Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles.

Abstract:

:Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The nature of signaling between apoptotic cells and their neighboring cells remains largely unknown. Here we show that a fraction of apoptotic cells produce and release CrkI-containing microvesicles (distinct from exosomes and apoptotic bodies), which induce proliferation in neighboring cells upon contact. We provide visual evidence of CPS by videomicroscopy. We show that purified vesicles in vitro and in vivo are sufficient to stimulate proliferation in other cells. Our data demonstrate that CrkI inactivation by ExoT bacterial toxin or by mutagenesis blocks vesicle formation in apoptotic cells and inhibits CPS, thus uncoupling apoptosis from CPS. We further show that c-Jun amino-terminal kinase (JNK) plays a pivotal role in mediating vesicle-induced CPS in recipient cells. CPS could have important ramifications in diseases that involve apoptotic cell death.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Gupta KH,Goldufsky JW,Wood SJ,Tardi NJ,Moorthy GS,Gilbert DZ,Zayas JP,Hahm E,Altintas MM,Reiser J,Shafikhani SH

doi

10.1016/j.devcel.2017.05.014

subject

Has Abstract

pub_date

2017-06-19 00:00:00

pages

674-684.e5

issue

6

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(17)30422-7

journal_volume

41

pub_type

杂志文章
  • Reaching a genetic and molecular understanding of skeletal development.

    abstract::In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes an...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/s1534-5807(02)00157-0

    authors: Karsenty G,Wagner EF

    更新日期:2002-04-01 00:00:00

  • The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C.

    abstract::One G protein-coupled receptor (GPCR) can activate more than one G protein, but the physiologic importance of such activation has not been demonstrated in vivo. We have generated mice expressing exclusively a mutant form of the PTH/PTHrP receptor (DSEL) that activates adenylyl cyclase normally but not phospholipase C ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(02)00218-6

    authors: Guo J,Chung UI,Kondo H,Bringhurst FR,Kronenberg HM

    更新日期:2002-08-01 00:00:00

  • Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites.

    abstract::The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLA...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.05.011

    authors: González Montoro A,Auffarth K,Hönscher C,Bohnert M,Becker T,Warscheid B,Reggiori F,van der Laan M,Fröhlich F,Ungermann C

    更新日期:2018-06-04 00:00:00

  • Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap complex patterns mammalian CNS.

    abstract::Regulating cell proliferation and differentiation in CNS development requires both extraordinary complexity and precision. Neural progenitors receive graded overlapping signals from midline signaling centers, yet each makes a unique cell fate decision in a spatiotemporally restricted pattern. The Nde1-Lis1 complex reg...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.04.006

    authors: Lanctot AA,Peng CY,Pawlisz AS,Joksimovic M,Feng Y

    更新日期:2013-05-13 00:00:00

  • Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

    abstract::Hedgehog (Hh) signaling during development and in postembryonic tissues requires activation of the 7TM oncoprotein Smoothened (Smo) by mechanisms that may involve endogenous lipidic modulators. Exogenous Smo ligands previously identified include the plant sterol cyclopamine (and its therapeutically useful synthetic mi...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.07.015

    authors: Myers BR,Sever N,Chong YC,Kim J,Belani JD,Rychnovsky S,Bazan JF,Beachy PA

    更新日期:2013-08-26 00:00:00

  • aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

    abstract::Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins. A C. elegans genetic screen revealed two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that interact strongly with sel-12/presenilin and aph-2/nicastrin. Human ap...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(02)00189-2

    authors: Francis R,McGrath G,Zhang J,Ruddy DA,Sym M,Apfeld J,Nicoll M,Maxwell M,Hai B,Ellis MC,Parks AL,Xu W,Li J,Gurney M,Myers RL,Himes CS,Hiebsch R,Ruble C,Nye JS,Curtis D

    更新日期:2002-07-01 00:00:00

  • Making a Choice: How Cadherin Switching Controls Cell Migration.

    abstract::Cells that undergo epithelial-to-mesenchymal transitions (EMTs) commonly switch from expressing E-cadherin to N-cadherin. But why this occurs is not well understood. In the current issue of Developmental Cell, Scarpa et al. (2015) identify a reason: cadherin switching controls Rac signaling to determine how cell locom...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2015.08.002

    authors: Priya R,Yap AS

    更新日期:2015-08-24 00:00:00

  • Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth.

    abstract::The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback me...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2015.10.003

    authors: Okamoto N,Nishimura T

    更新日期:2015-11-09 00:00:00

  • Memorizing Shape to Orient Cell Division.

    abstract::A century ago, Oscar Hertwig discovered that cells orient their cleavage plane orthogonal to their long axis. Reporting recently in Nature, Bosveld et al. (2016) shed light on how, showing that NuMA/Mud localization at tricellular junctions provides mitotic cells with the memory of interphase shape used to orient clea...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2016.03.005

    authors: Michel M,Dahmann C

    更新日期:2016-03-21 00:00:00

  • A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.

    abstract::The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM) at the centrosome to organize the mitotic spindle. Cilia themselves respond to growth signals, prompting cilia resorption and cell cycle re-entry. We describe ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.10.027

    authors: Ford MJ,Yeyati PL,Mali GR,Keighren MA,Waddell SH,Mjoseng HK,Douglas AT,Hall EA,Sakaue-Sawano A,Miyawaki A,Meehan RR,Boulter L,Jackson IJ,Mill P,Mort RL

    更新日期:2018-11-19 00:00:00

  • Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis.

    abstract::Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(02)00153-3

    authors: Wang ZY,Nakano T,Gendron J,He J,Chen M,Vafeados D,Yang Y,Fujioka S,Yoshida S,Asami T,Chory J

    更新日期:2002-04-01 00:00:00

  • High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b.

    abstract::High-molecular-weight hyaluronan, a major component of the extracellular matrix, is anti-oncogenic, whereas low-molecular-weight hyaluronan is pro-oncogenic, though the mechanisms underlying the size-dependent opposite bioactivities of hyaluronan remain uncertain. We show here that treatment with high-molecular-weight...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.04.018

    authors: Ooki T,Murata-Kamiya N,Takahashi-Kanemitsu A,Wu W,Hatakeyama M

    更新日期:2019-05-20 00:00:00

  • ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.

    abstract::Cell polarity plays a key role in the development of the central nervous system (CNS). Interestingly, disruption of cell polarity is seen in many cancers. ASPP2 is a haplo-insufficient tumor suppressor and an activator of the p53 family. In this study, we show that ASPP2 controls the polarity and proliferation of neur...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2010.06.003

    authors: Sottocornola R,Royer C,Vives V,Tordella L,Zhong S,Wang Y,Ratnayaka I,Shipman M,Cheung A,Gaston-Massuet C,Ferretti P,Molnár Z,Lu X

    更新日期:2010-07-20 00:00:00

  • Proteostatic hotspots in amyloid fibrils protect us from neurodegeneration.

    abstract::Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligo...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2015.03.009

    authors: Singh JK,Balch WE

    更新日期:2015-03-23 00:00:00

  • DjPiwiB: A Rich Nuclear Inheritance for Descendants of Planarian Stem Cells.

    abstract::Stem cell differentiation involves a delicate balance of gene expression and transposon repression. In this issue of Developmental Cell, Shibata et al. (2016) show that a PIWI protein expressed in planarian stem cells is inherited by their differentiating descendants to ensure regenerative capacity of the flatworm via...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2016.04.022

    authors: Tharp ME,Bortvin A

    更新日期:2016-05-09 00:00:00

  • A Transcriptional Lineage of the Early C. elegans Embryo.

    abstract::During embryonic development, cells must establish fates, morphologies, and behaviors in coordination with one another to form a functional body. A prevalent hypothesis for how this coordination is achieved is that each cell's fate and behavior is determined by a defined mixture of RNAs. Only recently has it become po...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.07.025

    authors: Tintori SC,Osborne Nishimura E,Golden P,Lieb JD,Goldstein B

    更新日期:2016-08-22 00:00:00

  • HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

    abstract::The genetic networks that govern vertebrate development are well studied, but how the interactions of trans-acting factors with cis-regulatory modules (CRMs) are integrated into spatiotemporal regulation of gene expression is not clear. The transcriptional regulator HAND2 is required during limb, heart, and branchial ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2014.09.018

    authors: Osterwalder M,Speziale D,Shoukry M,Mohan R,Ivanek R,Kohler M,Beisel C,Wen X,Scales SJ,Christoffels VM,Visel A,Lopez-Rios J,Zeller R

    更新日期:2014-11-10 00:00:00

  • Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

    abstract::Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.01.005

    authors: Langer EM,Feng Y,Zhaoyuan H,Rauscher FJ 3rd,Kroll KL,Longmore GD

    更新日期:2008-03-01 00:00:00

  • EGF receptor signaling regulates pulses of cell delamination from the Drosophila ectoderm.

    abstract::Many different intercellular signaling pathways are known but, for most, it is unclear whether they can generate oscillating cell behaviors. Here we use time-lapse analysis of Drosophila embryogenesis to show that oenocytes delaminate from the ectoderm in discrete bursts of three. This pulsatile process has a 1 hour p...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2004.10.016

    authors: Brodu V,Elstob PR,Gould AP

    更新日期:2004-12-01 00:00:00

  • Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle.

    abstract::The Golgi apparatus undergoes a ubiquitin-dependent disassembly and reassembly process during each cycle of cell division. Here we report the identification of the Golgi t-SNARE syntaxin 5 (Syn5) as the ubiquitinated substrate. Syn5 is monoubiquitinated by the ubiquitin ligase HACE1 in early mitosis and deubiquitinate...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.06.001

    authors: Huang S,Tang D,Wang Y

    更新日期:2016-07-11 00:00:00

  • Interplay between the dividing cell and its neighbors regulates adherens junction formation during cytokinesis in epithelial tissue.

    abstract::How adherens junctions (AJs) are formed upon cell division is largely unexplored. Here, we found that AJ formation is coordinated with cytokinesis and relies on an interplay between the dividing cell and its neighbors. During contraction of the cytokinetic ring, the neighboring cells locally accumulate Myosin II and p...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2012.11.019

    authors: Herszterg S,Leibfried A,Bosveld F,Martin C,Bellaiche Y

    更新日期:2013-02-11 00:00:00

  • Regulation of ARGONAUTE10 Expression Enables Temporal and Spatial Precision in Axillary Meristem Initiation in Arabidopsis.

    abstract::Axillary meristems (AMs) give rise to lateral shoots and are critical to plant architecture. Understanding how developmental cues and environmental signals impact AM development will enable the improvement of plant architecture in agriculture. Here, we show that ARGONAUTE10 (AGO10), which sequesters miR165/166, promot...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.10.019

    authors: Zhang C,Fan L,Le BH,Ye P,Mo B,Chen X

    更新日期:2020-12-07 00:00:00

  • MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells.

    abstract::The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms driving initiation of this specialized process are largely undefined. In this issue of Developmental Cell,Ishiguro et al. (2020) identified the transcription factor MEIOSIN as a gatekeeper of meiotic initiation in both male and female germ c...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2020.02.002

    authors: Oatley JM,Griswold MD

    更新日期:2020-02-24 00:00:00

  • PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts.

    abstract::Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs). Phosphorylation of Baz by PAR-1 and aPKC is required for its function in epithelia, but little is known about the dephosphorylation mechanisms that antagonize the activities of these kinases or about the relevance of Baz...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.04.011

    authors: Krahn MP,Egger-Adam D,Wodarz A

    更新日期:2009-06-01 00:00:00

  • Organizing Complex Tissue Architecture by Pushing and Pulling Cell Contacts.

    abstract::Changes to cell shape and interaction drive animal tissue morphogenesis. Reporting now in Developmental Cell, Del Signore et al. (2018) describe active lengthening of cell-cell contacts by Arp2/3-based actin networks. Through cycles of contact lengthening and shortening, the developing Drosophila eye passes through va...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2018.02.003

    authors: Zhang Y,Harris TJC

    更新日期:2018-02-26 00:00:00

  • Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification.

    abstract::Phase separation represents an important form of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regulated. In zebrafish, the Balbiani body (Bb) and the germ plasm (Gp) are intimately linked phase-separated structures essential for ge...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.07.009

    authors: Roovers EF,Kaaij LJT,Redl S,Bronkhorst AW,Wiebrands K,de Jesus Domingues AM,Huang HY,Han CT,Riemer S,Dosch R,Salvenmoser W,Grün D,Butter F,van Oudenaarden A,Ketting RF

    更新日期:2018-08-06 00:00:00

  • IRE1, a double-edged sword in pre-miRNA slicing and cell death.

    abstract::IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2012.10.025

    authors: Hassler J,Cao SS,Kaufman RJ

    更新日期:2012-11-13 00:00:00

  • Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis.

    abstract::Signaling receptors are internalized and regulated by clathrin-mediated endocytosis (CME). Two clathrin light chain isoforms, CLCa and CLCb, are integral components of the endocytic machinery whose differential functions remain unknown. We report that CLCb is specifically upregulated in non-small-cell lung cancer (NSC...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2017.01.007

    authors: Chen PH,Bendris N,Hsiao YJ,Reis CR,Mettlen M,Chen HY,Yu SL,Schmid SL

    更新日期:2017-02-06 00:00:00

  • A dual role for UVRAG in maintaining chromosomal stability independent of autophagy.

    abstract::Autophagy defects have recently been associated with chromosomal instability, a hallmark of human cancer. However, the functional specificity and mechanism of action of autophagy-related factors in genome stability remain elusive. Here we report that UVRAG, an autophagic tumor suppressor, plays a dual role in chromoso...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.12.027

    authors: Zhao Z,Oh S,Li D,Ni D,Pirooz SD,Lee JH,Yang S,Lee JY,Ghozalli I,Costanzo V,Stark JM,Liang C

    更新日期:2012-05-15 00:00:00

  • HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes.

    abstract::Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including ischemia and cancer. Despite their importance, mechanisms by which pathways mediated by these transcription factors interact with one another are not fully unde...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2015.04.021

    authors: Guimarães-Camboa N,Stowe J,Aneas I,Sakabe N,Cattaneo P,Henderson L,Kilberg MS,Johnson RS,Chen J,McCulloch AD,Nobrega MA,Evans SM,Zambon AC

    更新日期:2015-06-08 00:00:00