Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster.

abstract：:hunchback regulates the temporal identity of neuroblasts in Drosophila. Here we show that hbl-1, the C. elegans hunchback ortholog, also controls temporal patterning. Furthermore, hbl-1 is a probable target of microRNA regulation through its 3'UTR. hbl-1 loss-of-function causes the precocious expression of adult seam ...

journal_title：Developmental cell

authors： Lin SY,Johnson SM,Abraham M,Vella MC,Pasquinelli A,Gamberi C,Gottlieb E,Slack FJ

更新日期：2003-05-01 00:00:00

abstract：:The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transi...

journal_title：Developmental cell

authors： Jung H,Mazzoni EO,Soshnikova N,Hanley O,Venkatesh B,Duboule D,Dasen JS

更新日期：2014-04-28 00:00:00

abstract：:Gap junctions are present in most tissues and play essential roles in various biological processes. However, we know surprisingly little about the molecular mechanisms underlying gap junction formation. Here, we uncover the essential role of a conserved EGF- and laminin-G-domain-containing protein nlr-1/CASPR in the r...

journal_title：Developmental cell

authors： Meng L,Yan D

更新日期：2020-12-07 00:00:00

abstract：:Border cells in the Drosophila ovary originate within an epithelium, detach from it, invade neighboring nurse cells, and migrate as a coherent cluster. This migration has served as a useful genetic model for understanding epithelial cell motility. The prevailing model of growth factor-mediated chemotaxis in general, a...

journal_title：Developmental cell

authors： Prasad M,Montell DJ

更新日期：2007-06-01 00:00:00

abstract：:Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and emb...

journal_title：Developmental cell

authors： Calvanese V,Mikkola HK

更新日期：2016-03-07 00:00:00

abstract：:Protein transport between the ER and the Golgi in mammalian cells occurs via large pleiomorphic carriers, and most current models suggest that these are formed by the fusion of small ER-derived COPII vesicles. We have examined the dynamics and structural features of these carriers during and after their formation from...

journal_title：Developmental cell

authors： Mironov AA,Mironov AA Jr,Beznoussenko GV,Trucco A,Lupetti P,Smith JD,Geerts WJ,Koster AJ,Burger KN,Martone ME,Deerinck TJ,Ellisman MH,Luini A

更新日期：2003-10-01 00:00:00

abstract：:A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies o...

journal_title：Developmental cell

authors： He F,Wen Y,Deng J,Lin X,Lu LJ,Jiao R,Ma J

更新日期：2008-10-01 00:00:00

abstract：:We have identified and characterized a novel C. elegans gene, ced-12, that functions in the conserved GTPase signaling pathway mediated by CED-2/Crkll, CED-5/DOCK180, and CED-10/Rac to control cell migration and phagocytosis of apoptotic cells. We provide evidence that ced-12 likely acts upstream of ced-10 during cell...

journal_title：Developmental cell

authors： Wu YC,Tsai MC,Cheng LC,Chou CJ,Weng NY

更新日期：2001-10-01 00:00:00

abstract：:Plants are an excellent system for studying developmental biology. Depending on the species, they can be easily transformed and mutagenized, undergo grafts, tolerate changes in chromosome number, and provide fertile offspring after wide species crosses. Most importantly, they are perpetually embryonic, and thus develo...

journal_title：Developmental cell

authors： Fletcher JC,Hake S

更新日期：2002-10-01 00:00:00

abstract：:Advances in molecular biology continue to help us uncover how information written into genes provides a blueprint for the initiation and orchestration of programs and processes that control cell division, cell-type specification, cell migration, cellular differentiation, and cell death. Clearly, molecular elements int...

journal_title：Developmental cell

authors： Pappu RV

更新日期：2020-10-12 00:00:00

abstract：:The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable in both the eye and wing. The nonautonomous function is dishevelled (dsh...

journal_title：Developmental cell

authors： Strutt H,Strutt D

更新日期：2002-12-01 00:00:00

abstract：:MicroRNAs are abundant in animal genomes, yet little is known about their functions in vivo. Here, we report the production of 80 new Drosophila miRNA mutants by targeted homologous recombination. These mutants remove 104 miRNAs. Together with 15 previously reported mutants, this collection includes 95 mutants deletin...

journal_title：Developmental cell

authors： Chen YW,Song S,Weng R,Verma P,Kugler JM,Buescher M,Rouam S,Cohen SM

更新日期：2014-12-22 00:00:00

abstract：:The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors;...

journal_title：Developmental cell

authors： Baek S,Oh TG,Secker G,Sutton DL,Okuda KS,Paterson S,Bower NI,Toubia J,Koltowska K,Capon SJ,Baillie GJ,Simons C,Muscat GEO,Lagendijk AK,Smith KA,Harvey NL,Hogan BM

更新日期：2019-04-22 00:00:00

abstract：:It has recently been reported that a common side effect of translation-blocking morpholino antisense oligonucleotides is the induction of a set of innate immune response genes in Xenopus embryos and that splicing-blocking morpholinos lead to unexpected off-target mis-splicing events. Here, we present an analysis of al...

journal_title：Developmental cell

authors： Paraiso KD,Blitz IL,Zhou JJ,Cho KWY

更新日期：2019-05-20 00:00:00

abstract：:Dynamic rearrangements of the actin cytoskeleton play a key role in numerous cellular processes. In Drosophila, fusion between a muscle founder cell and a fusion competent myoblast (FCM) is mediated by an invasive, F-actin-enriched podosome-like structure (PLS). Here, we show that the dynamics of the PLS is controlled...

journal_title：Developmental cell

authors： Jin P,Duan R,Luo F,Zhang G,Hong SN,Chen EH

更新日期：2011-05-17 00:00:00

abstract：:The spinal cord and mesodermal tissues of the trunk such as the vertebral column and skeletal musculature derive from neuro-mesodermal progenitors (NMPs). Sox2, Brachyury (T), and Tbx6 have been correlated with NMP potency and lineage choice; however, their exact role and interaction in these processes have not yet be...

journal_title：Developmental cell

authors： Koch F,Scholze M,Wittler L,Schifferl D,Sudheer S,Grote P,Timmermann B,Macura K,Herrmann BG

更新日期：2017-09-11 00:00:00

abstract：:All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated transgenic mice expressing a tamoxifen-inducible Ngn3 fusion protei...

journal_title：Developmental cell

authors： Johansson KA,Dursun U,Jordan N,Gu G,Beermann F,Gradwohl G,Grapin-Botton A

更新日期：2007-03-01 00:00:00

abstract：:Asymmetric cell division--where two dissimilar daughter cells are produced--relies on asymmetric positioning of the telophase spindle midzone, which specifies the cleavage furrow. Ou et al. (2010) now report in Science a mechanism of asymmetric midzone positioning driven by a polarized cortical distribution of the con...

journal_title：Developmental cell

authors： Li R

更新日期：2010-11-16 00:00:00

abstract：:The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback me...

journal_title：Developmental cell

authors： Okamoto N,Nishimura T

更新日期：2015-11-09 00:00:00

abstract：:The Hippo/Yki and RB/E2F pathways both regulate tissue growth by affecting cell proliferation and survival, but interactions between these parallel control systems are poorly defined. In this study, we demonstrate that interaction between Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses ...

journal_title：Developmental cell

authors： Zhang P,Pei C,Wang X,Xiang J,Sun BF,Cheng Y,Qi X,Marchetti M,Xu JW,Sun YP,Edgar BA,Yuan Z

更新日期：2017-12-04 00:00:00

abstract：:Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the facto...

journal_title：Developmental cell

authors： Symmons O,Pan L,Remeseiro S,Aktas T,Klein F,Huber W,Spitz F

更新日期：2016-12-05 00:00:00

abstract：:Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship be...

journal_title：Developmental cell

authors： Yarychkivska O,Shaham S

更新日期：2020-05-04 00:00:00

abstract：:Localization of the actin crosslinking protein, alpha-actinin, to the cleavage furrow has been previously reported. However, its functions during cytokinesis remain poorly understood. We have analyzed the functions of alpha-actinin during cytokinesis by a combination of molecular manipulations and imaging-based techni...

journal_title：Developmental cell

authors： Mukhina S,Wang YL,Murata-Hori M

更新日期：2007-10-01 00:00:00

abstract：:To maintain mechanical homeostasis, cells must recognize and respond to changes in cytoskeletal integrity. By imaging live cells expressing fluorescently tagged cytoskeletal proteins, we observed that actin stress fibers undergo local, acute, force-induced elongation and thinning events that compromise their stress tr...

journal_title：Developmental cell

authors： Smith MA,Blankman E,Gardel ML,Luettjohann L,Waterman CM,Beckerle MC

更新日期：2010-09-14 00:00:00

abstract：:Regulating cell proliferation and differentiation in CNS development requires both extraordinary complexity and precision. Neural progenitors receive graded overlapping signals from midline signaling centers, yet each makes a unique cell fate decision in a spatiotemporally restricted pattern. The Nde1-Lis1 complex reg...

journal_title：Developmental cell

authors： Lanctot AA,Peng CY,Pawlisz AS,Joksimovic M,Feng Y

更新日期：2013-05-13 00:00:00

abstract：:Renewing tissues have the remarkable ability to continually produce both proliferative progenitor and specialized differentiated cell types. How are complex milieus of microenvironmental signals interpreted to coordinate tissue-cell-type composition? Here, we investigate the responses of intestinal epithelium to indiv...

journal_title：Developmental cell

authors： Sanman LE,Chen IW,Bieber JM,Steri V,Trentesaux C,Hann B,Klein OD,Wu LF,Altschuler SJ

更新日期：2021-01-15 00:00:00

abstract：:Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A central hypothesis in organisms ranging from yeast to vertebrates is that nuclear size scales to cell size. This implies that nuclei may reach steady-state sizes set by limiting cytoplasmic pools of size-regulating components. By m...

journal_title：Developmental cell

authors： Mukherjee RN,Sallé J,Dmitrieff S,Nelson KM,Oakey J,Minc N,Levy DL

更新日期：2020-08-10 00:00:00

abstract：:Autophagy defects have recently been associated with chromosomal instability, a hallmark of human cancer. However, the functional specificity and mechanism of action of autophagy-related factors in genome stability remain elusive. Here we report that UVRAG, an autophagic tumor suppressor, plays a dual role in chromoso...

journal_title：Developmental cell

authors： Zhao Z,Oh S,Li D,Ni D,Pirooz SD,Lee JH,Yang S,Lee JY,Ghozalli I,Costanzo V,Stark JM,Liang C

更新日期：2012-05-15 00:00:00

abstract：:Large intergenic noncoding (linc) RNAs constitute a new dimension of posttranscriptional gene regulation. In this issue of Developmental Cell, Wang et al. (2013) find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR-145, thus regulating core pluripotency factors Oct...

journal_title：Developmental cell

authors： Cheng EC,Lin H

更新日期：2013-04-15 00:00:00

abstract：:Drosophila proprioceptors (chordotonal organs) are structured as a linear array of four lineage-related cells: a neuron, a glial cell, and two accessory cells, called cap and ligament, between which the neuron is stretched. To function properly as stretch receptors, chordotonal organs must be stably anchored at both e...

journal_title：Developmental cell

authors： Inbal A,Volk T,Salzberg A

更新日期：2004-08-01 00:00:00