Abstract：
:Nuclear size plays pivotal roles in gene expression, embryo development, and disease. A central hypothesis in organisms ranging from yeast to vertebrates is that nuclear size scales to cell size. This implies that nuclei may reach steady-state sizes set by limiting cytoplasmic pools of size-regulating components. By monitoring nuclear dynamics in early sea urchin embryos, we found that nuclei undergo substantial growth in each interphase, reaching a maximal size prior to mitosis that declined steadily over the course of development. Manipulations of cytoplasmic volume through multiple chemical and physical means ruled out cell size as a major determinant of nuclear size and growth. Rather, our data suggest that the perinuclear endoplasmic reticulum, accumulated through dynein activity, serves as a limiting membrane pool that sets nuclear surface growth rate. Partitioning of this local pool at each cell division modulates nuclear growth kinetics and dictates size scaling throughout early development.
journal_name
Dev Celljournal_title
Developmental cellauthors
Mukherjee RN,Sallé J,Dmitrieff S,Nelson KM,Oakey J,Minc N,Levy DLdoi
10.1016/j.devcel.2020.05.003subject
Has Abstractpub_date
2020-08-10 00:00:00pages
395-409.e7issue
3eissn
1534-5807issn
1878-1551pii
S1534-5807(20)30359-2journal_volume
54pub_type
杂志文章abstract：:The eukaryotic cell cycle, driven by both transcriptional and posttranslational mechanisms, is the central molecular oscillator underlying tissue growth throughout animals. Although genome-wide studies have investigated cell-cycle-associated transcription in unicellular systems, global patterns of periodic transcripti...
journal_title：Developmental cell
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abstract：:One of today's most powerful technologies in biomedical research--the creation of mutant mice by gene targeting in embryonic stem (ES) cells--was finally celebrated in this year's Nobel Prize in Medicine. The history of how ES cells were first discovered and genetically manipulated highlights the importance of collabo...
journal_title：Developmental cell
pub_type： 传,社论,历史文章
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abstract：:It is intuitive to speculate that nutrient availability may influence differentiation of mammalian cells. Nonetheless, a comprehensive complement of the molecular determinants involved in this process has not been elucidated yet. Here, we have investigated how nutrients (glucose) affect skeletal myogenesis. Glucose re...
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journal_title：Developmental cell
pub_type： 杂志文章,评审
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type：
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2019-04-08 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2010-06-15 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2005-11-01 00:00:00
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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更新日期：2013-07-29 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2002-12-01 00:00:00
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pub_type： 评论,杂志文章
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更新日期：2010-10-19 00:00:00
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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更新日期：2019-04-08 00:00:00
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journal_title：Developmental cell
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更新日期：2006-02-01 00:00:00
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journal_title：Developmental cell
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更新日期：2018-04-23 00:00:00
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