Dystroglycan and perlecan provide a basal cue required for epithelial polarity during energetic stress.

abstract：:DSL ligands promote proteolysis of the Notch receptor, to release active Notch intracellular domain (N(ICD)). Conversely, the E3 ubiquitin ligase Deltex can activate ligand-independent Notch proteolysis and signaling. Here we show that Deltex effects require endocytic trafficking by HOPS and AP-3 complexes. Our data s...

journal_title：Developmental cell

authors： Wilkin M,Tongngok P,Gensch N,Clemence S,Motoki M,Yamada K,Hori K,Taniguchi-Kanai M,Franklin E,Matsuno K,Baron M

更新日期：2008-11-01 00:00:00

abstract：:Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. ...

journal_title：Developmental cell

authors： Griffin CA,Kafadar KA,Pavlath GK

更新日期：2009-11-01 00:00:00

abstract：:Centromere chromatin containing histone H3 variant CENP-A is required for accurate chromosome segregation as a foundation for kinetochore assembly. Human centromere chromatin assembles on a part of the long α-satellite (alphoid) DNA array, where it is flanked by pericentric heterochromatin. Heterochromatin spreads int...

journal_title：Developmental cell

authors： Ohzeki J,Shono N,Otake K,Martins NM,Kugou K,Kimura H,Nagase T,Larionov V,Earnshaw WC,Masumoto H

更新日期：2016-06-06 00:00:00

abstract：:Boundary formation and epithelialization are crucial processes in the morphological segmentation of vertebrate somites. By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes. Fibronectin proteins accumulate at somite boundari...

journal_title：Developmental cell

authors： Koshida S,Kishimoto Y,Ustumi H,Shimizu T,Furutani-Seiki M,Kondoh H,Takada S

更新日期：2005-04-01 00:00:00

abstract：:The neural crest is a transient, multipotent embryonic cell population in vertebrates giving rise to diverse cell types in adults via intermediate progenitors. The in vivo cell-fate potential and lineage segregation of these postembryonic progenitors is poorly understood, and it is unknown if and when the progenitors ...

journal_title：Developmental cell

authors： Singh AP,Dinwiddie A,Mahalwar P,Schach U,Linker C,Irion U,Nüsslein-Volhard C

更新日期：2016-08-08 00:00:00

abstract：:The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transi...

journal_title：Developmental cell

authors： Jung H,Mazzoni EO,Soshnikova N,Hanley O,Venkatesh B,Duboule D,Dasen JS

更新日期：2014-04-28 00:00:00

abstract：:It has recently been reported that a common side effect of translation-blocking morpholino antisense oligonucleotides is the induction of a set of innate immune response genes in Xenopus embryos and that splicing-blocking morpholinos lead to unexpected off-target mis-splicing events. Here, we present an analysis of al...

journal_title：Developmental cell

authors： Paraiso KD,Blitz IL,Zhou JJ,Cho KWY

更新日期：2019-05-20 00:00:00

abstract：:The effect of intracellular vesicle trafficking on stem-cell behavior is largely unexplored. We screened the Drosophila sorting nexins (SNXs) and discovered that one, SH3PX1, profoundly affects gut homeostasis and lifespan. SH3PX1 restrains intestinal stem cell (ISC) division through an endocytosis-autophagy network t...

journal_title：Developmental cell

authors： Zhang P,Holowatyj AN,Roy T,Pronovost SM,Marchetti M,Liu H,Ulrich CM,Edgar BA

更新日期：2019-05-20 00:00:00

abstract：:Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals. ...

journal_title：Developmental cell

authors： Scott K

更新日期：2003-03-01 00:00:00

abstract：:A paper in the February issue of Molecular Cell describes the structure of the apoptosome, a multicomponent death machine, deciphered by cryoelectron microscopy. This structure explains the assembly of the machine, the tentative location of the subcomponents, and proposes a mechanism for initiating the death signal. ...

journal_title：Developmental cell

authors： Salvesen GS,Renatus M

更新日期：2002-03-01 00:00:00

abstract：:The intestine is an organ with an exceptionally high rate of cell turnover, and perturbations in this process can lead to severe diseases such as cancer or intestinal atrophy. Nutrition has a profound impact on intestinal volume and cellular architecture. However, how intestinal homeostasis is maintained in fluctuatin...

journal_title：Developmental cell

authors： Mattila J,Kokki K,Hietakangas V,Boutros M

更新日期：2018-10-08 00:00:00

abstract：:Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...

journal_title：Developmental cell

authors： Perdiguero E,Serrano AL,Muñoz-Cánoves P

更新日期：2017-07-24 00:00:00

abstract：:All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated transgenic mice expressing a tamoxifen-inducible Ngn3 fusion protei...

journal_title：Developmental cell

authors： Johansson KA,Dursun U,Jordan N,Gu G,Beermann F,Gradwohl G,Grapin-Botton A

更新日期：2007-03-01 00:00:00

abstract：:The connection between cell fate transitions and metabolic shifts is gaining momentum in the study of cell differentiation in embryonic development, adult stem cells, and cancer pathogenesis. Here, we explore how metabolic transitions influence post-translational modifications (PTMs), which play central roles in the a...

journal_title：Developmental cell

authors： Tarazona OA,Pourquié O

更新日期：2020-07-20 00:00:00

abstract：:RNA-binding Fox (Rbfox) proteins have well-established roles in regulating alternative splicing, but specific Rbfox isoforms lack nuclear localization signals and accumulate in the cytoplasm. The potential splicing-independent functions of these proteins remain unknown. Here we demonstrate that cytoplasmic Drosophila ...

journal_title：Developmental cell

authors： Carreira-Rosario A,Bhargava V,Hillebrand J,Kollipara RK,Ramaswami M,Buszczak M

更新日期：2016-03-07 00:00:00

abstract：:Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation...

journal_title：Developmental cell

authors： Wang X,Kopinke D,Lin J,McPherson AD,Duncan RN,Otsuna H,Moro E,Hoshijima K,Grunwald DJ,Argenton F,Chien CB,Murtaugh LC,Dorsky RI

更新日期：2012-09-11 00:00:00

abstract：:Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...

journal_title：Developmental cell

authors： Miao R,Li M,Zhang Q,Yang C,Wang X

更新日期：2020-01-06 00:00:00

abstract：:The conserved Hedgehog signaling pathway is essential for embryonic development and tissue homeostasis and is tightly regulated. In this issue of Developmental Cell, Ma et al. (2016) demonstrate that sumoylation works in parallel with phosphorylation to stabilize Smoothened, antagonizing its ubiquitination and subsequ...

journal_title：Developmental cell

authors： Qi Y,Liu H,Lin X

更新日期：2016-11-21 00:00:00

abstract：:Autophagy defects have recently been associated with chromosomal instability, a hallmark of human cancer. However, the functional specificity and mechanism of action of autophagy-related factors in genome stability remain elusive. Here we report that UVRAG, an autophagic tumor suppressor, plays a dual role in chromoso...

journal_title：Developmental cell

authors： Zhao Z,Oh S,Li D,Ni D,Pirooz SD,Lee JH,Yang S,Lee JY,Ghozalli I,Costanzo V,Stark JM,Liang C

更新日期：2012-05-15 00:00:00

abstract：:Plants are an excellent system for studying developmental biology. Depending on the species, they can be easily transformed and mutagenized, undergo grafts, tolerate changes in chromosome number, and provide fertile offspring after wide species crosses. Most importantly, they are perpetually embryonic, and thus develo...

journal_title：Developmental cell

authors： Fletcher JC,Hake S

更新日期：2002-10-01 00:00:00

abstract：:Centrosomes in mammalian cells have recently been implicated in cytokinesis; however, their role in this process is poorly defined. Here, we describe a human coiled-coil protein, Cep55 (centrosome protein 55 kDa), that localizes to the mother centriole during interphase. Despite its association with gamma-TuRC anchori...

journal_title：Developmental cell

authors： Fabbro M,Zhou BB,Takahashi M,Sarcevic B,Lal P,Graham ME,Gabrielli BG,Robinson PJ,Nigg EA,Ono Y,Khanna KK

更新日期：2005-10-01 00:00:00

abstract：:We have identified and characterized a novel C. elegans gene, ced-12, that functions in the conserved GTPase signaling pathway mediated by CED-2/Crkll, CED-5/DOCK180, and CED-10/Rac to control cell migration and phagocytosis of apoptotic cells. We provide evidence that ced-12 likely acts upstream of ced-10 during cell...

journal_title：Developmental cell

authors： Wu YC,Tsai MC,Cheng LC,Chou CJ,Weng NY

更新日期：2001-10-01 00:00:00

abstract：:Messenger RNAs (mRNAs) are synthesized in the cell nucleus and transported through nuclear pores to the cytoplasm for protein synthesis. Reporting in Nature Cell Biology, Mor et al. now track in living cells in real time the journey of single mRNA molecules as they transit from nucleus to cytoplasm. ...

journal_title：Developmental cell

authors： Carmo-Fonseca M

更新日期：2010-06-15 00:00:00

abstract：:High-molecular-weight hyaluronan, a major component of the extracellular matrix, is anti-oncogenic, whereas low-molecular-weight hyaluronan is pro-oncogenic, though the mechanisms underlying the size-dependent opposite bioactivities of hyaluronan remain uncertain. We show here that treatment with high-molecular-weight...

journal_title：Developmental cell

authors： Ooki T,Murata-Kamiya N,Takahashi-Kanemitsu A,Wu W,Hatakeyama M

更新日期：2019-05-20 00:00:00

abstract：:The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly...

journal_title：Developmental cell

authors： Hattori Y,Usui T,Satoh D,Moriyama S,Shimono K,Itoh T,Shirahige K,Uemura T

更新日期：2013-12-09 00:00:00

abstract：:Mutations in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-mediated cleavage and regulates the Wnt and CHOP pathways by binding the transcription factors TCF and CHOP, disrupting their intera...

journal_title：Developmental cell

authors： Merrick D,Chapin H,Baggs JE,Yu Z,Somlo S,Sun Z,Hogenesch JB,Caplan MJ

更新日期：2012-01-17 00:00:00

abstract：:Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal cholesterol content. In Niemann-Pick type C (NPC), loss of the cholestero...

journal_title：Developmental cell

authors： Davis OB,Shin HR,Lim CY,Wu EY,Kukurugya M,Maher CF,Perera RM,Ordonez MP,Zoncu R

更新日期：2020-12-07 00:00:00

abstract：:Advances in molecular biology continue to help us uncover how information written into genes provides a blueprint for the initiation and orchestration of programs and processes that control cell division, cell-type specification, cell migration, cellular differentiation, and cell death. Clearly, molecular elements int...

journal_title：Developmental cell

authors： Pappu RV

更新日期：2020-10-12 00:00:00

abstract：:In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targetin...

journal_title：Developmental cell

authors： Kim DH,Park MJ,Gwon GH,Silkov A,Xu ZY,Yang EC,Song S,Song K,Kim Y,Yoon HS,Honig B,Cho W,Cho Y,Hwang I

更新日期：2014-09-08 00:00:00

abstract：:FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly visualized in live embryos. To address whether differential signaling is associated with particular cell fates and states, we generated a targe...

journal_title：Developmental cell

authors： Simon CS,Rahman S,Raina D,Schröter C,Hadjantonakis AK

更新日期：2020-11-09 00:00:00