当前位置： SCI文献检索 > DEVELOPMENTAL CELL期刊下所有文献 > The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.

The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.

Abstract：

:Passenger proteins migrate from inner centromeres to the spindle midzone during late mitosis, and those described to date are essential both for proper chromosome segregation and for completion of cell cleavage. We have purified and cloned the human passenger protein TD-60, and we here report that it is a member of the RCC1 family and that it binds preferentially the nucleotide-free form of the small G protein Rac1. Using siRNA, we further demonstrate that the absence of TD-60 substantially suppresses overall spindle assembly, blocks cells in prometaphase, and activates the spindle assembly checkpoint. These defects suggest TD-60 may have a role in global spindle assembly or may be specifically required to integrate kinetochores into the mitotic spindle. The latter is consistent with a TD-60 requirement for recruitment of the passenger proteins survivin and Aurora B, and suggests that like other passenger proteins, TD-60 is involved in regulation of cell cleavage.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Mollinari C,Reynaud C,Martineau-Thuillier S,Monier S,Kieffer S,Garin J,Andreassen PR,Boulet A,Goud B,Kleman JP,Margolis RL

doi

10.1016/s1534-5807(03)00205-3

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

295-307

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(03)00205-3

journal_volume

5

pub_type

杂志文章

相关文献

DEVELOPMENTAL CELL文献大全
  • A receptor for meningococcus: eliciting β-arrestin signaling for barrier breaching.

    abstract：:In a recent issue of Cell, Coureuil et al. (2010) show that type IV pili of Neisseria meningitidis-the causative bacterium of cerebrospinal meningitis-bind to the endothelial β2-adrenoceptor and elicit biased β-arrestin signaling resulting in microvilli formation and paracytotic bacterial migration. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2010.12.011

    authors： Tourret J,Finlay BB

    更新日期：2011-01-18 00:00:00

  • LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis.

    abstract：:Several genes are known to regulate circadian rhythms in Arabidopsis, but the identity of the central oscillator has not been established. LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved. Here we demonstrate that, as shown previously for CCA1, inactivation of LHY shortens the pe...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(02)00170-3

    authors： Mizoguchi T,Wheatley K,Hanzawa Y,Wright L,Mizoguchi M,Song HR,Carré IA,Coupland G

    更新日期：2002-05-01 00:00:00

  • A Mad that wears two hats: Mad1's control of nuclear trafficking.

    abstract：:In a recent issue of Molecular Cell, Cairo et al. (2013) report that the spindle checkpoint protein Mad1 shuttles between unattached kinetochores and nuclear pores. Mobile Mad1 inhibits the import receptor Kap121p, thus indirectly changing spindle dynamics. This adds nuclear transport control to the mitotic roles of M...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2013.01.003

    authors： Dasso M

    更新日期：2013-01-28 00:00:00

  • Wnt signals and frizzled activity orient anterior-posterior axon outgrowth in C. elegans.

    abstract：:Secreted proteins of the Wnt family affect axon guidance, asymmetric cell division, and cell fate. We show here that C. elegans Wnts acting through Frizzled receptors can shape axon and dendrite trajectories by reversing the anterior-posterior polarity of neurons. In lin-44/Wnt and lin-17/Frizzled mutants, the polarit...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2006.01.013

    authors： Hilliard MA,Bargmann CI

    更新日期：2006-03-01 00:00:00

  • Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

    abstract：:Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2008.01.005

    authors： Langer EM,Feng Y,Zhaoyuan H,Rauscher FJ 3rd,Kroll KL,Longmore GD

    更新日期：2008-03-01 00:00:00

  • Stem cells on fire: inflammatory signaling in HSC emergence.

    abstract：:Inflammatory pathways protect the body from infection and promote healing following injury. Recent reports demonstrate the surprising involvement of these pathways during hematopoietic stem cell emergence from the hemogenic endothelium in both zebrafish and mice. ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2014.11.026

    authors： Veldman MB,Lin S

    更新日期：2014-12-08 00:00:00

  • Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.

    abstract：:Regulated turnover of integrin receptors is essential for cell adhesion and migration. Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis, yet proteins required for the internalization of this pro-invasive integrin remain to be identified. Here, we uncover formin-lik...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.06.015

    authors： Wang Y,Arjonen A,Pouwels J,Ta H,Pausch P,Bange G,Engel U,Pan X,Fackler OT,Ivaska J,Grosse R

    更新日期：2015-08-24 00:00:00

  • Dystroglycan and AMP kinase: polarity's protectors when the power goes out.

    abstract：:The AMP-stimulated protein kinase regulates epithelial polarity under conditions of energy depletion by phosphorylating the myosin regulatory light chain. In this issue of Developmental Cell, Mirouse et al. demonstrate that dystroglycan and perlecan, an extracellular matrix receptor and its ligand, help localize myosi...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2008.12.004

    authors： Zhang L,Seo-Mayer P,Caplan MJ

    更新日期：2009-01-01 00:00:00

  • Chk1: a double agent in cell cycle checkpoints.

    abstract：:Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al.(2007) present evidence to indicate that Chk1 als...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2007.01.005

    authors： Yu H

    更新日期：2007-02-01 00:00:00

  • SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells.

    abstract：:The noncoding Xist RNA triggers silencing of one of the two female X chromosomes during X inactivation in mammals. Gene silencing by Xist is restricted to a special developmental context in early embryos and specific hematopoietic precursors. Here, we show that Xist can initiate silencing in a lymphoma model. We ident...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2009.03.006

    authors： Agrelo R,Souabni A,Novatchkova M,Haslinger C,Leeb M,Komnenovic V,Kishimoto H,Gresh L,Kohwi-Shigematsu T,Kenner L,Wutz A

    更新日期：2009-04-01 00:00:00

  • Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila.

    abstract：:Somatic muscle formation in Drosophila requires fusion of muscle founder cells with fusion-competent myoblasts. In a genetic screen for genes that control muscle development, we identified antisocial (ants), a gene that encodes an ankyrin repeat-, TPR repeat-, and RING finger-containing protein, required for myoblast ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(01)00084-3

    authors： Chen EH,Olson EN

    更新日期：2001-11-01 00:00:00

  • WRAMPing up calcium in migrating cells by localized ER transport.

    abstract：:Morphological plasticity and front-rear polarity are essential for directed cell migration. In this issue of Developmental Cell, Witze et al. (2013) demonstrate that Wnt5a-mediated signaling induces localization of the cortical endoplasmic reticulum to the trailing edge of melanoma cells and mediates calcium flux, rea...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2013.09.013

    authors： Mladinich KM,Huttenlocher A

    更新日期：2013-09-30 00:00:00

  • Do morphogen gradients arise by diffusion?

    abstract：:Many patterns of cell and tissue organization are specified during development by gradients of morphogens, substances that assign different cell fates at different concentrations. Gradients form by morphogen transport from a localized site, but whether this occurs by simple diffusion or by more elaborate mechanisms is...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(02)00179-x

    authors： Lander AD,Nie Q,Wan FY

    更新日期：2002-06-01 00:00:00

  • Meiosis researchers exchange information in the Alps.

    abstract：:The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(03)00336-8

    authors： Dernburg AF

    更新日期：2003-11-01 00:00:00

  • SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.

    abstract：:Prior to the pairing and recombination between homologous chromosomes during meiosis, telomeres attach to the nuclear envelope and form a transient cluster. However, the protein factors mediating meiotic telomere attachment to the nuclear envelope and the requirement of this attachment for homolog pairing and synapsis...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2007.03.018

    authors： Ding X,Xu R,Yu J,Xu T,Zhuang Y,Han M

    更新日期：2007-06-01 00:00:00

  • Brassinosteroid/Abscisic Acid Antagonism in Balancing Growth and Stress.

    abstract：:In this issue of Developmental Cell, Gui et al. (2016) show that an abscisic acid-inducible remorin protein in rice directly interacts with critical brassinosteroid signaling components to attenuate the brassinosteroid response, thus illuminating one aspect of the brassinosteroid/abscisic acid antagonism. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2016.07.005

    authors： Clouse SD

    更新日期：2016-07-25 00:00:00

  • ORP-Mediated ER Contact with Endocytic Sites Facilitates Actin Polymerization.

    abstract：:Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Her...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2017.10.031

    authors： Encinar Del Dedo J,Idrissi FZ,Fernandez-Golbano IM,Garcia P,Rebollo E,Krzyzanowski MK,Grötsch H,Geli MI

    更新日期：2017-12-04 00:00:00

  • Muscle building; mechanisms of myotube guidance and attachment site selection.

    abstract：:The complex muscle patterns of higher organisms arise as migrating myoblasts are guided toward and connect with specific attachment sites. We review here the current understanding of myotube migration, focusing on its dynamic nature and the few molecular cues that have been identified to date. Much of this knowledge c...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.devcel.2004.06.010

    authors： Schnorrer F,Dickson BJ

    更新日期：2004-07-01 00:00:00

  • Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse.

    abstract：:We present new approaches to cis-regulatory module (CRM) discovery in the common scenario where relevant transcription factors and/or motifs are unknown. Beginning with a small list of CRMs mediating a common gene expression pattern, we search genome-wide for CRMs with similar functionality, using new statistical scor...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2009.09.002

    authors： Kantorovitz MR,Kazemian M,Kinston S,Miranda-Saavedra D,Zhu Q,Robinson GE,Göttgens B,Halfon MS,Sinha S

    更新日期：2009-10-01 00:00:00

  • Putting Your Best Egg Forward.

    abstract：:In a recent issue of Nature, Bohnert and Kenyon (2017) describe a signaling pathway that prevents transgenerational inheritance of cytoplasmic protein aggregates. Fertilizing sperm trigger aggregate clearance in the ovum by a microautophagy-like effector mechanism mediated by inter-organelle communication between lyso...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2017.12.016

    authors： Patil CK,Denic V

    更新日期：2018-01-08 00:00:00

  • Making a Choice: How Cadherin Switching Controls Cell Migration.

    abstract：:Cells that undergo epithelial-to-mesenchymal transitions (EMTs) commonly switch from expressing E-cadherin to N-cadherin. But why this occurs is not well understood. In the current issue of Developmental Cell, Scarpa et al. (2015) identify a reason: cadherin switching controls Rac signaling to determine how cell locom...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2015.08.002

    authors： Priya R,Yap AS

    更新日期：2015-08-24 00:00:00

  • The WW domain protein Kibra acts upstream of Hippo in Drosophila.

    abstract：:The conserved Hippo kinase pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Whereas the function of the core kinase cascade, consisting of the serine/threonine kinases Hippo and Warts, in phosphorylating and thereby inactivating the transcri...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2009.12.013

    authors： Baumgartner R,Poernbacher I,Buser N,Hafen E,Stocker H

    更新日期：2010-02-16 00:00:00

  • Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.

    abstract：:Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.12.014

    authors： Huang J,Liu X,Li D,Shao Z,Cao H,Zhang Y,Trompouki E,Bowman TV,Zon LI,Yuan GC,Orkin SH,Xu J

    更新日期：2016-01-11 00:00:00

  • Germ Cells Get by with a Little Cannibalistic Help from Their Friends.

    abstract：:During development, primordial germ cells (PGCs) navigate a complex journey to generate the germline. In a recent paper in Nature Cell Biology, Nance and colleagues (Abdu et al., 2016) have discovered an unexpected step along the way: PGCs get cut in half by endodermal cells. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2016.12.003

    authors： Krishna S,Overholtzer M

    更新日期：2016-12-19 00:00:00

  • Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud.

    abstract：:The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlying this process remain obscure. Here, we used time-lapse microscopy together with several ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.09.001

    authors： Packard A,Georgas K,Michos O,Riccio P,Cebrian C,Combes AN,Ju A,Ferrer-Vaquer A,Hadjantonakis AK,Zong H,Little MH,Costantini F

    更新日期：2013-11-11 00:00:00

  • Regulation of ARGONAUTE10 Expression Enables Temporal and Spatial Precision in Axillary Meristem Initiation in Arabidopsis.

    abstract：:Axillary meristems (AMs) give rise to lateral shoots and are critical to plant architecture. Understanding how developmental cues and environmental signals impact AM development will enable the improvement of plant architecture in agriculture. Here, we show that ARGONAUTE10 (AGO10), which sequesters miR165/166, promot...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.10.019

    authors： Zhang C,Fan L,Le BH,Ye P,Mo B,Chen X

    更新日期：2020-12-07 00:00:00

  • Functional diversification of Dicer-like proteins and small RNAs required for genome sculpting.

    abstract：:In eukaryotes, small RNAs (sRNAs) have key roles in development, gene expression regulation, and genome integrity maintenance. In ciliates, such as Paramecium, sRNAs form the heart of an epigenetic system that has evolved from core eukaryotic gene silencing components to selectively target DNA for deletion. In Paramec...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.12.010

    authors： Sandoval PY,Swart EC,Arambasic M,Nowacki M

    更新日期：2014-01-27 00:00:00

  • A molecular base for cell sorting at embryonic boundaries: contact inhibition of cadherin adhesion by ephrin/ Eph-dependent contractility.

    abstract：:The mechanism responsible for subdividing the embryo into individual tissues is a fundamental, yet still poorly understood, question in developmental biology. Various general hypotheses have been proposed, involving differences in cell adhesion, contractility, or contact-mediated repulsion. However, the key parameter ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.09.004

    authors： Fagotto F,Rohani N,Touret AS,Li R

    更新日期：2013-10-14 00:00:00

  • Painting a Clearer Picture of Chromatin.

    abstract：:Elucidating chromatin's 3D shape is critical to understanding its function, but the fine structure of chromatin domains remains poorly resolved. In a recent report in Nature, Boettiger et al. (2016) visualize chromatin in super-resolution, gaining unprecedented insight into chromatin architecture. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2016.02.002

    authors： Finn EH,Misteli T,Shachar S

    更新日期：2016-02-22 00:00:00

  • Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects.

    abstract：:Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.02.006

    authors： Zalc A,Rattenbach R,Auradé F,Cadot B,Relaix F

    更新日期：2015-04-06 00:00:00