Abstract：
:Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gonadal sex reversal caused by disruption to Sry expression. Gadd45γ is expressed in a dynamic fashion in somatic cells of the developing gonads from 10.5 days postcoitum (dpc) to 12.5 dpc. Gadd45γ and Map3k4 genetically interact during sex determination, and transgenic overexpression of Map3k4 rescues gonadal defects in Gadd45γ-deficient embryos. Sex reversal in both mutants is associated with reduced phosphorylation of p38 MAPK and GATA4. In addition, embryos lacking both p38α and p38β also exhibit XY gonadal sex reversal. Taken together, our data suggest a requirement for GADD45γ in promoting MAP3K4-mediated activation of p38 MAPK signaling in embryonic gonadal somatic cells for testis determination in the mouse.
journal_name
Dev Celljournal_title
Developmental cellauthors
Warr N,Carre GA,Siggers P,Faleato JV,Brixey R,Pope M,Bogani D,Childers M,Wells S,Scudamore CL,Tedesco M,del Barco Barrantes I,Nebreda AR,Trainor PA,Greenfield Adoi
10.1016/j.devcel.2012.09.016subject
Has Abstractpub_date
2012-11-13 00:00:00pages
1020-31issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(12)00427-3journal_volume
23pub_type
杂志文章abstract：:Pericytes are critical for cerebrovascular maturation and development of the blood-brain barrier (BBB), but their role in maintenance of the adult BBB, and how CNS pericytes differ from those of other tissues, is less well understood. We show that the forkhead transcription factor Foxf2 is specifically expressed in pe...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.05.008
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abstract：:The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transi...
journal_title：Developmental cell
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abstract：:Neuroblastomas are associated with KIF1Bβ mutations within tumor suppressor region 1p36. In this issue of Developmental Cell, Li et al. (2016) show that KIF1Bβ binding releases calcineurin autoinhibition, leading to dephosphorylation of the DRP1 GTPase and subsequent mitochondrial fragmentation. KIF1Bβ impairment caus...
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abstract：:Recent data indicate that cystic fibrosis (CF) airway mucus is anaerobic. This suggests that Pseudomonas aeruginosa infection in CF reflects biofilm formation and persistence in an anaerobic environment. P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide...
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pub_type： 杂志文章
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abstract：:Autophagy is the major cellular process responsible for bulk cytoplasmic degradation. Two reports in this issue of Developmental Cell describe how both PI3 kinase and TOR signaling in Drosophila are critical for controlling autophagy in response to developmental and environmental cues. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2021-01-25 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.09.004
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abstract：:The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibited absent or mispl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.03.026
更新日期：2015-05-26 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.08.004
更新日期：2008-09-01 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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更新日期：2015-03-23 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.06.003
更新日期：2012-08-14 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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更新日期：2010-10-19 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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更新日期：2014-07-14 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.11.008
更新日期：2005-01-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章,评审
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更新日期：2017-05-22 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00156-4
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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更新日期：2015-07-27 00:00:00
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.07.011
更新日期：2010-08-17 00:00:00
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2003-05-01 00:00:00
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journal_title：Developmental cell
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更新日期：2019-09-23 00:00:00
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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更新日期：2016-09-12 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/s1534-5807(04)00070-x
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