Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila.

abstract：:The viral genomes of alpha- and gamma-retroviruses follow an outbound route through the cytoplasm before assembling with the budding particle at the plasma membrane. We show here that murine leukemia virus (MLV) RNAs are transported on lysosomes and transferrin-positive endosomes. Transport on transferrin-positive ves...

journal_title：Developmental cell

authors： Basyuk E,Galli T,Mougel M,Blanchard JM,Sitbon M,Bertrand E

更新日期：2003-07-01 00:00:00

abstract：:Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligo...

journal_title：Developmental cell

authors： Singh JK,Balch WE

更新日期：2015-03-23 00:00:00

abstract：:The anterior visceral endoderm plays a pivotal role in establishing anterior-posterior polarity of the mouse embryo, but the molecular nature of the signals required remains to be determined. Here, we demonstrate that Cerberus-like(-/-);Lefty1(-/-) compound mutants can develop a primitive streak ectopically in the emb...

journal_title：Developmental cell

authors： Perea-Gomez A,Vella FD,Shawlot W,Oulad-Abdelghani M,Chazaud C,Meno C,Pfister V,Chen L,Robertson E,Hamada H,Behringer RR,Ang SL

更新日期：2002-11-01 00:00:00

abstract：:Asymmetric cell division--where two dissimilar daughter cells are produced--relies on asymmetric positioning of the telophase spindle midzone, which specifies the cleavage furrow. Ou et al. (2010) now report in Science a mechanism of asymmetric midzone positioning driven by a polarized cortical distribution of the con...

journal_title：Developmental cell

authors： Li R

更新日期：2010-11-16 00:00:00

abstract：:Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP(2)-synthesizing enzyme, PIPKIγi2, in regulation of exocyst complex control of cell polarity and polarized integrin trafficking during migration. Loss of PIPKIγ...

journal_title：Developmental cell

authors： Thapa N,Sun Y,Schramp M,Choi S,Ling K,Anderson RA

更新日期：2012-01-17 00:00:00

abstract：:Many human genes generate mRNAs with alternative 3' untranslated regions (3' UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3' UTRs to encipher protein localizatio...

journal_title：Developmental cell

authors： Portz B,Shorter J

更新日期：2018-12-03 00:00:00

abstract：:Precise cell division control is critical for developmental patterning. For the differentiation of a functional stoma, a cellular valve for efficient gas exchange, the single symmetric division of an immediate precursor is absolutely essential. Yet, the mechanism governing this event remains unclear. Here we report co...

journal_title：Developmental cell

authors： Han SK,Qi X,Sugihara K,Dang JH,Endo TA,Miller KL,Kim ED,Miura T,Torii KU

更新日期：2018-05-07 00:00:00

abstract：:Vertebrate ancestors had only cone-like photoreceptors. The duplex retina evolved in jawless vertebrates with the advent of highly photosensitive rod-like photoreceptors. Despite cones being the arbiters of high-resolution color vision, rods emerged as the dominant photoreceptor in mammals during a nocturnal phase ear...

journal_title：Developmental cell

authors： Kim JW,Yang HJ,Oel AP,Brooks MJ,Jia L,Plachetzki DC,Li W,Allison WT,Swaroop A

更新日期：2016-06-20 00:00:00

abstract：:The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds. ...

journal_title：Developmental cell

authors： Bazan JF,Janda CY,Garcia KC

更新日期：2012-08-14 00:00:00

abstract：:Autophagy is the major cellular process responsible for bulk cytoplasmic degradation. Two reports in this issue of Developmental Cell describe how both PI3 kinase and TOR signaling in Drosophila are critical for controlling autophagy in response to developmental and environmental cues. ...

journal_title：Developmental cell

authors： Grewal SS,Saucedo LJ

更新日期：2004-08-01 00:00:00

abstract：:Drosophila gurken mRNA is localized by dynein-mediated transport to a crescent near the oocyte nucleus, thus targeting the TGFalpha signal and forming the primary embryonic axes. Here, we show that gurken and the I factor, a non-LTR retrotransposon, share a small consensus RNA stem loop of defined secondary structure,...

journal_title：Developmental cell

authors： Van De Bor V,Hartswood E,Jones C,Finnegan D,Davis I

更新日期：2005-07-01 00:00:00

abstract：:Septins are polymerizing GTP binding proteins required for cortical organization during cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed mainly in postmitotic neural cells and postmeiotic male germ cells. In mouse and human spermatozoa, SEPT4 and other septins are found in the annul...

journal_title：Developmental cell

authors： Ihara M,Kinoshita A,Yamada S,Tanaka H,Tanigaki A,Kitano A,Goto M,Okubo K,Nishiyama H,Ogawa O,Takahashi C,Itohara S,Nishimune Y,Noda M,Kinoshita M

更新日期：2005-03-01 00:00:00

abstract：:The 6th European Meiosis Workshop, sponsored by EMBO and organized by Franz Klein of the University of Vienna, met in mid-September. More than 150 participants who have not discovered anything more interesting than sex gathered in a bucolic Alpine valley near the town of Obertraun, Austria, surrounded by granite massi...

journal_title：Developmental cell

authors： Dernburg AF

更新日期：2003-11-01 00:00:00

abstract：:Eukaryotic genomes are organized within the nucleus through interactions with inner nuclear membrane (INM) proteins. How chromatin tethering to the INM is controlled in interphase and how this process contributes to subsequent mitotic nuclear envelope (NE) remodeling remains unclear. We have probed these fundamental q...

journal_title：Developmental cell

authors： Pieper GH,Sprenger S,Teis D,Oliferenko S

更新日期：2020-04-06 00:00:00

abstract：:The Golgi apparatus undergoes a ubiquitin-dependent disassembly and reassembly process during each cycle of cell division. Here we report the identification of the Golgi t-SNARE syntaxin 5 (Syn5) as the ubiquitinated substrate. Syn5 is monoubiquitinated by the ubiquitin ligase HACE1 in early mitosis and deubiquitinate...

journal_title：Developmental cell

authors： Huang S,Tang D,Wang Y

更新日期：2016-07-11 00:00:00

abstract：:Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A central hypothesis in organisms ranging from yeast to vertebrates is that nuclear size scales to cell size. This implies that nuclei may reach steady-state sizes set by limiting cytoplasmic pools of size-regulating components. By m...

journal_title：Developmental cell

authors： Mukherjee RN,Sallé J,Dmitrieff S,Nelson KM,Oakey J,Minc N,Levy DL

更新日期：2020-08-10 00:00:00

abstract：:The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, c...

journal_title：Developmental cell

authors： Bhaskar PT,Hay N

更新日期：2007-04-01 00:00:00

abstract：:Zebrafish heart regeneration occurs through the activation of cardiomyocyte proliferation in areas of trauma. Here, we show that within 3 hr of ventricular injury, the entire endocardium undergoes morphological changes and induces expression of the retinoic acid (RA)-synthesizing enzyme raldh2. By one day posttrauma, ...

journal_title：Developmental cell

authors： Kikuchi K,Holdway JE,Major RJ,Blum N,Dahn RD,Begemann G,Poss KD

更新日期：2011-03-15 00:00:00

abstract：:Normal cellular development and function require tight spatiotemporal control of actin assembly. Formins are potent actin assembly factors that protect the growing ends of actin filaments from capping proteins. However, it is unresolved how the duration of formin-mediated actin assembly events is controlled, whether f...

journal_title：Developmental cell

authors： Chesarone M,Gould CJ,Moseley JB,Goode BL

更新日期：2009-02-01 00:00:00

abstract：:Proteins are degraded from the ER by endoplasmic reticulum-associated degradation (ERAD). In a recent issue of Molecular Cell, Fleig et al. (2012) describe a role for a ubiquitin-binding rhomboid protease, RHBDL4, in degradation of select ERAD substrates. These findings and the significance of rhomboids and other intr...

journal_title：Developmental cell

authors： Tsai YC,Weissman AM

更新日期：2012-09-11 00:00:00

abstract：:RhoA stimulates cell contractility by recruiting downstream effectors to the cortical plasma membrane. We now show that direct binding by anillin is required for effective signaling: this antagonizes the otherwise labile membrane association of GTP-RhoA to promote effector recruitment. However, since its binding to Rh...

journal_title：Developmental cell

authors： Budnar S,Husain KB,Gomez GA,Naghibosadat M,Varma A,Verma S,Hamilton NA,Morris RG,Yap AS

更新日期：2019-06-17 00:00:00

abstract：:Boundary formation and epithelialization are crucial processes in the morphological segmentation of vertebrate somites. By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes. Fibronectin proteins accumulate at somite boundari...

journal_title：Developmental cell

authors： Koshida S,Kishimoto Y,Ustumi H,Shimizu T,Furutani-Seiki M,Kondoh H,Takada S

更新日期：2005-04-01 00:00:00

abstract：:Two major functions of the epigenome are to regulate gene expression and to suppress transposons. It is unclear how these functions are balanced during physiological challenges requiring tissue regeneration, where exquisite coordination of gene expression is essential. Transcriptomic analysis of seven time points foll...

journal_title：Developmental cell

authors： Wang S,Zhang C,Hasson D,Desai A,SenBanerjee S,Magnani E,Ukomadu C,Lujambio A,Bernstein E,Sadler KC

更新日期：2019-07-01 00:00:00

abstract：:For 20 years, researchers have thought that circadian clocks are defined by feedback loops of transcription and translation. The rediscovery of posttranslational circadian oscillators in diverse organisms forces us to rethink this paradigm. Meanwhile, the original "basic" feedback loops of canonical circadian clocks h...

journal_title：Developmental cell

authors： Brown SA,Kowalska E,Dallmann R

更新日期：2012-03-13 00:00:00

abstract：:We have identified and characterized a novel C. elegans gene, ced-12, that functions in the conserved GTPase signaling pathway mediated by CED-2/Crkll, CED-5/DOCK180, and CED-10/Rac to control cell migration and phagocytosis of apoptotic cells. We provide evidence that ced-12 likely acts upstream of ced-10 during cell...

journal_title：Developmental cell

authors： Wu YC,Tsai MC,Cheng LC,Chou CJ,Weng NY

更新日期：2001-10-01 00:00:00

abstract：:The Hippo/Yki and RB/E2F pathways both regulate tissue growth by affecting cell proliferation and survival, but interactions between these parallel control systems are poorly defined. In this study, we demonstrate that interaction between Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses ...

journal_title：Developmental cell

authors： Zhang P,Pei C,Wang X,Xiang J,Sun BF,Cheng Y,Qi X,Marchetti M,Xu JW,Sun YP,Edgar BA,Yuan Z

更新日期：2017-12-04 00:00:00

abstract：:Heparan sulfate (HS) proteoglycans modulate the activity of multiple growth factors on the cell surface and extracellular matrix. However, it remains unclear how the HS chains control the movement and reception of growth factors into targeted receiving cells during mammalian morphogenetic processes. Here, we found tha...

journal_title：Developmental cell

authors： Shimokawa K,Kimura-Yoshida C,Nagai N,Mukai K,Matsubara K,Watanabe H,Matsuda Y,Mochida K,Matsuo I

更新日期：2011-08-16 00:00:00

abstract：:Pericytes are critical for cerebrovascular maturation and development of the blood-brain barrier (BBB), but their role in maintenance of the adult BBB, and how CNS pericytes differ from those of other tissues, is less well understood. We show that the forkhead transcription factor Foxf2 is specifically expressed in pe...

journal_title：Developmental cell

authors： Reyahi A,Nik AM,Ghiami M,Gritli-Linde A,Pontén F,Johansson BR,Carlsson P

更新日期：2015-07-06 00:00:00

abstract：:Branching morphogenesis is a key process in the formation of vascular networks. To date, little is known regarding the molecular events regulating this process. We investigated the involvement of synectin in this process. In zebrafish embryos, synectin knockdown resulted in a hypoplastic dorsal aorta and hypobranched,...

journal_title：Developmental cell

authors： Chittenden TW,Claes F,Lanahan AA,Autiero M,Palac RT,Tkachenko EV,Elfenbein A,Ruiz de Almodovar C,Dedkov E,Tomanek R,Li W,Westmore M,Singh JP,Horowitz A,Mulligan-Kehoe MJ,Moodie KL,Zhuang ZW,Carmeliet P,Simons M

更新日期：2006-06-01 00:00:00

abstract：:Our vasculature plays diverse and critical roles in homeostasis and disease. In recent decades, the use of zebrafish has driven our understanding of vascular development into new areas, identifying new genes and mechanisms controlling vessel formation and allowing unprecedented observation of the cellular and molecula...

journal_title：Developmental cell

authors： Hogan BM,Schulte-Merker S

更新日期：2017-09-25 00:00:00