Abstract:
:Several genes are known to regulate circadian rhythms in Arabidopsis, but the identity of the central oscillator has not been established. LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved. Here we demonstrate that, as shown previously for CCA1, inactivation of LHY shortens the period of circadian rhythms in gene expression and leaf movements. By constructing lhy cca1-1 double mutants, we show that LHY and CCA1 are partially redundant and essential for the maintenance of circadian rhythms in constant light. Under light/dark cycles the lhy cca1-1 plants show dramatically earlier phases of expression of GI and TOC1, genes associated with the generation of circadian rhythms and the promotion of LHY and CCA1 expression. We conclude that LHY and CCA1 appear to be negative regulatory elements required for central oscillator function.
journal_name
Dev Celljournal_title
Developmental cellauthors
Mizoguchi T,Wheatley K,Hanzawa Y,Wright L,Mizoguchi M,Song HR,Carré IA,Coupland Gdoi
10.1016/s1534-5807(02)00170-3keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
629-41issue
5eissn
1534-5807issn
1878-1551pii
S1534-5807(02)00170-3journal_volume
2pub_type
杂志文章abstract::22q11 deletion (del22q11) syndrome is characterized genetically by heterozygous deletions within chromosome 22q11 and clinically by a constellation of congenital malformations of the aortic arch, heart, thymus, and parathyroid glands described as DiGeorge syndrome (DGS). Here, we report that compound heterozygosity of...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.12.002
更新日期:2006-01-01 00:00:00
abstract::Cells in a variety of developmental contexts sense extracellular cues that are given locally on their surfaces, and subsequently amplify the initial signal to achieve cell polarization. Drosophila wing cells acquire planar polarity along the proximal-distal (P-D) axis, in which the amplification of the presumptive cue...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.11.016
更新日期:2006-02-01 00:00:00
abstract::The spinal cord and mesodermal tissues of the trunk such as the vertebral column and skeletal musculature derive from neuro-mesodermal progenitors (NMPs). Sox2, Brachyury (T), and Tbx6 have been correlated with NMP potency and lineage choice; however, their exact role and interaction in these processes have not yet be...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2017.07.021
更新日期:2017-09-11 00:00:00
abstract::Melanocortin 4 receptor (Mc4r) plays a crucial role in the central control of energy homeostasis, but its role in peripheral organs has not been fully explored. We have investigated the roles of hypothalamus-mediated energy metabolism during Xenopus limb regeneration. We report that hypothalamus injury inhibits Xenopu...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2018.07.021
更新日期:2018-08-20 00:00:00
abstract::Boundary formation and epithelialization are crucial processes in the morphological segmentation of vertebrate somites. By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes. Fibronectin proteins accumulate at somite boundari...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.03.006
更新日期:2005-04-01 00:00:00
abstract::Directional cell migration is critical for metazoan development. We define two molecular pathways that activate the Arp2/3 complex during neuroblast migration in Caenorhabditis elegans. The transmembrane protein MIG-13/Lrp12 is linked to the Arp2/3 nucleation-promoting factors WAVE or WASP through direct interactions ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.09.029
更新日期:2016-10-24 00:00:00
abstract::As they enter mitosis, animal cells undergo profound actin-dependent changes in shape to become round. Here we identify the Cdk1 substrate, Ect2, as a central regulator of mitotic rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its accompanying actin remodeling. Ect2 is ...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2012.06.003
更新日期:2012-08-14 00:00:00
abstract::In the field of breast biology, there is a growing appreciation for the "gatekeeping function" of basal cells during development and disease processes yet mechanisms regulating the generation of these cells are poorly understood. Here, we report that the proliferation of basal cells is controlled by SLIT/ROBO1 signali...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2011.05.012
更新日期:2011-06-14 00:00:00
abstract::The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase-mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular C...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.02.006
更新日期:2006-03-01 00:00:00
abstract::Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the facto...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2016.10.015
更新日期:2016-12-05 00:00:00
abstract::Formation of the embryonic heart tube requires the medial migration and merger of bilateral precursor populations. A new study of zebrafish cardiogenesis published in this issue of Developmental Cell indicates that precursor migration involves formation of a coherent epithelium and that fibronectin plays an important ...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/s1534-5807(04)00070-x
更新日期:2004-03-01 00:00:00
abstract::The sense organs of the vertebrate head comprise structures as varied as the eye, inner ear, and olfactory epithelium. In the early embryo, these assorted structures share a common developmental origin within the preplacodal region and acquire specific characteristics only later. Here we demonstrate a fundamental simi...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.08.009
更新日期:2006-10-01 00:00:00
abstract::In a recent issue of Molecular Cell, Cairo et al. (2013) report that the spindle checkpoint protein Mad1 shuttles between unattached kinetochores and nuclear pores. Mobile Mad1 inhibits the import receptor Kap121p, thus indirectly changing spindle dynamics. This adds nuclear transport control to the mitotic roles of M...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.01.003
更新日期:2013-01-28 00:00:00
abstract::In response to cellular stress, mitochondria remodel their structure by organelle division and fusion. In this issue of Developmental Cell, Cooper et al. (2014) report that a nuclear protein, cyclin C, is recruited from nuclei to mitochondria upon oxidative stress and promotes mitochondrial division and apoptosis of t...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2014.01.010
更新日期:2014-01-27 00:00:00
abstract::Changes to cell shape and interaction drive animal tissue morphogenesis. Reporting now in Developmental Cell, Del Signore et al. (2018) describe active lengthening of cell-cell contacts by Arp2/3-based actin networks. Through cycles of contact lengthening and shortening, the developing Drosophila eye passes through va...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2018.02.003
更新日期:2018-02-26 00:00:00
abstract::A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies o...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.09.004
更新日期:2008-10-01 00:00:00
abstract::We show that Rap2, a member of the Ras GTPase family, positively regulates Activin/Nodal signaling activity by controlling the trafficking of its receptors. In the absence of ligand activation, Rap2 directs internalized Activin/Nodal receptors into a recycling pathway, thereby preventing their degradation and maintain...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.05.004
更新日期:2008-07-01 00:00:00
abstract::Genome condensation during mitosis presents a chromatin landscape largely inaccessible to RNA polymerase II and most transcription factors. Caravaca et al. (2013) now report in Genes and Development that the pioneer transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable gene ex...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2013.02.005
更新日期:2013-02-25 00:00:00
abstract::The anterior visceral endoderm plays a pivotal role in establishing anterior-posterior polarity of the mouse embryo, but the molecular nature of the signals required remains to be determined. Here, we demonstrate that Cerberus-like(-/-);Lefty1(-/-) compound mutants can develop a primitive streak ectopically in the emb...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/s1534-5807(02)00321-0
更新日期:2002-11-01 00:00:00
abstract::Myosin phosphatase-targeting subunit 1 (MYPT1) binds to the catalytic subunit of protein phosphatase 1 (PP1C). This binding is believed to target PP1C to specific substrates including myosin II, thus controlling cellular contractility. Surprisingly, we found that during mitosis, mammalian MYPT1 binds to polo-like kina...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2008.02.013
更新日期:2008-05-01 00:00:00
abstract::The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell abl...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2015.11.025
更新日期:2015-12-21 00:00:00
abstract::Transmission of the human parasite Brugia malayi relies on the sustained production of larvae in blood. In this issue of Developmental Cell,Foray et al. (2018) use methods developed in the model nematode C. elegans to reveal how a symbiotic bacterium supports the female germ cell development underlying this massive fe...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2018.04.006
更新日期:2018-04-23 00:00:00
abstract::Secreted proteins of the Wnt family affect axon guidance, asymmetric cell division, and cell fate. We show here that C. elegans Wnts acting through Frizzled receptors can shape axon and dendrite trajectories by reversing the anterior-posterior polarity of neurons. In lin-44/Wnt and lin-17/Frizzled mutants, the polarit...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2006.01.013
更新日期:2006-03-01 00:00:00
abstract::Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown (Rhee et al.,2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/beta-catenin...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2006.05.007
更新日期:2006-06-01 00:00:00
abstract::Cells that undergo epithelial-to-mesenchymal transitions (EMTs) commonly switch from expressing E-cadherin to N-cadherin. But why this occurs is not well understood. In the current issue of Developmental Cell, Scarpa et al. (2015) identify a reason: cadherin switching controls Rac signaling to determine how cell locom...
journal_title:Developmental cell
pub_type: 评论,杂志文章
doi:10.1016/j.devcel.2015.08.002
更新日期:2015-08-24 00:00:00
abstract::In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes an...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/s1534-5807(02)00157-0
更新日期:2002-04-01 00:00:00
abstract::BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin. However, it remains unknown whether BMP signaling can promote self-renewal of adult somatic stem cells. In this study, we sh...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2005.09.013
更新日期:2005-11-01 00:00:00
abstract::In eukaryotes, small RNAs (sRNAs) have key roles in development, gene expression regulation, and genome integrity maintenance. In ciliates, such as Paramecium, sRNAs form the heart of an epigenetic system that has evolved from core eukaryotic gene silencing components to selectively target DNA for deletion. In Paramec...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2013.12.010
更新日期:2014-01-27 00:00:00
abstract::The complex muscle patterns of higher organisms arise as migrating myoblasts are guided toward and connect with specific attachment sites. We review here the current understanding of myotube migration, focusing on its dynamic nature and the few molecular cues that have been identified to date. Much of this knowledge c...
journal_title:Developmental cell
pub_type: 杂志文章,评审
doi:10.1016/j.devcel.2004.06.010
更新日期:2004-07-01 00:00:00
abstract::Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the bloodstream, reach distant organs, and locally modify the microenvironment. However, visualizing these events in vivo still faces major hurdles. Here...
journal_title:Developmental cell
pub_type: 杂志文章
doi:10.1016/j.devcel.2019.01.014
更新日期:2019-02-25 00:00:00