Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors.

Abstract:

:Drosophila proprioceptors (chordotonal organs) are structured as a linear array of four lineage-related cells: a neuron, a glial cell, and two accessory cells, called cap and ligament, between which the neuron is stretched. To function properly as stretch receptors, chordotonal organs must be stably anchored at both edges. The cap cells are anchored to the cuticle through specialized lineage-related attachment cells. However, the mechanism by which the ligament cells at the other edge of the organ attach is not known. Here, we report the identification of specialized attachment cells that anchor the ligament cells of pentascolopidial chordotonal organs (lch5) to the cuticle. The ligament attachment cells are recruited by the approaching ligament cells upon reaching their attachment site, through an EGFR-dependent mechanism. Molecular characterization of lch5 attachment cells demonstrated that they share significant properties with Drosophila tendon cells and with mammalian proprioceptive organs.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Inbal A,Volk T,Salzberg A

doi

10.1016/j.devcel.2004.07.001

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

241-50

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(04)00237-0

journal_volume

7

pub_type

杂志文章
  • Planar Differential Growth Rates Initiate Precise Fold Positions in Complex Epithelia.

    abstract::Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have been studied, but the precise positioning of folds in complex, multi-folded epithelia is less...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.09.009

    authors: Tozluoǧlu M,Duda M,Kirkland NJ,Barrientos R,Burden JJ,Muñoz JJ,Mao Y

    更新日期:2019-11-04 00:00:00

  • Drosophila left/right asymmetry establishment is controlled by the Hox gene abdominal-B.

    abstract::In Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2012.11.013

    authors: Coutelis JB,Géminard C,Spéder P,Suzanne M,Petzoldt AG,Noselli S

    更新日期:2013-01-14 00:00:00

  • Global analysis of the meiotic crossover landscape.

    abstract::Tight control of the number and distribution of crossovers is of great importance for meiosis. Crossovers establish chiasmata, which are physical connections between homologous chromosomes that provide the tension necessary to align chromosomes on the meiotic spindle. Understanding the mechanisms underlying crossover ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.07.006

    authors: Chen SY,Tsubouchi T,Rockmill B,Sandler JS,Richards DR,Vader G,Hochwagen A,Roeder GS,Fung JC

    更新日期:2008-09-01 00:00:00

  • Membrane targeting of endocytic adaptors: cargo and lipid do it together.

    abstract::The adaptor complex AP-2 plays an important role in cargo selection and clathrin lattice formation during clathrin-mediated endocytosis. In a recent issue of Molecular Cell, Honing et al. demonstrate that high-affinity AP-2 membrane association is achieved through a combination of low-affinity interactions with membra...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2005.05.013

    authors: Gaidarov I,Keen JH

    更新日期:2005-06-01 00:00:00

  • A wapl a day keeps the sisters apart: wapl and cohesin dynamics.

    abstract::Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests that a dynamic interaction between the cohesin complex and chromat...

    journal_title:Developmental cell

    pub_type: 社论

    doi:10.1016/j.devcel.2006.11.010

    authors: Rankin S

    更新日期:2006-12-01 00:00:00

  • EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulation.

    abstract::In Drosophila, commitment of a cell to a sense organ precursor (SOP) fate requires bHLH proneural transcription factor upregulation, a process that depends in most cases on the interplay of proneural gene autoregulation and inhibitory Notch signaling. A subset of SOPs are selected by a recruitment pathway involving EG...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2004.09.015

    authors: zur Lage PI,Powell LM,Prentice DR,McLaughlin P,Jarman AP

    更新日期:2004-11-01 00:00:00

  • Antagonistic growth regulation by Dpp and Fat drives uniform cell proliferation.

    abstract::We use the Dpp morphogen gradient in the Drosophila wing disc as a model to address the fundamental question of how a gradient of a growth factor can produce uniform growth. We first show that proper expression and subcellular localization of components in the Fat tumor-suppressor pathway, which have been argued to de...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2010.11.007

    authors: Schwank G,Tauriello G,Yagi R,Kranz E,Koumoutsakos P,Basler K

    更新日期:2011-01-18 00:00:00

  • Melanocortin Receptor 4 Signaling Regulates Vertebrate Limb Regeneration.

    abstract::Melanocortin 4 receptor (Mc4r) plays a crucial role in the central control of energy homeostasis, but its role in peripheral organs has not been fully explored. We have investigated the roles of hypothalamus-mediated energy metabolism during Xenopus limb regeneration. We report that hypothalamus injury inhibits Xenopu...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.07.021

    authors: Zhang M,Chen Y,Xu H,Yang L,Yuan F,Li L,Xu Y,Chen Y,Zhang C,Lin G

    更新日期:2018-08-20 00:00:00

  • GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic responses.

    abstract::Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signal...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2012.02.002

    authors: Whitford R,Fernandez A,Tejos R,Pérez AC,Kleine-Vehn J,Vanneste S,Drozdzecki A,Leitner J,Abas L,Aerts M,Hoogewijs K,Baster P,De Groodt R,Lin YC,Storme V,Van de Peer Y,Beeckman T,Madder A,Devreese B,Luschnig C,Friml

    更新日期:2012-03-13 00:00:00

  • The grapes of incompatibility.

    abstract::When two colonies of the tunicate Botryllus contact each other, they either fuse into a single colony or mount a destructive reaction, which keeps them apart. Which of the two reactions takes place is determined by a single, highly polymorphic fusion/histocompatibility (FuHC) locus. Recent communications report the cl...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2005.12.009

    authors: Klein J

    更新日期:2006-01-01 00:00:00

  • Terminating histone synthesis to preserve centromere integrity.

    abstract::Histone protein synthesis is activated as cells enter S phase to allow packaging of the newly replicated DNA into chromatin. In this issue of Developmental Cell, Takayama and coworkers elucidate a mechanism for silencing histone expression at the end of S phase in S. pombe. Failure to shut off histone expression disru...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2010.03.004

    authors: Marzluff WF

    更新日期:2010-03-16 00:00:00

  • Tsukushi functions as an organizer inducer by inhibition of BMP activity in cooperation with chordin.

    abstract::During chick gastrulation, inhibition of BMP signaling is required for primitive streak formation and induction of Hensen's node. We have identified a unique secreted protein, Tsukushi (TSK), which belongs to the Small Leucine-Rich Proteoglycan (SLRP) family and is expressed in the primitive streak and Hensen's node. ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2004.08.014

    authors: Ohta K,Lupo G,Kuriyama S,Keynes R,Holt CE,Harris WA,Tanaka H,Ohnuma SI

    更新日期:2004-09-01 00:00:00

  • Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification.

    abstract::Phase separation represents an important form of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regulated. In zebrafish, the Balbiani body (Bb) and the germ plasm (Gp) are intimately linked phase-separated structures essential for ge...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.07.009

    authors: Roovers EF,Kaaij LJT,Redl S,Bronkhorst AW,Wiebrands K,de Jesus Domingues AM,Huang HY,Han CT,Riemer S,Dosch R,Salvenmoser W,Grün D,Butter F,van Oudenaarden A,Ketting RF

    更新日期:2018-08-06 00:00:00

  • Chromosome Segregation and Peptidoglycan Remodeling Are Coordinated at a Highly Stabilized Septal Pore to Maintain Bacterial Spore Development.

    abstract::Asymmetric division, a hallmark of endospore development, generates two cells, a larger mother cell and a smaller forespore. Approximately 75% of the forespore chromosome must be translocated across the division septum into the forespore by the DNA translocase SpoIIIE. Asymmetric division also triggers cell-specific t...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.12.006

    authors: Mohamed A,Chan H,Luhur J,Bauda E,Gallet B,Morlot C,Cole L,Awad M,Crawford S,Lyras D,Rudner DZ,Rodrigues CDA

    更新日期:2021-01-11 00:00:00

  • A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size.

    abstract::The Hippo/Yki and RB/E2F pathways both regulate tissue growth by affecting cell proliferation and survival, but interactions between these parallel control systems are poorly defined. In this study, we demonstrate that interaction between Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2017.10.033

    authors: Zhang P,Pei C,Wang X,Xiang J,Sun BF,Cheng Y,Qi X,Marchetti M,Xu JW,Sun YP,Edgar BA,Yuan Z

    更新日期:2017-12-04 00:00:00

  • Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells.

    abstract::Dynein recruitment to the nuclear envelope is required for pre-mitotic nucleus-centrosome interactions in nonneuronal cells and for apical nuclear migration in neural stem cells. In each case, dynein is recruited to the nuclear envelope (NE) specifically during G2 via two nuclear pore-mediated mechanisms involving Ran...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2015.04.022

    authors: Baffet AD,Hu DJ,Vallee RB

    更新日期:2015-06-22 00:00:00

  • Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.

    abstract::During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis. Rac1 null cells migrate markedly less efficiently, but s...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.07.008

    authors: Li A,Ma Y,Yu X,Mort RL,Lindsay CR,Stevenson D,Strathdee D,Insall RH,Chernoff J,Snapper SB,Jackson IJ,Larue L,Sansom OJ,Machesky LM

    更新日期:2011-10-18 00:00:00

  • Myosin-II puts the squeeze on asymmetric cell division.

    abstract::Asymmetric cell division--where two dissimilar daughter cells are produced--relies on asymmetric positioning of the telophase spindle midzone, which specifies the cleavage furrow. Ou et al. (2010) now report in Science a mechanism of asymmetric midzone positioning driven by a polarized cortical distribution of the con...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2010.10.016

    authors: Li R

    更新日期:2010-11-16 00:00:00

  • Nuclear Scaling Is Coordinated among Individual Nuclei in Multinucleated Muscle Fibers.

    abstract::Optimal cell performance depends on cell size and the appropriate relative size, i.e., scaling, of the nucleus. How nuclear scaling is regulated and contributes to cell function is poorly understood, especially in skeletal muscle fibers, which are among the largest cells, containing hundreds of nuclei. Here, we presen...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.02.020

    authors: Windner SE,Manhart A,Brown A,Mogilner A,Baylies MK

    更新日期:2019-04-08 00:00:00

  • Brassinosteroid/Abscisic Acid Antagonism in Balancing Growth and Stress.

    abstract::In this issue of Developmental Cell, Gui et al. (2016) show that an abscisic acid-inducible remorin protein in rice directly interacts with critical brassinosteroid signaling components to attenuate the brassinosteroid response, thus illuminating one aspect of the brassinosteroid/abscisic acid antagonism. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2016.07.005

    authors: Clouse SD

    更新日期:2016-07-25 00:00:00

  • A ubiquitin-binding rhomboid protease aimed at ERADication.

    abstract::Proteins are degraded from the ER by endoplasmic reticulum-associated degradation (ERAD). In a recent issue of Molecular Cell, Fleig et al. (2012) describe a role for a ubiquitin-binding rhomboid protease, RHBDL4, in degradation of select ERAD substrates. These findings and the significance of rhomboids and other intr...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2012.08.015

    authors: Tsai YC,Weissman AM

    更新日期:2012-09-11 00:00:00

  • The Tubulin Code in Microtubule Dynamics and Information Encoding.

    abstract::Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton. Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin isoforms and post-translational modifications, a "tubulin code," which is thought to support the diverse morphology and dynamics of microtu...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2020.06.008

    authors: Roll-Mecak A

    更新日期:2020-07-06 00:00:00

  • Filopodia: the cellular quills of hedgehog signaling?

    abstract::Reporting in Nature, Sanders et al. (2013) implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb. Actin-based filopodia transport Shh from producing cells, while filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway. These findings suggest a new mechanism of ligand m...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2013.05.008

    authors: McMahon AP,Hasso SM

    更新日期:2013-05-28 00:00:00

  • The utility of prions.

    abstract::Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals. However, recent work in fungi indicates that prions are not simply aberrations of protein folding, but are in fact widespread, conserve...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/s1534-5807(02)00118-1

    authors: Osherovich LZ,Weissman JS

    更新日期:2002-02-01 00:00:00

  • Radial WNT5A-Guided Post-mitotic Filopodial Pathfinding Is Critical for Midgut Tube Elongation.

    abstract::The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.06.011

    authors: Wang S,Cebrian C,Schnell S,Gumucio DL

    更新日期:2018-07-16 00:00:00

  • Chemokine signaling mediates self-organizing tissue migration in the zebrafish lateral line.

    abstract::The shape of most complex organ systems arises from the directed migration of cohesive groups of cells. Here, we dissect the role of the chemokine guidance receptor Cxcr4b in regulating the collective migration of one such cohesive tissue, the zebrafish lateral line primordium. Using in vivo imaging, we show that the ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2006.02.019

    authors: Haas P,Gilmour D

    更新日期:2006-05-01 00:00:00

  • The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova.

    abstract::The gastrulating vertebrate embryo develops three germlayers: ectoderm, mesoderm, and endoderm. Zebrafish endoderm differentiation starts with the activation of sox17 by casanova (cas). We report that spg (pou2/Oct4) is essential for endoderm formation. Embryos devoid of maternal and zygotic spg function (MZspg) lack ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(03)00396-4

    authors: Reim G,Mizoguchi T,Stainier DY,Kikuchi Y,Brand M

    更新日期:2004-01-01 00:00:00

  • T-box time in England.

    abstract::T-box genes encode DNA binding transcription factors known to regulate a wide variety of developmental processes during embryogenesis and are present in the genomes of all multicellular animals. Indeed, alongside other more familiar families of developmental regulators such as Hox, Sox, and Pax, T-box genes constitute...

    journal_title:Developmental cell

    pub_type:

    doi:10.1016/s1534-5807(02)00330-1

    authors: Gibson-Brown JJ

    更新日期:2002-11-01 00:00:00

  • Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation.

    abstract::Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is normally restricted to proliferating cells. However, high levels of cyclin E are expressed in the adult brain. The function of ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.08.009

    authors: Odajima J,Wills ZP,Ndassa YM,Terunuma M,Kretschmannova K,Deeb TZ,Geng Y,Gawrzak S,Quadros IM,Newman J,Das M,Jecrois ME,Yu Q,Li N,Bienvenu F,Moss SJ,Greenberg ME,Marto JA,Sicinski P

    更新日期:2011-10-18 00:00:00

  • Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.

    abstract::Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediating these invasions, however, remains unclear. Utilizing the genetically and visually accessible model of anchor cell (AC) inva...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.06.006

    authors: Hagedorn EJ,Yashiro H,Ziel JW,Ihara S,Wang Z,Sherwood DR

    更新日期:2009-08-01 00:00:00