LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis.


:Several genes are known to regulate circadian rhythms in Arabidopsis, but the identity of the central oscillator has not been established. LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved. Here we demonstrate that, as shown previously for CCA1, inactivation of LHY shortens the period of circadian rhythms in gene expression and leaf movements. By constructing lhy cca1-1 double mutants, we show that LHY and CCA1 are partially redundant and essential for the maintenance of circadian rhythms in constant light. Under light/dark cycles the lhy cca1-1 plants show dramatically earlier phases of expression of GI and TOC1, genes associated with the generation of circadian rhythms and the promotion of LHY and CCA1 expression. We conclude that LHY and CCA1 appear to be negative regulatory elements required for central oscillator function.


Dev Cell


Developmental cell


Mizoguchi T,Wheatley K,Hanzawa Y,Wright L,Mizoguchi M,Song HR,Carré IA,Coupland G





Has Abstract


2002-05-01 00:00:00














  • Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.

    abstract::Gastric acid secretion by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation. Here, we found that TRPML1 (ML1), a protein that is mutated in type IV mucolipidosis (ML-IV), is a tubulovesicular ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Sahoo N,Gu M,Zhang X,Raval N,Yang J,Bekier M,Calvo R,Patnaik S,Wang W,King G,Samie M,Gao Q,Sahoo S,Sundaresan S,Keeley TM,Wang Y,Marugan J,Ferrer M,Samuelson LC,Merchant JL,Xu H

    更新日期:2017-05-08 00:00:00

  • The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase.

    abstract::The majority of excitatory synaptic transmission in the brain occurs at dendritic spines, which are actin-rich protrusions on the dendrites. The asymmetric nature of these structures suggests that proteins regulating cell polarity might be involved in their formation. Indeed, the polarity protein PAR-3 is required for...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Zhang H,Macara IG

    更新日期:2008-02-01 00:00:00

  • Sex and the MHC.

    abstract::Major histocompatibility complex class Ib molecules may play a surprising role in pheromone detection in mammals. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章,评审


    authors: Scott K

    更新日期:2003-03-01 00:00:00

  • N-WASP Guides Cancer Cells toward LPA.

    abstract::The actin remodeling factor N-WASP is best known as an Arp2/3 complex activator in processes like endocytosis, extracellular matrix degradation, and host-pathogen interaction. In this issue of Developmental Cell, Juin et al. establish a novel trafficking function for N-WASP in driving lysophosphatidic acid-dependent c...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Rottner K,Schaks M

    更新日期:2019-11-18 00:00:00

  • Absence of Radial Spokes in Mouse Node Cilia Is Required for Rotational Movement but Confers Ultrastructural Instability as a Trade-Off.

    abstract::Determination of left-right asymmetry in mouse embryos is established by a leftward fluid flow that is generated by clockwise rotation of node cilia. How node cilia achieve stable unidirectional rotation has remained unknown, however. Here we show that brief exposure to the microtubule-stabilizing drug paclitaxel (Tax...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Shinohara K,Chen D,Nishida T,Misaki K,Yonemura S,Hamada H

    更新日期:2015-10-26 00:00:00

  • Linking Smokers' Susceptibility to Tuberculosis with Lysosomal Storage Disorders.

    abstract::Reporting in Cell, Berg et al. (2016) reveal a connection between genetic lysosomal storage disorders and the ability of macrophages to migrate and control mycobacterial infection. This insight, resulting from a zebrafish genetic screen, inspired the authors to propose an explanation for the increased susceptibility o...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审


    authors: Meijer AH,Aerts JM

    更新日期:2016-04-18 00:00:00

  • The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage.

    abstract::The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors;...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Baek S,Oh TG,Secker G,Sutton DL,Okuda KS,Paterson S,Bower NI,Toubia J,Koltowska K,Capon SJ,Baillie GJ,Simons C,Muscat GEO,Lagendijk AK,Smith KA,Harvey NL,Hogan BM

    更新日期:2019-04-22 00:00:00

  • Asymmetric cell divisions: a view from plant development.

    abstract::All complex multicellular organisms must solve the problem of generating diverse and appropriately patterned cell types. Asymmetric division, in which a single mother cell gives rise to daughters with distinct identities, is instrumental in the generation of cellular diversity and higher-level patterns. In animal syst...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审


    authors: Abrash EB,Bergmann DC

    更新日期:2009-06-01 00:00:00

  • Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations.

    abstract::The myogenic regulatory genes Myf5, Mrf4, Myod, and Myogenin likely arose by gene duplications during evolution, presumably to address the more demanding requirements of the vertebrate body plan. Two cell lineages were proposed to be regulated independently by Myf5 and Myod to safeguard against tissue failure. Here we...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Comai G,Sambasivan R,Gopalakrishnan S,Tajbakhsh S

    更新日期:2014-12-08 00:00:00

  • Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis.

    abstract::The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell abl...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Prochazka J,Prochazkova M,Du W,Spoutil F,Tureckova J,Hoch R,Shimogori T,Sedlacek R,Rubenstein JL,Wittmann T,Klein OD

    更新日期:2015-12-21 00:00:00

  • Brassinosteroid/Abscisic Acid Antagonism in Balancing Growth and Stress.

    abstract::In this issue of Developmental Cell, Gui et al. (2016) show that an abscisic acid-inducible remorin protein in rice directly interacts with critical brassinosteroid signaling components to attenuate the brassinosteroid response, thus illuminating one aspect of the brassinosteroid/abscisic acid antagonism. ...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Clouse SD

    更新日期:2016-07-25 00:00:00

  • Dynamic Control of dNTP Synthesis in Early Embryos.

    abstract::Exponential increase of cell numbers in early embryos requires large amounts of DNA precursors (deoxyribonucleoside triphosphates (dNTPs)). Little is understood about how embryos satisfy this demand. We examined dNTP metabolism in the early Drosophila embryo, in which gastrulation is preceded by 13 sequential nuclear ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Song Y,Marmion RA,Park JO,Biswas D,Rabinowitz JD,Shvartsman SY

    更新日期:2017-08-07 00:00:00

  • PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts.

    abstract::Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs). Phosphorylation of Baz by PAR-1 and aPKC is required for its function in epithelia, but little is known about the dephosphorylation mechanisms that antagonize the activities of these kinases or about the relevance of Baz...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Krahn MP,Egger-Adam D,Wodarz A

    更新日期:2009-06-01 00:00:00

  • A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition.

    abstract::Ribosomes perform protein synthesis but are also involved in signaling processes, the full extent of which are still being uncovered. We report that phenotypes of mutating ribosomal proteins (Rps) are largely due to signaling. Using Drosophila, we discovered that a bZip-domain protein, Xrp1, becomes elevated in Rp mut...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Lee CH,Kiparaki M,Blanco J,Folgado V,Ji Z,Kumar A,Rimesso G,Baker NE

    更新日期:2018-08-20 00:00:00

  • Copper homeostasis: specialized functions of the late secretory pathway.

    abstract::Differentiated cells have evolved mechanisms to adapt the functions of the late secretory pathway to the specific needs of the organism. Reporting in this issue of Developmental Cell, Polishchuk et al. (2014) demonstrate that hepatocytes utilize a unique exocytic aspect of the late endosomal/lysosomal compartment to m...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Gitlin JD

    更新日期:2014-06-23 00:00:00

  • Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis.

    abstract::Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspa...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Desai BN,Krapivinsky G,Navarro B,Krapivinsky L,Carter BC,Febvay S,Delling M,Penumaka A,Ramsey IS,Manasian Y,Clapham DE

    更新日期:2012-06-12 00:00:00

  • Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.

    abstract::While autophagy is thought to be an essential process in some cancer cells, it is unknown if or how such cancer cells can circumvent autophagy inhibition. To address this, we developed a CRISPR/Cas9 assay with dynamic live-cell imaging to measure acute effects of knockout (KO) of autophagy genes compared to known esse...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Towers CG,Fitzwalter BE,Regan D,Goodspeed A,Morgan MJ,Liu CW,Gustafson DL,Thorburn A

    更新日期:2019-09-23 00:00:00

  • Evolving Hox activity profiles govern diversity in locomotor systems.

    abstract::The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transi...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Jung H,Mazzoni EO,Soshnikova N,Hanley O,Venkatesh B,Duboule D,Dasen JS

    更新日期:2014-04-28 00:00:00

  • Lipoprotein-heparan sulfate interactions in the Hh pathway.

    abstract::The Drosophila lipoprotein particle, Lipophorin, bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens. Here we show that Lipophorin interacts with the he...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Eugster C,Panáková D,Mahmoud A,Eaton S

    更新日期:2007-07-01 00:00:00

  • Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.

    abstract::Understanding the mechanisms driving tissue and organ formation requires knowledge across scales. How do signaling pathways specify distinct tissue types? How does the patterning system control morphogenesis? How do these processes evolve? The Drosophila egg chamber, where EGF and BMP signaling intersect to specify un...

    journal_title:Developmental cell

    pub_type: 杂志文章,评审


    authors: Osterfield M,Berg CA,Shvartsman SY

    更新日期:2017-05-22 00:00:00

  • Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching.

    abstract::Airway smooth muscle is best known for its role as an airway constrictor in diseases such as asthma. However, its function in lung development is debated. A prevalent model, supported by in vitro data, posits that airway smooth muscle promotes lung branching through peristalsis and pushing intraluminal fluid to branch...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Young RE,Jones MK,Hines EA,Li R,Luo Y,Shi W,Verheyden JM,Sun X

    更新日期:2020-04-06 00:00:00

  • Tracking HSC Origin: From Bench to Placenta.

    abstract::Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and emb...

    journal_title:Developmental cell

    pub_type: 评论,杂志文章


    authors: Calvanese V,Mikkola HK

    更新日期:2016-03-07 00:00:00

  • Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools.

    abstract::Dickkopf-1 (Dkk1) is a secreted Wnt antagonist with a well-established role in head induction during development. Numerous studies have emerged implicating Dkk1 in various malignancies and neurodegenerative diseases through an unknown mechanism. Using zebrafish gastrulation as a model for collective cell migration, we...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Johansson M,Giger FA,Fielding T,Houart C

    更新日期:2019-12-16 00:00:00

  • Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.

    abstract::The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1. We discovered tha...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Latifkar A,Ling L,Hingorani A,Johansen E,Clement A,Zhang X,Hartman J,Fischbach C,Lin H,Cerione RA,Antonyak MA

    更新日期:2019-05-06 00:00:00

  • Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.

    abstract::The role of Lefty2 in left-right patterning was investigated by analysis of mutant mice that lack asymmetric expression of lefty2. These animals exhibited various situs defects including left isomerism. The asymmetric expression of nodal was prolonged and the expression of Pitx2 was upregulated in the mutant embryos. ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Meno C,Takeuchi J,Sakuma R,Koshiba-Takeuchi K,Ohishi S,Saijoh Y,Miyazaki J,ten Dijke P,Ogura T,Hamada H

    更新日期:2001-07-01 00:00:00

  • Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.

    abstract::In multicellular organisms, cell size is tightly controlled by nutrients and growth factors. Increasing ambient glucose induces enhanced protein synthesis and cell size. Continued exposure of cells to high glucose in vivo, as apparent under pathological conditions, results in cell hypertrophy and tissue damage. We dem...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Wu L,Derynck R

    更新日期:2009-07-01 00:00:00

  • Directional cell migration, but not proliferation, drives hair placode morphogenesis.

    abstract::Epithelial reorganization involves coordinated changes in cell shapes and movements. This restructuring occurs during formation of placodes, ectodermal thickenings that initiate the morphogenesis of epithelial organs including hair, mammary gland, and tooth. Signaling pathways in ectodermal placode formation are well ...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Ahtiainen L,Lefebvre S,Lindfors PH,Renvoisé E,Shirokova V,Vartiainen MK,Thesleff I,Mikkola ML

    更新日期:2014-03-10 00:00:00

  • Moonlighting at the Centrosome: RXRα Turns to Plk1.

    abstract::One of the hardest working mitotic proteins, Polo-like kinase 1 (PLK1), functions at mitotic entry, cytokinesis, and many steps in between. In this issue, Xie et al. (2020) describe a centrosome-specific interaction between PLK1 and Retinoid X Receptor-α and they test selective inhibition of this interaction as an ant...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Dos Santos A,Elowe S

    更新日期:2020-12-21 00:00:00

  • Midgut Laterality Is Driven by Hyaluronan on the Right.

    abstract::For many years, biologists have focused on the role of Pitx2, expressed on the left side of developing embryos, in governing organ laterality. Here, we identify a different pathway during left-right asymmetry initiated by the right side of the embryo. Surprisingly, this conserved mechanism is orchestrated by the extra...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Sivakumar A,Mahadevan A,Lauer ME,Narvaez RJ,Ramesh S,Demler CM,Souchet NR,Hascall VC,Midura RJ,Garantziotis S,Frank DB,Kimata K,Kurpios NA

    更新日期:2018-09-10 00:00:00

  • CNS myelin wrapping is driven by actin disassembly.

    abstract::Myelin is essential in vertebrates for the rapid propagation of action potentials, but the molecular mechanisms driving its formation remain largely unknown. Here we show that the initial stage of process extension and axon ensheathment by oligodendrocytes requires dynamic actin filament assembly by the Arp2/3 complex...

    journal_title:Developmental cell

    pub_type: 杂志文章


    authors: Zuchero JB,Fu MM,Sloan SA,Ibrahim A,Olson A,Zaremba A,Dugas JC,Wienbar S,Caprariello AV,Kantor C,Leonoudakis D,Lariosa-Willingham K,Kronenberg G,Gertz K,Soderling SH,Miller RH,Barres BA

    更新日期:2015-07-27 00:00:00