Abstract：
:Localization of the actin crosslinking protein, alpha-actinin, to the cleavage furrow has been previously reported. However, its functions during cytokinesis remain poorly understood. We have analyzed the functions of alpha-actinin during cytokinesis by a combination of molecular manipulations and imaging-based techniques. alpha-actinin gradually dissipated from the cleavage furrow as cytokinesis progressed. Overexpression of alpha-actinin caused increased accumulation of actin filaments because of inhibition of actin turnover, leading to cytokinesis failure. Global depletion of alpha-actinin by siRNA caused a decrease in the density of actin filaments throughout the cell cortex, surprisingly inducing accelerated cytokinesis and ectopic furrows. Local ablation of alpha-actinin induced accelerated cytokinesis specifically at the site of irradiation. Neither overexpression nor depletion of alpha-actinin had an apparent effect on myosin II organization. We conclude that cytokinesis in mammalian cells requires tightly regulated remodeling of the cortical actin network mediated by alpha-actinin in coordination with actomyosin-based cortical contractions.
journal_name
Dev Celljournal_title
Developmental cellauthors
Mukhina S,Wang YL,Murata-Hori Mdoi
10.1016/j.devcel.2007.08.003subject
Has Abstractpub_date
2007-10-01 00:00:00pages
554-65issue
4eissn
1534-5807issn
1878-1551pii
S1534-5807(07)00303-6journal_volume
13pub_type
杂志文章abstract：:The interchromosome domain (ICD) model proposes that genes are selectively positioned at the surfaces of chromosome territories to facilitate their regulation. A paper in the May 13 issue of the Journal of Cell Biology provides evidence that supports a reinterpretation of this model. ...
journal_title：Developmental cell
pub_type： 杂志文章
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abstract：:Positioning organs in the body often requires the movement of multiple tissues, yet the molecular and cellular mechanisms coordinating such movements are largely unknown. Here, we show that bidirectional signaling between EphrinB1 and EphB3b coordinates the movements of the hepatic endoderm and adjacent lateral plate ...
journal_title：Developmental cell
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abstract：:Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional ...
journal_title：Developmental cell
pub_type： 杂志文章
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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abstract：:The sense organs of the vertebrate head comprise structures as varied as the eye, inner ear, and olfactory epithelium. In the early embryo, these assorted structures share a common developmental origin within the preplacodal region and acquire specific characteristics only later. Here we demonstrate a fundamental simi...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.08.009
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journal_title：Developmental cell
pub_type： 评论,杂志文章
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abstract：:Lysosomes degrade macromolecular cargos, recycle catabolites, and serve as signaling platforms to maintain cell homeostasis, but their role at the tissue level is unclear. Here, we investigate lysosome regulation and function during C. elegans molting, a specialized extracellular matrix (ECM) remodeling process essent...
journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2015.03.009
更新日期：2015-03-23 00:00:00
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journal_title：Developmental cell
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doi：10.1016/j.devcel.2019.07.010
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journal_title：Developmental cell
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更新日期：2008-03-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2012-08-14 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.03.023
更新日期：2014-06-09 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.11.020
更新日期：2008-02-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.05.021
更新日期：2019-07-22 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2011.07.008
更新日期：2011-10-18 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2006.10.009
更新日期：2006-11-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章
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更新日期：2020-12-07 00:00:00
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journal_title：Developmental cell
pub_type：
doi：10.1016/s1534-5807(02)00299-x
更新日期：2002-10-01 00:00:00
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journal_title：Developmental cell
pub_type： 杂志文章,评审
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更新日期：2003-02-01 00:00:00
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journal_title：Developmental cell
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journal_title：Developmental cell
pub_type： 杂志文章
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journal_title：Developmental cell
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journal_title：Developmental cell
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更新日期：2008-01-01 00:00:00
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journal_title：Developmental cell
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更新日期：2016-01-11 00:00:00
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journal_title：Developmental cell
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journal_title：Developmental cell
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journal_title：Developmental cell
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