Abstract：
:The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell ablation, and confocal live imaging, we identified a migratory population of Fgf8-expressing epithelial cells in the embryonic mandible. These Fgf8-expressing progenitors furnish the epithelial cells required for tooth development, and the progenitor population migrates toward a Shh-expressing region in the mandible, where the tooth placode will initiate. Inhibition of Fgf and Shh signaling disrupted the oriented migration of cells, leading to a failure of tooth development. These results demonstrate the importance of intraepithelial cell migration in proper positioning of an initiating organ.
journal_name
Dev Celljournal_title
Developmental cellauthors
Prochazka J,Prochazkova M,Du W,Spoutil F,Tureckova J,Hoch R,Shimogori T,Sedlacek R,Rubenstein JL,Wittmann T,Klein ODdoi
10.1016/j.devcel.2015.11.025subject
Has Abstractpub_date
2015-12-21 00:00:00pages
713-24issue
6eissn
1534-5807issn
1878-1551pii
S1534-5807(15)00760-1journal_volume
35pub_type
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