A receptor for meningococcus: eliciting β-arrestin signaling for barrier breaching.

abstract：:The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1. We discovered tha...

journal_title：Developmental cell

authors： Latifkar A,Ling L,Hingorani A,Johansen E,Clement A,Zhang X,Hartman J,Fischbach C,Lin H,Cerione RA,Antonyak MA

更新日期：2019-05-06 00:00:00

abstract：:In response to cellular stress, mitochondria remodel their structure by organelle division and fusion. In this issue of Developmental Cell, Cooper et al. (2014) report that a nuclear protein, cyclin C, is recruited from nuclei to mitochondria upon oxidative stress and promotes mitochondrial division and apoptosis of t...

journal_title：Developmental cell

authors： Adachi Y,Sesaki H

更新日期：2014-01-27 00:00:00

abstract：:Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al. (2013) suggest that the ER-...

journal_title：Developmental cell

authors： Bernard A,Klionsky DJ

更新日期：2013-04-29 00:00:00

abstract：:The developmental mechanisms that orchestrate differentiation of specific nephron segments are incompletely understood, and the factors that maintain their terminal differentiation after nephrogenesis remain largely unknown. Here, the transcription factor AP-2β is shown to be required for the differentiation of distal...

journal_title：Developmental cell

authors： Marneros AG

更新日期：2020-08-10 00:00:00

abstract：:One of today's most powerful technologies in biomedical research--the creation of mutant mice by gene targeting in embryonic stem (ES) cells--was finally celebrated in this year's Nobel Prize in Medicine. The history of how ES cells were first discovered and genetically manipulated highlights the importance of collabo...

journal_title：Developmental cell

authors： Hogan B

更新日期：2007-12-01 00:00:00

abstract：:Signaling receptors are internalized and regulated by clathrin-mediated endocytosis (CME). Two clathrin light chain isoforms, CLCa and CLCb, are integral components of the endocytic machinery whose differential functions remain unknown. We report that CLCb is specifically upregulated in non-small-cell lung cancer (NSC...

journal_title：Developmental cell

authors： Chen PH,Bendris N,Hsiao YJ,Reis CR,Mettlen M,Chen HY,Yu SL,Schmid SL

更新日期：2017-02-06 00:00:00

abstract：:Advances in molecular biology continue to help us uncover how information written into genes provides a blueprint for the initiation and orchestration of programs and processes that control cell division, cell-type specification, cell migration, cellular differentiation, and cell death. Clearly, molecular elements int...

journal_title：Developmental cell

authors： Pappu RV

更新日期：2020-10-12 00:00:00

abstract：:Large intergenic noncoding (linc) RNAs constitute a new dimension of posttranscriptional gene regulation. In this issue of Developmental Cell, Wang et al. (2013) find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR-145, thus regulating core pluripotency factors Oct...

journal_title：Developmental cell

authors： Cheng EC,Lin H

更新日期：2013-04-15 00:00:00

abstract：:The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase-mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular C...

journal_title：Developmental cell

authors： Lin A

更新日期：2006-03-01 00:00:00

abstract：:Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation...

journal_title：Developmental cell

authors： Wang X,Kopinke D,Lin J,McPherson AD,Duncan RN,Otsuna H,Moro E,Hoshijima K,Grunwald DJ,Argenton F,Chien CB,Murtaugh LC,Dorsky RI

更新日期：2012-09-11 00:00:00

abstract：:Actomyosin flows are involved in a variety of cellular processes, including cytokinesis, cell migration, polarization, and morphogenesis. In epithelia, flow polarization orients cell deformations. It is unclear, however, how flows are polarized and how global patterns of junction remodeling emerge from flow polarizati...

journal_title：Developmental cell

authors： Levayer R,Lecuit T

更新日期：2013-07-29 00:00:00

abstract：:How cells sense their physical microenvironment remains incompletely understood. In two recent Science articles, Lomakin et al. (2020) and Venturini et al. (2020) demonstrate that progressive nuclear deformation associated with cellular confinement triggers intracellular events that promote cell contractility and migr...

journal_title：Developmental cell

authors： Long JT,Lammerding J

更新日期：2021-01-25 00:00:00

abstract：:Localization of the actin crosslinking protein, alpha-actinin, to the cleavage furrow has been previously reported. However, its functions during cytokinesis remain poorly understood. We have analyzed the functions of alpha-actinin during cytokinesis by a combination of molecular manipulations and imaging-based techni...

journal_title：Developmental cell

authors： Mukhina S,Wang YL,Murata-Hori M

更新日期：2007-10-01 00:00:00

abstract：:The Hox family transcription factors control diversified morphogenesis during development and evolution. They function in concert with Pbc cofactor proteins. Pbc proteins bind the Hox hexapeptide (HX) motif and are thereby thought to confer DNA binding specificity. Here we report that mutation of the AbdA HX motif doe...

journal_title：Developmental cell

authors： Merabet S,Kambris Z,Capovilla M,Bérenger H,Pradel J,Graba Y

更新日期：2003-05-01 00:00:00

abstract：:NAD(H)-binding proteins play important roles in cell-cycle and developmental signaling in eukaryotes. We identified a bifunctional NAD(H)-binding regulator (KidO) that integrates cell-fate signaling with cytokinesis in the bacterium Caulobacter crescentus. KidO stimulates the DivJ kinase and directly acts on the cytok...

journal_title：Developmental cell

authors： Radhakrishnan SK,Pritchard S,Viollier PH

更新日期：2010-01-19 00:00:00

abstract：:BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin. However, it remains unknown whether BMP signaling can promote self-renewal of adult somatic stem cells. In this study, we sh...

journal_title：Developmental cell

authors： Kirilly D,Spana EP,Perrimon N,Padgett RW,Xie T

更新日期：2005-11-01 00:00:00

abstract：:Local translation allows spatial control of gene expression. Here, we performed a dual protein-mRNA localization screen, using smFISH on 523 human cell lines expressing GFP-tagged genes. 32 mRNAs displayed specific cytoplasmic localizations with local translation at unexpected locations, including cytoplasmic protrusi...

journal_title：Developmental cell

authors： Chouaib R,Safieddine A,Pichon X,Imbert A,Kwon OS,Samacoits A,Traboulsi AM,Robert MC,Tsanov N,Coleno E,Poser I,Zimmer C,Hyman A,Le Hir H,Zibara K,Peter M,Mueller F,Walter T,Bertrand E

更新日期：2020-09-28 00:00:00

abstract：:During the first five rounds of cell division in the mouse embryo, spindles assemble in the absence of centrioles. Spindle formation initiates around chromosomes, but the microtubule nucleating process remains unclear. Here we demonstrate that Plk4, a protein kinase known as a master regulator of centriole formation, ...

journal_title：Developmental cell

authors： Coelho PA,Bury L,Sharif B,Riparbelli MG,Fu J,Callaini G,Glover DM,Zernicka-Goetz M

更新日期：2013-12-09 00:00:00

abstract：:Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspa...

journal_title：Developmental cell

authors： Desai BN,Krapivinsky G,Navarro B,Krapivinsky L,Carter BC,Febvay S,Delling M,Penumaka A,Ramsey IS,Manasian Y,Clapham DE

更新日期：2012-06-12 00:00:00

abstract：:Initiation of DNA replication must be restricted to occur only once per cell cycle. In most bacteria, DnaA protein binds replication origins and promotes the initiation of DNA replication. We have found that in Bacillus subtilis, DnaA only colocalizes with origin regions at early or late stages of the cell cycle, when...

journal_title：Developmental cell

authors： Soufo CD,Soufo HJ,Noirot-Gros MF,Steindorf A,Noirot P,Graumann PL

更新日期：2008-12-01 00:00:00

abstract：:Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-...

journal_title：Developmental cell

authors： Wang ZY,Nakano T,Gendron J,He J,Chen M,Vafeados D,Yang Y,Fujioka S,Yoshida S,Asami T,Chory J

更新日期：2002-04-01 00:00:00

abstract：:Our vasculature plays diverse and critical roles in homeostasis and disease. In recent decades, the use of zebrafish has driven our understanding of vascular development into new areas, identifying new genes and mechanisms controlling vessel formation and allowing unprecedented observation of the cellular and molecula...

journal_title：Developmental cell

authors： Hogan BM,Schulte-Merker S

更新日期：2017-09-25 00:00:00

abstract：:Neutrophils, in response to a chemoattractant gradient, undergo dynamic F-actin remodeling, a process important for their directional migration or chemotaxis. However, signaling mechanisms for chemoattractants to regulate the process are incompletely understood. Here, we characterized chemoattractant-activated signali...

journal_title：Developmental cell

authors： Tang W,Zhang Y,Xu W,Harden TK,Sondek J,Sun L,Li L,Wu D

更新日期：2011-12-13 00:00:00

abstract：:Smad4 is a central intracellular effector of TGF-beta signaling. Smad-independent TGF-beta pathways, such as those mediated by p38 MAPK, have been identified in cell culture systems, but their in vivo functional mechanisms remain unclear. In this study, we investigated the role of TGF-beta signaling in tooth and palat...

journal_title：Developmental cell

authors： Xu X,Han J,Ito Y,Bringas P Jr,Deng C,Chai Y

更新日期：2008-08-01 00:00:00

abstract：:Efficient regeneration following injury is critical for maintaining tissue function and enabling organismal survival. Cells reconstituting damaged tissue are often generated from resident stem or progenitor cells or from cells that have dedifferentiated and become proliferative. While lineage-tracing studies have defi...

journal_title：Developmental cell

authors： Iyengar S,Kasheta M,Ceol CJ

更新日期：2015-06-22 00:00:00

abstract：:Dickkopf-1 (Dkk1) is a secreted Wnt antagonist with a well-established role in head induction during development. Numerous studies have emerged implicating Dkk1 in various malignancies and neurodegenerative diseases through an unknown mechanism. Using zebrafish gastrulation as a model for collective cell migration, we...

journal_title：Developmental cell

authors： Johansson M,Giger FA,Fielding T,Houart C

更新日期：2019-12-16 00:00:00

abstract：:Tetrapod limbs display a great variety of forms and functions. In an attempt to understand factors influencing this diversity, Cretekos and colleagues, in a recent issue of Genes & Development, provide molecular insight into the evolution of wing morphology in bats. ...

journal_title：Developmental cell

authors： Weatherbee SD

更新日期：2008-02-01 00:00:00

abstract：:Oriented cell division plays a key role in controlling organogenesis. The mechanisms for regulating division orientation at the whole-organ level are only starting to become understood. By combining 3D time-lapse imaging, mouse genetics, and mathematical modeling, we find that global orientation of cell division is th...

journal_title：Developmental cell

authors： Tang Z,Hu Y,Wang Z,Jiang K,Zhan C,Marshall WF,Tang N

更新日期：2018-02-05 00:00:00

abstract：:The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin during tissue morphogenesis have been identified, but the role of the microtubule cytoskeleton is less clear. Here, we show that during tubulogenesis of the saliv...

journal_title：Developmental cell

authors： Booth AJR,Blanchard GB,Adams RJ,Röper K

更新日期：2014-06-09 00:00:00

abstract：:The sense organs of the vertebrate head comprise structures as varied as the eye, inner ear, and olfactory epithelium. In the early embryo, these assorted structures share a common developmental origin within the preplacodal region and acquire specific characteristics only later. Here we demonstrate a fundamental simi...

journal_title：Developmental cell

authors： Bailey AP,Bhattacharyya S,Bronner-Fraser M,Streit A

更新日期：2006-10-01 00:00:00