DEPDC1B coordinates de-adhesion events and cell-cycle progression at mitosis.

abstract：:The Rho GTPase Cdc42 is essential for polarized growth of budding yeast. Temporal control of Cdc42 depends partly on the activity of its GTPase-activating proteins (GAPs). In this issue of Developmental Cell, Saito et al. report that Cdc42 GAP activity is regulated by the phospholipid composition of the bud-tip membra...

journal_title：Developmental cell

authors： Menon AK

更新日期：2007-11-01 00:00:00

abstract：:Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...

journal_title：Developmental cell

authors： Carballido-López R,Errington J

更新日期：2003-01-01 00:00:00

abstract：:The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlying this process remain obscure. Here, we used time-lapse microscopy together with several ...

journal_title：Developmental cell

authors： Packard A,Georgas K,Michos O,Riccio P,Cebrian C,Combes AN,Ju A,Ferrer-Vaquer A,Hadjantonakis AK,Zong H,Little MH,Costantini F

更新日期：2013-11-11 00:00:00

abstract：:Reporting in Developmental Cell, Schlaitz et al. (2013) show that endoplasmic reticulum (ER) membrane exclusion from the mitotic spindle is an active process requiring REEP membrane proteins. REEP protein depletion results in ER membrane retention on the spindle and chromosomes, leading to defects in chromosome segreg...

journal_title：Developmental cell

authors： Burke B

更新日期：2013-08-12 00:00:00

abstract：:The majority of excitatory synaptic transmission in the brain occurs at dendritic spines, which are actin-rich protrusions on the dendrites. The asymmetric nature of these structures suggests that proteins regulating cell polarity might be involved in their formation. Indeed, the polarity protein PAR-3 is required for...

journal_title：Developmental cell

authors： Zhang H,Macara IG

更新日期：2008-02-01 00:00:00

abstract：:Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown (Rhee et al.,2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/beta-catenin...

journal_title：Developmental cell

authors： Korswagen HC

更新日期：2006-06-01 00:00:00

abstract：:Centromere chromatin containing histone H3 variant CENP-A is required for accurate chromosome segregation as a foundation for kinetochore assembly. Human centromere chromatin assembles on a part of the long α-satellite (alphoid) DNA array, where it is flanked by pericentric heterochromatin. Heterochromatin spreads int...

journal_title：Developmental cell

authors： Ohzeki J,Shono N,Otake K,Martins NM,Kugou K,Kimura H,Nagase T,Larionov V,Earnshaw WC,Masumoto H

更新日期：2016-06-06 00:00:00

abstract：:Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...

journal_title：Developmental cell

authors： Perdiguero E,Serrano AL,Muñoz-Cánoves P

更新日期：2017-07-24 00:00:00

abstract：:The Golgi apparatus undergoes a ubiquitin-dependent disassembly and reassembly process during each cycle of cell division. Here we report the identification of the Golgi t-SNARE syntaxin 5 (Syn5) as the ubiquitinated substrate. Syn5 is monoubiquitinated by the ubiquitin ligase HACE1 in early mitosis and deubiquitinate...

journal_title：Developmental cell

authors： Huang S,Tang D,Wang Y

更新日期：2016-07-11 00:00:00

abstract：:Morphological plasticity and front-rear polarity are essential for directed cell migration. In this issue of Developmental Cell, Witze et al. (2013) demonstrate that Wnt5a-mediated signaling induces localization of the cortical endoplasmic reticulum to the trailing edge of melanoma cells and mediates calcium flux, rea...

journal_title：Developmental cell

authors： Mladinich KM,Huttenlocher A

更新日期：2013-09-30 00:00:00

abstract：:Hox proteins gain specificity by interacting with TALE-class cofactors. In a recent issue of Cell and in this issue of Developmental Cell, Crocker et al. (2015) and Amin et al. (2015), respectively, demonstrate that non-canonical Hox/TALE binding sequences play a major role in the regionalized regulation of target gen...

journal_title：Developmental cell

authors： Merabet S,Lohmann I

更新日期：2015-02-09 00:00:00

abstract：:Formation of the embryonic heart tube requires the medial migration and merger of bilateral precursor populations. A new study of zebrafish cardiogenesis published in this issue of Developmental Cell indicates that precursor migration involves formation of a coherent epithelium and that fibronectin plays an important ...

journal_title：Developmental cell

authors： Glickman NS,Yelon D

更新日期：2004-03-01 00:00:00

abstract：:In this issue of Developmental Cell, Weavers and Skaer (2013) show that interplay between two opposing forces generated by tip cell attachment to muscles and migration of kink cells allows for the formation of the looped shape and positioning of renal tubules within the body of a fly larva. ...

journal_title：Developmental cell

authors： Lenard A,Affolter M

更新日期：2013-11-11 00:00:00

abstract：:We have identified and characterized a novel C. elegans gene, ced-12, that functions in the conserved GTPase signaling pathway mediated by CED-2/Crkll, CED-5/DOCK180, and CED-10/Rac to control cell migration and phagocytosis of apoptotic cells. We provide evidence that ced-12 likely acts upstream of ced-10 during cell...

journal_title：Developmental cell

authors： Wu YC,Tsai MC,Cheng LC,Chou CJ,Weng NY

更新日期：2001-10-01 00:00:00

abstract：:Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the E...

journal_title：Developmental cell

authors： Henne WM,Buchkovich NJ,Emr SD

更新日期：2011-07-19 00:00:00

abstract：:To maintain proper organ size, nature has devised trans-organ communication systems-involving both paracrine and circulating regulatory factors-to safeguard homeostasis. In this issue of Developmental Cell, Ji et al. (2019) now describe an enterohepatic feedback loop that balances tissue size and function in the mamma...

journal_title：Developmental cell

authors： Merrell AJ,Stanger BZ

更新日期：2019-02-25 00:00:00

abstract：:The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, c...

journal_title：Developmental cell

authors： Bhaskar PT,Hay N

更新日期：2007-04-01 00:00:00

abstract：:A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin immunoprecipitation and transcriptional profiling identified direct target genes shared by each pathway within nephron progenitors. Wnt4 and Fgf8 are e...

journal_title：Developmental cell

authors： Park JS,Ma W,O'Brien LL,Chung E,Guo JJ,Cheng JG,Valerius MT,McMahon JA,Wong WH,McMahon AP

更新日期：2012-09-11 00:00:00

abstract：:One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an ant...

journal_title：Developmental cell

authors： Dos Santos A,Elowe S

更新日期：2020-12-21 00:00:00

abstract：:TORC1 regulates growth and metabolism, in part, by influencing transcriptional programs. Here, we identify REPTOR and REPTOR-BP as transcription factors downstream of TORC1 that are required for ∼ 90% of the transcriptional induction that occurs upon TORC1 inhibition in Drosophila. Thus, REPTOR and REPTOR-BP are major...

journal_title：Developmental cell

authors： Tiebe M,Lutz M,De La Garza A,Buechling T,Boutros M,Teleman AA

更新日期：2015-05-04 00:00:00

abstract：:Drosophila gurken mRNA is localized by dynein-mediated transport to a crescent near the oocyte nucleus, thus targeting the TGFalpha signal and forming the primary embryonic axes. Here, we show that gurken and the I factor, a non-LTR retrotransposon, share a small consensus RNA stem loop of defined secondary structure,...

journal_title：Developmental cell

authors： Van De Bor V,Hartswood E,Jones C,Finnegan D,Davis I

更新日期：2005-07-01 00:00:00

abstract：:DNA crosslinking agents are commonly used in cancer chemotherapy; however, responses of normal tissues to these agents have not been widely investigated. We reveal in mouse interfollicular epidermal, mammary and hair follicle epithelia that genotoxicity does not promote apoptosis but paradoxically induces hyperplasia ...

journal_title：Developmental cell

authors： Seldin L,Macara IG

更新日期：2020-12-07 00:00:00

abstract：:Several genes have been implicated in heart tube formation, yet we know little about underlying cellular mechanisms. We analyzed the cellular architecture of the migrating myocardial precursors, and find that they form coherent epithelia that mature as they move medially. Mutant analyses indicate that the cardia bifid...

journal_title：Developmental cell

authors： Trinh LA,Stainier DY

更新日期：2004-03-01 00:00:00

abstract：:The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transi...

journal_title：Developmental cell

authors： Jung H,Mazzoni EO,Soshnikova N,Hanley O,Venkatesh B,Duboule D,Dasen JS

更新日期：2014-04-28 00:00:00

abstract：:Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associated RNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear whether it plays any roles in early GSC...

journal_title：Developmental cell

authors： Ma X,Zhu X,Han Y,Story B,Do T,Song X,Wang S,Zhang Y,Blanchette M,Gogol M,Hall K,Peak A,Anoja P,Xie T

更新日期：2017-04-24 00:00:00

abstract：:To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate with depolymerizing microtubules, which undergo dramatic structural changes forming curved protofilaments, has yet to b...

journal_title：Developmental cell

authors： Schmidt JC,Arthanari H,Boeszoermenyi A,Dashkevich NM,Wilson-Kubalek EM,Monnier N,Markus M,Oberer M,Milligan RA,Bathe M,Wagner G,Grishchuk EL,Cheeseman IM

更新日期：2012-11-13 00:00:00

abstract：:In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...

journal_title：Developmental cell

authors： Long F

更新日期：2019-06-03 00:00:00

abstract：:Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long distances and organizes the intracellular microtubule (MT) network. How dynein motor activity is harnessed for these diverse functions remains unknown. Here, we have uncovered a mechanism for how processive dynein-dynactin compl...

journal_title：Developmental cell

authors： Tan R,Foster PJ,Needleman DJ,McKenney RJ

更新日期：2018-01-22 00:00:00

abstract：:Exposing cells to folding stress causes a subset of their proteins to misfold and accumulate in inclusion bodies (IBs). IB formation and clearance are both active processes, but little is known about their mechanism. To shed light on this issue, we performed a screen with over 4,000 fluorescently tagged yeast proteins...

journal_title：Developmental cell

authors： Moldavski O,Amen T,Levin-Zaidman S,Eisenstein M,Rogachev I,Brandis A,Kaganovich D,Schuldiner M

更新日期：2015-06-08 00:00:00

abstract：:Normal cellular development and function require tight spatiotemporal control of actin assembly. Formins are potent actin assembly factors that protect the growing ends of actin filaments from capping proteins. However, it is unresolved how the duration of formin-mediated actin assembly events is controlled, whether f...

journal_title：Developmental cell

authors： Chesarone M,Gould CJ,Moseley JB,Goode BL

更新日期：2009-02-01 00:00:00