Abstract：
:Drosophila proprioceptors (chordotonal organs) are structured as a linear array of four lineage-related cells: a neuron, a glial cell, and two accessory cells, called cap and ligament, between which the neuron is stretched. To function properly as stretch receptors, chordotonal organs must be stably anchored at both edges. The cap cells are anchored to the cuticle through specialized lineage-related attachment cells. However, the mechanism by which the ligament cells at the other edge of the organ attach is not known. Here, we report the identification of specialized attachment cells that anchor the ligament cells of pentascolopidial chordotonal organs (lch5) to the cuticle. The ligament attachment cells are recruited by the approaching ligament cells upon reaching their attachment site, through an EGFR-dependent mechanism. Molecular characterization of lch5 attachment cells demonstrated that they share significant properties with Drosophila tendon cells and with mammalian proprioceptive organs.
journal_name
Dev Celljournal_title
Developmental cellauthors
Inbal A,Volk T,Salzberg Adoi
10.1016/j.devcel.2004.07.001keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
241-50issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(04)00237-0journal_volume
7pub_type
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