当前位置： SCI文献检索 > DEVELOPMENTAL CELL期刊下所有文献 > ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.

ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.

Abstract：

:Cell polarity plays a key role in the development of the central nervous system (CNS). Interestingly, disruption of cell polarity is seen in many cancers. ASPP2 is a haplo-insufficient tumor suppressor and an activator of the p53 family. In this study, we show that ASPP2 controls the polarity and proliferation of neural progenitors in vivo, leading to the formation of neuroblastic rosettes that resemble primitive neuroepithelial tumors. Consistent with its role in cell polarity, ASPP2 influences interkinetic nuclear migration and lamination during CNS development. Mechanistically, ASPP2 maintains the integrity of tight/adherens junctions. ASPP2 binds Par-3 and controls its apical/junctional localization without affecting its expression or Par-3/aPKC lambda binding. The junctional localization of ASPP2 and Par-3 is interdependent, suggesting that they are prime targets for each other. These results identify ASPP2 as a regulator of Par-3, which plays a key role in controlling cell proliferation, polarity, and tissue organization during CNS development.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Sottocornola R,Royer C,Vives V,Tordella L,Zhong S,Wang Y,Ratnayaka I,Shipman M,Cheung A,Gaston-Massuet C,Ferretti P,Molnár Z,Lu X

doi

10.1016/j.devcel.2010.06.003

subject

Has Abstract

pub_date

2010-07-20 00:00:00

pages

126-37

issue

1

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(10)00293-5

journal_volume

19

pub_type

杂志文章

相关文献

DEVELOPMENTAL CELL文献大全
  • The utility of prions.

    abstract：:Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals. However, recent work in fungi indicates that prions are not simply aberrations of protein folding, but are in fact widespread, conserve...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/s1534-5807(02)00118-1

    authors： Osherovich LZ,Weissman JS

    更新日期：2002-02-01 00:00:00

  • A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph.

    abstract：:Activation of Cyclin D/Cdk4 stimulates progression through the G1-S phase of the cell cycle in many organisms. In Drosophila, Cyclin D/Cdk4 also induces cell growth independently of cell cycle progression. In this issue of Developmental Cell, Frei and Edgar reveal that Cyclin D/Cdk4-stimulated growth requires Hph, a p...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/s1534-5807(04)00031-0

    authors： Duronio RJ

    更新日期：2004-02-01 00:00:00

  • A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation.

    abstract：:The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin during tissue morphogenesis have been identified, but the role of the microtubule cytoskeleton is less clear. Here, we show that during tubulogenesis of the saliv...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2014.03.023

    authors： Booth AJR,Blanchard GB,Adams RJ,Röper K

    更新日期：2014-06-09 00:00:00

  • Meiosis researchers exchange information in the Alps.

    abstract：:The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(03)00336-8

    authors： Dernburg AF

    更新日期：2003-11-01 00:00:00

  • piRNA Rules of Engagement.

    abstract：:piRNAs are known to silence transposable elements, but not all piRNAs match transposon sequences. Recent studies from Shen et al. (2018) and Zhang et al. (2018) identify rules for piRNA target recognition in Caenorhabditis elegans. Permissive pairing rules allow targeting of essentially all germline mRNAs, while prote...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2018.03.006

    authors： Svendsen JM,Montgomery TA

    更新日期：2018-03-26 00:00:00

  • Spindle position in symmetric cell divisions during epiboly is controlled by opposing and dynamic apicobasal forces.

    abstract：:Orientation of cell division is a vital aspect of tissue morphogenesis and growth. Asymmetric divisions generate cell fate diversity and epithelial stratification, whereas symmetric divisions contribute to tissue growth, spreading, and elongation. Here, we describe a mechanism for positioning the spindle in symmetric ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2012.01.002

    authors： Woolner S,Papalopulu N

    更新日期：2012-04-17 00:00:00

  • Memorizing Shape to Orient Cell Division.

    abstract：:A century ago, Oscar Hertwig discovered that cells orient their cleavage plane orthogonal to their long axis. Reporting recently in Nature, Bosveld et al. (2016) shed light on how, showing that NuMA/Mud localization at tricellular junctions provides mitotic cells with the memory of interphase shape used to orient clea...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2016.03.005

    authors： Michel M,Dahmann C

    更新日期：2016-03-21 00:00:00

  • The transcription factor MEF2C is required for craniofacial development.

    abstract：:MEF2 transcription factors are well-established regulators of muscle development. We have discovered an unanticipated role for MEF2C in the neural crest, where tissue-specific inactivation results in neonatal lethality due to severe craniofacial defects. We show that MEF2C is required for expression of the Dlx5, Dlx6,...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2007.03.007

    authors： Verzi MP,Agarwal P,Brown C,McCulley DJ,Schwarz JJ,Black BL

    更新日期：2007-04-01 00:00:00

  • Competition between Blown fuse and WASP for WIP binding regulates the dynamics of WASP-dependent actin polymerization in vivo.

    abstract：:Dynamic rearrangements of the actin cytoskeleton play a key role in numerous cellular processes. In Drosophila, fusion between a muscle founder cell and a fusion competent myoblast (FCM) is mediated by an invasive, F-actin-enriched podosome-like structure (PLS). Here, we show that the dynamics of the PLS is controlled...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2011.04.007

    authors： Jin P,Duan R,Luo F,Zhang G,Hong SN,Chen EH

    更新日期：2011-05-17 00:00:00

  • The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage.

    abstract：:The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors;...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2019.03.017

    authors： Baek S,Oh TG,Secker G,Sutton DL,Okuda KS,Paterson S,Bower NI,Toubia J,Koltowska K,Capon SJ,Baillie GJ,Simons C,Muscat GEO,Lagendijk AK,Smith KA,Harvey NL,Hogan BM

    更新日期：2019-04-22 00:00:00

  • Epithelial Morphogenesis: Size Matters.

    abstract：:In this issue of Developmental Cell, Gibson and colleagues (Ramanathan et al., 2019) investigate the relationship between size and shape in epithelial cells. They find that cell size impacts cell shape, with unexpected consequences for epithelial growth and morphogenesis, particularly the clonal dynamics of epithelial...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2019.09.015

    authors： Thompson BJ

    更新日期：2019-10-07 00:00:00

  • The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova.

    abstract：:The gastrulating vertebrate embryo develops three germlayers: ectoderm, mesoderm, and endoderm. Zebrafish endoderm differentiation starts with the activation of sox17 by casanova (cas). We report that spg (pou2/Oct4) is essential for endoderm formation. Embryos devoid of maternal and zygotic spg function (MZspg) lack ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(03)00396-4

    authors： Reim G,Mizoguchi T,Stainier DY,Kikuchi Y,Brand M

    更新日期：2004-01-01 00:00:00

  • Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration.

    abstract：:Directional cell migration is critical for metazoan development. We define two molecular pathways that activate the Arp2/3 complex during neuroblast migration in Caenorhabditis elegans. The transmembrane protein MIG-13/Lrp12 is linked to the Arp2/3 nucleation-promoting factors WAVE or WASP through direct interactions ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2016.09.029

    authors： Zhu Z,Chai Y,Jiang Y,Li W,Hu H,Li W,Wu JW,Wang ZX,Huang S,Ou G

    更新日期：2016-10-24 00:00:00

  • The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.

    abstract：:Asymmetric cell divisions generate cellular diversity. In Drosophila, embryonic neuroblasts target cell fate determinants basally, rotate their spindles by 90 degrees to align with the apical-basal axis, and divide asymmetrically in a stem cell-like fashion. In this process, apically localized Bazooka recruits Inscute...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/s1534-5807(03)00020-0

    authors： Petritsch C,Tavosanis G,Turck CW,Jan LY,Jan YN

    更新日期：2003-02-01 00:00:00

  • Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.

    abstract：:The Par polarity complex creates mutually exclusive cortical domains in diverse animal cells. Activity of the atypical protein kinase C (aPKC) is a key output of the Par complex as phosphorylation removes substrates from the Par domain. Here, we investigate how diverse, apparently unrelated Par substrates couple phosp...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.09.016

    authors： Bailey MJ,Prehoda KE

    更新日期：2015-10-26 00:00:00

  • At the roots of a never-ending cycle.

    abstract：:Recent studies have yielded a number of important insights into the mechanisms of hair follicle development and cycling and have highlighted the particularly important roles played by stem cells and Wnt signaling pathways. ...

    journal_title：Developmental cell

    pub_type： 杂志文章,评审

    doi：10.1016/s1534-5807(01)00022-3

    authors： Fuchs E,Merrill BJ,Jamora C,DasGupta R

    更新日期：2001-07-01 00:00:00

  • 3' UTRs in the Eye of the TIGER.

    abstract：:Many human genes generate mRNAs with alternative 3' untranslated regions (3' UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3' UTRs to encipher protein localizatio...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2018.11.022

    authors： Portz B,Shorter J

    更新日期：2018-12-03 00:00:00

  • Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.

    abstract：:Enhancers are the primary determinants of cell identity, but the regulatory components controlling enhancer turnover during lineage commitment remain largely unknown. Here we compare the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progeni...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2015.12.014

    authors： Huang J,Liu X,Li D,Shao Z,Cao H,Zhang Y,Trompouki E,Bowman TV,Zon LI,Yuan GC,Orkin SH,Xu J

    更新日期：2016-01-11 00:00:00

  • How the sea squirt nucleus tells mesoderm not to be endoderm.

    abstract：:Sea squirts are simple invertebrate chordates. In this issue of Developmental Cell, Takatori et al. show nuclear migration within ascidian mesendodermal cells enables polarized localization of Not mRNA, which encodes a homeobox protein that distinguishes mesoderm from endoderm fates. The link between nuclear migration...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2010.10.002

    authors： Parton RM,Davis I

    更新日期：2010-10-19 00:00:00

  • TRANSPORTER OF IBA1 Links Auxin and Cytokinin to Influence Root Architecture.

    abstract：:Developmental processes that control root system architecture are critical for soil exploration by plants, allowing for uptake of water and nutrients. Conversion of the auxin precursor indole-3-butyric acid (IBA) to active auxin (indole-3-acetic acid; IAA) modulates lateral root formation. However, mechanisms governin...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2019.06.010

    authors： Michniewicz M,Ho CH,Enders TA,Floro E,Damodaran S,Gunther LK,Powers SK,Frick EM,Topp CN,Frommer WB,Strader LC

    更新日期：2019-09-09 00:00:00

  • Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis.

    abstract：:Netrin-1 was recently proposed to play an important role in embryonic and pathological angiogenesis. However, data reported led to the apparently contradictory conclusions that netrin-1 is either a pro- or an antiangiogenic factor. Here, we reconcile these opposing observations by demonstrating that netrin-1 acts as a...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2009.02.006

    authors： Castets M,Coissieux MM,Delloye-Bourgeois C,Bernard L,Delcros JG,Bernet A,Laudet V,Mehlen P

    更新日期：2009-04-01 00:00:00

  • Epigenetic Compensation Promotes Liver Regeneration.

    abstract：:Two major functions of the epigenome are to regulate gene expression and to suppress transposons. It is unclear how these functions are balanced during physiological challenges requiring tissue regeneration, where exquisite coordination of gene expression is essential. Transcriptomic analysis of seven time points foll...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2019.05.034

    authors： Wang S,Zhang C,Hasson D,Desai A,SenBanerjee S,Magnani E,Ukomadu C,Lujambio A,Bernstein E,Sadler KC

    更新日期：2019-07-01 00:00:00

  • A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning.

    abstract：:Spindle positioning is an essential feature of asymmetric cell division. The conserved PAR proteins together with heterotrimeric G proteins control spindle positioning in animal cells, but how these are linked is not known. In C. elegans, PAR protein activity leads to asymmetric spindle placement through cortical asym...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2008.06.002

    authors： Panbianco C,Weinkove D,Zanin E,Jones D,Divecha N,Gotta M,Ahringer J

    更新日期：2008-08-01 00:00:00

  • HEC of a job regulating stem cells.

    abstract：:In this issue of Developmental Cell, Schuster et al. (2014) describe the signals regulated by the bHLH transcription factor HEC1 during Arabidopsis stem cell maintenance. HEC1 acts antagonistically with other factors, integrating multiple cues to provide a balance between cellular differentiation and proliferation. ...

    journal_title：Developmental cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.devcel.2014.02.006

    authors： Sparks EE,Benfey PN

    更新日期：2014-02-24 00:00:00

  • Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1.

    abstract：:The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia. Here we demonstrate an unexpected mechanism of Dyn2 action in these contexts via direct binding to the Rac1 guanine nucleotide exch...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.02.010

    authors： Razidlo GL,Wang Y,Chen J,Krueger EW,Billadeau DD,McNiven MA

    更新日期：2013-03-25 00:00:00

  • Tracing cells for tracking cell lineage and clonal behavior.

    abstract：:Reconstructing the lineage of cells is central to understanding development and is now also an important issue in stem cell research. Technological advances in genetically engineered permanent cell labeling, together with a multiplicity of fluorescent markers and sophisticated imaging, open new possibilities for prosp...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2011.07.019

    authors： Buckingham ME,Meilhac SM

    更新日期：2011-09-13 00:00:00

  • Pigment Cell Progenitors in Zebrafish Remain Multipotent through Metamorphosis.

    abstract：:The neural crest is a transient, multipotent embryonic cell population in vertebrates giving rise to diverse cell types in adults via intermediate progenitors. The in vivo cell-fate potential and lineage segregation of these postembryonic progenitors is poorly understood, and it is unknown if and when the progenitors ...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2016.06.020

    authors： Singh AP,Dinwiddie A,Mahalwar P,Schach U,Linker C,Irion U,Nüsslein-Volhard C

    更新日期：2016-08-08 00:00:00

  • External mechanical cues trigger the establishment of the anterior-posterior axis in early mouse embryos.

    abstract：:Mouse anterior-posterior axis polarization is preceded by formation of the distal visceral endoderm (DVE) by unknown mechanisms. Here, we show by in vitro culturing of embryos immediately after implantation in microfabricated cavities that the external mechanical cues exerted on the embryo are crucial for DVE formatio...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2013.09.026

    authors： Hiramatsu R,Matsuoka T,Kimura-Yoshida C,Han SW,Mochida K,Adachi T,Takayama S,Matsuo I

    更新日期：2013-10-28 00:00:00

  • Kinetochore-dependent microtubule rescue ensures their efficient and sustained interactions in early mitosis.

    abstract：:How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microtubule interactions is unknown. Here, we studied this during early mitosis in Saccharomyces cerevisiae. When a microtubule shrinks and its plus end reaches a kinetochore bound to its lateral surface, the microtubule end attempts to tether...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2011.09.006

    authors： Gandhi SR,Gierliński M,Mino A,Tanaka K,Kitamura E,Clayton L,Tanaka TU

    更新日期：2011-11-15 00:00:00

  • AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis.

    abstract：:The developmental mechanisms that orchestrate differentiation of specific nephron segments are incompletely understood, and the factors that maintain their terminal differentiation after nephrogenesis remain largely unknown. Here, the transcription factor AP-2β is shown to be required for the differentiation of distal...

    journal_title：Developmental cell

    pub_type： 杂志文章

    doi：10.1016/j.devcel.2020.05.026

    authors： Marneros AG

    更新日期：2020-08-10 00:00:00