当前位置： SCI文献检索 > DEVELOPMENTAL CELL期刊下所有文献 > The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.

The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.

Abstract：

:To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate with depolymerizing microtubules, which undergo dramatic structural changes forming curved protofilaments, has yet to be defined in vertebrates. Here, we demonstrate that the conserved kinetochore-localized Ska1 complex tracks with depolymerizing microtubule ends and associates with both the microtubule lattice and curved protofilaments. In contrast, the Ndc80 complex, a central player in the kinetochore-microtubule interface, binds only to the straight microtubule lattice and lacks tracking activity. We demonstrate that the Ska1 complex imparts its tracking capability to the Ndc80 complex. Finally, we present a structure of the Ska1 microtubule-binding domain that reveals its interaction with microtubules and its regulation by Aurora B. This work defines an integrated kinetochore-microtubule interface formed by the Ska1 and Ndc80 complexes that associates with depolymerizing microtubules, potentially by interacting with curved microtubule protofilaments.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Schmidt JC,Arthanari H,Boeszoermenyi A,Dashkevich NM,Wilson-Kubalek EM,Monnier N,Markus M,Oberer M,Milligan RA,Bathe M,Wagner G,Grishchuk EL,Cheeseman IM

doi

10.1016/j.devcel.2012.09.012

subject

Has Abstract

pub_date

2012-11-13 00:00:00

pages

968-80

issue

5

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(12)00423-6

journal_volume

23

pub_type

杂志文章

相关文献

DEVELOPMENTAL CELL文献大全
  • Architecture and Characteristics of Bacterial Nanotubes.

    abstract：:Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously identified a mode of bacterial communication mediated by nanotubes bridging neighboring cells. Here, we elucidate nanotube architecture, dynamics, and molecular compo...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2016.01.013

    authors： Dubey GP,Malli Mohan GB,Dubrovsky A,Amen T,Tsipshtein S,Rouvinski A,Rosenberg A,Kaganovich D,Sherman E,Medalia O,Ben-Yehuda S

    更新日期：2016-02-22 00:00:00

  • Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.

    abstract：:The anterior visceral endoderm plays a pivotal role in establishing anterior-posterior polarity of the mouse embryo, but the molecular nature of the signals required remains to be determined. Here, we demonstrate that Cerberus-like(-/-);Lefty1(-/-) compound mutants can develop a primitive streak ectopically in the emb...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(02)00321-0

    authors： Perea-Gomez A,Vella FD,Shawlot W,Oulad-Abdelghani M,Chazaud C,Meno C,Pfister V,Chen L,Robertson E,Hamada H,Behringer RR,Ang SL

    更新日期：2002-11-01 00:00:00

  • Regulation of stem cells by intersecting gradients of long-range niche signals.

    abstract：:We have used Drosophila ovarian follicle stem cells (FSCs) to study how stem cells are regulated by external signals and draw three main conclusions. First, the spatial definition of supportive niche positions for FSCs depends on gradients of Hh and JAK-STAT pathway ligands, which emanate from opposite, distant sites....

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2012.09.010

    authors： Vied C,Reilein A,Field NS,Kalderon D

    更新日期：2012-10-16 00:00:00

  • Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms.

    abstract：:Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associated RNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear whether it plays any roles in early GSC...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2017.03.023

    authors： Ma X,Zhu X,Han Y,Story B,Do T,Song X,Wang S,Zhang Y,Blanchette M,Gogol M,Hall K,Peak A,Anoja P,Xie T

    更新日期：2017-04-24 00:00:00

  • Geometrical Details Matter for Mechanical Modeling of Cell Morphogenesis.

    abstract：:Morphogenesis of wavy epidermal pavement cells in plants has fascinated researchers for decades. A mechanical mechanism had been proposed in which the anticlinal cell walls, forming the in-plane cell borders, feature contiguous stiff and soft zones that generate waves upon stretching. We replicated this model as desig...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2019.05.001

    authors： Bidhendi AJ,Geitmann A

    更新日期：2019-07-01 00:00:00

  • WRAMPing up calcium in migrating cells by localized ER transport.

    abstract：:Morphological plasticity and front-rear polarity are essential for directed cell migration. In this issue of Developmental Cell, Witze et al. (2013) demonstrate that Wnt5a-mediated signaling induces localization of the cortical endoplasmic reticulum to the trailing edge of melanoma cells and mediates calcium flux, rea...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2013.09.013

    authors： Mladinich KM,Huttenlocher A

    更新日期：2013-09-30 00:00:00

  • Nuclear Deformation Lets Cells Gauge Their Physical Confinement.

    abstract：:How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migr...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2021.01.002

    authors： Long JT,Lammerding J

    更新日期：2021-01-25 00:00:00

  • Specific Isoforms of the Guanine-Nucleotide Exchange Factor dPix Couple Neuromuscular Synapse Growth to Muscle Growth.

    abstract：:Developmental growth requires coordination between the growth rates of individual tissues and organs. Here, we examine how Drosophila neuromuscular synapses grow to match the size of their target muscles. We show that changes in muscle growth driven by autonomous modulation of insulin receptor signaling produce corres...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.05.015

    authors： Ho CH,Treisman JE

    更新日期：2020-07-06 00:00:00

  • Hedgehog signaling in development and cancer.

    abstract：:The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signalin...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.devcel.2008.11.010

    authors： Jiang J,Hui CC

    更新日期：2008-12-01 00:00:00

  • Fibronectin regulates epithelial organization during myocardial migration in zebrafish.

    abstract：:Several genes have been implicated in heart tube formation, yet we know little about underlying cellular mechanisms. We analyzed the cellular architecture of the migrating myocardial precursors, and find that they form coherent epithelia that mature as they move medially. Mutant analyses indicate that the cardia bifid...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(04)00063-2

    authors： Trinh LA,Stainier DY

    更新日期：2004-03-01 00:00:00

  • Alpha-actinin is required for tightly regulated remodeling of the actin cortical network during cytokinesis.

    abstract：:Localization of the actin crosslinking protein, alpha-actinin, to the cleavage furrow has been previously reported. However, its functions during cytokinesis remain poorly understood. We have analyzed the functions of alpha-actinin during cytokinesis by a combination of molecular manipulations and imaging-based techni...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2007.08.003

    authors： Mukhina S,Wang YL,Murata-Hori M

    更新日期：2007-10-01 00:00:00

  • The ESCRT pathway.

    abstract：:Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the E...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.devcel.2011.05.015

    authors： Henne WM,Buchkovich NJ,Emr SD

    更新日期：2011-07-19 00:00:00

  • Evolving Hox activity profiles govern diversity in locomotor systems.

    abstract：:The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transi...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2014.03.008

    authors： Jung H,Mazzoni EO,Soshnikova N,Hanley O,Venkatesh B,Duboule D,Dasen JS

    更新日期：2014-04-28 00:00:00

  • Memorizing Shape to Orient Cell Division.

    abstract：:A century ago, Oscar Hertwig discovered that cells orient their cleavage plane orthogonal to their long axis. Reporting recently in Nature, Bosveld et al. (2016) shed light on how, showing that NuMA/Mud localization at tricellular junctions provides mitotic cells with the memory of interphase shape used to orient clea...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2016.03.005

    authors： Michel M,Dahmann C

    更新日期：2016-03-21 00:00:00

  • Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad.

    abstract：:beta-Catenin signaling determines the proximal-distal axis of the C. elegans gonad by promoting distal fate in asymmetrically dividing somatic gonad precursor cells (SGPs). Impaired function of the Wnt effector POP-1/TCF, its coactivator SYS-1/beta-catenin, and of upstream components including beta-catenin WRM-1 cause...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2006.06.003

    authors： Asahina M,Valenta T,Silhankova M,Korinek V,Jindra M

    更新日期：2006-08-01 00:00:00

  • A molecular base for cell sorting at embryonic boundaries: contact inhibition of cadherin adhesion by ephrin/ Eph-dependent contractility.

    abstract：:The mechanism responsible for subdividing the embryo into individual tissues is a fundamental, yet still poorly understood, question in developmental biology. Various general hypotheses have been proposed, involving differences in cell adhesion, contractility, or contact-mediated repulsion. However, the key parameter ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.09.004

    authors： Fagotto F,Rohani N,Touret AS,Li R

    更新日期：2013-10-14 00:00:00

  • Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos.

    abstract：:Boundary formation and epithelialization are crucial processes in the morphological segmentation of vertebrate somites. By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes. Fibronectin proteins accumulate at somite boundari...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2005.03.006

    authors： Koshida S,Kishimoto Y,Ustumi H,Shimizu T,Furutani-Seiki M,Kondoh H,Takada S

    更新日期：2005-04-01 00:00:00

  • Reaching a genetic and molecular understanding of skeletal development.

    abstract：:In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes an...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/s1534-5807(02)00157-0

    authors： Karsenty G,Wagner EF

    更新日期：2002-04-01 00:00:00

  • ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.

    abstract：:Cell polarity plays a key role in the development of the central nervous system (CNS). Interestingly, disruption of cell polarity is seen in many cancers. ASPP2 is a haplo-insufficient tumor suppressor and an activator of the p53 family. In this study, we show that ASPP2 controls the polarity and proliferation of neur...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2010.06.003

    authors： Sottocornola R,Royer C,Vives V,Tordella L,Zhong S,Wang Y,Ratnayaka I,Shipman M,Cheung A,Gaston-Massuet C,Ferretti P,Molnár Z,Lu X

    更新日期：2010-07-20 00:00:00

  • HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

    abstract：:The genetic networks that govern vertebrate development are well studied, but how the interactions of trans-acting factors with cis-regulatory modules (CRMs) are integrated into spatiotemporal regulation of gene expression is not clear. The transcriptional regulator HAND2 is required during limb, heart, and branchial ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2014.09.018

    authors： Osterwalder M,Speziale D,Shoukry M,Mohan R,Ivanek R,Kohler M,Beisel C,Wen X,Scales SJ,Christoffels VM,Visel A,Lopez-Rios J,Zeller R

    更新日期：2014-11-10 00:00:00

  • Arabidopsis Serrate Coordinates Histone Methyltransferases ATXR5/6 and RNA Processing Factor RDR6 to Regulate Transposon Expression.

    abstract：:Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formatio...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2018.05.023

    authors： Ma Z,Castillo-González C,Wang Z,Sun D,Hu X,Shen X,Potok ME,Zhang X

    更新日期：2018-06-18 00:00:00

  • Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching.

    abstract：:Airway smooth muscle is best known for its role as an airway constrictor in diseases such as asthma. However, its function in lung development is debated. A prevalent model, supported by in vitro data, posits that airway smooth muscle promotes lung branching through peristalsis and pushing intraluminal fluid to branch...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.02.001

    authors： Young RE,Jones MK,Hines EA,Li R,Luo Y,Shi W,Verheyden JM,Sun X

    更新日期：2020-04-06 00:00:00

  • A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition.

    abstract：:Ribosomes perform protein synthesis but are also involved in signaling processes, the full extent of which are still being uncovered. We report that phenotypes of mutating ribosomal proteins (Rps) are largely due to signaling. Using Drosophila, we discovered that a bZip-domain protein, Xrp1, becomes elevated in Rp mut...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2018.07.003

    authors： Lee CH,Kiparaki M,Blanco J,Folgado V,Ji Z,Kumar A,Rimesso G,Baker NE

    更新日期：2018-08-20 00:00:00

  • Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.

    abstract：:Metazoans express three unfolded protein response transducers (IRE1, PERK, and ATF6) ubiquitously to cope with endoplasmic reticulum (ER) stress. ATF6 is an ER membrane-bound transcription factor activated by ER stress-induced proteolysis and has been duplicated in mammals. Here, we generated ATF6alpha- and ATF6beta-k...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2007.07.018

    authors： Yamamoto K,Sato T,Matsui T,Sato M,Okada T,Yoshida H,Harada A,Mori K

    更新日期：2007-09-01 00:00:00

  • A role for C. elegans Eph RTK signaling in PTEN regulation.

    abstract：:PTEN is one of the most commonly lost tumor suppressors in human cancer and is known to inhibit insulin signaling. Eph receptor tyrosine kinases (RTKs) have also been implicated in cancer formation and progression, and they have diverse functions, including nervous and vascular system development. We show that in C. e...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2009.08.009

    authors： Brisbin S,Liu J,Boudreau J,Peng J,Evangelista M,Chin-Sang I

    更新日期：2009-10-01 00:00:00

  • The Perinuclear ER Scales Nuclear Size Independently of Cell Size in Early Embryos.

    abstract：:Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A central hypothesis in organisms ranging from yeast to vertebrates is that nuclear size scales to cell size. This implies that nuclei may reach steady-state sizes set by limiting cytoplasmic pools of size-regulating components. By m...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.05.003

    authors： Mukherjee RN,Sallé J,Dmitrieff S,Nelson KM,Oakey J,Minc N,Levy DL

    更新日期：2020-08-10 00:00:00

  • A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action.

    abstract：:The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase-mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular C...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2006.02.006

    authors： Lin A

    更新日期：2006-03-01 00:00:00

  • Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier.

    abstract：:Pericytes are critical for cerebrovascular maturation and development of the blood-brain barrier (BBB), but their role in maintenance of the adult BBB, and how CNS pericytes differ from those of other tissues, is less well understood. We show that the forkhead transcription factor Foxf2 is specifically expressed in pe...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.05.008

    authors： Reyahi A,Nik AM,Ghiami M,Gritli-Linde A,Pontén F,Johansson BR,Carlsson P

    更新日期：2015-07-06 00:00:00

  • Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.

    abstract：:The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2005.07.013

    authors： Langevin J,Morgan MJ,Sibarita JB,Aresta S,Murthy M,Schwarz T,Camonis J,Bellaïche Y

    更新日期：2005-09-01 00:00:00

  • Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics.

    abstract：:FGF/ERK signaling is crucial for the patterning and proliferation of cell lineages that comprise the mouse blastocyst. However, ERK signaling dynamics have never been directly visualized in live embryos. To address whether differential signaling is associated with particular cell fates and states, we generated a targe...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.09.030

    authors： Simon CS,Rahman S,Raina D,Schröter C,Hadjantonakis AK

    更新日期：2020-11-09 00:00:00