Muscle building; mechanisms of myotube guidance and attachment site selection.

abstract：:Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formatio...

journal_title：Developmental cell

authors： Ma Z,Castillo-González C,Wang Z,Sun D,Hu X,Shen X,Potok ME,Zhang X

更新日期：2018-06-18 00:00:00

abstract：:Large intergenic noncoding (linc) RNAs constitute a new dimension of posttranscriptional gene regulation. In this issue of Developmental Cell, Wang et al. (2013) find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR-145, thus regulating core pluripotency factors Oct...

journal_title：Developmental cell

authors： Cheng EC,Lin H

更新日期：2013-04-15 00:00:00

abstract：:Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and emb...

journal_title：Developmental cell

authors： Calvanese V,Mikkola HK

更新日期：2016-03-07 00:00:00

abstract：:In vertebrates, the microtubule binding protein TPX2 is required for meiotic and mitotic spindle assembly. TPX2 is also known to bind to and activate Aurora A kinase and target it to the spindle. However, the relationship between the TPX2-Aurora A interaction and the role of TPX2 in spindle assembly is unclear. Here, ...

journal_title：Developmental cell

authors： Ozlü N,Srayko M,Kinoshita K,Habermann B,O'toole ET,Müller-Reichert T,Schmalz N,Desai A,Hyman AA

更新日期：2005-08-01 00:00:00

abstract：:Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited by the time required to generate stable mutant lines. We describe a system for gene knockout that consistently produces null phenotypes in G0 zebrafish. Yolk injection of sets of four CRISPR/Cas9 ribonucleoprotein complexes redu...

journal_title：Developmental cell

authors： Wu RS,Lam II,Clay H,Duong DN,Deo RC,Coughlin SR

更新日期：2018-07-02 00:00:00

abstract：:Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al. (2013) suggest that the ER-...

journal_title：Developmental cell

authors： Bernard A,Klionsky DJ

更新日期：2013-04-29 00:00:00

abstract：:Angiogenesis is responsible for tissue vascularization during development, as well as in pathological contexts, including cancer and ischemia. Vascular endothelial growth factors (VEGFs) regulate angiogenesis by acting through VEGF receptors to induce endothelial cell signaling. VEGF is processed in the extracellular ...

journal_title：Developmental cell

authors： De Angelis JE,Lagendijk AK,Chen H,Tromp A,Bower NI,Tunny KA,Brooks AJ,Bakkers J,Francois M,Yap AS,Simons C,Wicking C,Hogan BM,Smith KA

更新日期：2017-01-23 00:00:00

abstract：:In response to cellular stress, mitochondria remodel their structure by organelle division and fusion. In this issue of Developmental Cell, Cooper et al. (2014) report that a nuclear protein, cyclin C, is recruited from nuclei to mitochondria upon oxidative stress and promotes mitochondrial division and apoptosis of t...

journal_title：Developmental cell

authors： Adachi Y,Sesaki H

更新日期：2014-01-27 00:00:00

abstract：:Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the adipogenic fate of FAPs in injured and diseased muscle by restraining Hedgehog signaling. ...

journal_title：Developmental cell

authors： Perdiguero E,Serrano AL,Muñoz-Cánoves P

更新日期：2017-07-24 00:00:00

abstract：:Recent studies have yielded a number of important insights into the mechanisms of hair follicle development and cycling and have highlighted the particularly important roles played by stem cells and Wnt signaling pathways. ...

journal_title：Developmental cell

authors： Fuchs E,Merrill BJ,Jamora C,DasGupta R

更新日期：2001-07-01 00:00:00

abstract：:Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However, spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging. Here, we developed an optimized protocol for single-molecule transcript imaging in the intact pancreas and used it to identify a sub-po...

journal_title：Developmental cell

authors： Farack L,Golan M,Egozi A,Dezorella N,Bahar Halpern K,Ben-Moshe S,Garzilli I,Tóth B,Roitman L,Krizhanovsky V,Itzkovitz S

更新日期：2019-01-07 00:00:00

abstract：:The Decapentaplegic and Notch signaling pathways are thought to direct regional specification in the Drosophila eye-antennal epithelium by controlling the expression of selector genes for the eye (Eyeless/Pax6, Eyes absent) and/or antenna (Distal-less). Here, we investigate the function of these signaling pathways in ...

journal_title：Developmental cell

authors： Kenyon KL,Ranade SS,Curtiss J,Mlodzik M,Pignoni F

更新日期：2003-09-01 00:00:00

abstract：:In the field of breast biology, there is a growing appreciation for the "gatekeeping function" of basal cells during development and disease processes yet mechanisms regulating the generation of these cells are poorly understood. Here, we report that the proliferation of basal cells is controlled by SLIT/ROBO1 signali...

journal_title：Developmental cell

authors： Macias H,Moran A,Samara Y,Moreno M,Compton JE,Harburg G,Strickland P,Hinck L

更新日期：2011-06-14 00:00:00

abstract：:Neutrophils, in response to a chemoattractant gradient, undergo dynamic F-actin remodeling, a process important for their directional migration or chemotaxis. However, signaling mechanisms for chemoattractants to regulate the process are incompletely understood. Here, we characterized chemoattractant-activated signali...

journal_title：Developmental cell

authors： Tang W,Zhang Y,Xu W,Harden TK,Sondek J,Sun L,Li L,Wu D

更新日期：2011-12-13 00:00:00

abstract：:During chick gastrulation, inhibition of BMP signaling is required for primitive streak formation and induction of Hensen's node. We have identified a unique secreted protein, Tsukushi (TSK), which belongs to the Small Leucine-Rich Proteoglycan (SLRP) family and is expressed in the primitive streak and Hensen's node. ...

journal_title：Developmental cell

authors： Ohta K,Lupo G,Kuriyama S,Keynes R,Holt CE,Harris WA,Tanaka H,Ohnuma SI

更新日期：2004-09-01 00:00:00

abstract：:The conserved Hippo kinase pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Whereas the function of the core kinase cascade, consisting of the serine/threonine kinases Hippo and Warts, in phosphorylating and thereby inactivating the transcri...

journal_title：Developmental cell

authors： Baumgartner R,Poernbacher I,Buser N,Hafen E,Stocker H

更新日期：2010-02-16 00:00:00

abstract：:IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote ...

journal_title：Developmental cell

authors： Hassler J,Cao SS,Kaufman RJ

更新日期：2012-11-13 00:00:00

abstract：:The noncoding Xist RNA triggers silencing of one of the two female X chromosomes during X inactivation in mammals. Gene silencing by Xist is restricted to a special developmental context in early embryos and specific hematopoietic precursors. Here, we show that Xist can initiate silencing in a lymphoma model. We ident...

journal_title：Developmental cell

authors： Agrelo R,Souabni A,Novatchkova M,Haslinger C,Leeb M,Komnenovic V,Kishimoto H,Gresh L,Kohwi-Shigematsu T,Kenner L,Wutz A

更新日期：2009-04-01 00:00:00

abstract：:Infectious, self-propagating protein aggregates (prions) as well as structurally related amyloid fibrils have traditionally been associated with neurodegenerative diseases in mammals. However, recent work in fungi indicates that prions are not simply aberrations of protein folding, but are in fact widespread, conserve...

journal_title：Developmental cell

authors： Osherovich LZ,Weissman JS

更新日期：2002-02-01 00:00:00

abstract：:Stem cell differentiation involves a delicate balance of gene expression and transposon repression. In this issue of Developmental Cell, Shibata et al. (2016) show that a PIWI protein expressed in planarian stem cells is inherited by their differentiating descendants to ensure regenerative capacity of the flatworm via...

journal_title：Developmental cell

authors： Tharp ME,Bortvin A

更新日期：2016-05-09 00:00:00

abstract：:All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated transgenic mice expressing a tamoxifen-inducible Ngn3 fusion protei...

journal_title：Developmental cell

authors： Johansson KA,Dursun U,Jordan N,Gu G,Beermann F,Gradwohl G,Grapin-Botton A

更新日期：2007-03-01 00:00:00

abstract：:Dynamin family members are large GTPases that assemble into multimeric spirals. These spirals promote membrane fission or fusion, or they inhibit processes such as viral replication. Two new studies by Chappie et al. and Gao et al. in a recent issue of Nature identify interactions between subunits of dynamin spirals, ...

journal_title：Developmental cell

authors： van der Bliek AM,Payne GS

更新日期：2010-05-18 00:00:00

abstract：:Trunk neural crest cells are generated at the border between the neural plate and nonneural ectoderm, where they initiate a distinct program of gene expression, undergo an epithelial-mesenchymal transition (EMT), and delaminate from the neuroepithelium. Here, we provide evidence that members of three families of trans...

journal_title：Developmental cell

authors： Cheung M,Chaboissier MC,Mynett A,Hirst E,Schedl A,Briscoe J

更新日期：2005-02-01 00:00:00

abstract：:One G protein-coupled receptor (GPCR) can activate more than one G protein, but the physiologic importance of such activation has not been demonstrated in vivo. We have generated mice expressing exclusively a mutant form of the PTH/PTHrP receptor (DSEL) that activates adenylyl cyclase normally but not phospholipase C ...

journal_title：Developmental cell

authors： Guo J,Chung UI,Kondo H,Bringhurst FR,Kronenberg HM

更新日期：2002-08-01 00:00:00

abstract：:The early midgut undergoes intensive elongation, but the underlying cellular and molecular mechanisms are unknown. The early midgut epithelium is pseudostratified, and its nuclei travel between apical and basal surfaces in concert with cell cycle. Using 3D confocal imaging and 2D live imaging, we profiled behaviors of...

journal_title：Developmental cell

authors： Wang S,Cebrian C,Schnell S,Gumucio DL

更新日期：2018-07-16 00:00:00

abstract：:The expression of autophagy and lysosomal genes is coordinated by the transcription factor EB (TFEB). In this issue of Developmental Cell, Chen et al. identify an evolutionary conserved mode of TFEB regulation, which entails the inhibition of TFEB phase separation in the nucleus by inositol polyphosphate multikinase. ...

journal_title：Developmental cell

authors： Ferrari L,Martens S

更新日期：2020-12-07 00:00:00

abstract：:Although the mechanisms underlying the spatial pattern formation of sensory maps have been extensively investigated, those triggering sensory map formation during development are largely unknown. Here we show that the birth of pups instructively and selectively regulates the initiation of barrel formation in the somat...

journal_title：Developmental cell

authors： Toda T,Homma D,Tokuoka H,Hayakawa I,Sugimoto Y,Ichinose H,Kawasaki H

更新日期：2013-10-14 00:00:00

abstract：:We have used Drosophila ovarian follicle stem cells (FSCs) to study how stem cells are regulated by external signals and draw three main conclusions. First, the spatial definition of supportive niche positions for FSCs depends on gradients of Hh and JAK-STAT pathway ligands, which emanate from opposite, distant sites....

journal_title：Developmental cell

authors： Vied C,Reilein A,Field NS,Kalderon D

更新日期：2012-10-16 00:00:00

abstract：:22q11 deletion (del22q11) syndrome is characterized genetically by heterozygous deletions within chromosome 22q11 and clinically by a constellation of congenital malformations of the aortic arch, heart, thymus, and parathyroid glands described as DiGeorge syndrome (DGS). Here, we report that compound heterozygosity of...

journal_title：Developmental cell

authors： Guris DL,Duester G,Papaioannou VE,Imamoto A

更新日期：2006-01-01 00:00:00

abstract：:Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation...

journal_title：Developmental cell

authors： Wang X,Kopinke D,Lin J,McPherson AD,Duncan RN,Otsuna H,Moro E,Hoshijima K,Grunwald DJ,Argenton F,Chien CB,Murtaugh LC,Dorsky RI

更新日期：2012-09-11 00:00:00