Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.

abstract：:COPII vesicles assemble at ER subdomains called transitional ER (tER) sites, but the mechanism that generates tER sites is unknown. To study tER biogenesis, we analyzed the transmembrane protein Sec12, which initiates COPII vesicle formation. Sec12 is concentrated at discrete tER sites in the budding yeast Pichia past...

journal_title：Developmental cell

authors： Soderholm J,Bhattacharyya D,Strongin D,Markovitz V,Connerly PL,Reinke CA,Glick BS

更新日期：2004-05-01 00:00:00

abstract：:The actin remodeling factor N-WASP is best known as an Arp2/3 complex activator in processes like endocytosis, extracellular matrix degradation, and host-pathogen interaction. In this issue of Developmental Cell, Juin et al. establish a novel trafficking function for N-WASP in driving lysophosphatidic acid-dependent c...

journal_title：Developmental cell

authors： Rottner K,Schaks M

更新日期：2019-11-18 00:00:00

abstract：:Stem cell differentiation involves a delicate balance of gene expression and transposon repression. In this issue of Developmental Cell, Shibata et al. (2016) show that a PIWI protein expressed in planarian stem cells is inherited by their differentiating descendants to ensure regenerative capacity of the flatworm via...

journal_title：Developmental cell

authors： Tharp ME,Bortvin A

更新日期：2016-05-09 00:00:00

abstract：:Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Propagation of CENP-A chromatin is uncoupled from DNA replication initiating only during mitotic exit. We now demonstrate that ...

journal_title：Developmental cell

authors： Silva MC,Bodor DL,Stellfox ME,Martins NM,Hochegger H,Foltz DR,Jansen LE

更新日期：2012-01-17 00:00:00

abstract：:Branching morphogenesis is a key process in the formation of vascular networks. To date, little is known regarding the molecular events regulating this process. We investigated the involvement of synectin in this process. In zebrafish embryos, synectin knockdown resulted in a hypoplastic dorsal aorta and hypobranched,...

journal_title：Developmental cell

authors： Chittenden TW,Claes F,Lanahan AA,Autiero M,Palac RT,Tkachenko EV,Elfenbein A,Ruiz de Almodovar C,Dedkov E,Tomanek R,Li W,Westmore M,Singh JP,Horowitz A,Mulligan-Kehoe MJ,Moodie KL,Zhuang ZW,Carmeliet P,Simons M

更新日期：2006-06-01 00:00:00

abstract：:Mammary epithelial phagocytosis is critical for removal of apoptotic cells during involution, but the mechanisms governing this process are largely unknown. In this issue of Developmental Cell, Akhtar et al. (2016) provide insight into mechanisms regulating involution, demonstrating that Rac1 drives the switch from di...

journal_title：Developmental cell

authors： Naylor MJ

更新日期：2016-09-12 00:00:00

abstract：:Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-...

journal_title：Developmental cell

authors： Wang ZY,Nakano T,Gendron J,He J,Chen M,Vafeados D,Yang Y,Fujioka S,Yoshida S,Asami T,Chory J

更新日期：2002-04-01 00:00:00

abstract：:BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin. However, it remains unknown whether BMP signaling can promote self-renewal of adult somatic stem cells. In this study, we sh...

journal_title：Developmental cell

authors： Kirilly D,Spana EP,Perrimon N,Padgett RW,Xie T

更新日期：2005-11-01 00:00:00

abstract：:Neurite fasciculation through contact-dependent signaling is important for the wiring and function of the neuronal circuits. Here, we describe a type of axon-dendrite fasciculation in C. elegans, where proximal dendrites of the nociceptor PVD adhere to the axon of the ALA interneuron. This axon-dendrite fasciculation ...

journal_title：Developmental cell

authors： Chen CH,Hsu HW,Chang YH,Pan CL

更新日期：2019-01-28 00:00:00

abstract：:Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown. Here we show that the initial stage of process extension and axon ensheathment by oligodendrocytes requires dynamic actin filament assembly by the Arp2/3 complex...

journal_title：Developmental cell

authors： Zuchero JB,Fu MM,Sloan SA,Ibrahim A,Olson A,Zaremba A,Dugas JC,Wienbar S,Caprariello AV,Kantor C,Leonoudakis D,Lariosa-Willingham K,Kronenberg G,Gertz K,Soderling SH,Miller RH,Barres BA

更新日期：2015-07-27 00:00:00

abstract：:Exponential increase of cell numbers in early embryos requires large amounts of DNA precursors (deoxyribonucleoside triphosphates (dNTPs)). Little is understood about how embryos satisfy this demand. We examined dNTP metabolism in the early Drosophila embryo, in which gastrulation is preceded by 13 sequential nuclear ...

journal_title：Developmental cell

authors： Song Y,Marmion RA,Park JO,Biswas D,Rabinowitz JD,Shvartsman SY

更新日期：2017-08-07 00:00:00

abstract：:Macropinocytosis coordinates non-specific uptake of macromolecules and fluid. Cancers employ macropinocytosis to obtain nutrients to support their metabolic homeostasis. In this issue of Developmental Cell, Lee et al. (2019) report that glutamine deprivation boosts macropinocytosis via EGFR signaling induction, provid...

journal_title：Developmental cell

authors： Weerasekara VK,Patra KC,Bardeesy N

更新日期：2019-08-05 00:00:00

abstract：:A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin immunoprecipitation and transcriptional profiling identified direct target genes shared by each pathway within nephron progenitors. Wnt4 and Fgf8 are e...

journal_title：Developmental cell

authors： Park JS,Ma W,O'Brien LL,Chung E,Guo JJ,Cheng JG,Valerius MT,McMahon JA,Wong WH,McMahon AP

更新日期：2012-09-11 00:00:00

abstract：:Exposing cells to folding stress causes a subset of their proteins to misfold and accumulate in inclusion bodies (IBs). IB formation and clearance are both active processes, but little is known about their mechanism. To shed light on this issue, we performed a screen with over 4,000 fluorescently tagged yeast proteins...

journal_title：Developmental cell

authors： Moldavski O,Amen T,Levin-Zaidman S,Eisenstein M,Rogachev I,Brandis A,Kaganovich D,Schuldiner M

更新日期：2015-06-08 00:00:00

abstract：:The role of mitochondria in Drosophila programmed cell death remains unclear, although certain gene products that regulate cell death seem to be evolutionarily conserved. We find that developmental programmed cell death stimuli in vivo and multiple apoptotic stimuli ex vivo induce dramatic mitochondrial fragmentation ...

journal_title：Developmental cell

authors： Goyal G,Fell B,Sarin A,Youle RJ,Sriram V

更新日期：2007-05-01 00:00:00

abstract：:The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad ...

journal_title：Developmental cell

authors： Langevin J,Morgan MJ,Sibarita JB,Aresta S,Murthy M,Schwarz T,Camonis J,Bellaïche Y

更新日期：2005-09-01 00:00:00

abstract：:Passenger proteins migrate from inner centromeres to the spindle midzone during late mitosis, and those described to date are essential both for proper chromosome segregation and for completion of cell cleavage. We have purified and cloned the human passenger protein TD-60, and we here report that it is a member of th...

journal_title：Developmental cell

authors： Mollinari C,Reynaud C,Martineau-Thuillier S,Monier S,Kieffer S,Garin J,Andreassen PR,Boulet A,Goud B,Kleman JP,Margolis RL

更新日期：2003-08-01 00:00:00

abstract：:Oncogenic alterations in epithelial tissues often trigger apoptosis, suggesting an evolutionary mechanism by which organisms eliminate aberrant cells from epithelia. In Drosophila imaginal epithelia, clones of cells mutant for tumor suppressors, such as scrib or dlg, lose their polarity and are eliminated by cell deat...

journal_title：Developmental cell

authors： Igaki T,Pastor-Pareja JC,Aonuma H,Miura M,Xu T

更新日期：2009-03-01 00:00:00

abstract：:Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...

journal_title：Developmental cell

authors： Ewen-Campen B,Mohr SE,Hu Y,Perrimon N

更新日期：2017-10-09 00:00:00

abstract：:Many human genes generate mRNAs with alternative 3' untranslated regions (3' UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3' UTRs to encipher protein localizatio...

journal_title：Developmental cell

authors： Portz B,Shorter J

更新日期：2018-12-03 00:00:00

abstract：:Reporting in Cell, Berg et al. (2016) reveal a connection between genetic lysosomal storage disorders and the ability of macrophages to migrate and control mycobacterial infection. This insight, resulting from a zebrafish genetic screen, inspired the authors to propose an explanation for the increased susceptibility o...

journal_title：Developmental cell

authors： Meijer AH,Aerts JM

更新日期：2016-04-18 00:00:00

abstract：:The myogenic regulatory genes Myf5, Mrf4, Myod, and Myogenin likely arose by gene duplications during evolution, presumably to address the more demanding requirements of the vertebrate body plan. Two cell lineages were proposed to be regulated independently by Myf5 and Myod to safeguard against tissue failure. Here we...

journal_title：Developmental cell

authors： Comai G,Sambasivan R,Gopalakrishnan S,Tajbakhsh S

更新日期：2014-12-08 00:00:00

abstract：:The conserved Hedgehog signaling pathway is essential for embryonic development and tissue homeostasis and is tightly regulated. In this issue of Developmental Cell, Ma et al. (2016) demonstrate that sumoylation works in parallel with phosphorylation to stabilize Smoothened, antagonizing its ubiquitination and subsequ...

journal_title：Developmental cell

authors： Qi Y,Liu H,Lin X

更新日期：2016-11-21 00:00:00

abstract：:Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship be...

journal_title：Developmental cell

authors： Yarychkivska O,Shaham S

更新日期：2020-05-04 00:00:00

abstract：:Gastric acid secretion by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation. Here, we found that TRPML1 (ML1), a protein that is mutated in type IV mucolipidosis (ML-IV), is a tubulovesicular ...

journal_title：Developmental cell

authors： Sahoo N,Gu M,Zhang X,Raval N,Yang J,Bekier M,Calvo R,Patnaik S,Wang W,King G,Samie M,Gao Q,Sahoo S,Sundaresan S,Keeley TM,Wang Y,Marugan J,Ferrer M,Samuelson LC,Merchant JL,Xu H

更新日期：2017-05-08 00:00:00

abstract：:Microtubules are normally organized at centrosomes, but other sites can also serve as microtubule organizing centers (MTOCs). In this issue of Developmental Cell, Procter et al. (2018) show that the human cytomegalovirus virion assembly compartment acts as a dynamic Golgi-derived MTOC where EB3 nucleates microtubules ...

journal_title：Developmental cell

authors： Lyon SM,Kalejta RF

更新日期：2018-04-09 00:00:00

abstract：:Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously identified a mode of bacterial communication mediated by nanotubes bridging neighboring cells. Here, we elucidate nanotube architecture, dynamics, and molecular compo...

journal_title：Developmental cell

authors： Dubey GP,Malli Mohan GB,Dubrovsky A,Amen T,Tsipshtein S,Rouvinski A,Rosenberg A,Kaganovich D,Sherman E,Medalia O,Ben-Yehuda S

更新日期：2016-02-22 00:00:00

abstract：:Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to si...

journal_title：Developmental cell

authors： Graml V,Studera X,Lawson JLD,Chessel A,Geymonat M,Bortfeld-Miller M,Walter T,Wagstaff L,Piddini E,Carazo Salas RE

更新日期：2014-10-27 00:00:00

abstract：:The gastrulating vertebrate embryo develops three germlayers: ectoderm, mesoderm, and endoderm. Zebrafish endoderm differentiation starts with the activation of sox17 by casanova (cas). We report that spg (pou2/Oct4) is essential for endoderm formation. Embryos devoid of maternal and zygotic spg function (MZspg) lack ...

journal_title：Developmental cell

authors： Reim G,Mizoguchi T,Stainier DY,Kikuchi Y,Brand M

更新日期：2004-01-01 00:00:00

abstract：:Processing bodies (P bodies) are discrete cytoplasmic foci to which mRNA is routed for degradation. In mammalian cells, they are also associated with miRNA-induced translational silencing and siRNA-induced mRNA degradation. In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting prot...

journal_title：Developmental cell

authors： Anderson P

更新日期：2005-09-01 00:00:00