Abstract：
:Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H₂O₂)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly with the invaginating midgut primordium as it enters the embryo; however, in embryos from jafrac1 mutant mothers this association is disrupted, leaving some PGCs trailing on the outside of the embryo. We observed similar phenotypes in embryos from DE-cadherin/shotgun (shg) mutant mothers and were able to rescue the jafrac1 phenotype by increasing DE-cadherin levels. This and our biochemical evidence strongly suggest that Jafrac1-mediated reduction of H₂O₂ is required to maintain DE-cadherin protein levels in the early embryo. Our results present in vivo evidence of a peroxiredoxin regulating DE-cadherin-mediated adhesion.
journal_name
Dev Celljournal_title
Developmental cellauthors
DeGennaro M,Hurd TR,Siekhaus DE,Biteau B,Jasper H,Lehmann Rdoi
10.1016/j.devcel.2010.12.007subject
Has Abstractpub_date
2011-02-15 00:00:00pages
233-43issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(10)00588-5journal_volume
20pub_type
杂志文章abstract：:The Golgi apparatus undergoes a ubiquitin-dependent disassembly and reassembly process during each cycle of cell division. Here we report the identification of the Golgi t-SNARE syntaxin 5 (Syn5) as the ubiquitinated substrate. Syn5 is monoubiquitinated by the ubiquitin ligase HACE1 in early mitosis and deubiquitinate...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.06.001
更新日期：2016-07-11 00:00:00
abstract：:Nakada et al. revisit the controversial question of whether membrane lipids are able to diffuse from the axon of a neuron into the soma. Using single molecule imaging of a fluorescent phospholipid, the authors show that a diffusion barrier in the axon initial segment blocks the diffusion of lipids. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/s1534-5807(03)00240-5
更新日期：2003-08-01 00:00:00
abstract：:Dynein recruitment to the nuclear envelope is required for pre-mitotic nucleus-centrosome interactions in nonneuronal cells and for apical nuclear migration in neural stem cells. In each case, dynein is recruited to the nuclear envelope (NE) specifically during G2 via two nuclear pore-mediated mechanisms involving Ran...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2015.04.022
更新日期：2015-06-22 00:00:00
abstract：:Smad4 is a central intracellular effector of TGF-beta signaling. Smad-independent TGF-beta pathways, such as those mediated by p38 MAPK, have been identified in cell culture systems, but their in vivo functional mechanisms remain unclear. In this study, we investigated the role of TGF-beta signaling in tooth and palat...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.06.004
更新日期：2008-08-01 00:00:00
abstract：:The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00336-8
更新日期：2003-11-01 00:00:00
abstract：:Although many features of neurogenesis during development and in the adult are intrinsic to the neurogenic cells themselves, the role of the microenvironment is irrefutable. The neurogenic niche is a melting pot of cells and factors that influence CNS development. How do the diverse elements assemble and when? How doe...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2015.01.010
更新日期：2015-02-23 00:00:00
abstract：:Mbl is a bacterial actin homolog that controls cell morphogenesis in Bacillus subtilis. A functional GFP-Mbl fusion protein was used to examine the behavior of the helical cables formed by Mbl protein in live B. subtilis cells. The cables undergo dynamic changes during cell cycle progression. They are stable but not r...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00403-3
更新日期：2003-01-01 00:00:00
abstract：:In this issue of Developmental Cell, Yao et al. (2019) disrupt mitochondrial respiration in limb skeletal progenitors by conditionally deleting Tfam in the mouse embryo. They discover that not only is mitochondrial respiration dispensable for embryonic cartilage development, but also its elimination obviates the need ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2019.05.030
更新日期：2019-06-03 00:00:00
abstract：:Microtubules are normally organized at centrosomes, but other sites can also serve as microtubule organizing centers (MTOCs). In this issue of Developmental Cell, Procter et al. (2018) show that the human cytomegalovirus virion assembly compartment acts as a dynamic Golgi-derived MTOC where EB3 nucleates microtubules ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.03.014
更新日期：2018-04-09 00:00:00
abstract：:Protein transport between the ER and the Golgi in mammalian cells occurs via large pleiomorphic carriers, and most current models suggest that these are formed by the fusion of small ER-derived COPII vesicles. We have examined the dynamics and structural features of these carriers during and after their formation from...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00294-6
更新日期：2003-10-01 00:00:00
abstract：:Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signal...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.02.002
更新日期：2012-03-13 00:00:00
abstract：:The intestine is an organ with an exceptionally high rate of cell turnover, and perturbations in this process can lead to severe diseases such as cancer or intestinal atrophy. Nutrition has a profound impact on intestinal volume and cellular architecture. However, how intestinal homeostasis is maintained in fluctuatin...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.08.011
更新日期：2018-10-08 00:00:00
abstract：:Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear. Here, we show that mice lacking Gadd45γ also exhibit XY gonadal sex reversal ca...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.09.016
更新日期：2012-11-13 00:00:00
abstract：:The connection between cell fate transitions and metabolic shifts is gaining momentum in the study of cell differentiation in embryonic development, adult stem cells, and cancer pathogenesis. Here, we explore how metabolic transitions influence post-translational modifications (PTMs), which play central roles in the a...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/j.devcel.2020.06.035
更新日期：2020-07-20 00:00:00
abstract：:Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al. (2013) suggest that the ER-...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2013.04.004
更新日期：2013-04-29 00:00:00
abstract：:The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors;...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.03.017
更新日期：2019-04-22 00:00:00
abstract：:Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the facto...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.10.015
更新日期：2016-12-05 00:00:00
abstract：:The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney deve...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.04.012
更新日期：2015-05-04 00:00:00
abstract：:Many patterns of cell and tissue organization are specified during development by gradients of morphogens, substances that assign different cell fates at different concentrations. Gradients form by morphogen transport from a localized site, but whether this occurs by simple diffusion or by more elaborate mechanisms is...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(02)00179-x
更新日期：2002-06-01 00:00:00
abstract：:The monoallelic expression of imprinted genes is regulated by DNA methylation marks that originate from the oocyte or sperm. Li et al. (2008) show in this issue of Developmental Cell that the KRAB zinc finger protein Zfp57 contributes to the embryonic maintenance of these imprints. At one locus, Zfp57 is also involved...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2008.09.006
更新日期：2008-10-01 00:00:00
abstract：:A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin immunoprecipitation and transcriptional profiling identified direct target genes shared by each pathway within nephron progenitors. Wnt4 and Fgf8 are e...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.07.008
更新日期：2012-09-11 00:00:00
abstract：:MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor M...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2008.05.011
更新日期：2008-06-01 00:00:00
abstract：:The adult, virgin mammary gland is a highly organized tree-like structure formed by ducts with hollowed lumen. Although lumen formation during pubertal development appears to involve apoptosis, the molecular mechanisms that regulate this process are not known. Here, we demonstrate that disruption of the BH3-only proap...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.12.003
更新日期：2007-02-01 00:00:00
abstract：:We present new approaches to cis-regulatory module (CRM) discovery in the common scenario where relevant transcription factors and/or motifs are unknown. Beginning with a small list of CRMs mediating a common gene expression pattern, we search genome-wide for CRMs with similar functionality, using new statistical scor...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.09.002
更新日期：2009-10-01 00:00:00
abstract：:Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells sense and regulate its levels in vivo remains unclear. Here we show that PCYT1A, the rate-li...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.04.012
更新日期：2018-05-21 00:00:00
abstract：:The formation of epithelial tissues containing lumens requires not only the apical-basolateral polarization of cells, but also the coordinated orientation of this polarity such that the apical surfaces of neighboring cells all point toward the central lumen. Defects in extracellular matrix (ECM) signaling lead to inve...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.08.027
更新日期：2014-10-27 00:00:00
abstract：:Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have been studied, but the precise positioning of folds in complex, multi-folded epithelia is less...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.09.009
更新日期：2019-11-04 00:00:00
abstract：:A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies o...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.09.004
更新日期：2008-10-01 00:00:00
abstract：:In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targetin...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.07.026
更新日期：2014-09-08 00:00:00
abstract：:Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.01.020
更新日期：2008-04-01 00:00:00
