Sex and the MHC.

Abstract:

:Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Scott K

doi

10.1016/s1534-5807(03)00066-2

keywords:

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

290-1

issue

3

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(03)00066-2

journal_volume

4

pub_type

评论,杂志文章,评审
  • 3' UTRs in the Eye of the TIGER.

    abstract::Many human genes generate mRNAs with alternative 3' untranslated regions (3' UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3' UTRs to encipher protein localizatio...

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    doi:10.1016/j.devcel.2018.11.022

    authors: Portz B,Shorter J

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  • Arabidopsis Serrate Coordinates Histone Methyltransferases ATXR5/6 and RNA Processing Factor RDR6 to Regulate Transposon Expression.

    abstract::Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formatio...

    journal_title:Developmental cell

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    doi:10.1016/j.devcel.2018.05.023

    authors: Ma Z,Castillo-González C,Wang Z,Sun D,Hu X,Shen X,Potok ME,Zhang X

    更新日期:2018-06-18 00:00:00

  • Tissue-Scale Mechanical Coupling Reduces Morphogenetic Noise to Ensure Precision during Epithelial Folding.

    abstract::Morphological constancy is universal in developing systems. It is unclear whether precise morphogenesis stems from faithful mechanical interpretation of gene expression patterns. We investigate the formation of the cephalic furrow, an epithelial fold that is precisely positioned with a linear morphology. Fold initiati...

    journal_title:Developmental cell

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    doi:10.1016/j.devcel.2020.02.012

    authors: Eritano AS,Bromley CL,Bolea Albero A,Schütz L,Wen FL,Takeda M,Fukaya T,Sami MM,Shibata T,Lemke S,Wang YC

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  • The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis.

    abstract::While GDNF signaling through the Ret receptor is critical for kidney development, its specific role in branching morphogenesis of the epithelial ureteric bud (UB) is unclear. Ret expression defines a population of UB "tip cells" distinct from cells of the tubular "trunks," but how these cells contribute to UB growth i...

    journal_title:Developmental cell

    pub_type: 杂志文章

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    authors: Shakya R,Watanabe T,Costantini F

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  • The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances.

    abstract::Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the facto...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2016.10.015

    authors: Symmons O,Pan L,Remeseiro S,Aktas T,Klein F,Huber W,Spitz F

    更新日期:2016-12-05 00:00:00

  • Quantitative modeling in cell biology: what is it good for?

    abstract::Recently, there has been a surge in the number of pioneering studies combining experiments with quantitative modeling to explain both relatively simple modules of molecular machinery of the cell and to achieve system-level understanding of cellular networks. Here we discuss the utility and methods of modeling and revi...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审

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    authors: Mogilner A,Wollman R,Marshall WF

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  • Tissue Sculpting by Fibrils.

    abstract::In this issue of Developmental Cell, Isabella and Horne-Badovinac (2016) show that Rab10 directs site-specific secretion of basement membrane components, which assemble into fibrils that spool out to elongate the Drosophila egg chamber. These findings establish the basement membrane's active role in tissue sculpting. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

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  • A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size.

    abstract::The Hippo/Yki and RB/E2F pathways both regulate tissue growth by affecting cell proliferation and survival, but interactions between these parallel control systems are poorly defined. In this study, we demonstrate that interaction between Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2017.10.033

    authors: Zhang P,Pei C,Wang X,Xiang J,Sun BF,Cheng Y,Qi X,Marchetti M,Xu JW,Sun YP,Edgar BA,Yuan Z

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  • Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models.

    abstract::Appropriate axonal growth and connectivity are essential for functional wiring of the brain. Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations disrupt primary cilia function, are characterized by axonal tract malformations. However, little is known about how cilia-driven signaling r...

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    pub_type: 杂志文章

    doi:10.1016/j.devcel.2019.11.005

    authors: Guo J,Otis JM,Suciu SK,Catalano C,Xing L,Constable S,Wachten D,Gupton S,Lee J,Lee A,Blackley KH,Ptacek T,Simon JM,Schurmans S,Stuber GD,Caspary T,Anton ES

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  • Wnt3a plays a major role in the segmentation clock controlling somitogenesis.

    abstract::The vertebral column derives from somites generated by segmentation of presomitic mesoderm (PSM). Somitogenesis involves a molecular oscillator, the segmentation clock, controlling periodic Notch signaling in the PSM. Here, we establish a novel link between Wnt/beta-catenin signaling and the segmentation clock. Axin2,...

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    pub_type: 杂志文章

    doi:10.1016/s1534-5807(03)00055-8

    authors: Aulehla A,Wehrle C,Brand-Saberi B,Kemler R,Gossler A,Kanzler B,Herrmann BG

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  • Nucleosome-depleted regions in cell-cycle-regulated promoters ensure reliable gene expression in every cell cycle.

    abstract::Many promoters in eukaryotes have nucleosome-depleted regions (NDRs) containing transcription factor binding sites. However, the functional significance of NDRs is not well understood. Here, we examine NDR function in two cell cycle-regulated promoters, CLN2pr and HOpr, by varying nucleosomal coverage of the binding s...

    journal_title:Developmental cell

    pub_type: 杂志文章

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  • Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells.

    abstract::Efficient regeneration following injury is critical for maintaining tissue function and enabling organismal survival. Cells reconstituting damaged tissue are often generated from resident stem or progenitor cells or from cells that have dedifferentiated and become proliferative. While lineage-tracing studies have defi...

    journal_title:Developmental cell

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  • Fate mapping embryonic blood in zebrafish: multi- and unipotential lineages are segregated at gastrulation.

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    doi:10.1016/j.devcel.2009.04.007

    authors: Warga RM,Kane DA,Ho RK

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  • Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier.

    abstract::The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of these isolated neurons. Their profiles were similarly...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.10.024

    authors: Hattori Y,Usui T,Satoh D,Moriyama S,Shimono K,Itoh T,Shirahige K,Uemura T

    更新日期:2013-12-09 00:00:00

  • Tracing cells for tracking cell lineage and clonal behavior.

    abstract::Reconstructing the lineage of cells is central to understanding development and is now also an important issue in stem cell research. Technological advances in genetically engineered permanent cell labeling, together with a multiplicity of fluorescent markers and sophisticated imaging, open new possibilities for prosp...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2011.07.019

    authors: Buckingham ME,Meilhac SM

    更新日期:2011-09-13 00:00:00

  • Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos.

    abstract::Boundary formation and epithelialization are crucial processes in the morphological segmentation of vertebrate somites. By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes. Fibronectin proteins accumulate at somite boundari...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2005.03.006

    authors: Koshida S,Kishimoto Y,Ustumi H,Shimizu T,Furutani-Seiki M,Kondoh H,Takada S

    更新日期:2005-04-01 00:00:00

  • Components of Intraflagellar Transport Complex A Function Independently of the Cilium to Regulate Canonical Wnt Signaling in Drosophila.

    abstract::The development of multicellular organisms requires the precisely coordinated regulation of an evolutionarily conserved group of signaling pathways. Temporal and spatial control of these signaling cascades is achieved through networks of regulatory proteins, segregation of pathway components in specific subcellular co...

    journal_title:Developmental cell

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    doi:10.1016/j.devcel.2015.07.016

    authors: Balmer S,Dussert A,Collu GM,Benitez E,Iomini C,Mlodzik M

    更新日期:2015-09-28 00:00:00

  • External mechanical cues trigger the establishment of the anterior-posterior axis in early mouse embryos.

    abstract::Mouse anterior-posterior axis polarization is preceded by formation of the distal visceral endoderm (DVE) by unknown mechanisms. Here, we show by in vitro culturing of embryos immediately after implantation in microfabricated cavities that the external mechanical cues exerted on the embryo are crucial for DVE formatio...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2013.09.026

    authors: Hiramatsu R,Matsuoka T,Kimura-Yoshida C,Han SW,Mochida K,Adachi T,Takayama S,Matsuo I

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  • Chemokine signaling mediates self-organizing tissue migration in the zebrafish lateral line.

    abstract::The shape of most complex organ systems arises from the directed migration of cohesive groups of cells. Here, we dissect the role of the chemokine guidance receptor Cxcr4b in regulating the collective migration of one such cohesive tissue, the zebrafish lateral line primordium. Using in vivo imaging, we show that the ...

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  • Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.

    abstract::In vertebrate embryos, retinoic acid (RA) synthesized in the mesoderm by Raldh2 emanates to the hindbrain neuroepithelium, where it induces anteroposterior (AP)-restricted Hox expression patterns and rhombomere segmentation. However, how appropriate spatiotemporal RA activity is generated in the hindbrain is poorly un...

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    authors: Vitobello A,Ferretti E,Lampe X,Vilain N,Ducret S,Ori M,Spetz JF,Selleri L,Rijli FM

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  • HCMV Assembly Is Totally Tubular.

    abstract::Microtubules are normally organized at centrosomes, but other sites can also serve as microtubule organizing centers (MTOCs). In this issue of Developmental Cell, Procter et al. (2018) show that the human cytomegalovirus virion assembly compartment acts as a dynamic Golgi-derived MTOC where EB3 nucleates microtubules ...

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    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2018.03.014

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  • Plant cell polarity: sterols enter into action after cytokinesis.

    abstract::In yeast and animal cells, the sterol composition of membranes is a key factor that controls the polarity of membrane proteins by regulating their intracellular trafficking or lateral diffusion. A recent study in Nature Cell Biology demonstrates that plant sterols play a major role in the acquisition of cell polarity ...

    journal_title:Developmental cell

    pub_type: 杂志文章

    doi:10.1016/j.devcel.2008.02.007

    authors: Jaillais Y,Gaude T

    更新日期:2008-03-01 00:00:00

  • A receptor for meningococcus: eliciting β-arrestin signaling for barrier breaching.

    abstract::In a recent issue of Cell, Coureuil et al. (2010) show that type IV pili of Neisseria meningitidis-the causative bacterium of cerebrospinal meningitis-bind to the endothelial β2-adrenoceptor and elicit biased β-arrestin signaling resulting in microvilli formation and paracytotic bacterial migration. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2010.12.011

    authors: Tourret J,Finlay BB

    更新日期:2011-01-18 00:00:00

  • Chk1: a double agent in cell cycle checkpoints.

    abstract::Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al.(2007) present evidence to indicate that Chk1 als...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.devcel.2007.01.005

    authors: Yu H

    更新日期:2007-02-01 00:00:00

  • The transcriptional control of trunk neural crest induction, survival, and delamination.

    abstract::Trunk neural crest cells are generated at the border between the neural plate and nonneural ectoderm, where they initiate a distinct program of gene expression, undergo an epithelial-mesenchymal transition (EMT), and delaminate from the neuroepithelium. Here, we provide evidence that members of three families of trans...

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  • Systematic study of Drosophila microRNA functions using a collection of targeted knockout mutations.

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  • A wapl a day keeps the sisters apart: wapl and cohesin dynamics.

    abstract::Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests that a dynamic interaction between the cohesin complex and chromat...

    journal_title:Developmental cell

    pub_type: 社论

    doi:10.1016/j.devcel.2006.11.010

    authors: Rankin S

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  • Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms.

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    doi:10.1016/j.devcel.2017.03.023

    authors: Ma X,Zhu X,Han Y,Story B,Do T,Song X,Wang S,Zhang Y,Blanchette M,Gogol M,Hall K,Peak A,Anoja P,Xie T

    更新日期:2017-04-24 00:00:00

  • Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation.

    abstract::Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is normally restricted to proliferating cells. However, high levels of cyclin E are expressed in the adult brain. The function of ...

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    pub_type: 杂志文章

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    authors: Odajima J,Wills ZP,Ndassa YM,Terunuma M,Kretschmannova K,Deeb TZ,Geng Y,Gawrzak S,Quadros IM,Newman J,Das M,Jecrois ME,Yu Q,Li N,Bienvenu F,Moss SJ,Greenberg ME,Marto JA,Sicinski P

    更新日期:2011-10-18 00:00:00

  • C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair.

    abstract::Reactive oxygen species (ROS) such as hydrogen peroxide are generated at wound sites and act as long-range signals in wound healing. The roles of other ROS in wound repair are little explored. Here, we reveal a cytoprotective role for mitochondrial ROS (mtROS) in Caenorhabditis elegans skin wound healing. We show that...

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    pub_type: 杂志文章

    doi:10.1016/j.devcel.2014.08.002

    authors: Xu S,Chisholm AD

    更新日期:2014-10-13 00:00:00