Abstract：
:Positive autoregulation is an effective mechanism for the long-term maintenance of a transcription factor's expression. This strategy is widely deployed in cell lineages, where the autoregulatory factor controls the activity of a battery of genes that constitute the differentiation program of a postmitotic cell type. In Drosophila, the Notch pathway transcription factor Suppressor of Hairless activates its own expression, specifically in the socket cell of external sensory organs, via an autoregulatory enhancer called the ASE. Here, we show that the ASE is composed of several enhancer submodules, each of which can independently initiate weak Su(H) autoregulation. Cross-activation by these submodules is critical to ensure that Su(H) rises above a threshold level necessary to activate a maintenance submodule, which then sustains long-term Su(H) autoregulation. Our study reveals the use of interlinked positive-feedback loops to control autoregulation dynamically and provides mechanistic insight into initiation, establishment, and maintenance of the autoregulatory state.
journal_name
Dev Celljournal_title
Developmental cellauthors
Liu F,Posakony JWdoi
10.1016/j.devcel.2014.02.005subject
Has Abstractpub_date
2014-04-14 00:00:00pages
88-101issue
1eissn
1534-5807issn
1878-1551pii
S1534-5807(14)00098-7journal_volume
29pub_type
杂志文章abstract：:The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback me...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.10.003
更新日期：2015-11-09 00:00:00
abstract：:The orientation of the mitotic spindle plays a key role in determining whether a polarized cell will divide symmetrically or asymmetrically. In most cell types, cytoplasmic dynein plays a critical role in spindle orientation. However, how dynein directs opposite spindle poles toward distinct and predetermined cell end...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.02.018
更新日期：2006-04-01 00:00:00
abstract：:The conserved Hippo kinase pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Whereas the function of the core kinase cascade, consisting of the serine/threonine kinases Hippo and Warts, in phosphorylating and thereby inactivating the transcri...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.12.013
更新日期：2010-02-16 00:00:00
abstract：:The intestine is an organ with an exceptionally high rate of cell turnover, and perturbations in this process can lead to severe diseases such as cancer or intestinal atrophy. Nutrition has a profound impact on intestinal volume and cellular architecture. However, how intestinal homeostasis is maintained in fluctuatin...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.08.011
更新日期：2018-10-08 00:00:00
abstract：:Drosophila gurken mRNA is localized by dynein-mediated transport to a crescent near the oocyte nucleus, thus targeting the TGFalpha signal and forming the primary embryonic axes. Here, we show that gurken and the I factor, a non-LTR retrotransposon, share a small consensus RNA stem loop of defined secondary structure,...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.04.012
更新日期：2005-07-01 00:00:00
abstract：:The eukaryotic nucleus has been the neglected child of cell biology. The "International Symposium on Functional Organization of the Nucleus" held in January on Awaji Island, Japan, highlighted recent work on nuclear organization and function. Emerging from this conference was a holistic view in which diverse chemical ...
journal_title：Developmental cell
pub_type：
doi：10.1016/j.devcel.2007.02.014
更新日期：2007-03-01 00:00:00
abstract：:The combination of fluid and mechanical properties exhibited by cell membranes enables a wealth of physical phenomena, many of which also have biological functions. A recent study in Cell (Shi et al., 2018) now shows that membrane tension in the cell may not be as simple as it first seemed. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.12.011
更新日期：2019-01-07 00:00:00
abstract：:Germ cells, the cells that give rise to sperm and egg, maintain the potential to recreate all cell types in a new individual. This wide developmental potential, or totipotency, is manifested in unusual tumors called teratomas, in which germ cells undergo somatic differentiation. Although recent studies have implicated...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.08.003
更新日期：2009-09-01 00:00:00
abstract：:Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.11.016
更新日期：2006-02-01 00:00:00
abstract：:Because mitochondria have outer and inner membranes, the fusion of two mitochondria requires the coordinated fusion of four lipid bilayers. Fusion of the outer membranes requires mitofusins. A new study published in Cell (Meeusen et al., 2006) shows that inner membrane fusion requires the dynamin-related protein Mgm1/...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.10.009
更新日期：2006-11-01 00:00:00
abstract：:IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2012.10.025
更新日期：2012-11-13 00:00:00
abstract：:The developmental mechanisms that orchestrate differentiation of specific nephron segments are incompletely understood, and the factors that maintain their terminal differentiation after nephrogenesis remain largely unknown. Here, the transcription factor AP-2β is shown to be required for the differentiation of distal...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.05.026
更新日期：2020-08-10 00:00:00
abstract：:In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.05.030
更新日期：2019-06-03 00:00:00
abstract：:RITS (RNA-induced initiation of transcriptional gene silencing complex) plays diverse roles in heterochromatin regulation: silencing transcription by recruitment of chromatin modifiers and destroying transcripts by RNAi. In a recent issue of Molecular Cell, Li et al. now show that the polymerization of Tas3, a compone...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.05.002
更新日期：2009-05-01 00:00:00
abstract：:Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins. A C. elegans genetic screen revealed two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that interact strongly with sel-12/presenilin and aph-2/nicastrin. Human ap...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00189-2
更新日期：2002-07-01 00:00:00
abstract：:Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspa...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.04.006
更新日期：2012-06-12 00:00:00
abstract：:Metazoans express three unfolded protein response transducers (IRE1, PERK, and ATF6) ubiquitously to cope with endoplasmic reticulum (ER) stress. ATF6 is an ER membrane-bound transcription factor activated by ER stress-induced proteolysis and has been duplicated in mammals. Here, we generated ATF6alpha- and ATF6beta-k...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.07.018
更新日期：2007-09-01 00:00:00
abstract：:Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal cholesterol content. In Niemann-Pick type C (NPC), loss of the cholestero...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.11.016
更新日期：2020-12-07 00:00:00
abstract：:CLASPs are mammalian microtubule-stabilizing proteins that can mediate the interaction between distal microtubule ends and the cell cortex. Using mass spectrometry-based assays, we have identified two CLASP partners, LL5beta and ELKS. LL5beta and ELKS form a complex that colocalizes with CLASPs at the cortex of HeLa c...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.05.012
更新日期：2006-07-01 00:00:00
abstract：:One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an ant...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.11.027
更新日期：2020-12-21 00:00:00
abstract：:The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28(th) issue of Molecular Cell. In this work, the authors show that p21-activated ki...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2005.10.005
更新日期：2005-11-01 00:00:00
abstract：:The connection between cell fate transitions and metabolic shifts is gaining momentum in the study of cell differentiation in embryonic development, adult stem cells, and cancer pathogenesis. Here, we explore how metabolic transitions influence post-translational modifications (PTMs), which play central roles in the a...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2020.06.035
更新日期：2020-07-20 00:00:00
abstract：:Macropinocytosis coordinates non-specific uptake of macromolecules and fluid. Cancers employ macropinocytosis to obtain nutrients to support their metabolic homeostasis. In this issue of Developmental Cell, Lee et al. (2019) report that glutamine deprivation boosts macropinocytosis via EGFR signaling induction, provid...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.07.020
更新日期：2019-08-05 00:00:00
abstract：:Pericytes are critical for cerebrovascular maturation and development of the blood-brain barrier (BBB), but their role in maintenance of the adult BBB, and how CNS pericytes differ from those of other tissues, is less well understood. We show that the forkhead transcription factor Foxf2 is specifically expressed in pe...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.05.008
更新日期：2015-07-06 00:00:00
abstract：:The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM) at the centrosome to organize the mitotic spindle. Cilia themselves respond to growth signals, prompting cilia resorption and cell cycle re-entry. We describe ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.10.027
更新日期：2018-11-19 00:00:00
abstract：:Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including ischemia and cancer. Despite their importance, mechanisms by which pathways mediated by these transcription factors interact with one another are not fully unde...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.04.021
更新日期：2015-06-08 00:00:00
abstract：:Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players. ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00298-3
更新日期：2003-10-01 00:00:00
abstract：:Activation of Cyclin D/Cdk4 stimulates progression through the G1-S phase of the cell cycle in many organisms. In Drosophila, Cyclin D/Cdk4 also induces cell growth independently of cell cycle progression. In this issue of Developmental Cell, Frei and Edgar reveal that Cyclin D/Cdk4-stimulated growth requires Hph, a p...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/s1534-5807(04)00031-0
更新日期：2004-02-01 00:00:00
abstract：:The myogenic regulatory genes Myf5, Mrf4, Myod, and Myogenin likely arose by gene duplications during evolution, presumably to address the more demanding requirements of the vertebrate body plan. Two cell lineages were proposed to be regulated independently by Myf5 and Myod to safeguard against tissue failure. Here we...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.11.005
更新日期：2014-12-08 00:00:00
abstract：:The Drosophila lipoprotein particle, Lipophorin, bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens. Here we show that Lipophorin interacts with the he...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.04.019
更新日期：2007-07-01 00:00:00
