Abstract：
:Angiogenesis is responsible for tissue vascularization during development, as well as in pathological contexts, including cancer and ischemia. Vascular endothelial growth factors (VEGFs) regulate angiogenesis by acting through VEGF receptors to induce endothelial cell signaling. VEGF is processed in the extracellular matrix (ECM), but the complexity of ECM control of VEGF signaling and angiogenesis remains far from understood. In a forward genetic screen, we identified angiogenesis defects in tmem2 zebrafish mutants that lack both arterial and venous Vegf/Vegfr/Erk signaling. Strikingly, tmem2 mutants display increased hyaluronic acid (HA) surrounding developing vessels. Angiogenesis in tmem2 mutants was rescued, or restored after failed sprouting, by degrading this increased HA. Furthermore, oligomerized HA or overexpression of Vegfc rescued angiogenesis in tmem2 mutants. Based on these data, and the known structure of Tmem2, we find that Tmem2 regulates HA turnover to promote normal Vegf signaling during developmental angiogenesis.
journal_name
Dev Celljournal_title
Developmental cellauthors
De Angelis JE,Lagendijk AK,Chen H,Tromp A,Bower NI,Tunny KA,Brooks AJ,Bakkers J,Francois M,Yap AS,Simons C,Wicking C,Hogan BM,Smith KAdoi
10.1016/j.devcel.2016.12.017subject
Has Abstractpub_date
2017-01-23 00:00:00pages
123-136issue
2eissn
1534-5807issn
1878-1551pii
S1534-5807(16)30912-1journal_volume
40pub_type
评论,杂志文章abstract：:In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes an...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(02)00157-0
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abstract：:Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast...
journal_title：Developmental cell
pub_type： 杂志文章,评审
doi：10.1016/s1534-5807(01)00098-3
更新日期：2002-01-01 00:00:00
abstract：:Asymmetric cell divisions generate cellular diversity. In Drosophila, embryonic neuroblasts target cell fate determinants basally, rotate their spindles by 90 degrees to align with the apical-basal axis, and divide asymmetrically in a stem cell-like fashion. In this process, apically localized Bazooka recruits Inscute...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/s1534-5807(03)00020-0
更新日期：2003-02-01 00:00:00
abstract：:The conserved Hedgehog signaling pathway is essential for embryonic development and tissue homeostasis and is tightly regulated. In this issue of Developmental Cell, Ma et al. (2016) demonstrate that sumoylation works in parallel with phosphorylation to stabilize Smoothened, antagonizing its ubiquitination and subsequ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2016.11.001
更新日期：2016-11-21 00:00:00
abstract：:Boundary formation and epithelialization are crucial processes in the morphological segmentation of vertebrate somites. By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes. Fibronectin proteins accumulate at somite boundari...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2005.03.006
更新日期：2005-04-01 00:00:00
abstract：:It is intuitive to speculate that nutrient availability may influence differentiation of mammalian cells. Nonetheless, a comprehensive complement of the molecular determinants involved in this process has not been elucidated yet. Here, we have investigated how nutrients (glucose) affect skeletal myogenesis. Glucose re...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.02.004
更新日期：2008-05-01 00:00:00
abstract：:We developed a comprehensive dataset that samples the mouse transcriptome every 6 hr, from gastrulation through organogenesis. We observe an abrupt increase in overall transcript diversity at the onset of organogenesis (e8.0); the genes that comprise these changes are preferentially clustered along chromosome 7 and co...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.10.004
更新日期：2007-12-01 00:00:00
abstract：:Pontin and reptin are conserved AAA+ ATPases identified in chromatin-remodeling complexes. In a recent issue of Cell, Venteicher et al. provide new insight into the function of pontin and reptin in telomerase biogenesis, which is important for cellular senescence, aging, and cancer. These unexpected findings have impl...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2008.03.018
更新日期：2008-04-01 00:00:00
abstract：:Human centromeres are defined by alpha satellite DNA arrays that are distinct and chromosome specific. Most human chromosomes contain multiple alpha satellite arrays that are competent for centromere assembly. Here, we show that human centromeres are defined by chromosome-specific RNAs linked to underlying organizatio...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.07.001
更新日期：2017-08-07 00:00:00
abstract：:The blood brain barrier (BBB) is critical to ensure proper nervous system function and organismal health. In this issue of Developmental Cell, Babatz and colleagues explore the mechanisms of BBB maintenance and uncover a potential evolutionary link by which BBB glia construct paracellular barriers to ensure uninterrup...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.11.036
更新日期：2018-12-17 00:00:00
abstract：:In this issue of Developmental Cell, Gui et al. (2016) show that an abscisic acid-inducible remorin protein in rice directly interacts with critical brassinosteroid signaling components to attenuate the brassinosteroid response, thus illuminating one aspect of the brassinosteroid/abscisic acid antagonism. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2016.07.005
更新日期：2016-07-25 00:00:00
abstract：:Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited by the time required to generate stable mutant lines. We describe a system for gene knockout that consistently produces null phenotypes in G0 zebrafish. Yolk injection of sets of four CRISPR/Cas9 ribonucleoprotein complexes redu...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.06.003
更新日期：2018-07-02 00:00:00
abstract：:We use the Dpp morphogen gradient in the Drosophila wing disc as a model to address the fundamental question of how a gradient of a growth factor can produce uniform growth. We first show that proper expression and subcellular localization of components in the Fat tumor-suppressor pathway, which have been argued to de...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2010.11.007
更新日期：2011-01-18 00:00:00
abstract：:Orientation of cell division is a vital aspect of tissue morphogenesis and growth. Asymmetric divisions generate cell fate diversity and epithelial stratification, whereas symmetric divisions contribute to tissue growth, spreading, and elongation. Here, we describe a mechanism for positioning the spindle in symmetric ...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.01.002
更新日期：2012-04-17 00:00:00
abstract：:How metabolism is rewired during embryonic development is still largely unknown, as it remains a major technical challenge to resolve metabolic activities or metabolite levels with spatiotemporal resolution. Here, we investigated metabolic changes during development of organogenesis-stage mouse embryos, focusing on th...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2017.01.015
更新日期：2017-02-27 00:00:00
abstract：:The noncoding Xist RNA triggers silencing of one of the two female X chromosomes during X inactivation in mammals. Gene silencing by Xist is restricted to a special developmental context in early embryos and specific hematopoietic precursors. Here, we show that Xist can initiate silencing in a lymphoma model. We ident...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2009.03.006
更新日期：2009-04-01 00:00:00
abstract：:What coordinates the internal leading and trailing edges in collectively migrating cells is largely unknown. In this issue of Developmental Cell, Barlan et al. (2017) delineate a Fat2/Lar planar signaling pathway at the basal, motile cell-cell contacts of Drosophila egg chamber follicle cells. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2017.02.025
更新日期：2017-03-13 00:00:00
abstract：:Inherited mtDNA mutations cause severe human disease. In most species, mitochondria are inherited maternally through mechanisms that are poorly understood. Genes that specifically control the inheritance of mitochondria in the germline are unknown. Here, we show that the long isoform of the protein Oskar regulates the...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2016.11.004
更新日期：2016-12-05 00:00:00
abstract：:The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLA...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2018.05.011
更新日期：2018-06-04 00:00:00
abstract：:To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate with depolymerizing microtubules, which undergo dramatic structural changes forming curved protofilaments, has yet to b...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2012.09.012
更新日期：2012-11-13 00:00:00
abstract：:Two major functions of the epigenome are to regulate gene expression and to suppress transposons. It is unclear how these functions are balanced during physiological challenges requiring tissue regeneration, where exquisite coordination of gene expression is essential. Transcriptomic analysis of seven time points foll...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2019.05.034
更新日期：2019-07-01 00:00:00
abstract：:Signaling circuits often coordinate cellular membranes and actin filaments at distinct sites to direct cell behavior. In this issue of Developmental Cell, Bershteyn et al. outline how the molecular scaffold protein, MIM, which bends membranes and binds actin filaments, is at the middle of one such circuit to regulate ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2010.07.021
更新日期：2010-08-17 00:00:00
abstract：:In this issue of Developmental Cell, Tang et al. (2018) and Li et al. (2018) combine genetic manipulation, mechanical perturbation, and live imaging to show how mechanical forces and local growth factors intersect to influence epithelial behavior and cell fate specification within the developing lung. ...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2018.01.015
更新日期：2018-02-05 00:00:00
abstract：:The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms driving initiation of this specialized process are largely undefined. In this issue of Developmental Cell,Ishiguro et al. (2020) identified the transcription factor MEIOSIN as a gatekeeper of meiotic initiation in both male and female germ c...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2020.02.002
更新日期：2020-02-24 00:00:00
abstract：:MicroRNAs are abundant in animal genomes, yet little is known about their functions in vivo. Here, we report the production of 80 new Drosophila miRNA mutants by targeted homologous recombination. These mutants remove 104 miRNAs. Together with 15 previously reported mutants, this collection includes 95 mutants deletin...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2014.11.029
更新日期：2014-12-22 00:00:00
abstract：:Adult neurogenic niches are present in both vertebrates and invertebrates. Where do stem cells populating these niches originate, and what are the mechanisms maintaining their self-renewal? In this issue of Developmental Cell, Benton et al. (2014) show that in crayfish, hemolymph-derived cells enter a neurogenic niche...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2014.07.024
更新日期：2014-08-11 00:00:00
abstract：:Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al.(2007) present evidence to indicate that Chk1 als...
journal_title：Developmental cell
pub_type： 评论,杂志文章
doi：10.1016/j.devcel.2007.01.005
更新日期：2007-02-01 00:00:00
abstract：:The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia. Here we demonstrate an unexpected mechanism of Dyn2 action in these contexts via direct binding to the Rac1 guanine nucleotide exch...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2013.02.010
更新日期：2013-03-25 00:00:00
abstract：:The developmental mechanisms that orchestrate differentiation of specific nephron segments are incompletely understood, and the factors that maintain their terminal differentiation after nephrogenesis remain largely unknown. Here, the transcription factor AP-2β is shown to be required for the differentiation of distal...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2020.05.026
更新日期：2020-08-10 00:00:00
abstract：:Metazoans express three unfolded protein response transducers (IRE1, PERK, and ATF6) ubiquitously to cope with endoplasmic reticulum (ER) stress. ATF6 is an ER membrane-bound transcription factor activated by ER stress-induced proteolysis and has been duplicated in mammals. Here, we generated ATF6alpha- and ATF6beta-k...
journal_title：Developmental cell
pub_type： 杂志文章
doi：10.1016/j.devcel.2007.07.018
更新日期：2007-09-01 00:00:00
