Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content.

abstract：:Lymphatic vessels are essential for tissue homeostasis and immune surveillance and contribute to pathological conditions. Lymphatic endothelium differentiates from veins and forms an independent vascular tree with only few connections to the venous circulation. Failure of blood and lymphatic vessel separation results ...

journal_title：Developmental cell

authors： Böhmer R,Neuhaus B,Bühren S,Zhang D,Stehling M,Böck B,Kiefer F

更新日期：2010-03-16 00:00:00

abstract：:Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for either Tet1 or Tet2 are viable, raising the question of whether these enzymes have overlapping roles in development. Here we have generated Tet1 and Tet2 double-knockout (DKO)...

journal_title：Developmental cell

authors： Dawlaty MM,Breiling A,Le T,Raddatz G,Barrasa MI,Cheng AW,Gao Q,Powell BE,Li Z,Xu M,Faull KF,Lyko F,Jaenisch R

更新日期：2013-02-11 00:00:00

abstract：:While GDNF signaling through the Ret receptor is critical for kidney development, its specific role in branching morphogenesis of the epithelial ureteric bud (UB) is unclear. Ret expression defines a population of UB "tip cells" distinct from cells of the tubular "trunks," but how these cells contribute to UB growth i...

journal_title：Developmental cell

authors： Shakya R,Watanabe T,Costantini F

更新日期：2005-01-01 00:00:00

abstract：:During organogenesis, coherent organ growth arises from spatiotemporally coordinated decisions of individual cells. In the root of Arabidopsis thaliana, this coordination results in the establishment of a division and a differentiation zone. Cells continuously move through these zones; thus, a major question is how th...

journal_title：Developmental cell

authors： Salvi E,Rutten JP,Di Mambro R,Polverari L,Licursi V,Negri R,Dello Ioio R,Sabatini S,Ten Tusscher K

更新日期：2020-05-18 00:00:00

abstract：:Theoretical modeling is central to elucidating underlying principles of emergent properties of complex systems. In cell and developmental biology, the last 15 years have witnessed a convergence of empirical and modeling approaches for fresh perspectives. The role of cell division in coordinating size, shape, and fate ...

journal_title：Developmental cell

authors： Bellaïche Y

更新日期：2016-09-26 00:00:00

abstract：:To maintain mechanical homeostasis, cells must recognize and respond to changes in cytoskeletal integrity. By imaging live cells expressing fluorescently tagged cytoskeletal proteins, we observed that actin stress fibers undergo local, acute, force-induced elongation and thinning events that compromise their stress tr...

journal_title：Developmental cell

authors： Smith MA,Blankman E,Gardel ML,Luettjohann L,Waterman CM,Beckerle MC

更新日期：2010-09-14 00:00:00

abstract：:Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited by the time required to generate stable mutant lines. We describe a system for gene knockout that consistently produces null phenotypes in G0 zebrafish. Yolk injection of sets of four CRISPR/Cas9 ribonucleoprotein complexes redu...

journal_title：Developmental cell

authors： Wu RS,Lam II,Clay H,Duong DN,Deo RC,Coughlin SR

更新日期：2018-07-02 00:00:00

abstract：:Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associated RNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear whether it plays any roles in early GSC...

journal_title：Developmental cell

authors： Ma X,Zhu X,Han Y,Story B,Do T,Song X,Wang S,Zhang Y,Blanchette M,Gogol M,Hall K,Peak A,Anoja P,Xie T

更新日期：2017-04-24 00:00:00

abstract：:Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. ...

journal_title：Developmental cell

authors： Griffin CA,Kafadar KA,Pavlath GK

更新日期：2009-11-01 00:00:00

abstract：:Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fe...

journal_title：Developmental cell

authors： Haag ES,Lo TW

更新日期：2018-04-23 00:00:00

abstract：:Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is normally restricted to proliferating cells. However, high levels of cyclin E are expressed in the adult brain. The function of ...

journal_title：Developmental cell

authors： Odajima J,Wills ZP,Ndassa YM,Terunuma M,Kretschmannova K,Deeb TZ,Geng Y,Gawrzak S,Quadros IM,Newman J,Das M,Jecrois ME,Yu Q,Li N,Bienvenu F,Moss SJ,Greenberg ME,Marto JA,Sicinski P

更新日期：2011-10-18 00:00:00

abstract：:Orientation of cell division is a vital aspect of tissue morphogenesis and growth. Asymmetric divisions generate cell fate diversity and epithelial stratification, whereas symmetric divisions contribute to tissue growth, spreading, and elongation. Here, we describe a mechanism for positioning the spindle in symmetric ...

journal_title：Developmental cell

authors： Woolner S,Papalopulu N

更新日期：2012-04-17 00:00:00

abstract：:Ribosomes perform protein synthesis but are also involved in signaling processes, the full extent of which are still being uncovered. We report that phenotypes of mutating ribosomal proteins (Rps) are largely due to signaling. Using Drosophila, we discovered that a bZip-domain protein, Xrp1, becomes elevated in Rp mut...

journal_title：Developmental cell

authors： Lee CH,Kiparaki M,Blanco J,Folgado V,Ji Z,Kumar A,Rimesso G,Baker NE

更新日期：2018-08-20 00:00:00

abstract：:Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gonadal sex reversal ca...

journal_title：Developmental cell

authors： Warr N,Carre GA,Siggers P,Faleato JV,Brixey R,Pope M,Bogani D,Childers M,Wells S,Scudamore CL,Tedesco M,del Barco Barrantes I,Nebreda AR,Trainor PA,Greenfield A

更新日期：2012-11-13 00:00:00

abstract：:Cells entering mitosis become rounded, lose attachment to the substrate, and increase their cortical rigidity. Pivotal to these events is the dismantling of focal adhesions (FAs). How mitotic reshaping is linked to commitment to divide is unclear. Here, we show that DEPDC1B, a protein that accumulates in G2, coordinat...

journal_title：Developmental cell

authors： Marchesi S,Montani F,Deflorian G,D'Antuono R,Cuomo A,Bologna S,Mazzoccoli C,Bonaldi T,Di Fiore PP,Nicassio F

更新日期：2014-11-24 00:00:00

abstract：:Processing bodies (P bodies) are discrete cytoplasmic foci to which mRNA is routed for degradation. In mammalian cells, they are also associated with miRNA-induced translational silencing and siRNA-induced mRNA degradation. In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting prot...

journal_title：Developmental cell

authors： Anderson P

更新日期：2005-09-01 00:00:00

abstract：:In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which the SSC-ECM interface is regulated and the outcome of such interactions on stem cell fate in vivo remain unknown. Here we demonstrate...

journal_title：Developmental cell

authors： Tang Y,Rowe RG,Botvinick EL,Kurup A,Putnam AJ,Seiki M,Weaver VM,Keller ET,Goldstein S,Dai J,Begun D,Saunders T,Weiss SJ

更新日期：2013-05-28 00:00:00

abstract：:SnoN regulates multiple signaling pathways, including TGF-β/Smad and p53, and displays both pro-oncogenic and anti-oncogenic activities in human cancer. We have observed previously that both its intracellular localization and expression levels are sensitive to cell density, suggesting that it may crosstalk with Hippo ...

journal_title：Developmental cell

authors： Zhu Q,Le Scolan E,Jahchan N,Ji X,Xu A,Luo K

更新日期：2016-06-06 00:00:00

abstract：:NAD(H)-binding proteins play important roles in cell-cycle and developmental signaling in eukaryotes. We identified a bifunctional NAD(H)-binding regulator (KidO) that integrates cell-fate signaling with cytokinesis in the bacterium Caulobacter crescentus. KidO stimulates the DivJ kinase and directly acts on the cytok...

journal_title：Developmental cell

authors： Radhakrishnan SK,Pritchard S,Viollier PH

更新日期：2010-01-19 00:00:00

abstract：:The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, c...

journal_title：Developmental cell

authors： Bhaskar PT,Hay N

更新日期：2007-04-01 00:00:00

abstract：:The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms driving initiation of this specialized process are largely undefined. In this issue of Developmental Cell,Ishiguro et al. (2020) identified the transcription factor MEIOSIN as a gatekeeper of meiotic initiation in both male and female germ c...

journal_title：Developmental cell

authors： Oatley JM,Griswold MD

更新日期：2020-02-24 00:00:00

abstract：:The appearance of Oskar protein occurs coincident with localization of oskar mRNA to the posterior pole of the Drosophila oocyte, and earlier accumulation of the protein is prevented by translational repression. We find that the nascent polypeptide-associated complex (NAC) is required for correct localization of oskar...

journal_title：Developmental cell

authors： Braat AK,Yan N,Arn E,Harrison D,Macdonald PM

更新日期：2004-07-01 00:00:00

abstract：:Centrosomes in mammalian cells have recently been implicated in cytokinesis; however, their role in this process is poorly defined. Here, we describe a human coiled-coil protein, Cep55 (centrosome protein 55 kDa), that localizes to the mother centriole during interphase. Despite its association with gamma-TuRC anchori...

journal_title：Developmental cell

authors： Fabbro M,Zhou BB,Takahashi M,Sarcevic B,Lal P,Graham ME,Gabrielli BG,Robinson PJ,Nigg EA,Ono Y,Khanna KK

更新日期：2005-10-01 00:00:00

abstract：:The insulin-like peptide (ILP) family plays key biological roles in the control of body growth. Although the functions of ILPs are well understood, the mechanisms by which organisms sense their nutrient status and thereby control ILP production remain largely unknown. Here, we show that signaling relay and feedback me...

journal_title：Developmental cell

authors： Okamoto N,Nishimura T

更新日期：2015-11-09 00:00:00

abstract：:The interchromosome domain (ICD) model proposes that genes are selectively positioned at the surfaces of chromosome territories to facilitate their regulation. A paper in the May 13 issue of the Journal of Cell Biology provides evidence that supports a reinterpretation of this model. ...

journal_title：Developmental cell

authors： Kosak ST,Groudine M

更新日期：2002-06-01 00:00:00

abstract：:hunchback regulates the temporal identity of neuroblasts in Drosophila. Here we show that hbl-1, the C. elegans hunchback ortholog, also controls temporal patterning. Furthermore, hbl-1 is a probable target of microRNA regulation through its 3'UTR. hbl-1 loss-of-function causes the precocious expression of adult seam ...

journal_title：Developmental cell

authors： Lin SY,Johnson SM,Abraham M,Vella MC,Pasquinelli A,Gamberi C,Gottlieb E,Slack FJ

更新日期：2003-05-01 00:00:00

abstract：:Hedgehog (Hh) signaling during development and in postembryonic tissues requires activation of the 7TM oncoprotein Smoothened (Smo) by mechanisms that may involve endogenous lipidic modulators. Exogenous Smo ligands previously identified include the plant sterol cyclopamine (and its therapeutically useful synthetic mi...

journal_title：Developmental cell

authors： Myers BR,Sever N,Chong YC,Kim J,Belani JD,Rychnovsky S,Bazan JF,Beachy PA

更新日期：2013-08-26 00:00:00

abstract：:During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis. Rac1 null cells migrate markedly less efficiently, but s...

journal_title：Developmental cell

authors： Li A,Ma Y,Yu X,Mort RL,Lindsay CR,Stevenson D,Strathdee D,Insall RH,Chernoff J,Snapper SB,Jackson IJ,Larue L,Sansom OJ,Machesky LM

更新日期：2011-10-18 00:00:00

abstract：:The Frizzled (Fz) receptor is required cell autonomously in Wnt/beta-catenin and planar cell polarity (PCP) signaling. In addition to these requirements, Fz acts nonautonomously during PCP establishment: wild-type cells surrounding fz(-) patches reorient toward the fz(-) cells. The molecular mechanism(s) of nonautonom...

journal_title：Developmental cell

authors： Wu J,Mlodzik M

更新日期：2008-09-01 00:00:00

abstract：:Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal cholesterol content. In Niemann-Pick type C (NPC), loss of the cholestero...

journal_title：Developmental cell

authors： Davis OB,Shin HR,Lim CY,Wu EY,Kukurugya M,Maher CF,Perera RM,Ordonez MP,Zoncu R

更新日期：2020-12-07 00:00:00