Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila.

Abstract:

:Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish "winners" from "losers" during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as "winners" or "losers." In Drosophila, the fwe locus produces three isoforms, fwe(ubi), fwe(Lose-A), and fwe(Lose-B). Basal levels of fwe(ubi) are constantly produced. During competition, the fwe(Lose) isoforms are upregulated in prospective loser cells. Cell-cell comparison of relative fwe(Lose) and fwe(ubi) levels ultimately determines which cell undergoes apoptosis. This "extracellular code" may constitute an ancient mechanism to terminate competitive conflicts among cells.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Rhiner C,López-Gay JM,Soldini D,Casas-Tinto S,Martín FA,Lombardía L,Moreno E

doi

10.1016/j.devcel.2010.05.010

subject

Has Abstract

pub_date

2010-06-15 00:00:00

pages

985-98

issue

6

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(10)00218-2

journal_volume

18

pub_type

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