Abstract:
:In this issue of Developmental Cell, Ren et al. (2019) identify the embryonic origin of cardiac pacemaker cells in zebrafish and implicate Wnt5b in promoting their differentiation. Furthermore, canonical Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells in vitro, advancing the therapeutic potential of biological pacemakers.
journal_name
Dev Celljournal_title
Developmental cellauthors
Burns CG,Burns CEdoi
10.1016/j.devcel.2019.09.002subject
Has Abstractpub_date
2019-09-23 00:00:00pages
675-676issue
6eissn
1534-5807issn
1878-1551pii
S1534-5807(19)30731-2journal_volume
50pub_type
评论,杂志文章abstract::Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Propagation of CENP-A chromatin is uncoupled from DNA replication initiating only during mitotic exit. We now demonstrate that ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.10.014
更新日期:2012-01-17 00:00:00
abstract::Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing the outflow tract, right ventricle, and much of the atria. isl1 expression and lineage tracing of isl1-expressing progenitors demonstrate that Isl1 is a marker for a distinct population of undifferentiated cardiac progenitors t...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(03)00363-0
更新日期:2003-12-01 00:00:00
abstract::Reporting in Nature, Sanders et al. (2013) implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb. Actin-based filopodia transport Shh from producing cells, while filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway. These findings suggest a new mechanism of ligand m...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.05.008
更新日期:2013-05-28 00:00:00
abstract::Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures defined as regions of the ER that tightly associate with the plasma membrane. However, little is known about the mechanisms that tether these organelles together and why such connections are maintained. Using a quantitative proteomic appr...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.11.004
更新日期:2012-12-11 00:00:00
abstract::Orientation of cell division is a vital aspect of tissue morphogenesis and growth. Asymmetric divisions generate cell fate diversity and epithelial stratification, whereas symmetric divisions contribute to tissue growth, spreading, and elongation. Here, we describe a mechanism for positioning the spindle in symmetric ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.01.002
更新日期:2012-04-17 00:00:00
abstract::Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly w...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.12.007
更新日期:2011-02-15 00:00:00
abstract::Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00153-3
更新日期:2002-04-01 00:00:00
abstract::It has recently been reported that a common side effect of translation-blocking morpholino antisense oligonucleotides is the induction of a set of innate immune response genes in Xenopus embryos and that splicing-blocking morpholinos lead to unexpected off-target mis-splicing events. Here, we present an analysis of al...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2019.04.019
更新日期:2019-05-20 00:00:00
abstract::Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish "winners" from "losers" during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.05.010
更新日期:2010-06-15 00:00:00
abstract::Drosophila gurken mRNA is localized by dynein-mediated transport to a crescent near the oocyte nucleus, thus targeting the TGFalpha signal and forming the primary embryonic axes. Here, we show that gurken and the I factor, a non-LTR retrotransposon, share a small consensus RNA stem loop of defined secondary structure,...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.04.012
更新日期:2005-07-01 00:00:00
abstract::In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes an...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(02)00157-0
更新日期:2002-04-01 00:00:00
abstract::Cell stress often triggers inflammation as a protective response to tissue damage or infection. In this issue of Developmental Cell, Sullivan et al. (2020) reveal an unexpected role for TRAIL receptors in ER-stress-induced inflammation. ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2020.03.004
更新日期:2020-03-23 00:00:00
abstract::Recently, there has been a surge in the number of pioneering studies combining experiments with quantitative modeling to explain both relatively simple modules of molecular machinery of the cell and to achieve system-level understanding of cellular networks. Here we discuss the utility and methods of modeling and revi...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2006.08.004
更新日期:2006-09-01 00:00:00
abstract::Differentiated cells have evolved mechanisms to adapt the functions of the late secretory pathway to the specific needs of the organism. Reporting in this issue of Developmental Cell, Polishchuk et al. (2014) demonstrate that hepatocytes utilize a unique exocytic aspect of the late endosomal/lysosomal compartment to m...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2014.06.002
更新日期:2014-06-23 00:00:00
abstract::Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited by the time required to generate stable mutant lines. We describe a system for gene knockout that consistently produces null phenotypes in G0 zebrafish. Yolk injection of sets of four CRISPR/Cas9 ribonucleoprotein complexes redu...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.06.003
更新日期:2018-07-02 00:00:00
abstract::Although the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. Here we show that the birth of pups instructively and selectively regulates the initiation of barrel formation in the somat...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.09.002
更新日期:2013-10-14 00:00:00
abstract::Migrating fibroblasts undergo contact inhibition of locomotion (CIL), a process that was discovered five decades ago and still is not fully understood at the molecular level. We identify the Slit2-Robo4-srGAP2 signaling network as a key regulator of CIL in fibroblasts. CIL involves highly dynamic contact protrusions w...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.09.002
更新日期:2015-10-12 00:00:00
abstract::The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transi...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.03.008
更新日期:2014-04-28 00:00:00
abstract::Pontin and reptin are conserved AAA+ ATPases identified in chromatin-remodeling complexes. In a recent issue of Cell, Venteicher et al. provide new insight into the function of pontin and reptin in telomerase biogenesis, which is important for cellular senescence, aging, and cancer. These unexpected findings have impl...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.03.018
更新日期:2008-04-01 00:00:00
abstract::A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies o...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.09.004
更新日期:2008-10-01 00:00:00
abstract::Exposure to environmental teratogenic pollutant leads to severe birth defects. However, the biological events underlying these developmental abnormalities remain undefined. Here, we report a molecular link between an environmental stress response pathway and key developmental genes during craniofacial development. Str...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.02.006
更新日期:2015-04-06 00:00:00
abstract::Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during mitosis-a process termed centrosome maturation. How centrosomes mature remains mysterious. Here, we identify a domain in Drosophila Cnn that appears to be phospho...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2014.02.013
更新日期:2014-03-31 00:00:00
abstract::The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable in both the eye and wing. The nonautonomous function is dishevelled (dsh...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00363-5
更新日期:2002-12-01 00:00:00
abstract::The AMP-stimulated protein kinase regulates epithelial polarity under conditions of energy depletion by phosphorylating the myosin regulatory light chain. In this issue of Developmental Cell, Mirouse et al. demonstrate that dystroglycan and perlecan, an extracellular matrix receptor and its ligand, help localize myosi...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2008.12.004
更新日期:2009-01-01 00:00:00
abstract::Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A hig...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2017.10.001
更新日期:2017-11-20 00:00:00
abstract::Vertebrate gastrulation requires coordination of mesoderm specification with morphogenetic movements. While both of these processes require FGF signaling, it is not known how mesoderm specification and cell movements are coordinated during gastrulation. The related Sprouty and Spred protein families are recently disco...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.02.011
更新日期:2005-05-01 00:00:00
abstract::Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediating these invasions, however, remains unclear. Utilizing the genetically and visually accessible model of anchor cell (AC) inva...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2009.06.006
更新日期:2009-08-01 00:00:00
abstract::Spindle positioning is an essential feature of asymmetric cell division. The conserved PAR proteins together with heterotrimeric G proteins control spindle positioning in animal cells, but how these are linked is not known. In C. elegans, PAR protein activity leads to asymmetric spindle placement through cortical asym...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.06.002
更新日期:2008-08-01 00:00:00
abstract::Many promoters in eukaryotes have nucleosome-depleted regions (NDRs) containing transcription factor binding sites. However, the functional significance of NDRs is not well understood. Here, we examine NDR function in two cell cycle-regulated promoters, CLN2pr and HOpr, by varying nucleosomal coverage of the binding s...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2010.02.007
更新日期:2010-04-20 00:00:00
abstract::Somatic muscle formation in Drosophila requires fusion of muscle founder cells with fusion-competent myoblasts. In a genetic screen for genes that control muscle development, we identified antisocial (ants), a gene that encodes an ankyrin repeat-, TPR repeat-, and RING finger-containing protein, required for myoblast ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(01)00084-3
更新日期:2001-11-01 00:00:00