Abstract:
:Changes in the genetic makeup of an organism can extend lifespan significantly if they promote tolerance to environmental insults and thus prevent the general deterioration of cellular function that is associated with aging. Here, we introduce the Jun N-terminal kinase (JNK) signaling pathway as a genetic determinant of aging in Drosophila melanogaster. Based on expression profiling experiments, we demonstrate that JNK functions at the center of a signal transduction network that coordinates the induction of protective genes in response to oxidative challenge. JNK signaling activity thus alleviates the toxic effects of reactive oxygen species (ROS). In addition, we show that flies with mutations that augment JNK signaling accumulate less oxidative damage and live dramatically longer than wild-type flies. Our work thus identifies the evolutionarily conserved JNK signaling pathway as a major genetic factor in the control of longevity.
journal_name
Dev Celljournal_title
Developmental cellauthors
Wang MC,Bohmann D,Jasper Hdoi
10.1016/s1534-5807(03)00323-xkeywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
811-6issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(03)00323-Xjournal_volume
5pub_type
杂志文章abstract::In this issue of Developmental Cell, Weavers and Skaer (2013) show that interplay between two opposing forces generated by tip cell attachment to muscles and migration of kink cells allows for the formation of the looped shape and positioning of renal tubules within the body of a fly larva. ...
journal_title:Developmental cell
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