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Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration.

Abstract：

:Directional cell migration is critical for metazoan development. We define two molecular pathways that activate the Arp2/3 complex during neuroblast migration in Caenorhabditis elegans. The transmembrane protein MIG-13/Lrp12 is linked to the Arp2/3 nucleation-promoting factors WAVE or WASP through direct interactions with ABL-1 or SEM-5/Grb2, respectively. WAVE mutations partially impaired F-actin organization and decelerated cell migration, and WASP mutations did not inhibit cell migration but enhanced migration defects in WAVE-deficient cells. Purified SEM-5 and MIG-2 synergistically stimulated the F-actin branching activity of WASP-Arp2/3 in vitro. In GFP knockin animals, WAVE and WASP were largely organized into separate clusters at the leading edge, and the amount of WASP was less than WAVE but could be elevated by WAVE mutations. Our results indicate that the MIG-13-WAVE pathway provides the major force for directional cell motility, whereas MIG-13-WASP partially compensates for its loss, underscoring their coordinated activities in facilitating robust cell migration.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Zhu Z,Chai Y,Jiang Y,Li W,Hu H,Li W,Wu JW,Wang ZX,Huang S,Ou G

doi

10.1016/j.devcel.2016.09.029

subject

Has Abstract

pub_date

2016-10-24 00:00:00

pages

224-238

issue

2

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(16)30679-7

journal_volume

39

pub_type

杂志文章

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