Abstract：
:During chick gastrulation, inhibition of BMP signaling is required for primitive streak formation and induction of Hensen's node. We have identified a unique secreted protein, Tsukushi (TSK), which belongs to the Small Leucine-Rich Proteoglycan (SLRP) family and is expressed in the primitive streak and Hensen's node. Grafts of cells expressing TSK in combination with the middle primitive streak induce an ectopic Hensen's node, while electroporation of TSK siRNA inhibits induction of the node. In Xenopus embryos, TSK can block BMP function and induce a secondary dorsal axis, while it can dorsalize ventral mesoderm and induce neural tissue in embryonic explants. Biochemical analysis shows that TSK binds directly to both BMP and chordin and forms a ternary complex with them. These observations indicate that TSK is an essential dorsalizing factor involved in the induction of Hensen's node.
journal_name
Dev Celljournal_title
Developmental cellauthors
Ohta K,Lupo G,Kuriyama S,Keynes R,Holt CE,Harris WA,Tanaka H,Ohnuma SIdoi
10.1016/j.devcel.2004.08.014keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
347-358issue
3eissn
1534-5807issn
1878-1551journal_volume
7pub_type
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