Wnt signaling regulates postembryonic hypothalamic progenitor differentiation.

Abstract:

:Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation of unspecified hypothalamic progenitors in the embryo. At later stages, including adulthood, sequential activation and inhibition of Wnt activity is required for the differentiation of neural progenitors and negatively regulates radial glia differentiation. The presence of Wnt activity is conserved in hypothalamic progenitors of the adult mouse, where it plays a conserved role in inhibiting the differentiation of radial glia. This study establishes the vertebrate hypothalamus as a model for Wnt-regulated postembryonic neural progenitor differentiation and defines specific roles for Wnt signaling in neurogenesis.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Wang X,Kopinke D,Lin J,McPherson AD,Duncan RN,Otsuna H,Moro E,Hoshijima K,Grunwald DJ,Argenton F,Chien CB,Murtaugh LC,Dorsky RI

doi

10.1016/j.devcel.2012.07.012

subject

Has Abstract

pub_date

2012-09-11 00:00:00

pages

624-36

issue

3

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(12)00331-0

journal_volume

23

pub_type

杂志文章
  • Epithelial Morphogenesis: Size Matters.

    abstract::In this issue of Developmental Cell, Gibson and colleagues (Ramanathan et al., 2019) investigate the relationship between size and shape in epithelial cells. They find that cell size impacts cell shape, with unexpected consequences for epithelial growth and morphogenesis, particularly the clonal dynamics of epithelial...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2019.09.015

    authors: Thompson BJ

    更新日期:2019-10-07 00:00:00

  • The undiscovered country: chromosome territories and the organization of transcription.

    abstract::The interchromosome domain (ICD) model proposes that genes are selectively positioned at the surfaces of chromosome territories to facilitate their regulation. A paper in the May 13 issue of the Journal of Cell Biology provides evidence that supports a reinterpretation of this model. ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(02)00196-x

    authors: Kosak ST,Groudine M

    更新日期:2002-06-01 00:00:00

  • Membrane Mechanics in Living Cells.

    abstract::The combination of fluid and mechanical properties exhibited by cell membranes enables a wealth of physical phenomena, many of which also have biological functions. A recent study in Cell (Shi et al., 2018) now shows that membrane tension in the cell may not be as simple as it first seemed. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2018.12.011

    authors: Groves JT

    更新日期:2019-01-07 00:00:00

  • Axon targeting meets protein trafficking: Comm takes Robo to the cleaners.

    abstract::Axon guidance at the Drosophila midline relies on dynamic regulation of the guidance receptor Robo by its negative regulator Comm. Recent findings demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signaling by promoting the sorting of Robo into the endocytic pathway. ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/s1534-5807(02)00260-5

    authors: Rosenzweig M,Garrity P

    更新日期:2002-09-01 00:00:00

  • Tensing Up for Lipid Droplet Formation.

    abstract::Lipid droplets are fat storage organelles in cells that physically resemble stable oil-water emulsion droplets. In this issue of Developmental Cell, Ben M'barek et al. (2017) show that the resemblance is more than superficial: physical principles governing emulsion stability also control lipid droplet nucleation and g...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.devcel.2017.06.001

    authors: Roux A,Loewith R

    更新日期:2017-06-19 00:00:00

  • Role of lipid metabolism in smoothened derepression in hedgehog signaling.

    abstract::The binding of Hedgehog (Hh) to its receptor Patched causes derepression of Smoothened (Smo), resulting in the activation of the Hh pathway. Here, we show that Smo activation is dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P). Loss of STT4 kinase, which is required for the generatio...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2010.06.007

    authors: Yavari A,Nagaraj R,Owusu-Ansah E,Folick A,Ngo K,Hillman T,Call G,Rohatgi R,Scott MP,Banerjee U

    更新日期:2010-07-20 00:00:00

  • Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier.

    abstract::The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.10.024

    authors: Hattori Y,Usui T,Satoh D,Moriyama S,Shimono K,Itoh T,Shirahige K,Uemura T

    更新日期:2013-12-09 00:00:00

  • Multiplexing MIM.

    abstract::Signaling circuits often coordinate cellular membranes and actin filaments at distinct sites to direct cell behavior. In this issue of Developmental Cell, Bershteyn et al. outline how the molecular scaffold protein, MIM, which bends membranes and binds actin filaments, is at the middle of one such circuit to regulate ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2010.07.021

    authors: Kozminski KG,Schafer DA

    更新日期:2010-08-17 00:00:00

  • An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development.

    abstract::Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.10.020

    authors: Miao R,Li M,Zhang Q,Yang C,Wang X

    更新日期:2020-01-06 00:00:00

  • Mitotic spindle orientation: semaphorin-plexin signaling flags the way.

    abstract::The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney deve...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2015.04.012

    authors: Humbert PO,Gödde NJ

    更新日期:2015-05-04 00:00:00

  • Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth.

    abstract::The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback me...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2015.10.003

    authors: Okamoto N,Nishimura T

    更新日期:2015-11-09 00:00:00

  • Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression.

    abstract::Although autophagy is being pursued as a therapeutic target in clinical oncology trials, its effects on metastasis, the principal cause of cancer mortality, remain unclear. Here, we utilize mammary cancer models to temporally delete essential autophagy regulators during carcinoma progression. Though genetic ablation o...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.01.025

    authors: Marsh T,Kenific CM,Suresh D,Gonzalez H,Shamir ER,Mei W,Tankka A,Leidal AM,Kalavacherla S,Woo K,Werb Z,Debnath J

    更新日期:2020-03-09 00:00:00

  • Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR.

    abstract::Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype ga...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2017.09.020

    authors: Ewen-Campen B,Mohr SE,Hu Y,Perrimon N

    更新日期:2017-10-09 00:00:00

  • Plant cell polarity: sterols enter into action after cytokinesis.

    abstract::In yeast and animal cells, the sterol composition of membranes is a key factor that controls the polarity of membrane proteins by regulating their intracellular trafficking or lateral diffusion. A recent study in Nature Cell Biology demonstrates that plant sterols play a major role in the acquisition of cell polarity ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.02.007

    authors: Jaillais Y,Gaude T

    更新日期:2008-03-01 00:00:00

  • Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse.

    abstract::We present new approaches to cis-regulatory module (CRM) discovery in the common scenario where relevant transcription factors and/or motifs are unknown. Beginning with a small list of CRMs mediating a common gene expression pattern, we search genome-wide for CRMs with similar functionality, using new statistical scor...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.09.002

    authors: Kantorovitz MR,Kazemian M,Kinston S,Miranda-Saavedra D,Zhu Q,Robinson GE,Göttgens B,Halfon MS,Sinha S

    更新日期:2009-10-01 00:00:00

  • HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes.

    abstract::Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including ischemia and cancer. Despite their importance, mechanisms by which pathways mediated by these transcription factors interact with one another are not fully unde...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2015.04.021

    authors: Guimarães-Camboa N,Stowe J,Aneas I,Sakabe N,Cattaneo P,Henderson L,Kilberg MS,Johnson RS,Chen J,McCulloch AD,Nobrega MA,Evans SM,Zambon AC

    更新日期:2015-06-08 00:00:00

  • Pigment Cell Progenitors in Zebrafish Remain Multipotent through Metamorphosis.

    abstract::The neural crest is a transient, multipotent embryonic cell population in vertebrates giving rise to diverse cell types in adults via intermediate progenitors. The in vivo cell-fate potential and lineage segregation of these postembryonic progenitors is poorly understood, and it is unknown if and when the progenitors ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.06.020

    authors: Singh AP,Dinwiddie A,Mahalwar P,Schach U,Linker C,Irion U,Nüsslein-Volhard C

    更新日期:2016-08-08 00:00:00

  • Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle.

    abstract::The Golgi apparatus undergoes a ubiquitin-dependent disassembly and reassembly process during each cycle of cell division. Here we report the identification of the Golgi t-SNARE syntaxin 5 (Syn5) as the ubiquitinated substrate. Syn5 is monoubiquitinated by the ubiquitin ligase HACE1 in early mitosis and deubiquitinate...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.06.001

    authors: Huang S,Tang D,Wang Y

    更新日期:2016-07-11 00:00:00

  • The cytokinin-activated transcription factor ARR2 promotes plant immunity via TGA3/NPR1-dependent salicylic acid signaling in Arabidopsis.

    abstract::Cytokinins affect plant immunity to various pathogens; however, the mechanisms coupling plant-derived cytokinins to pathogen responses have been elusive. Here, we found that plant-derived cytokinins promote resistance of Arabidopsis to Pseudomonas syringae pv. tomato DC3000 (Pst). Modulated cytokinin levels or signali...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2010.07.011

    authors: Choi J,Huh SU,Kojima M,Sakakibara H,Paek KH,Hwang I

    更新日期:2010-08-17 00:00:00

  • Human SEIPIN Binds Anionic Phospholipids.

    abstract::The biogenesis of lipid droplets (LDs) and the development of adipocytes are two key aspects of mammalian fat storage. SEIPIN, an integral membrane protein of the endoplasmic reticulum (ER), plays a critical role in both LD formation and adipogenesis. The molecular function of SEIPIN, however, has yet to be elucidated...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2018.09.010

    authors: Yan R,Qian H,Lukmantara I,Gao M,Du X,Yan N,Yang H

    更新日期:2018-10-22 00:00:00

  • The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism.

    abstract::Mutations in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-mediated cleavage and regulates the Wnt and CHOP pathways by binding the transcription factors TCF and CHOP, disrupting their intera...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.10.028

    authors: Merrick D,Chapin H,Baggs JE,Yu Z,Somlo S,Sun Z,Hogenesch JB,Caplan MJ

    更新日期:2012-01-17 00:00:00

  • Picket and other fences in biological membranes.

    abstract::Nakada et al. revisit the controversial question of whether membrane lipids are able to diffuse from the axon of a neuron into the soma. Using single molecule imaging of a fluorescent phospholipid, the authors show that a diffusion barrier in the axon initial segment blocks the diffusion of lipids. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/s1534-5807(03)00240-5

    authors: Boiko T,Winckler B

    更新日期:2003-08-01 00:00:00

  • A molecular base for cell sorting at embryonic boundaries: contact inhibition of cadherin adhesion by ephrin/ Eph-dependent contractility.

    abstract::The mechanism responsible for subdividing the embryo into individual tissues is a fundamental, yet still poorly understood, question in developmental biology. Various general hypotheses have been proposed, involving differences in cell adhesion, contractility, or contact-mediated repulsion. However, the key parameter ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.09.004

    authors: Fagotto F,Rohani N,Touret AS,Li R

    更新日期:2013-10-14 00:00:00

  • Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals.

    abstract::p120-catenin is an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. Despite recent advances in understanding the roles that p120-catenin and Kaiso play in downstream modulation of Wnt/beta-catenin signaling, the identity of t...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2006.09.022

    authors: Park JI,Ji H,Jun S,Gu D,Hikasa H,Li L,Sokol SY,McCrea PD

    更新日期:2006-11-01 00:00:00

  • The Tubulin Code in Microtubule Dynamics and Information Encoding.

    abstract::Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton. Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin isoforms and post-translational modifications, a "tubulin code," which is thought to support the diverse morphology and dynamics of microtu...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.devcel.2020.06.008

    authors: Roll-Mecak A

    更新日期:2020-07-06 00:00:00

  • Brassinosteroid/Abscisic Acid Antagonism in Balancing Growth and Stress.

    abstract::In this issue of Developmental Cell, Gui et al. (2016) show that an abscisic acid-inducible remorin protein in rice directly interacts with critical brassinosteroid signaling components to attenuate the brassinosteroid response, thus illuminating one aspect of the brassinosteroid/abscisic acid antagonism. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2016.07.005

    authors: Clouse SD

    更新日期:2016-07-25 00:00:00

  • Sizing up lung stem cells.

    abstract::Mammalian lungs are comprised of conducting airways and alveoli. How the distinct epithelial linings of these two zones are differentially specified and maintained is not fully understood. In this issue of Developmental Cell, two groups find critical roles for the Hippo pathway in regulation of lung progenitor cell di...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2014.07.002

    authors: Rock JR

    更新日期:2014-07-28 00:00:00

  • Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.

    abstract::Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediating these invasions, however, remains unclear. Utilizing the genetically and visually accessible model of anchor cell (AC) inva...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2009.06.006

    authors: Hagedorn EJ,Yashiro H,Ziel JW,Ihara S,Wang Z,Sherwood DR

    更新日期:2009-08-01 00:00:00

  • Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos.

    abstract::Connecting phosphorylation events to kinases and phosphatases is key to understanding the molecular organization and signaling dynamics of networks. We have generated a validated set of transgenic RNA-interference reagents for knockdown and characterization of all protein kinases and phosphatases present during early ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2014.07.027

    authors: Sopko R,Foos M,Vinayagam A,Zhai B,Binari R,Hu Y,Randklev S,Perkins LA,Gygi SP,Perrimon N

    更新日期:2014-10-13 00:00:00

  • Chromosome Segregation and Peptidoglycan Remodeling Are Coordinated at a Highly Stabilized Septal Pore to Maintain Bacterial Spore Development.

    abstract::Asymmetric division, a hallmark of endospore development, generates two cells, a larger mother cell and a smaller forespore. Approximately 75% of the forespore chromosome must be translocated across the division septum into the forespore by the DNA translocase SpoIIIE. Asymmetric division also triggers cell-specific t...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2020.12.006

    authors: Mohamed A,Chan H,Luhur J,Bauda E,Gallet B,Morlot C,Cole L,Awad M,Crawford S,Lyras D,Rudner DZ,Rodrigues CDA

    更新日期:2021-01-11 00:00:00