Abstract：
:Pontin and reptin are conserved AAA+ ATPases identified in chromatin-remodeling complexes. In a recent issue of Cell, Venteicher et al. provide new insight into the function of pontin and reptin in telomerase biogenesis, which is important for cellular senescence, aging, and cancer. These unexpected findings have implications for new avenues for development of effective therapeutic drugs in human disease.
journal_name
Dev Celljournal_title
Developmental cellauthors
Baek SHdoi
10.1016/j.devcel.2008.03.018subject
Has Abstractpub_date
2008-04-01 00:00:00pages
459-61issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(08)00129-9journal_volume
14pub_type
杂志文章abstract：:Heparan sulfate (HS) proteoglycans modulate the activity of multiple growth factors on the cell surface and extracellular matrix. However, it remains unclear how the HS chains control the movement and reception of growth factors into targeted receiving cells during mammalian morphogenetic processes. Here, we found tha...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.06.027
更新日期：2011-08-16 00:00:00
abstract：:Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the E...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2011.05.015
更新日期：2011-07-19 00:00:00
abstract：:Trunk neural crest cells are generated at the border between the neural plate and nonneural ectoderm, where they initiate a distinct program of gene expression, undergo an epithelial-mesenchymal transition (EMT), and delaminate from the neuroepithelium. Here, we provide evidence that members of three families of trans...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.12.010
更新日期：2005-02-01 00:00:00
abstract：:Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(01)00098-3
更新日期：2002-01-01 00:00:00
abstract：:During zebrafish gastrulation, mesendoderm progenitor cells differentiate to mesoderm or endoderm cells. In this issue of Developmental Cell, Barone and colleagues (2017) show that the interplay between cell-cell contact duration and morphogen signaling can control this fate segregation, providing a new framework for ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.10.006
更新日期：2017-10-23 00:00:00
abstract：:Mouse anterior-posterior axis polarization is preceded by formation of the distal visceral endoderm (DVE) by unknown mechanisms. Here, we show by in vitro culturing of embryos immediately after implantation in microfabricated cavities that the external mechanical cues exerted on the embryo are crucial for DVE formatio...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.09.026
更新日期：2013-10-28 00:00:00
abstract：:The sense organs of the vertebrate head comprise structures as varied as the eye, inner ear, and olfactory epithelium. In the early embryo, these assorted structures share a common developmental origin within the preplacodal region and acquire specific characteristics only later. Here we demonstrate a fundamental simi...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.08.009
更新日期：2006-10-01 00:00:00
abstract：:The kinase Plk1 plays multiple roles in regulating mitotic progression, including stabilization of spindle poles, but its substrates are largely unknown. A new study by Yamamoto and coworkers has identified a centrosomal protein, Kizuna (Kiz), as a mitotic substrate of Plk1 (Oshimori et al., 2006). Phosphorylation of ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.09.012
更新日期：2006-10-01 00:00:00
abstract：:Because mitochondria have outer and inner membranes, the fusion of two mitochondria requires the coordinated fusion of four lipid bilayers. Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.10.009
更新日期：2006-11-01 00:00:00
abstract：:Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the facto...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.10.015
更新日期：2016-12-05 00:00:00
abstract：:Mammalian neurulation is completed when the dorsolateral neural folds bend inwards, their tips make adhesive contacts across the midline, and the epithelia remodel to create a closed neural tube. Two recent papers (one by Camerer et al. in this issue of Developmental Cell) demonstrate a vital role for protease-activat...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2010.01.002
更新日期：2010-01-19 00:00:00
abstract：:Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals. However, recent work in fungi indicates that prions are not simply aberrations of protein folding, but are in fact widespread, conserve...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(02)00118-1
更新日期：2002-02-01 00:00:00
abstract：:Pericytes are critical for cerebrovascular maturation and development of the blood-brain barrier (BBB), but their role in maintenance of the adult BBB, and how CNS pericytes differ from those of other tissues, is less well understood. We show that the forkhead transcription factor Foxf2 is specifically expressed in pe...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.05.008
更新日期：2015-07-06 00:00:00
abstract：:Despite their external bilateral symmetry, vertebrates have internal left/right (L/R) asymmetries required for optimal organ function. BMP-induced epithelial to mesenchymal transition (EMT) in the lateral plate mesoderm (LPM) triggers L/R asymmetric cell movements toward the midline, higher from the right, which are c...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.09.012
更新日期：2019-11-18 00:00:00
abstract：:The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1. We discovered tha...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.03.011
更新日期：2019-05-06 00:00:00
abstract：:The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.07.013
更新日期：2005-09-01 00:00:00
abstract：:Genome condensation during mitosis presents a chromatin landscape largely inaccessible to RNA polymerase II and most transcription factors. Caravaca et al. (2013) now report in Genes and Development that the pioneer transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable gene ex...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2013.02.005
更新日期：2013-02-25 00:00:00
abstract：:Plants are an excellent system for studying developmental biology. Depending on the species, they can be easily transformed and mutagenized, undergo grafts, tolerate changes in chromosome number, and provide fertile offspring after wide species crosses. Most importantly, they are perpetually embryonic, and thus develo...
journal_title：Developmental cell
pub_type：
doi：10.1016/s1534-5807(02)00299-x
更新日期：2002-10-01 00:00:00
abstract：:Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The nature of signaling between apoptotic cells and their neighboring cells remains largely unknown. Here we show that a fraction of apoptotic ce...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.05.014
更新日期：2017-06-19 00:00:00
abstract：:In this issue of Developmental Cell, Chakraborty et al. report that efficient advancement through G1/S phase requires the downregulation of Nup96 levels during M phase. The authors show that oscillations in Nup96 levels plays a key role in maintaining normal cell proliferation, likely by regulating the export of speci...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2008.10.010
更新日期：2008-11-01 00:00:00
abstract：:The majority of excitatory synaptic transmission in the brain occurs at dendritic spines, which are actin-rich protrusions on the dendrites. The asymmetric nature of these structures suggests that proteins regulating cell polarity might be involved in their formation. Indeed, the polarity protein PAR-3 is required for...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.11.020
更新日期：2008-02-01 00:00:00
abstract：:While GDNF signaling through the Ret receptor is critical for kidney development, its specific role in branching morphogenesis of the epithelial ureteric bud (UB) is unclear. Ret expression defines a population of UB "tip cells" distinct from cells of the tubular "trunks," but how these cells contribute to UB growth i...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2004.11.008
更新日期：2005-01-01 00:00:00
abstract：:Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human diseases, such as cancer. Our aim here is to provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and microRNA regul...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2010.10.005
更新日期：2010-11-16 00:00:00
abstract：:The binding of Hedgehog (Hh) to its receptor Patched causes derepression of Smoothened (Smo), resulting in the activation of the Hh pathway. Here, we show that Smo activation is dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P). Loss of STT4 kinase, which is required for the generatio...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.06.007
更新日期：2010-07-20 00:00:00
abstract：:The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids once all chromosomes are attached via kinetochores by microtubules of the mitotic spindle. Reporting in Developmental Cell, Silió et al. (2015) show that in human cells the signaling cascade controlling the checkpoint ope...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.11.021
更新日期：2015-12-07 00:00:00
abstract：:Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Propagation of CENP-A chromatin is uncoupled from DNA replication initiating only during mitotic exit. We now demonstrate that ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.10.014
更新日期：2012-01-17 00:00:00
abstract：:Centromere chromatin containing histone H3 variant CENP-A is required for accurate chromosome segregation as a foundation for kinetochore assembly. Human centromere chromatin assembles on a part of the long α-satellite (alphoid) DNA array, where it is flanked by pericentric heterochromatin. Heterochromatin spreads int...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.05.006
更新日期：2016-06-06 00:00:00
abstract：:CPEB is a sequence-specific RNA binding protein that regulates translation during vertebrate oocyte maturation. Adult female CPEB knockout mice contained vestigial ovaries that were devoid of oocytes; ovaries from mid-gestation embryos contained oocytes that were arrested at the pachytene stage. Male CPEB null mice al...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(01)00025-9
更新日期：2001-08-01 00:00:00
abstract：:While autophagy is thought to be an essential process in some cancer cells, it is unknown if or how such cancer cells can circumvent autophagy inhibition. To address this, we developed a CRISPR/Cas9 assay with dynamic live-cell imaging to measure acute effects of knockout (KO) of autophagy genes compared to known esse...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.07.010
更新日期：2019-09-23 00:00:00
abstract：:p120-catenin is an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. Despite recent advances in understanding the roles that p120-catenin and Kaiso play in downstream modulation of Wnt/beta-catenin signaling, the identity of t...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.09.022
更新日期：2006-11-01 00:00:00
