Defining a PARticular pathway of neural tube closure.

abstract：:Positive autoregulation is an effective mechanism for the long-term maintenance of a transcription factor's expression. This strategy is widely deployed in cell lineages, where the autoregulatory factor controls the activity of a battery of genes that constitute the differentiation program of a postmitotic cell type. ...

journal_title：Developmental cell

authors： Liu F,Posakony JW

更新日期：2014-04-14 00:00:00

abstract：:Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...

journal_title：Developmental cell

authors： Carballido-López R,Errington J

更新日期：2003-01-01 00:00:00

abstract：:We have identified and characterized a novel C. elegans gene, ced-12, that functions in the conserved GTPase signaling pathway mediated by CED-2/Crkll, CED-5/DOCK180, and CED-10/Rac to control cell migration and phagocytosis of apoptotic cells. We provide evidence that ced-12 likely acts upstream of ced-10 during cell...

journal_title：Developmental cell

authors： Wu YC,Tsai MC,Cheng LC,Chou CJ,Weng NY

更新日期：2001-10-01 00:00:00

abstract：:Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular processes are poorly defined. Here, we show that subcellular localization of RP-mRNAs acts as a key regulator of their transla...

journal_title：Developmental cell

authors： Dermit M,Dodel M,Lee FCY,Azman MS,Schwenzer H,Jones JL,Blagden SP,Ule J,Mardakheh FK

更新日期：2020-11-09 00:00:00

abstract：:In eukaryotes, small RNAs (sRNAs) have key roles in development, gene expression regulation, and genome integrity maintenance. In ciliates, such as Paramecium, sRNAs form the heart of an epigenetic system that has evolved from core eukaryotic gene silencing components to selectively target DNA for deletion. In Paramec...

journal_title：Developmental cell

authors： Sandoval PY,Swart EC,Arambasic M,Nowacki M

更新日期：2014-01-27 00:00:00

abstract：:Epithelial cells acquire mesenchymal characteristics during development, wound healing and inflammation, and in cancer and fibrosis. With increasing appreciation of different roles of epithelial-mesenchymal transition (EMT), we address the question of how to define and recognize EMT processes and discuss their propert...

journal_title：Developmental cell

authors： Derynck R,Weinberg RA

更新日期：2019-05-06 00:00:00

abstract：:Fission yeast Pat1 kinase inhibits sexual differentiation by phosphorylating the meiotic inducer Mei2 and the transcription factor Ste11. Here, we show how Pat1 downregulates these proteins. Mei2 is degraded via a ubiquitin-proteasome pathway in a phosphorylation-dependent fashion. The E2 Ubc2 and the E3 Ubr1 are requ...

journal_title：Developmental cell

authors： Kitamura K,Katayama S,Dhut S,Sato M,Watanabe Y,Yamamoto M,Toda T

更新日期：2001-09-01 00:00:00

abstract：:The Drosophila gene neuralized (neur) has long been recognized to be essential for the proper execution of a wide variety of processes mediated by the Notch (N) pathway, but its role in the pathway has been elusive. In this report, we present genetic and biochemical evidence that Neur is a RING-type, E3 ubiquitin liga...

journal_title：Developmental cell

authors： Lai EC,Deblandre GA,Kintner C,Rubin GM

更新日期：2001-12-01 00:00:00

abstract：:Epithelial tubes are found in many vital organs and require uniform and correct tube diameters for optimal function. Tube size depends on apical membrane growth and subapical cytoskeletal reorganization, but the cues that coordinate these events to ensure functional tube shape remain elusive. We find that epithelial t...

journal_title：Developmental cell

authors： Tonning A,Hemphälä J,Tång E,Nannmark U,Samakovlis C,Uv A

更新日期：2005-09-01 00:00:00

abstract：:Reporting in Cell, Berg et al. (2016) reveal a connection between genetic lysosomal storage disorders and the ability of macrophages to migrate and control mycobacterial infection. This insight, resulting from a zebrafish genetic screen, inspired the authors to propose an explanation for the increased susceptibility o...

journal_title：Developmental cell

authors： Meijer AH,Aerts JM

更新日期：2016-04-18 00:00:00

abstract：:The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback me...

journal_title：Developmental cell

authors： Okamoto N,Nishimura T

更新日期：2015-11-09 00:00:00

abstract：:The genetic networks that govern vertebrate development are well studied, but how the interactions of trans-acting factors with cis-regulatory modules (CRMs) are integrated into spatiotemporal regulation of gene expression is not clear. The transcriptional regulator HAND2 is required during limb, heart, and branchial ...

journal_title：Developmental cell

authors： Osterwalder M,Speziale D,Shoukry M,Mohan R,Ivanek R,Kohler M,Beisel C,Wen X,Scales SJ,Christoffels VM,Visel A,Lopez-Rios J,Zeller R

更新日期：2014-11-10 00:00:00

abstract：:Several genes are known to regulate circadian rhythms in Arabidopsis, but the identity of the central oscillator has not been established. LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved. Here we demonstrate that, as shown previously for CCA1, inactivation of LHY shortens the pe...

journal_title：Developmental cell

authors： Mizoguchi T,Wheatley K,Hanzawa Y,Wright L,Mizoguchi M,Song HR,Carré IA,Coupland G

更新日期：2002-05-01 00:00:00

abstract：:Steroid hormones have long been thought to enter target cells via passive diffusion through the plasma membrane. Now, reporting in Developmental Cell, Okamoto et al. (2018) demonstrate that, at least for Drosophila, steroid hormones require a protein transporter for cellular entry. ...

journal_title：Developmental cell

authors： Neuman SD,Bashirullah A

更新日期：2018-11-05 00:00:00

abstract：:Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP(2)-synthesizing enzyme, PIPKIγi2, in regulation of exocyst complex control of cell polarity and polarized integrin trafficking during migration. Loss of PIPKIγ...

journal_title：Developmental cell

authors： Thapa N,Sun Y,Schramp M,Choi S,Ling K,Anderson RA

更新日期：2012-01-17 00:00:00

abstract：:Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing the outflow tract, right ventricle, and much of the atria. isl1 expression and lineage tracing of isl1-expressing progenitors demonstrate that Isl1 is a marker for a distinct population of undifferentiated cardiac progenitors t...

journal_title：Developmental cell

authors： Cai CL,Liang X,Shi Y,Chu PH,Pfaff SL,Chen J,Evans S

更新日期：2003-12-01 00:00:00

abstract：:Adult neurogenic niches are present in both vertebrates and invertebrates. Where do stem cells populating these niches originate, and what are the mechanisms maintaining their self-renewal? In this issue of Developmental Cell, Benton et al. (2014) show that in crayfish, hemolymph-derived cells enter a neurogenic niche...

journal_title：Developmental cell

authors： Hartenstein V

更新日期：2014-08-11 00:00:00

abstract：:As they enter mitosis, animal cells undergo profound actin-dependent changes in shape to become round. Here we identify the Cdk1 substrate, Ect2, as a central regulator of mitotic rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its accompanying actin remodeling. Ect2 is ...

journal_title：Developmental cell

authors： Matthews HK,Delabre U,Rohn JL,Guck J,Kunda P,Baum B

更新日期：2012-08-14 00:00:00

abstract：:MEF2 transcription factors are well-established regulators of muscle development. We have discovered an unanticipated role for MEF2C in the neural crest, where tissue-specific inactivation results in neonatal lethality due to severe craniofacial defects. We show that MEF2C is required for expression of the Dlx5, Dlx6,...

journal_title：Developmental cell

authors： Verzi MP,Agarwal P,Brown C,McCulley DJ,Schwarz JJ,Black BL

更新日期：2007-04-01 00:00:00

abstract：:Stem cell differentiation involves a delicate balance of gene expression and transposon repression. In this issue of Developmental Cell, Shibata et al. (2016) show that a PIWI protein expressed in planarian stem cells is inherited by their differentiating descendants to ensure regenerative capacity of the flatworm via...

journal_title：Developmental cell

authors： Tharp ME,Bortvin A

更新日期：2016-05-09 00:00:00

abstract：:Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...

journal_title：Developmental cell

authors： Miao R,Li M,Zhang Q,Yang C,Wang X

更新日期：2020-01-06 00:00:00

abstract：:Dystroglycan localizes to the basal domain of epithelial cells and has been reported to play a role in apical-basal polarity. Here, we show that Dystroglycan null mutant follicle cells have normal apical-basal polarity, but lose the planar polarity of their basal actin stress fibers, a phenotype it shares with Dystrop...

journal_title：Developmental cell

authors： Mirouse V,Christoforou CP,Fritsch C,St Johnston D,Ray RP

更新日期：2009-01-01 00:00:00

abstract：:Axon guidance at the Drosophila midline relies on dynamic regulation of the guidance receptor Robo by its negative regulator Comm. Recent findings demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signaling by promoting the sorting of Robo into the endocytic pathway. ...

journal_title：Developmental cell

authors： Rosenzweig M,Garrity P

更新日期：2002-09-01 00:00:00

abstract：:Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown. Here we show that the initial stage of process extension and axon ensheathment by oligodendrocytes requires dynamic actin filament assembly by the Arp2/3 complex...

journal_title：Developmental cell

authors： Zuchero JB,Fu MM,Sloan SA,Ibrahim A,Olson A,Zaremba A,Dugas JC,Wienbar S,Caprariello AV,Kantor C,Leonoudakis D,Lariosa-Willingham K,Kronenberg G,Gertz K,Soderling SH,Miller RH,Barres BA

更新日期：2015-07-27 00:00:00

abstract：:Cells that undergo epithelial-to-mesenchymal transitions (EMTs) commonly switch from expressing E-cadherin to N-cadherin. But why this occurs is not well understood. In the current issue of Developmental Cell, Scarpa et al. (2015) identify a reason: cadherin switching controls Rac signaling to determine how cell locom...

journal_title：Developmental cell

authors： Priya R,Yap AS

更新日期：2015-08-24 00:00:00

abstract：:In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targetin...

journal_title：Developmental cell

authors： Kim DH,Park MJ,Gwon GH,Silkov A,Xu ZY,Yang EC,Song S,Song K,Kim Y,Yoon HS,Honig B,Cho W,Cho Y,Hwang I

更新日期：2014-09-08 00:00:00

abstract：:Mouse anterior-posterior axis polarization is preceded by formation of the distal visceral endoderm (DVE) by unknown mechanisms. Here, we show by in vitro culturing of embryos immediately after implantation in microfabricated cavities that the external mechanical cues exerted on the embryo are crucial for DVE formatio...

journal_title：Developmental cell

authors： Hiramatsu R,Matsuoka T,Kimura-Yoshida C,Han SW,Mochida K,Adachi T,Takayama S,Matsuo I

更新日期：2013-10-28 00:00:00

abstract：:How metabolism is rewired during embryonic development is still largely unknown, as it remains a major technical challenge to resolve metabolic activities or metabolite levels with spatiotemporal resolution. Here, we investigated metabolic changes during development of organogenesis-stage mouse embryos, focusing on th...

journal_title：Developmental cell

authors： Bulusu V,Prior N,Snaebjornsson MT,Kuehne A,Sonnen KF,Kress J,Stein F,Schultz C,Sauer U,Aulehla A

更新日期：2017-02-27 00:00:00

abstract：:One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an ant...

journal_title：Developmental cell

authors： Dos Santos A,Elowe S

更新日期：2020-12-21 00:00:00

abstract：:Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited by the time required to generate stable mutant lines. We describe a system for gene knockout that consistently produces null phenotypes in G0 zebrafish. Yolk injection of sets of four CRISPR/Cas9 ribonucleoprotein complexes redu...

journal_title：Developmental cell

authors： Wu RS,Lam II,Clay H,Duong DN,Deo RC,Coughlin SR

更新日期：2018-07-02 00:00:00