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Organization of Embryonic Morphogenesis via Mechanical Information.

Abstract：

:Embryonic organizers establish gradients of diffusible signaling molecules to pattern the surrounding cells. Here, we elucidate an additional mechanism of embryonic organizers that is a secondary consequence of morphogen signaling. Using pharmacological and localized transgenic perturbations, 4D imaging of the zebrafish embryo, systematic analysis of cell motion, and computational modeling, we find that the vertebrate tail organizer orchestrates morphogenesis over distances beyond the range of morphogen signaling. The organizer regulates the rate and coherence of cell motion in the elongating embryo using mechanical information that is transmitted via relay between neighboring cells. This mechanism is similar to a pressure front in granular media and other jammed systems, but in the embryo the mechanical information emerges from self-propelled cell movement and not force transfer between cells. The propagation likely relies upon local biochemical signaling that affects cell contractility, cell adhesion, and/or cell polarity but is independent of transcription and translation.

journal_name

Dev Cell

journal_title

Developmental cell

authors

Das D,Jülich D,Schwendinger-Schreck J,Guillon E,Lawton AK,Dray N,Emonet T,O'Hern CS,Shattuck MD,Holley SA

doi

10.1016/j.devcel.2019.05.014

subject

Has Abstract

pub_date

2019-06-17 00:00:00

pages

829-839.e5

issue

6

eissn

1534-5807

issn

1878-1551

pii

S1534-5807(19)30386-7

journal_volume

49

pub_type

杂志文章

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