regulation of plant meristem function. By modulating endocytic trafficking of PIN1, cytokinin controls auxin flux and, therefore, auxin gradients. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Stepanova AN,Alonso JM

    更新日期:2011-10-18 00:00:00

  • Germ Cells Get by with a Little Cannibalistic Help from Their Friends.

    abstract::During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in half by endodermal cells. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Krishna S,Overholtzer M

    更新日期:2016-12-19 00:00:00